ATE236881T1 - Durch strahlung aktivierte cytotoxin therapie - Google Patents
Durch strahlung aktivierte cytotoxin therapieInfo
- Publication number
- ATE236881T1 ATE236881T1 AT96927219T AT96927219T ATE236881T1 AT E236881 T1 ATE236881 T1 AT E236881T1 AT 96927219 T AT96927219 T AT 96927219T AT 96927219 T AT96927219 T AT 96927219T AT E236881 T1 ATE236881 T1 AT E236881T1
- Authority
- AT
- Austria
- Prior art keywords
- tumour cells
- radiation
- racp
- prodrug
- effector
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
- C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
- C07C225/32—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by at least three rings
- C07C225/34—Amino anthraquinones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Radiation-Therapy Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ27281595 | 1995-08-18 | ||
| PCT/NZ1996/000085 WO1997007101A1 (en) | 1995-08-18 | 1996-08-19 | Radiation-activated cytotoxin therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE236881T1 true ATE236881T1 (de) | 2003-04-15 |
Family
ID=19925392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96927219T ATE236881T1 (de) | 1995-08-18 | 1996-08-19 | Durch strahlung aktivierte cytotoxin therapie |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6071908A (de) |
| EP (2) | EP0850224B1 (de) |
| JP (1) | JP2000502988A (de) |
| AT (1) | ATE236881T1 (de) |
| AU (1) | AU722191B2 (de) |
| CA (1) | CA2229460A1 (de) |
| DE (1) | DE69627355T2 (de) |
| ES (1) | ES2196165T3 (de) |
| WO (1) | WO1997007101A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1465882B1 (de) | 2001-12-21 | 2011-08-24 | X-Ceptor Therapeutics, Inc. | Heterocyclische modulatoren von nukleären rezeptoren |
| RU2011141121A (ru) | 2009-03-11 | 2013-04-20 | Окленд Юнисервисиз Лимитед | Пролекарственные формы ингибиторов киназ и их применение в терапии |
| BR112012004720B1 (pt) * | 2009-09-02 | 2021-06-29 | Auckland Uniservices Limited | Inibidores de cinase, seus usos, profármaco e composição farmacêutica que o compreende |
| US20140271453A1 (en) | 2013-03-14 | 2014-09-18 | Abbott Laboratories | Methods for the early detection of lung cancer |
| CN113101372B (zh) * | 2019-12-24 | 2025-02-14 | 北京大学 | 具有辐射响应基团的缀合物及其用途 |
| CN120899945A (zh) * | 2025-10-11 | 2025-11-07 | 浙江大学 | 一种基于有机-无机动态组装的肿瘤靶向诊疗一体化系统及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4296030A (en) * | 1980-04-09 | 1981-10-20 | American Cyanamid Company | Metal chelates of 1,4-bis(substituted-amino-5,8-dihydroxy-anthraquinones |
| NZ201084A (en) * | 1982-06-25 | 1985-10-11 | New Zealand Dev Finance | 4-carboxamidoacridine derivatives and pharmaceutical compositions containing such |
-
1996
- 1996-08-19 AT AT96927219T patent/ATE236881T1/de not_active IP Right Cessation
- 1996-08-19 AU AU67111/96A patent/AU722191B2/en not_active Ceased
- 1996-08-19 JP JP9509188A patent/JP2000502988A/ja not_active Ceased
- 1996-08-19 EP EP96927219A patent/EP0850224B1/de not_active Expired - Lifetime
- 1996-08-19 WO PCT/NZ1996/000085 patent/WO1997007101A1/en not_active Ceased
- 1996-08-19 EP EP02009140A patent/EP1225169A1/de not_active Withdrawn
- 1996-08-19 CA CA002229460A patent/CA2229460A1/en not_active Abandoned
- 1996-08-19 ES ES96927219T patent/ES2196165T3/es not_active Expired - Lifetime
- 1996-08-19 US US09/011,528 patent/US6071908A/en not_active Expired - Fee Related
- 1996-08-19 DE DE69627355T patent/DE69627355T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1225169A1 (de) | 2002-07-24 |
| ES2196165T3 (es) | 2003-12-16 |
| EP0850224B1 (de) | 2003-04-09 |
| DE69627355D1 (de) | 2003-05-15 |
| AU722191B2 (en) | 2000-07-27 |
| US6071908A (en) | 2000-06-06 |
| AU6711196A (en) | 1997-03-12 |
| EP0850224A1 (de) | 1998-07-01 |
| WO1997007101A1 (en) | 1997-02-27 |
| DE69627355T2 (de) | 2004-02-12 |
| CA2229460A1 (en) | 1997-02-27 |
| JP2000502988A (ja) | 2000-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |