ATE236918T1 - Aromatische amide, ihrer verfahren zur herstellung ung verwendung als arzneimitteln - Google Patents

Aromatische amide, ihrer verfahren zur herstellung ung verwendung als arzneimitteln

Info

Publication number
ATE236918T1
ATE236918T1 AT99900500T AT99900500T ATE236918T1 AT E236918 T1 ATE236918 T1 AT E236918T1 AT 99900500 T AT99900500 T AT 99900500T AT 99900500 T AT99900500 T AT 99900500T AT E236918 T1 ATE236918 T1 AT E236918T1
Authority
AT
Austria
Prior art keywords
production
medicinal products
aromatic amides
amides
aromatic
Prior art date
Application number
AT99900500T
Other languages
English (en)
Inventor
Jean-Luc Haesslein
Michel Klich
Patrick Laurin
Branislav Musicki
Anne-Marie Periers
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9800116A external-priority patent/FR2773369B1/fr
Priority claimed from FR9812936A external-priority patent/FR2784681B1/fr
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE236918T1 publication Critical patent/ATE236918T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/075—Benzo[b]pyran-2-ones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT99900500T 1998-01-08 1999-01-07 Aromatische amide, ihrer verfahren zur herstellung ung verwendung als arzneimitteln ATE236918T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9800116A FR2773369B1 (fr) 1998-01-08 1998-01-08 Nouveaux amides aromatiques, leur procede de preparation et leur application comme medicaments
FR9812936A FR2784681B1 (fr) 1998-10-15 1998-10-15 Nouveaux amides aromatiques, leur procede de preparation et leur application comme medicaments
PCT/FR1999/000014 WO1999035155A1 (fr) 1998-01-08 1999-01-07 Nouveaux amides aromatiques, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number Publication Date
ATE236918T1 true ATE236918T1 (de) 2003-04-15

Family

ID=26234055

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99900500T ATE236918T1 (de) 1998-01-08 1999-01-07 Aromatische amide, ihrer verfahren zur herstellung ung verwendung als arzneimitteln

Country Status (36)

Country Link
US (2) US6420538B1 (de)
EP (1) EP1045856B1 (de)
JP (1) JP2002500229A (de)
KR (1) KR100604290B1 (de)
CN (2) CN1269833C (de)
AP (1) AP2000001857A0 (de)
AR (1) AR015211A1 (de)
AT (1) ATE236918T1 (de)
AU (1) AU750742B2 (de)
BR (1) BR9906819A (de)
CA (1) CA2317951A1 (de)
CO (1) CO4810298A1 (de)
CZ (1) CZ299840B6 (de)
DE (1) DE69906684T2 (de)
DK (1) DK1045856T3 (de)
DZ (1) DZ2702A1 (de)
EA (1) EA003275B1 (de)
ES (1) ES2192031T3 (de)
HU (1) HUP0100847A3 (de)
ID (1) ID27558A (de)
IL (1) IL137201A0 (de)
MA (1) MA26593A1 (de)
NO (1) NO20003496L (de)
NZ (1) NZ505523A (de)
PA (1) PA8466601A1 (de)
PE (1) PE20000175A1 (de)
PL (1) PL193130B1 (de)
PT (1) PT1045856E (de)
RS (1) RS50047B (de)
SA (1) SA99191247B1 (de)
SI (1) SI1045856T1 (de)
SK (1) SK284734B6 (de)
TN (1) TNSN99003A1 (de)
TR (1) TR200002009T2 (de)
TW (1) TW538046B (de)
WO (1) WO1999035155A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2749585B1 (fr) * 1996-06-11 1998-08-14 Hoechst Marion Roussel Inc Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments
TW538046B (en) * 1998-01-08 2003-06-21 Hoechst Marion Roussel Inc Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof
US6916846B2 (en) 2000-05-12 2005-07-12 Merck & Co. Inc. Coumermycin analogs as chemical dimerizers of chimeric proteins
PL362691A1 (en) * 2000-12-15 2004-11-02 Vertex Pharmaceuticals Incorporated Bacterial gyrase inhibitors and uses thereof
FR2844273B1 (fr) * 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
US7569591B2 (en) 2003-01-31 2009-08-04 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
AR042956A1 (es) 2003-01-31 2005-07-13 Vertex Pharma Inhibidores de girasa y usos de los mismos
US8193352B2 (en) 2003-01-31 2012-06-05 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8404852B2 (en) 2003-01-31 2013-03-26 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7618974B2 (en) 2003-01-31 2009-11-17 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7582641B2 (en) 2003-01-31 2009-09-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8071605B2 (en) 2008-12-12 2011-12-06 Astrazeneca Ab Piperidine compounds for use in the treatment of bacterial infections
TW201026694A (en) 2008-12-12 2010-07-16 Astrazeneca Ab Compound 468
TW201102065A (en) 2009-05-29 2011-01-16 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof
AR077971A1 (es) 2009-08-26 2011-10-05 Astrazeneca Ab Derivados heterociclicos de urea y metodos de uso de los mismos
US8859620B2 (en) 2009-08-31 2014-10-14 University Of Notre Dame Du Lac Phthalanilate compounds and methods of use
US8481552B2 (en) 2011-01-14 2013-07-09 Vertex Pharmaceuticals Incorporated Solid forms of gyrase inhibitor (R)-1-ethyl-3-[5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-YL]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-YL]urea
MX341342B (es) 2011-01-14 2016-08-17 Vertex Pharma Formas solidas del inhibidor de girasa (r)-1-etil-3-[6-fluoro-5-[2 -(1-hidroxi-1-metil-etil) pirimidin-5-il]-7-(tetrahidrofuran-2-il) -1h-benzimidazol-2-il]urea.
JP6085829B2 (ja) 2011-01-14 2017-03-01 スペロ トリネム， インコーポレイテッド ピリミジンジャイレースおよびトポイソメラーゼｉｖ阻害剤
KR101882172B1 (ko) 2011-01-14 2018-07-26 스페로 트리넴, 인코포레이티드 자이라제 및 토포이소머라제 ⅳ 억제제의 제조방법
ES2576298T3 (es) 2011-06-20 2016-07-06 Vertex Pharmaceuticals Incorporated Ésteres de fosfato de inhibidores de girasa y topoisomerasa
US9018216B2 (en) 2012-07-18 2015-04-28 Vertex Pharmaceuticals Incorporated Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof
US9572809B2 (en) 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases
EP3847172A1 (de) 2018-09-03 2021-07-14 Univerza v Ljubljani Neue klasse von dna-gyrase- und/oder topoisomerase-iv-inhibitoren mit aktivität gegen grampositive und gramnegative bakterien
EP4263503A1 (de) 2020-12-17 2023-10-25 Univerza V Ljubljani Neue n-phenylpyrrolamid-inhibitoren der dna-gyrase und topoisomerase iv mit antibakterieller wirkung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226978A (en) * 1978-03-13 1980-10-07 Miles Laboratories, Inc. β-Galactosyl-umbelliferone-labeled aminoglycoside antibiotics and intermediates in their preparation
EA002271B1 (ru) 1996-03-20 2002-02-28 Хехст Марион Руссель ТРИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ, ОБЛАДАЮЩИЕ АКТИВНОСТЬЮ В ОТНОШЕНИИ ИНТЕГРИНОВ, В ЧАСТНОСТИ В ОТНОШЕНИИ ИНТЕГРИНА АЛЬФАvБЕТА 3, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ, ИСПОЛЬЗУЕМЫЕ В ЭТОМ СПОСОБЕ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ МЕДИКАМЕНТОВ И СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ
FR2749585B1 (fr) * 1996-06-11 1998-08-14 Hoechst Marion Roussel Inc Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments
TW538046B (en) * 1998-01-08 2003-06-21 Hoechst Marion Roussel Inc Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof

Also Published As

Publication number Publication date
US6420538B1 (en) 2002-07-16
US6583119B2 (en) 2003-06-24
WO1999035155A1 (fr) 1999-07-15
AU750742B2 (en) 2002-07-25
MA26593A1 (fr) 2004-12-20
EP1045856B1 (de) 2003-04-09
ID27558A (id) 2001-04-12
BR9906819A (pt) 2000-10-17
SA99191247B1 (ar) 2006-09-20
HUP0100847A1 (hu) 2001-07-30
IL137201A0 (en) 2001-07-24
KR20010033939A (ko) 2001-04-25
PE20000175A1 (es) 2000-03-09
EA003275B1 (ru) 2003-04-24
DZ2702A1 (fr) 2003-09-01
CZ20002523A3 (cs) 2000-11-15
DE69906684T2 (de) 2003-11-06
CN1291988A (zh) 2001-04-18
NZ505523A (en) 2003-01-31
CN1269833C (zh) 2006-08-16
DK1045856T3 (da) 2003-07-21
PL341590A1 (en) 2001-04-23
SK284734B6 (sk) 2005-10-06
NO20003496D0 (no) 2000-07-07
HUP0100847A3 (en) 2003-07-28
KR100604290B1 (ko) 2006-07-28
CZ299840B6 (cs) 2008-12-10
CA2317951A1 (fr) 1999-07-15
TR200002009T2 (tr) 2001-05-21
NO20003496L (no) 2000-09-08
RS50047B (sr) 2008-11-28
PT1045856E (pt) 2003-08-29
CN1257164C (zh) 2006-05-24
PA8466601A1 (es) 2000-05-24
EA200000749A1 (ru) 2000-12-25
ES2192031T3 (es) 2003-09-16
SK10152000A3 (sk) 2001-07-10
YU42700A (sh) 2002-12-10
EP1045856A1 (de) 2000-10-25
TW538046B (en) 2003-06-21
AR015211A1 (es) 2001-04-18
CN1502617A (zh) 2004-06-09
JP2002500229A (ja) 2002-01-08
US20030060609A1 (en) 2003-03-27
SI1045856T1 (en) 2003-08-31
AP2000001857A0 (en) 2000-09-30
DE69906684D1 (de) 2003-05-15
CO4810298A1 (es) 1999-06-30
TNSN99003A1 (fr) 2005-11-10
AU1973699A (en) 1999-07-26
PL193130B1 (pl) 2007-01-31

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