ATE236919T1 - Vefahren zur herstellung von erythrmycinderivate - Google Patents

Vefahren zur herstellung von erythrmycinderivate

Info

Publication number: ATE236919T1
Authority: AT; Austria
Prior art keywords: sup; hydrogen; hydroxy; polar aprotic; erythrmycin
Prior art date: 1995-11-21

Application number

AT96936904T

Other languages

English (en)

Inventor

Jih-Hua Liu

George A Foster Jr

Stephen H Montgomery

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-21

Filing date

1996-10-25

Publication date

2003-04-15

1996-10-25 Application filed by Abbott Lab filed Critical Abbott Lab

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE236919T1 publication Critical patent/ATE236919T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
239000001257 hydrogen Substances 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
239000002585 base Substances 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 2
239000003880 polar aprotic solvent Substances 0.000 abstract 2
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
230000002152 alkylating effect Effects 0.000 abstract 1
230000029936 alkylation Effects 0.000 abstract 1
238000005804 alkylation reaction Methods 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
150000002923 oximes Chemical class 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT96936904T 1995-11-21 1996-10-25 Vefahren zur herstellung von erythrmycinderivate ATE236919T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/560,752 US5872229A (en)	1995-11-21	1995-11-21	Process for 6-O-alkylation of erythromycin derivatives
PCT/US1996/017017 WO1997019096A2 (en)	1995-11-21	1996-10-25	Process for 6-o-alkylation of erythromycin derivatives

Publications (1)

Publication Number	Publication Date
ATE236919T1 true ATE236919T1 (de)	2003-04-15

Family

ID=24239215

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96936904T ATE236919T1 (de)	1995-11-21	1996-10-25	Vefahren zur herstellung von erythrmycinderivate

Country Status (11)

Country	Link
US (2)	US5872229A (de)
EP (1)	EP0874862B1 (de)
JP (2)	JP2000500488A (de)
AT (1)	ATE236919T1 (de)
CA (1)	CA2237470C (de)
DE (1)	DE69627381T2 (de)
DK (1)	DK0874862T3 (de)
ES (1)	ES2196184T3 (de)
MX (1)	MX9804047A (de)
PT (1)	PT874862E (de)
WO (1)	WO1997019096A2 (de)

Families Citing this family (35)

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DE69730138T2 (de)	1996-07-29	2005-03-03	Abbott Laboratories, Abbott Park	Herstellung von kristallinen form ii von clarithromycin
US5858986A (en) *	1996-07-29	1999-01-12	Abbott Laboratories	Crystal form I of clarithromycin
US5844105A (en) *	1996-07-29	1998-12-01	Abbott Laboratories	Preparation of crystal form II of clarithromycin
US5945405A (en)	1997-01-17	1999-08-31	Abbott Laboratories	Crystal form O of clarithromycin
US5892008A (en) *	1997-12-16	1999-04-06	Abbott Laboratories	Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives
KR100317907B1 (ko) *	1998-11-24	2001-12-24	김 완 주	신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
US6437106B1 (en)	1999-06-24	2002-08-20	Abbott Laboratories	Process for preparing 6-o-substituted erythromycin derivatives
KR100336447B1 (ko) *	1999-11-24	2002-05-15	민경윤	클라리스로마이신의 개선된 제조방법
US6627743B1 (en)	1999-12-03	2003-09-30	Abbott Laboratories	6-O-methylerythromycin A crystal form III
WO2001044262A1 (en)	1999-12-16	2001-06-21	Teva Pharmaceutical Industries Ltd.	Processes for preparing clarithromycin polymorphs and novel polymorph iv
AU2261901A (en)	2000-01-11	2001-07-24	Teva Pharma	Processes for preparing clarithromycin polymorphs
US6544555B2 (en) *	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
US6565882B2 (en) *	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
KR20030047873A (ko) *	2000-02-29	2003-06-18	테바 파마슈티컬 인더스트리즈 리미티드	클라리트로마이신 및 클라리트로마이신 중간체의 제조방법, 실질적으로는 옥심이 제거된 클라리트로마이신 및이를 포함하는 약학적 조성물
RU2230748C2 (ru) *	2000-03-15	2004-06-20	Ханми Фарм. Ко., Лтд.	Способ получения кларитромицина в виде кристаллов формы ii
KR20000037126A (ko) *	2000-04-08	2000-07-05	김용규	6-메틸 에리스로마이신 ａ의 제조방법
US6541014B2 (en) *	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
US20020068078A1 (en) *	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
US6455680B1 (en)	2000-12-21	2002-09-24	Abbott Laboratories	Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
US20020197314A1 (en) *	2001-02-23	2002-12-26	Rudnic Edward M.	Anti-fungal composition
TWI246515B (en)	2001-05-30	2006-01-01	Abbott Lab	An arylation method for the functionalization of O-allyl erythromycin derivatives
US7435805B2 (en)	2003-05-30	2008-10-14	Glaxpsmithkline Istrazivacki	O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
AU2004258949B2 (en) *	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
JP2006528185A (ja) *	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
AU2004258953B2 (en) *	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
CA2535177A1 (en) *	2003-08-11	2005-02-24	Advancis Pharmaceutical Corporation	Robust pellet
US8062672B2 (en) *	2003-08-12	2011-11-22	Shionogi Inc.	Antibiotic product, use and formulation thereof
AU2004270170B2 (en) *	2003-08-29	2011-01-27	Shionogi, Inc.	Antibiotic product, use and formulation thereof
CA2538064C (en) *	2003-09-15	2013-12-17	Advancis Pharmaceutical Corporation	Antibiotic product, use and formulation thereof
AU2004308419B2 (en) *	2003-12-24	2011-06-02	Victory Pharma, Inc.	Enhanced absorption of modified release dosage forms
CA2572292A1 (en) *	2004-07-02	2006-02-09	Advancis Pharmaceutical Corporation	Tablet for pulsed delivery
US8778924B2 (en) *	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
US8299052B2 (en)	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
US20090054634A1 (en) *	2007-08-09	2009-02-26	Vinod Kumar Kansal	Process for the preparation of clarithromycin

Family Cites Families (25)

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Publication number	Priority date	Publication date	Assignee	Title
US3869444A (en)	1972-10-10	1975-03-04	Abbott Lab	Esters of erythromycin oxime
FR2473525A1 (fr)	1980-01-11	1981-07-17	Roussel Uclaf	Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4331803A (en)	1980-06-04	1982-05-25	Taisho Pharmaceutical Co., Ltd.	Novel erythromycin compounds
US4336368A (en)	1981-04-20	1982-06-22	Pfizer Inc.	4 Deoxy-4-methylene oleandomycin and derivatives thereof
JPS5896095A (ja)	1981-11-30	1983-06-07	Taisho Pharmaceut Co Ltd	１１−ｏ−アルキルエリスロマイシンａ誘導体
JPS5896097A (ja)	1981-12-01	1983-06-07	Taisho Pharmaceut Co Ltd	エリスロマイシンｂ誘導体
JPS5896098A (ja)	1981-12-03	1983-06-07	Taisho Pharmaceut Co Ltd	エリスロマイシンａ誘導体
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JPS60120895A (ja) *	1983-12-02	1985-06-28	Taisho Pharmaceut Co Ltd	６−０−メチル−２′−０，ν−ビス（ベンジルオキシカルボニル）−ν−デメチルエリスロマイシンａの製法
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US4670549A (en)	1985-03-18	1987-06-02	Taisho Pharmaceutical Co., Ltd.	Method for selective methylation of erythromycin a derivatives
JPS61229895A (ja)	1985-04-03	1986-10-14	Nippon Zeon Co Ltd	保護化デス−ｎ−メチルエリスロマイシン誘導体
US4640910A (en)	1985-11-12	1987-02-03	Abbott Laboratories	Erythromycin A silylated compounds and method of use
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JPH0764867B2 (ja) *	1986-09-18	1995-07-12	大正製薬株式会社	６−ｏ−メチルエリスロマイシンａ誘導体およびその製造方法
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JP2526951B2 (ja) *	1986-12-17	1996-08-21	大正製薬株式会社	エリスロマイシンａ誘導体およびその製造方法
KR960000434B1 (ko) *	1986-12-17	1996-01-06	다이쇼 세이야꾸 가부시끼가이샤	에리스로마이신 a유도체 및 그의 제조 방법
JP2751385B2 (ja)	1988-05-19	1998-05-18	大正製薬株式会社	エリスロマイシンａオキシム及びその塩の製造方法
JP2782793B2 (ja) *	1988-06-15	1998-08-06	大正製薬株式会社	エリスロマイシンａ誘導体およびその製造方法
US5302705A (en)	1989-10-07	1994-04-12	Taisho Pharmaceutical Co., Ltd.	6-O-methylerythromycin a oxime derivatives

1995
- 1995-11-21 US US08/560,752 patent/US5872229A/en not_active Ceased
1996
- 1996-10-25 DK DK96936904T patent/DK0874862T3/da active
- 1996-10-25 DE DE69627381T patent/DE69627381T2/de not_active Expired - Fee Related
- 1996-10-25 AT AT96936904T patent/ATE236919T1/de not_active IP Right Cessation
- 1996-10-25 JP JP9519720A patent/JP2000500488A/ja not_active Ceased
- 1996-10-25 WO PCT/US1996/017017 patent/WO1997019096A2/en not_active Ceased
- 1996-10-25 ES ES96936904T patent/ES2196184T3/es not_active Expired - Lifetime
- 1996-10-25 EP EP96936904A patent/EP0874862B1/de not_active Expired - Lifetime
- 1996-10-25 CA CA002237470A patent/CA2237470C/en not_active Expired - Fee Related
- 1996-10-25 PT PT96936904T patent/PT874862E/pt unknown
1998
- 1998-05-21 MX MX9804047A patent/MX9804047A/es not_active IP Right Cessation
2004
- 2004-03-22 US US10/806,089 patent/USRE39383E1/en not_active Expired - Lifetime
2007
- 2007-10-24 JP JP2007275992A patent/JP2008110976A/ja active Pending

Also Published As

Publication number	Publication date
MX9804047A (es)	1998-09-30
ES2196184T3 (es)	2003-12-16
EP0874862A2 (de)	1998-11-04
WO1997019096A2 (en)	1997-05-29
DK0874862T3 (da)	2003-07-28
PT874862E (pt)	2003-08-29
CA2237470C (en)	2005-01-18
WO1997019096A3 (en)	1997-07-03
JP2008110976A (ja)	2008-05-15
CA2237470A1 (en)	1997-05-29
DE69627381D1 (de)	2003-05-15
USRE39383E1 (en)	2006-11-07
US5872229A (en)	1999-02-16
JP2000500488A (ja)	2000-01-18
EP0874862B1 (de)	2003-04-09
DE69627381T2 (de)	2004-03-25

Legal Events

Date

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Title

Description

2003-11-15

UEP

Publication of translation of european patent specification

Ref document number: 0874862

Country of ref document: EP

2010-07-15

REN

Ceased due to non-payment of the annual fee

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ATE236919T1 (de)	2003-04-15	Vefahren zur herstellung von erythrmycinderivate
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BR0016506A (pt)	2002-08-27	Processo para preparar e isolar a 9-deoxo-9(z)-hidroxiiminoeritromicina a
ES8107190A1 (es)	1981-10-01	Un procedimiento para la preparacion de w-lactamas que con- tienen 5 a 14 atomos de carbono
GR3021336T3 (en)	1997-01-31	New process for the preparation of 20-oxo, 17-alpha, 21-dihydroxy derivatives of pregnane and new intermediates thereof.
HUP0000144A2 (hu)	2000-06-28	Eljárás hidroxi-heteroaromás vegyületek aril-aminokká való átalakítására
ES8304955A1 (es)	1983-04-16	"metodo para la produccion continua, semicontinua o intermitente de derivados oxadiazolidinicos".
KR940007004A (ko)	1994-04-26	4-메톡시벤질-1, 2, 3, 4, 5, 6, 7, 8- 옥타히드로이소퀴놀린의 제조방법
KR880007437A (ko)	1988-08-27	카르복실산 아미드의 제조 방법