ES2196184T3 - Proceso para la 6-o-alquilacion de derivados de eritromicina. - Google Patents

Proceso para la 6-o-alquilacion de derivados de eritromicina.

Info

Publication number
ES2196184T3
ES2196184T3 ES96936904T ES96936904T ES2196184T3 ES 2196184 T3 ES2196184 T3 ES 2196184T3 ES 96936904 T ES96936904 T ES 96936904T ES 96936904 T ES96936904 T ES 96936904T ES 2196184 T3 ES2196184 T3 ES 2196184T3
Authority
ES
Spain
Prior art keywords
sup
hydrogen
hydroxy
polar aprotic
rental
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96936904T
Other languages
English (en)
Inventor
Jih-Hua Liu
George A Foster Jr
Stephen H Montgomery
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2196184T3 publication Critical patent/ES2196184T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR COMPUESTOS 6 - O - ALQUIL ERITROMICINA CON FORMULA (I), EN DONDE R 1 ES UN ALQUILO INFERIOR, R 2 Y R 3 SON, INDEPENDIENTEMENTE UNO DE OTRO, SON HIDROGENO O UN GRUPO PROTECTOR DEL HIDROXI, EXCEPTO QUE R 2 Y R 3 NO PUEDEN SER SIMULTANEAMENTE HIDROGENO; Y ES OXIGENO O UNA OXIMA ESPECIFICAMENTE SUSTITUIDA; Y Z ES HIDROGENO, HIDROXI O GRUPO DE PROTECCION DEL HIDROXI; SE OBTIENEN POR REACCION DEL COMPUESTO, EN DONDE R 1 ES HIDROGENO CON UN ALQUILANTE, EN PRESENCIA DE UNA BASE FUERTE DE METAL ALCALINO Y TAMBIEN EN PRESENCIA DE UNA BASE DEBIL DE AMINA ORGANICA, EN UN DISOLVENTE POLAR, APROTICO Y APROPIADO CON MOVIMIENTO O AGITACION, O EN UNA MEZCLA DE TALES DISOLVENTES POLARES Y APROTICOS MANTENIDA A UNA TEMPERATURA DE REACCION Y DURANTE UN PERIODO DE TIEMPO SUFICIENTE PARA EFECTUAR LA ALQUILACION.
ES96936904T 1995-11-21 1996-10-25 Proceso para la 6-o-alquilacion de derivados de eritromicina. Expired - Lifetime ES2196184T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/560,752 US5872229A (en) 1995-11-21 1995-11-21 Process for 6-O-alkylation of erythromycin derivatives

Publications (1)

Publication Number Publication Date
ES2196184T3 true ES2196184T3 (es) 2003-12-16

Family

ID=24239215

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96936904T Expired - Lifetime ES2196184T3 (es) 1995-11-21 1996-10-25 Proceso para la 6-o-alquilacion de derivados de eritromicina.

Country Status (11)

Country Link
US (2) US5872229A (es)
EP (1) EP0874862B1 (es)
JP (2) JP2000500488A (es)
AT (1) ATE236919T1 (es)
CA (1) CA2237470C (es)
DE (1) DE69627381T2 (es)
DK (1) DK0874862T3 (es)
ES (1) ES2196184T3 (es)
MX (1) MX9804047A (es)
PT (1) PT874862E (es)
WO (1) WO1997019096A2 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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PT915899E (pt) * 1996-07-29 2004-11-30 Abbott Lab Preparacao da forma cristalina ii da eritromicina
US5858986A (en) * 1996-07-29 1999-01-12 Abbott Laboratories Crystal form I of clarithromycin
US5844105A (en) * 1996-07-29 1998-12-01 Abbott Laboratories Preparation of crystal form II of clarithromycin
US5945405A (en) 1997-01-17 1999-08-31 Abbott Laboratories Crystal form O of clarithromycin
US5892008A (en) * 1997-12-16 1999-04-06 Abbott Laboratories Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives
KR100317907B1 (ko) * 1998-11-24 2001-12-24 김 완 주 신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
KR100336447B1 (ko) * 1999-11-24 2002-05-15 민경윤 클라리스로마이신의 개선된 제조방법
US6627743B1 (en) 1999-12-03 2003-09-30 Abbott Laboratories 6-O-methylerythromycin A crystal form III
PT1254146E (pt) * 1999-12-16 2005-10-31 Teva Pharma Processos de preparacao de polimeros de claritromicina e novo polimorfo iv
PL356645A1 (en) * 2000-01-11 2004-06-28 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin polymorphs
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
AU2578701A (en) 2000-02-29 2001-09-12 Teva Pharma Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
CN1193036C (zh) * 2000-03-15 2005-03-16 韩美药品工业株式会社 制备甲红霉素－克拉霉素ⅱ型晶体的方法
KR20000037126A (ko) * 2000-04-08 2000-07-05 김용규 6-메틸 에리스로마이신 ａ의 제조방법
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US6455680B1 (en) 2000-12-21 2002-09-24 Abbott Laboratories Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
TWI246515B (en) 2001-05-30 2006-01-01 Abbott Lab An arylation method for the functionalization of O-allyl erythromycin derivatives
US7435805B2 (en) 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
CA2533292C (en) * 2003-07-21 2013-12-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
EP1648418A4 (en) * 2003-07-21 2011-11-16 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
EP1648415A4 (en) * 2003-07-21 2011-11-16 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
WO2005016311A1 (en) * 2003-08-11 2005-02-24 Advancis Pharmaceutical Corporation Robust pellet
CA2535398C (en) * 2003-08-12 2013-11-12 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
EP1658034A4 (en) * 2003-08-29 2011-06-22 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
WO2005027877A1 (en) * 2003-09-15 2005-03-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
AU2004308419B2 (en) * 2003-12-24 2011-06-02 Victory Pharma, Inc. Enhanced absorption of modified release dosage forms
US8715727B2 (en) * 2004-07-02 2014-05-06 Shionogi Inc. Tablet for pulsed delivery
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
US20090054634A1 (en) * 2007-08-09 2009-02-26 Vinod Kumar Kansal Process for the preparation of clarithromycin
CN117659108A (zh) * 2023-12-06 2024-03-08 江苏威奇达药业有限公司 一种连续流反应制备克拉霉素中间体的方法

Family Cites Families (25)

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Publication number Priority date Publication date Assignee Title
US3869444A (en) 1972-10-10 1975-03-04 Abbott Lab Esters of erythromycin oxime
FR2473525A1 (fr) 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
US4336368A (en) 1981-04-20 1982-06-22 Pfizer Inc. 4 Deoxy-4-methylene oleandomycin and derivatives thereof
JPS5896095A (ja) 1981-11-30 1983-06-07 Taisho Pharmaceut Co Ltd １１−ｏ−アルキルエリスロマイシンａ誘導体
JPS5896097A (ja) 1981-12-01 1983-06-07 Taisho Pharmaceut Co Ltd エリスロマイシンｂ誘導体
JPS5896098A (ja) 1981-12-03 1983-06-07 Taisho Pharmaceut Co Ltd エリスロマイシンａ誘導体
US4526889A (en) 1982-11-15 1985-07-02 Pfizer Inc. Epimeric azahomoerythromycin A derivative, intermediates and method of use
JPS60120895A (ja) * 1983-12-02 1985-06-28 Taisho Pharmaceut Co Ltd ６−０−メチル−２′−０，ν−ビス（ベンジルオキシカルボニル）−ν−デメチルエリスロマイシンａの製法
JPS60214796A (ja) * 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja) 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
PT82162B (en) 1985-03-12 1987-08-06 Beecham Group Plc Chemical compounds
GB8506380D0 (en) 1985-03-12 1985-04-11 Beecham Group Plc Chemical compounds
US4670549A (en) 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
JPS61229895A (ja) 1985-04-03 1986-10-14 Nippon Zeon Co Ltd 保護化デス−ｎ−メチルエリスロマイシン誘導体
US4640910A (en) 1985-11-12 1987-02-03 Abbott Laboratories Erythromycin A silylated compounds and method of use
JPS63107994A (ja) 1986-05-02 1988-05-12 Taisho Pharmaceut Co Ltd エリスロマイシン誘導体
US4740502A (en) 1986-06-20 1988-04-26 Abbott Laboratories Semisynthetic erythromycin antibiotics
JPH0764867B2 (ja) * 1986-09-18 1995-07-12 大正製薬株式会社 ６−ｏ−メチルエリスロマイシンａ誘導体およびその製造方法
DE3782994T2 (de) * 1986-09-18 1993-04-08 Taisho Pharma Co Ltd Erythromycin-a-derivate und verfahren zu ihrer herstellung.
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
JP2526951B2 (ja) * 1986-12-17 1996-08-21 大正製薬株式会社 エリスロマイシンａ誘導体およびその製造方法
JP2751385B2 (ja) 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法
JP2782793B2 (ja) * 1988-06-15 1998-08-06 大正製薬株式会社 エリスロマイシンａ誘導体およびその製造方法
US5302705A (en) 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives

Also Published As

Publication number Publication date
CA2237470C (en) 2005-01-18
MX9804047A (es) 1998-09-30
DE69627381D1 (de) 2003-05-15
WO1997019096A3 (en) 1997-07-03
EP0874862B1 (en) 2003-04-09
WO1997019096A2 (en) 1997-05-29
DE69627381T2 (de) 2004-03-25
US5872229A (en) 1999-02-16
JP2000500488A (ja) 2000-01-18
EP0874862A2 (en) 1998-11-04
DK0874862T3 (da) 2003-07-28
PT874862E (pt) 2003-08-29
CA2237470A1 (en) 1997-05-29
USRE39383E1 (en) 2006-11-07
JP2008110976A (ja) 2008-05-15
ATE236919T1 (de) 2003-04-15

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