ATE237336T1 - Stabile suppositorienformulierung von delta-9-thc (tetrahydrocannabinol) - Google Patents

Stabile suppositorienformulierung von delta-9-thc (tetrahydrocannabinol)

Info

Publication number: ATE237336T1
Authority: AT; Austria
Prior art keywords: delta; thc; tetrahydrocannabinol; suppository formulation; stable suppository
Prior art date: 1993-05-21

Application number

AT94917418T

Other languages

English (en)

Inventor

Mahmoud A Elsohly

Original Assignee

Univ Mississippi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-21

Filing date

1994-05-17

Publication date

2003-05-15

1994-05-17 Application filed by Univ Mississippi filed Critical Univ Mississippi

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE237336T1 publication Critical patent/ATE237336T1/de

Links

CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 title abstract 3
238000009472 formulation Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
239000000829 suppository Substances 0.000 title abstract 2
CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 title 1
229960004242 dronabinol Drugs 0.000 title 1
230000007774 longterm Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/15—Suppositories

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT94917418T 1993-05-21 1994-05-17 Stabile suppositorienformulierung von delta-9-thc (tetrahydrocannabinol) ATE237336T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/065,117 US5389375A (en)	1993-05-21	1993-05-21	Stable suppository formulations effecting bioavailability of Δ9 -thc
PCT/US1994/005512 WO1994027533A1 (en)	1993-05-21	1994-05-17	Stable suppository formulations effecting biovailability of δ9-thc

Publications (1)

Publication Number	Publication Date
ATE237336T1 true ATE237336T1 (de)	2003-05-15

Family

ID=22060436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94917418T ATE237336T1 (de)	1993-05-21	1994-05-17	Stabile suppositorienformulierung von delta-9-thc (tetrahydrocannabinol)

Country Status (11)

Country	Link
US (2)	US5389375A (de)
EP (1)	EP0752838B1 (de)
JP (1)	JPH08510741A (de)
KR (1)	KR100354403B1 (de)
AT (1)	ATE237336T1 (de)
CA (1)	CA2163363C (de)
DE (1)	DE69432527T2 (de)
DK (1)	DK0752838T3 (de)
MX (1)	MX9403799A (de)
PL (1)	PL175113B1 (de)
WO (1)	WO1994027533A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6132762A (en) *	1997-05-05	2000-10-17	Cristobal; Walter	Transcutaneous application of marijuana
US5847128A (en) *	1998-05-29	1998-12-08	Virginia Commonwealth University	Water soluble derivatives of cannabinoids
US6008383A (en) *	1998-10-26	1999-12-28	University Of Mississippi	Method of preparing delta-9-tetrahydrocannabinol esters
WO2000045813A1 (en) *	1999-02-04	2000-08-10	New Millennium Pharmaceutical Research, Inc.	Method for enhancement of delivery of thc by the administration of its prodrugs via the nasal route
CN1561990A (zh)	1999-03-22	2005-01-12	免疫力药品有限公司	治疗免疫疾病
US6566560B2 (en)	1999-03-22	2003-05-20	Immugen Pharmaceuticals, Inc.	Resorcinolic compounds
US6747058B1 (en)	1999-08-20	2004-06-08	Unimed Pharmaceuticals, Inc.	Stable composition for inhalation therapy comprising delta-9-tetrahydrocannabinol and semiaqueous solvent therefor
US7648696B2 (en) *	1999-08-20	2010-01-19	Unimed Pharmaceuticals, Llc	Composition for inhalation comprising delta-9-tetrahydrocannabinol in a semiaqueous solvent
US20020137802A1 (en) *	2000-09-28	2002-09-26	Travis Craig R.	Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation
US6541510B2 (en) *	2000-09-28	2003-04-01	Immugen Pharmaceuticals, Inc.	Antiviral methods and compounds
EP1321159A1 (de)	2001-12-21	2003-06-25	CHIESI FARMACEUTICI S.p.A.	Betätigungsvorrichtung für Druckdosierinhalator mit lasergebohrten Löchern
WO2003080043A1 (en) *	2002-03-18	2003-10-02	Immugen Pharmaceuticals, Inc.	Topical formulations of resorcinols and cannibinoids and methods of use
CA2573859A1 (en)	2004-07-19	2006-01-26	Cilag Ltd.	Method for obtaining pure tetrahydrocannabinol
TWI436991B (zh)	2004-11-22	2014-05-11	歐賽提克股份有限公司	用於純化反-（-）-△９-四氫大麻酚與反-（＋）-△９-四氫大麻酚之方法
CN101132781A (zh) *	2004-12-09	2008-02-27	茵西斯医疗公司	在室温下稳定的屈大麻酚剂型
TWI366460B (en) *	2005-06-16	2012-06-21	Euro Celtique Sa	Cannabinoid active pharmaceutical ingredient for improved dosage forms
CN102766128A (zh)	2005-09-29	2012-11-07	阿尔巴尼分子研究公司	δ-9-四氢大麻酚的生成方法
US20080112895A1 (en) *	2006-08-04	2008-05-15	Insys Therapeutics Inc.	Aqueous dronabinol formulations
US20080181942A1 (en) *	2006-11-30	2008-07-31	University Of Plymouth	Delta-9-THC compositions and methods for treating symptoms associated with multiple sclerosis
US20080175902A1 (en) *	2006-11-30	2008-07-24	University Of Plymouth	Methods for slowing the progression of multiple sclerosis
US7541384B2 (en)	2007-06-08	2009-06-02	Axcan Pharma Inc.	Mesalamine suppository
US8436051B2 (en) *	2007-06-08	2013-05-07	Aptalis Pharma Canada Inc.	Mesalamine suppository
US8217083B2 (en) *	2007-06-08	2012-07-10	Aptalis Pharma Canada Inc.	Mesalamine suppository
EP2176208B1 (de) *	2007-07-30	2015-01-21	Zynerba Pharmaceuticals, Inc.	Prodgrugs von cannabidiol, zusammensetzungen mit prodgrugs von cannabidiol und verfahren zu ihrer verwendung
EP2184983A1 (de) *	2007-08-06	2010-05-19	Insys Therapeutics Inc.	Orale cannabinoid-flüssigformulierungen und behandlungsverfahren
MX2010005931A (es)	2007-11-30	2010-06-15	Alltranz Inc	Profarmacos de tetrahidrocanabinol, composiciones que comprenden profarmacos de tetrahidrocanabinol y metodos para utilizar los mismos.
JP5518418B2 (ja) *	2008-10-06	2014-06-11	第一三共ヘルスケア株式会社	坐薬製剤組成物
WO2010051541A2 (en) *	2008-10-31	2010-05-06	The University Of Mississippi	Compositions containing delta-9-thc-amino acid esters and process of preparation
WO2018075730A1 (en) *	2016-10-21	2018-04-26	Axim Biotechnologies, Inc.	Suppositories comprising cannabinoids
EP3678658A4 (de)	2017-09-08	2021-05-05	Scicann Therapeutics Inc.	Zusammensetzungen mit einem cannabinoid und spilanthol
WO2019195943A1 (en) *	2018-04-13	2019-10-17	Urban Juve Provisions Inc.	Cannabis root extract, method of manufacture, method of use
US10751299B2 (en) *	2018-09-04	2020-08-25	Babak Ghalili	Cannabinoid and menthol compositions and methods
AU2021230540A1 (en)	2020-03-04	2022-10-13	Pleopharma, L.L.C.	Methods and compositions for treating cannabis use disorder and mitigating cannabinoid withdrawal
US12029718B2 (en)	2021-11-09	2024-07-09	Cct Sciences, Llc	Process for production of essentially pure delta-9-tetrahydrocannabinol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3728360A (en) *	1971-08-31	1973-04-17	Little Inc A	Ester derivatives of tetrahydrocannabinol
US4933363A (en) *	1988-08-16	1990-06-12	Elsohly Mahmoud A	Method for effecting systemic delivery of delta-9-tetrahydrocannabinol

1993
- 1993-05-21 US US08/065,117 patent/US5389375A/en not_active Expired - Lifetime
1994
- 1994-05-17 JP JP7500759A patent/JPH08510741A/ja active Pending
- 1994-05-17 CA CA002163363A patent/CA2163363C/en not_active Expired - Fee Related
- 1994-05-17 DK DK94917418T patent/DK0752838T3/da active
- 1994-05-17 AT AT94917418T patent/ATE237336T1/de not_active IP Right Cessation
- 1994-05-17 KR KR1019950705085A patent/KR100354403B1/ko not_active Expired - Fee Related
- 1994-05-17 PL PL94311706A patent/PL175113B1/pl not_active IP Right Cessation
- 1994-05-17 WO PCT/US1994/005512 patent/WO1994027533A1/en not_active Ceased
- 1994-05-17 DE DE69432527T patent/DE69432527T2/de not_active Expired - Fee Related
- 1994-05-17 EP EP94917418A patent/EP0752838B1/de not_active Expired - Lifetime
- 1994-05-23 MX MX9403799A patent/MX9403799A/es unknown
1995
- 1995-02-02 US US08/382,500 patent/US5508037A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2163363A1 (en)	1994-12-08
EP0752838A1 (de)	1997-01-15
AU6915194A (en)	1994-12-20
DK0752838T3 (da)	2003-08-11
PL175113B1 (pl)	1998-11-30
MX9403799A (es)	1997-02-28
US5508037A (en)	1996-04-16
JPH08510741A (ja)	1996-11-12
AU689110B2 (en)	1998-03-26
DE69432527D1 (de)	2003-05-22
CA2163363C (en)	2007-01-30
DE69432527T2 (de)	2004-04-08
WO1994027533A1 (en)	1994-12-08
KR100354403B1 (ko)	2002-12-26
US5389375A (en)	1995-02-14
EP0752838A4 (de)	1996-05-30
EP0752838B1 (de)	2003-04-16
PL311706A1 (en)	1996-03-04

Legal Events

Date	Code	Title	Description
2003-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE237336T1 (de)	2003-05-15	Stabile suppositorienformulierung von delta-9-thc (tetrahydrocannabinol)
DK0656774T3 (da)	1997-06-16	Kosmetiske og dermatologiske lysbeskyttelsesformuleringer med et indhold af thioler og/eller thiolderivater
DK0781551T3 (da)	2002-05-21	Retinoid-formuleringer i porøse mikrosfærer til nedsat irritation og forbedret stabilitet
DK0812198T3 (da)	2002-03-18	Stabilisering af prostaglandinpræparater
DK0650483T3 (da)	2000-03-27	(3R,4R)-Delta6-tetrahydrocannabinol-7-syrer
DK0578077T3 (da)	2000-01-31	Præparater, der indeholder retinsyrer og tocopherol
ATE156355T1 (de)	1997-08-15	Stabile zusammensetzungen von askorbinsäure
AU6022890A (en)	1991-02-14	Diarylacetylenes, the preparations and use thereof
DK0641343T3 (da)	2003-10-13	4-Mercaptoacetylamino-[2]benzazepinon(3)-derivater og anvendelse som enkefalinaseinhibitorer
FI943749L (fi)	1995-02-18	Taksaanijohdannaisten fosfono-oksimetyylieetterit
NO168988C (no)	1992-04-29	Anvendelse av en argininiumholdig buffer til formulering av stabile farmasoeytiske preparater inneholdende humanvevplasminogenaktivator
CO4290432A1 (es)	1996-04-17	Nuevos derivados de pirazinacarboxamida, su preparacion y su utilizacion en medicamentos.
DE69100809D1 (de)	1994-01-27	Wasserstoffperoxid enthaltende stabile Bleichmittelzusammensetzungen.
MX9204563A (es)	1993-02-01	Nuevos derivados de la (2-alquil-3-piridil)-metilpiperazina y composicion farmaceutica que los comprende.
NO923265D0 (no)	1992-08-20	Benzol(f)quinolinoner
ES2153835T3 (es)	2001-03-16	Formulaciones farmaceuticas estables a base de nicorandil.
DK0727996T3 (da)	2002-11-18	Fendazolformuleringer
ES2105605T3 (es)	1997-10-16	Antagonistas de taquiquinina, su preparacion y utilizacion en formulaciones farmaceuticas.
NO304874B1 (no)	1999-03-01	Anvendelse av kolesterolnedsettende tokoferolanaloger
MX9203383A (es)	1992-07-01	Nuevos derivados de piridobenzoindol y composiciones farmaceuticas que los contienen.
DK1156829T3 (da)	2007-09-10	Stabil formulering indeholdende fumagillin
PT89742A (pt)	1989-10-04	Processo de preparacao de 24r-cimnol e de suas composicoes farmaceuticas
PT97663A (pt)	1992-03-31	Processo de preparacao de 3'-desamino-4'-desoxi-4'-amino-8-fluoro-antraciclinas, de composicoes farmaceuticas que as contem e de seus intermediarios
MX9400068A (es)	1994-07-29	Metodo para estabilizar ditionito de sodio.
DK0597414T3 (da)	2000-05-29	Stabil formulering af sennaekstrakt