ATE237336T1 - Stabile suppositorienformulierung von delta-9-thc (tetrahydrocannabinol) - Google Patents

Stabile suppositorienformulierung von delta-9-thc (tetrahydrocannabinol)

Info

Publication number: ATE237336T1
Authority: AT; Austria
Prior art keywords: delta; thc; tetrahydrocannabinol; suppository formulation; stable suppository
Prior art date: 1993-05-21

Application number

AT94917418T

Other languages

English (en)

Inventor

Mahmoud A Elsohly

Original Assignee

Univ Mississippi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-21

Filing date

1994-05-17

Publication date

2003-05-15

1994-05-17 Application filed by Univ Mississippi filed Critical Univ Mississippi

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE237336T1 publication Critical patent/ATE237336T1/de

Links

CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 title abstract 3
238000009472 formulation Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
239000000829 suppository Substances 0.000 title abstract 2
CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 title 1
229960004242 dronabinol Drugs 0.000 title 1
230000007774 longterm Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/15—Suppositories

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT94917418T 1993-05-21 1994-05-17 Stabile suppositorienformulierung von delta-9-thc (tetrahydrocannabinol) ATE237336T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/065,117 US5389375A (en)	1993-05-21	1993-05-21	Stable suppository formulations effecting bioavailability of Δ9 -thc
PCT/US1994/005512 WO1994027533A1 (en)	1993-05-21	1994-05-17	Stable suppository formulations effecting biovailability of δ9-thc

Publications (1)

Publication Number	Publication Date
ATE237336T1 true ATE237336T1 (de)	2003-05-15

Family

ID=22060436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94917418T ATE237336T1 (de)	1993-05-21	1994-05-17	Stabile suppositorienformulierung von delta-9-thc (tetrahydrocannabinol)

Country Status (11)

Country	Link
US (2)	US5389375A (de)
EP (1)	EP0752838B1 (de)
JP (1)	JPH08510741A (de)
KR (1)	KR100354403B1 (de)
AT (1)	ATE237336T1 (de)
CA (1)	CA2163363C (de)
DE (1)	DE69432527T2 (de)
DK (1)	DK0752838T3 (de)
MX (1)	MX9403799A (de)
PL (1)	PL175113B1 (de)
WO (1)	WO1994027533A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6132762A (en) *	1997-05-05	2000-10-17	Cristobal; Walter	Transcutaneous application of marijuana
US5847128A (en) *	1998-05-29	1998-12-08	Virginia Commonwealth University	Water soluble derivatives of cannabinoids
US6008383A (en) *	1998-10-26	1999-12-28	University Of Mississippi	Method of preparing delta-9-tetrahydrocannabinol esters
WO2000045813A1 (en) *	1999-02-04	2000-08-10	New Millennium Pharmaceutical Research, Inc.	Method for enhancement of delivery of thc by the administration of its prodrugs via the nasal route
US6566560B2 (en)	1999-03-22	2003-05-20	Immugen Pharmaceuticals, Inc.	Resorcinolic compounds
BR0009200A (pt)	1999-03-22	2001-12-26	Immugen Pharmaceuticals Inc	Compostos e composições para o tratamento dedoenças associada com disfunção imune
US6747058B1 (en)	1999-08-20	2004-06-08	Unimed Pharmaceuticals, Inc.	Stable composition for inhalation therapy comprising delta-9-tetrahydrocannabinol and semiaqueous solvent therefor
US7648696B2 (en) *	1999-08-20	2010-01-19	Unimed Pharmaceuticals, Llc	Composition for inhalation comprising delta-9-tetrahydrocannabinol in a semiaqueous solvent
AU2001296402A1 (en) *	2000-09-28	2002-04-08	Immugen Pharmaceuticals, Inc.	Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation
US6541510B2 (en) *	2000-09-28	2003-04-01	Immugen Pharmaceuticals, Inc.	Antiviral methods and compounds
EP1321159A1 (de)	2001-12-21	2003-06-25	CHIESI FARMACEUTICI S.p.A.	Betätigungsvorrichtung für Druckdosierinhalator mit lasergebohrten Löchern
WO2003080043A1 (en) *	2002-03-18	2003-10-02	Immugen Pharmaceuticals, Inc.	Topical formulations of resorcinols and cannibinoids and methods of use
CA2573859A1 (en) *	2004-07-19	2006-01-26	Cilag Ltd.	Method for obtaining pure tetrahydrocannabinol
TWI369203B (en)	2004-11-22	2012-08-01	Euro Celtique Sa	Methods for purifying trans-(-)-△9-tetrahydrocannabinol and trans-(+)-△9-tetrahydrocannabinol
AU2005314021B2 (en) *	2004-12-09	2010-02-11	Insys Therapeutics, Inc.	Room-temperature stable dronabinol formulations
TWI366460B (en) *	2005-06-16	2012-06-21	Euro Celtique Sa	Cannabinoid active pharmaceutical ingredient for improved dosage forms
ZA200802767B (en) *	2005-09-29	2009-09-30	Amr Technology Inc	Process for production of delta-9-tetrahydrocannabinol
EP2046290A4 (de) *	2006-08-04	2011-08-17	Insys Therapeutics Inc	Wässrige dronabinolformulierungen
WO2008139263A2 (en) *	2006-11-30	2008-11-20	University Of Plymouth	Methods for slowing the progression of multiple sclerosis
US20080181942A1 (en) *	2006-11-30	2008-07-31	University Of Plymouth	Delta-9-THC compositions and methods for treating symptoms associated with multiple sclerosis
US7541384B2 (en)	2007-06-08	2009-06-02	Axcan Pharma Inc.	Mesalamine suppository
US8217083B2 (en) *	2007-06-08	2012-07-10	Aptalis Pharma Canada Inc.	Mesalamine suppository
US8436051B2 (en) *	2007-06-08	2013-05-07	Aptalis Pharma Canada Inc.	Mesalamine suppository
ES2534900T3 (es) *	2007-07-30	2015-04-30	Zynerba Pharmaceuticals, Inc.	Profármacos de cannabidiol, composiciones que comprenden los profármacos de cannabidiol y métodos de uso de los mismos
WO2009020666A1 (en) *	2007-08-06	2009-02-12	Insys Therapeutics Inc.	Oral cannabinoid liquid formulations and methods of treatment
JP5551604B2 (ja) *	2007-11-30	2014-07-16	オールトランツインコーポレイティド	テトラヒドロカンナビノールのプロドラッグ、テトラヒドロカンナビノールのプロドラッグを含む組成物、及び同一のものを使用する方法
JP5518418B2 (ja) *	2008-10-06	2014-06-11	第一三共ヘルスケア株式会社	坐薬製剤組成物
PL2352497T3 (pl) *	2008-10-31	2017-08-31	University Of Mississippi	Proces przygotowania estrów aminokwasowych delta-9-thc
WO2018075730A1 (en) *	2016-10-21	2018-04-26	Axim Biotechnologies, Inc.	Suppositories comprising cannabinoids
AU2018330807A1 (en)	2017-09-08	2020-03-05	Scicann Therapeutics Inc.	Compositions comprising a cannabinoid and spilanthol
WO2019195943A1 (en) *	2018-04-13	2019-10-17	Urban Juve Provisions Inc.	Cannabis root extract, method of manufacture, method of use
US10695301B2 (en) *	2018-09-04	2020-06-30	Babak Ghalili	Veterinary cannabinoid and menthol compositions and methods
MX2022010960A (es)	2020-03-04	2022-11-16	Pleopharma L L C	Métodos y composiciones para tratar el trastorno por uso de cannabis y mitigar la abstinencia de cannabinoides.
US12029718B2 (en)	2021-11-09	2024-07-09	Cct Sciences, Llc	Process for production of essentially pure delta-9-tetrahydrocannabinol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3728360A (en) *	1971-08-31	1973-04-17	Little Inc A	Ester derivatives of tetrahydrocannabinol
US4933363A (en) *	1988-08-16	1990-06-12	Elsohly Mahmoud A	Method for effecting systemic delivery of delta-9-tetrahydrocannabinol

1993
- 1993-05-21 US US08/065,117 patent/US5389375A/en not_active Expired - Lifetime
1994
- 1994-05-17 CA CA002163363A patent/CA2163363C/en not_active Expired - Fee Related
- 1994-05-17 KR KR1019950705085A patent/KR100354403B1/ko not_active Expired - Fee Related
- 1994-05-17 WO PCT/US1994/005512 patent/WO1994027533A1/en not_active Ceased
- 1994-05-17 PL PL94311706A patent/PL175113B1/pl not_active IP Right Cessation
- 1994-05-17 JP JP7500759A patent/JPH08510741A/ja active Pending
- 1994-05-17 DE DE69432527T patent/DE69432527T2/de not_active Expired - Fee Related
- 1994-05-17 EP EP94917418A patent/EP0752838B1/de not_active Expired - Lifetime
- 1994-05-17 DK DK94917418T patent/DK0752838T3/da active
- 1994-05-17 AT AT94917418T patent/ATE237336T1/de not_active IP Right Cessation
- 1994-05-23 MX MX9403799A patent/MX9403799A/es unknown
1995
- 1995-02-02 US US08/382,500 patent/US5508037A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0752838A1 (de)	1997-01-15
CA2163363C (en)	2007-01-30
PL311706A1 (en)	1996-03-04
CA2163363A1 (en)	1994-12-08
DK0752838T3 (da)	2003-08-11
DE69432527T2 (de)	2004-04-08
KR100354403B1 (ko)	2002-12-26
WO1994027533A1 (en)	1994-12-08
US5508037A (en)	1996-04-16
US5389375A (en)	1995-02-14
EP0752838A4 (de)	1996-05-30
EP0752838B1 (de)	2003-04-16
AU689110B2 (en)	1998-03-26
JPH08510741A (ja)	1996-11-12
MX9403799A (es)	1997-02-28
DE69432527D1 (de)	2003-05-22
PL175113B1 (pl)	1998-11-30
AU6915194A (en)	1994-12-20

Legal Events

Date	Code	Title	Description
2003-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69432527D1 (de)	2003-05-22	Stabile suppositorienformulierung von delta-9-thc (tetrahydrocannabinol)
DK0656774T3 (da)	1997-06-16	Kosmetiske og dermatologiske lysbeskyttelsesformuleringer med et indhold af thioler og/eller thiolderivater
DK0812198T3 (da)	2002-03-18	Stabilisering af prostaglandinpræparater
DK0650483T3 (da)	2000-03-27	(3R,4R)-Delta6-tetrahydrocannabinol-7-syrer
DE69617181D1 (de)	2002-01-03	Retinoid-Formulierungen in porösen Mikrokugeln für verringerte Irritation und verbesserte Stabilität
DK0578077T3 (da)	2000-01-31	Præparater, der indeholder retinsyrer og tocopherol
AU629669B2 (en)	1992-10-08	Diarylacetylenes, the preparations and use thereof
ATE156355T1 (de)	1997-08-15	Stabile zusammensetzungen von askorbinsäure
MX9205432A (es)	1993-03-31	Compuestos inhibidores de la biosintesis de leucotrienos y composicion farmaceutica que los contiene.
ATE208208T1 (de)	2001-11-15	Halogenid-enthaltende insulinzubereitungen
ATE98675T1 (de)	1994-01-15	Wasserstoffperoxid enthaltende stabile bleichmittelzusammensetzungen.
MX9204563A (es)	1993-02-01	Nuevos derivados de la (2-alquil-3-piridil)-metilpiperazina y composicion farmaceutica que los comprende.
NO923265D0 (no)	1992-08-20	Benzol(f)quinolinoner
ES2045484T3 (es)	1994-01-16	Nuevos derivados de la vitamina d: aplicaciones terapeuticas y a las dosificaciones de los metabolitos de la vitamina d.
ES2153835T3 (es)	2001-03-16	Formulaciones farmaceuticas estables a base de nicorandil.
ATE221780T1 (de)	2002-08-15	Fenbendazolformulierungen
ES2105605T3 (es)	1997-10-16	Antagonistas de taquiquinina, su preparacion y utilizacion en formulaciones farmaceuticas.
NO304874B1 (no)	1999-03-01	Anvendelse av kolesterolnedsettende tokoferolanaloger
UY24915A1 (es)	2000-12-29	Derivados de benzoxazindiona, aplicación de los mismos y medicamentos que los contienen
DK1156829T3 (da)	2007-09-10	Stabil formulering indeholdende fumagillin
PT89742A (pt)	1989-10-04	Processo de preparacao de 24r-cimnol e de suas composicoes farmaceuticas
FI896003A7 (fi)	1989-12-15	Prourokinaasin johdannaiset, joilla on alhainen molekyylipaino, ja nii tä sisältävät farmaseuttiset koostumukset
MX9400068A (es)	1994-07-29	Metodo para estabilizar ditionito de sodio.
DK0597414T3 (da)	2000-05-29	Stabil formulering af sennaekstrakt
ITPD930045A0 (it)	1993-03-04	Nuovi derivati o-solfatati di gangliosidi e lisogangliosidi