ATE209201T1 - Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren - Google Patents

Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren

Info

Publication number: ATE209201T1
Authority: AT; Austria
Prior art keywords: protein transferase; farnesyl; transferase inhibitors; derivatives usable; substituted
Prior art date: 1996-09-13

Application number

AT97941478T

Other languages

English (en)

Inventor

Arthur G Taveras

F George Njoroge

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-13

Filing date

1997-09-11

Publication date

2001-12-15

1997-09-11 Application filed by Schering Corp filed Critical Schering Corp

2001-12-15 Application granted granted Critical

2001-12-15 Publication of ATE209201T1 publication Critical patent/ATE209201T1/de

Links

XYNHQVIVVBWVAG-UHFFFAOYSA-N 4h-cyclohepta[f]quinoline Chemical class C1=CC=CC=C2C3=CC=CNC3=CC=C21 XYNHQVIVVBWVAG-UHFFFAOYSA-N 0.000 title 1
239000003528 protein farnesyltransferase inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
102000004357 Transferases Human genes 0.000 abstract 1
108090000992 Transferases Proteins 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
210000004881 tumor cell Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Indole Compounds (AREA)
Cosmetics (AREA)
Confectionery (AREA)
Enzymes And Modification Thereof (AREA)

AT97941478T 1996-09-13 1997-09-11 Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren ATE209201T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US71192596A	1996-09-13	1996-09-13
PCT/US1997/015905 WO1998011099A1 (en)	1996-09-13	1997-09-11	Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase

Publications (1)

Publication Number	Publication Date
ATE209201T1 true ATE209201T1 (de)	2001-12-15

Family

ID=24860067

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97941478T ATE209201T1 (de)	1996-09-13	1997-09-11	Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren

Country Status (20)

Country	Link
EP (1)	EP0931079B1 (de)
JP (1)	JP2001500508A (de)
KR (1)	KR20000036103A (de)
CN (1)	CN1122031C (de)
AT (1)	ATE209201T1 (de)
AU (1)	AU4337797A (de)
BR (1)	BR9711477A (de)
CA (1)	CA2264513C (de)
CZ (1)	CZ87499A3 (de)
DE (1)	DE69709774T2 (de)
ES (1)	ES2163195T3 (de)
HU (1)	HUP9904056A3 (de)
ID (1)	ID22156A (de)
IL (1)	IL128929A0 (de)
NO (1)	NO991229L (de)
NZ (1)	NZ334437A (de)
PL (1)	PL332253A1 (de)
SK (1)	SK33599A3 (de)
TR (1)	TR199901205T2 (de)
WO (1)	WO1998011099A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA985205B (en) *	1997-06-17	1998-12-15	Schering Corp	Novel n-substituted urea inhibitors of arnesyl-protein transferase
US6358968B1 (en)	1997-06-17	2002-03-19	Schering Corporation	N-substituted urea inhibitors of farnesyl-protein transferase
US6509346B2 (en)	1998-01-21	2003-01-21	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en)	1998-01-21	2003-09-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
CN1289336A (zh)	1998-01-21	2001-03-28	千禧药品公司	趋化因子受体拮抗剂和其使用方法
AU2335699A (en)	1998-01-21	1999-08-09	Kyowa Hakko Kogyo Co. Ltd.	Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en)	1998-09-04	2007-09-18	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use thereof
US6288083B1 (en)	1998-09-04	2001-09-11	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6503926B2 (en)	1998-09-04	2003-01-07	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US7541365B2 (en)	2001-11-21	2009-06-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
TWI291467B (en)	2002-11-13	2007-12-21	Millennium Pharm Inc	CCR1 antagonists and methods of use therefor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5719148A (en) *	1993-10-15	1998-02-17	Schering Corporation	Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) *	1993-10-15	2001-03-19	Schering Plough Corp	Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
MY119007A (en) *	1995-12-22	2005-03-31	Schering Corp	Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases.

1997
- 1997-09-11 ES ES97941478T patent/ES2163195T3/es not_active Expired - Lifetime
- 1997-09-11 EP EP97941478A patent/EP0931079B1/de not_active Expired - Lifetime
- 1997-09-11 BR BR9711477A patent/BR9711477A/pt unknown
- 1997-09-11 DE DE69709774T patent/DE69709774T2/de not_active Expired - Fee Related
- 1997-09-11 AU AU43377/97A patent/AU4337797A/en not_active Abandoned
- 1997-09-11 SK SK335-99A patent/SK33599A3/sk unknown
- 1997-09-11 PL PL97332253A patent/PL332253A1/xx unknown
- 1997-09-11 HU HU9904056A patent/HUP9904056A3/hu unknown
- 1997-09-11 CZ CZ99874A patent/CZ87499A3/cs unknown
- 1997-09-11 JP JP10513763A patent/JP2001500508A/ja not_active Ceased
- 1997-09-11 CA CA002264513A patent/CA2264513C/en not_active Expired - Fee Related
- 1997-09-11 AT AT97941478T patent/ATE209201T1/de not_active IP Right Cessation
- 1997-09-11 WO PCT/US1997/015905 patent/WO1998011099A1/en not_active Ceased
- 1997-09-11 NZ NZ334437A patent/NZ334437A/xx unknown
- 1997-09-11 KR KR1019997002125A patent/KR20000036103A/ko not_active Withdrawn
- 1997-09-11 ID IDW990087A patent/ID22156A/id unknown
- 1997-09-11 TR TR1999/01205T patent/TR199901205T2/xx unknown
- 1997-09-11 IL IL12892997A patent/IL128929A0/xx unknown
- 1997-09-11 CN CN97199527A patent/CN1122031C/zh not_active Expired - Fee Related
1999
- 1999-03-12 NO NO991229A patent/NO991229L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0931079A1 (de)	1999-07-28
BR9711477A (pt)	1999-08-24
HUP9904056A3 (en)	2001-10-29
JP2001500508A (ja)	2001-01-16
SK33599A3 (en)	2000-03-13
PL332253A1 (en)	1999-08-30
IL128929A0 (en)	2000-02-17
ID22156A (id)	1999-09-09
CN1236364A (zh)	1999-11-24
NO991229L (no)	1999-05-12
HUP9904056A2 (hu)	2000-04-28
NZ334437A (en)	2000-09-29
WO1998011099A1 (en)	1998-03-19
CA2264513C (en)	2004-03-30
DE69709774T2 (de)	2002-08-08
HK1018443A1 (en)	1999-12-24
CN1122031C (zh)	2003-09-24
TR199901205T2 (xx)	1999-07-21
NO991229D0 (no)	1999-03-12
CA2264513A1 (en)	1998-03-19
KR20000036103A (ko)	2000-06-26
EP0931079B1 (de)	2001-11-21
DE69709774D1 (de)	2002-02-21
ES2163195T3 (es)	2002-01-16
AU4337797A (en)	1998-04-02
CZ87499A3 (cs)	1999-08-11

Legal Events

Date	Code	Title	Description
2002-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE286046T1 (de)	2005-01-15	Trizyklische inhibitoren der farnesyl protein transferase
ATE209201T1 (de)	2001-12-15	Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren
NO991235L (no)	1999-05-10	Forbindelser anvendelige for inhibering av farnesylproteintransferase
ATE247106T1 (de)	2003-08-15	Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl protein transferase inhibitoren
NO991231D0 (no)	1999-03-12	Forbindelser for inhibering av farnesylproteintransferase