ATE238060T1 - Verwendung von eisenbindenden polymeren zur herstellung eines medikaments zur oralen verabreichung - Google Patents
Verwendung von eisenbindenden polymeren zur herstellung eines medikaments zur oralen verabreichungInfo
- Publication number
- ATE238060T1 ATE238060T1 AT94917977T AT94917977T ATE238060T1 AT E238060 T1 ATE238060 T1 AT E238060T1 AT 94917977 T AT94917977 T AT 94917977T AT 94917977 T AT94917977 T AT 94917977T AT E238060 T1 ATE238060 T1 AT E238060T1
- Authority
- AT
- Austria
- Prior art keywords
- iron
- medication
- producing
- oral administration
- binding polymers
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title abstract 3
- 102000008133 Iron-Binding Proteins Human genes 0.000 title abstract 2
- 108010035210 Iron-Binding Proteins Proteins 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- 206010065973 Iron Overload Diseases 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/065,546 US5487888A (en) | 1993-05-20 | 1993-05-20 | Iron-binding polymers for oral administration |
| PCT/US1994/005359 WO1994027621A1 (en) | 1993-05-20 | 1994-05-16 | Iron-binding polymers for oral administration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE238060T1 true ATE238060T1 (de) | 2003-05-15 |
Family
ID=22063466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94917977T ATE238060T1 (de) | 1993-05-20 | 1994-05-16 | Verwendung von eisenbindenden polymeren zur herstellung eines medikaments zur oralen verabreichung |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US5487888A (de) |
| EP (1) | EP0699072B1 (de) |
| JP (1) | JP3645259B2 (de) |
| AT (1) | ATE238060T1 (de) |
| AU (1) | AU6948994A (de) |
| DE (1) | DE69432559T2 (de) |
| WO (1) | WO1994027621A1 (de) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5487888A (en) * | 1993-05-20 | 1996-01-30 | Geltex, Inc. | Iron-binding polymers for oral administration |
| US5667775A (en) * | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5434270A (en) * | 1994-09-15 | 1995-07-18 | Eastman Kodak Company | Weakly basic polymerizable monomers and polymers prepared therefrom |
| CN1108801C (zh) * | 1995-01-12 | 2003-05-21 | 吉尔特药品公司 | 用于口服的磷酸盐结合聚合物 |
| EP0922461A4 (de) * | 1996-07-19 | 2002-07-17 | Nikken Chemicals Co Ltd | Heilmittel gegen hyperphosphatanämie |
| US6306384B1 (en) * | 1996-10-01 | 2001-10-23 | E-L Management Corp. | Skin battery cosmetic composition |
| US6423754B1 (en) * | 1997-06-18 | 2002-07-23 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with polyallylamine polymers |
| US5955415A (en) * | 1997-08-04 | 1999-09-21 | Lever Brothers Company, Division Of Conopco, Inc. | Detergent compositions containing polyethyleneimines for enhanced peroxygen bleach stability |
| US6566407B2 (en) | 1997-11-05 | 2003-05-20 | Geltex Pharmaceuticals, Inc. | Method for reducing oxalate |
| US5985938A (en) | 1997-11-05 | 1999-11-16 | Geltex Pharmaceuticals, Inc. | Method for reducing oxalate |
| US6368866B1 (en) | 1998-08-03 | 2002-04-09 | Reference Diagnostics, Inc. | Rapid separation assay for total iron binding capacity |
| US6362266B1 (en) | 1999-09-03 | 2002-03-26 | The Dow Chemical Company | Process for reducing cohesiveness of polyallylamine polymer gels during drying |
| US6180754B1 (en) * | 1999-09-03 | 2001-01-30 | The Dow Chemical Company | Process for producing cross-linked polyallylamine polymer |
| US20020054903A1 (en) * | 1999-10-19 | 2002-05-09 | Joseph Tyler | Direct compression polymer tablet core |
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| DE10009982A1 (de) * | 2000-03-03 | 2001-09-06 | Qiagen Gmbh | Polymere Anionenaustauscher und deren Verwendung in chromatographischen Verfahren |
| US6410643B1 (en) | 2000-03-09 | 2002-06-25 | Surmodics, Inc. | Solid phase synthesis method and reagent |
| US8263112B2 (en) * | 2000-11-20 | 2012-09-11 | Sorbent Therapeutics, Inc. | In vivo use of water absorbent polymers |
| AU2002232955A1 (en) | 2000-11-20 | 2002-05-27 | Dow Global Technologies Inc. | In vivo use of water absorbent polymers |
| NZ528829A (en) * | 2001-04-18 | 2006-06-30 | Genzyme Corp | Low salt forms of polyallylamine |
| WO2002085379A1 (en) * | 2001-04-18 | 2002-10-31 | Geltex Pharmaceuticals, Inc. | Method for improving vascular access in patients with vascular shunts |
| ES2637020T3 (es) * | 2001-04-18 | 2017-10-10 | Genzyme Corporation | Uso de polímero de amina para reducir la glucosa sérica |
| EP1923064B1 (de) | 2001-04-18 | 2017-06-28 | Genzyme Corporation | Verwendung von Aminpolymeren zur Minderung des Serumglukosegehaltes |
| WO2002085383A1 (en) * | 2001-04-18 | 2002-10-31 | Genzyme Corporation | Method for reducing copper levels and treating copper toxicosis |
| WO2002085380A1 (en) * | 2001-04-18 | 2002-10-31 | Geltex Pharmaceuticals, Inc. | Method for treating gout and reducing serum uric acid |
| WO2002085382A1 (en) | 2001-04-18 | 2002-10-31 | Genzyme Corporation | Methods of treating syndrome x with aliphatic polyamines |
| US7041280B2 (en) * | 2001-06-29 | 2006-05-09 | Genzyme Corporation | Aryl boronate functionalized polymers for treating obesity |
| AU2003225587A1 (en) * | 2002-02-21 | 2003-09-09 | University Of Oregon | Cross-linkable phosphonate-containing supramolecular complexes and their use for delivery of therapeutic and diagnostic agents |
| US20050129769A1 (en) * | 2002-06-03 | 2005-06-16 | Barry Stephen E. | Polymeric articles for carrying therapeutic agents |
| AU2003282867A1 (en) * | 2002-10-22 | 2004-05-13 | Genzyme Corporation | Amine polymers for promoting bone formation |
| EP1679962B1 (de) | 2003-10-20 | 2021-01-13 | Framework Therapeutics, L.L.C. | Zeolit-molekulare siebe für die entfernung von toxinen |
| US7459502B2 (en) * | 2003-11-03 | 2008-12-02 | Ilypsa, Inc. | Pharmaceutical compositions comprising crosslinked polyamine polymers |
| US7385012B2 (en) | 2003-11-03 | 2008-06-10 | Ilypsa, Inc. | Polyamine polymers |
| US7449605B2 (en) * | 2003-11-03 | 2008-11-11 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7608674B2 (en) * | 2003-11-03 | 2009-10-27 | Ilypsa, Inc. | Pharmaceutical compositions comprising cross-linked small molecule amine polymers |
| US7335795B2 (en) | 2004-03-22 | 2008-02-26 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7767768B2 (en) * | 2003-11-03 | 2010-08-03 | Ilypsa, Inc. | Crosslinked amine polymers |
| US8192758B2 (en) * | 2004-03-30 | 2012-06-05 | Relypsa, Inc. | Ion binding compositions |
| AU2005231424B2 (en) | 2004-03-30 | 2010-06-17 | Vifor Pharma Technology Ltd. | Ion binding polymers and uses thereof |
| US7854924B2 (en) * | 2004-03-30 | 2010-12-21 | Relypsa, Inc. | Methods and compositions for treatment of ion imbalances |
| US7429394B2 (en) * | 2004-03-30 | 2008-09-30 | Relypsa, Inc. | Ion binding compositions |
| US8282960B2 (en) * | 2004-03-30 | 2012-10-09 | Relypsa, Inc. | Ion binding compositions |
| US7556799B2 (en) * | 2004-03-30 | 2009-07-07 | Relypsa, Inc. | Ion binding polymers and uses thereof |
| US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| US20060177415A1 (en) * | 2004-11-01 | 2006-08-10 | Burke Steven K | Once a day formulation for phosphate binders |
| WO2006072054A1 (en) * | 2004-12-30 | 2006-07-06 | Genzyme Corporation | Zinc-containing treatments for hyperphosphatemia |
| EP1951266A2 (de) * | 2005-09-02 | 2008-08-06 | Genzyme Corporation | Verfahren zur entfernung von phosphat und dafür verwendetes polymer |
| PT1924246E (pt) | 2005-09-15 | 2016-02-10 | Genzyme Corp | Formulação sachê para polímeros com funcionalidade amina |
| GB2446076B (en) * | 2005-09-30 | 2010-11-24 | Ilypsa Inc | Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom |
| CA2624170C (en) * | 2005-09-30 | 2014-02-25 | Ilypsa, Inc. | Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal |
| CN101304739A (zh) * | 2005-11-08 | 2008-11-12 | 基酶有限公司 | 用于治疗高磷酸盐血症的含镁聚合物 |
| US7829644B2 (en) * | 2006-04-19 | 2010-11-09 | Uchicago Argonne, Llc | Gel-forming reagents and uses thereof for preparing microarrays |
| WO2007130463A2 (en) * | 2006-05-05 | 2007-11-15 | Genzyme Corporation | Amine condensation polymers as phosphate sequestrants |
| US20100135950A1 (en) * | 2006-07-05 | 2010-06-03 | Genzyme Corporation | Iron(II)-Containing Treatments for Hyperphosphatemia |
| AU2007275711A1 (en) * | 2006-07-18 | 2008-01-24 | Genzyme Corporation | Amine dendrimers |
| WO2008042222A2 (en) | 2006-09-29 | 2008-04-10 | Genzyme Corporation | Amide dendrimer compositions |
| EP2120972A1 (de) | 2006-12-14 | 2009-11-25 | Genzyme Corporation | Amido-amin-polymerzusammensetzungen |
| EP2114376A1 (de) * | 2007-02-23 | 2009-11-11 | Genzyme Corporation | Amin-polymerzusammensetzungen |
| EP2131820A1 (de) * | 2007-03-08 | 2009-12-16 | Genzyme Corporation | Sulfonpolymerzusammensetzungen |
| US20100166696A1 (en) * | 2007-04-27 | 2010-07-01 | Dhal Pradeep K | Amido-amine dendrimer compositions |
| EP2217215A1 (de) * | 2007-12-14 | 2010-08-18 | Genzyme Corporation | Beschichtete pharmazeutische zusammensetzungen |
| WO2009154747A1 (en) * | 2008-06-20 | 2009-12-23 | Genzyme Corporation | Pharmaceutical compositions |
| US8337824B2 (en) | 2008-08-22 | 2012-12-25 | Relypsa, Inc. | Linear polyol stabilized polyfluoroacrylate compositions |
| KR102150184B1 (ko) * | 2008-08-22 | 2020-08-31 | 리립사, 인크. | 가교결합된 양이온교환 폴리머, 조성물 및 고칼륨혈증 치료 용도 |
| US20100104527A1 (en) * | 2008-08-22 | 2010-04-29 | Relypsa, Inc. | Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties |
| WO2011109521A1 (en) | 2010-03-02 | 2011-09-09 | University Of Kansas | Polyamine-dihydroxybenzoic acid conjugate hydrogels as iron chelators |
| JP5882991B2 (ja) | 2010-05-14 | 2016-03-09 | ザ サン プロダクツ コーポレーション | ポリマー含有洗浄組成物ならびにその生成法および使用法 |
| WO2012096183A1 (ja) | 2011-01-14 | 2012-07-19 | 株式会社ダステック | 高分子鉄キレート剤 |
| CA2886788C (en) | 2012-10-08 | 2022-04-19 | Relypsa, Inc. | Potassium-binding agents for treating hypertension and hyperkalemia |
| CN103251648B (zh) | 2013-05-15 | 2015-08-05 | 乔敏 | 治疗血磷酸盐过多症及缺铁性贫血症的铁基蒙脱石药物及其制备方法 |
| MA41202A (fr) | 2014-12-18 | 2017-10-24 | Genzyme Corp | Copolymères polydiallymine réticulé pour le traitement du diabète de type 2 |
| DE102019208832A1 (de) | 2019-06-18 | 2020-12-24 | Henkel Ag & Co. Kgaa | Polymere für die Behandlung von Oberflächen |
| CN112047854B (zh) * | 2020-10-20 | 2021-07-02 | 中国科学院长春应用化学研究所 | 一种n-乙烯基烷基酰胺的制备方法 |
| CN121181441A (zh) * | 2025-11-25 | 2025-12-23 | 湖北天安日用化工有限公司 | 一种脂肪酰烷基氨基酸钠的合成、生产、制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE579299A (de) * | 1958-06-04 | |||
| US3308020A (en) * | 1961-09-22 | 1967-03-07 | Merck & Co Inc | Compositions and method for binding bile acids in vivo including hypocholesteremics |
| US3803237A (en) * | 1969-11-03 | 1974-04-09 | Upjohn Co | Reaction products of polyethylenepolyamines and chlorohydrins or epoxy containing compounds |
| ATE12511T1 (de) * | 1980-12-12 | 1985-04-15 | Smith & Nephew Ass | Polymere, deren herstellung und verwendungen. |
| US4504640A (en) * | 1982-05-19 | 1985-03-12 | Nitto Boseki Co., Ltd. | Process for producing monoallylamine polymer |
| GB2136068B (en) * | 1983-03-04 | 1986-07-30 | Honda Motor Co Ltd | Multi-speed transmission |
| JPS6090243A (ja) * | 1983-10-25 | 1985-05-21 | Nitto Boseki Co Ltd | 小球状モノアリルアミン橋かけ重合体の製造方法 |
| CA1220896A (en) * | 1983-11-10 | 1987-04-21 | Susumu Harada | Process for producing polymers of monoallylamine |
| US4540760A (en) * | 1984-01-11 | 1985-09-10 | Nitto Boseki Co. Ltd. | Process for producing polymers of monoallylamine |
| JPS60209523A (ja) * | 1984-04-03 | 1985-10-22 | Mitsubishi Petrochem Co Ltd | コレステロ−ル低下剤 |
| OA08092A (fr) * | 1984-05-11 | 1987-03-31 | Bristol Myers Co | Novel bile sequestrant resin and uses. |
| US4613616A (en) * | 1984-07-20 | 1986-09-23 | Research Corporation | Polymeric iron chelators |
| US5236701A (en) * | 1989-07-19 | 1993-08-17 | Lowchol Scientific Inc. | Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol |
| SE465155B (sv) * | 1989-12-19 | 1991-08-05 | Exploaterings Ab Tbf | Metallkelatbildande hydrofil polymer foer adsorption etc samt ett saett foer framstaellning av polymeren |
| CA2040996A1 (en) * | 1990-05-02 | 1991-11-03 | Robert L. Albright | Composition and method for controlling cholesterol |
| IE914179A1 (en) | 1990-12-07 | 1992-06-17 | Ici Plc | Nitrogen derivatives |
| CA2042870C (en) * | 1991-05-17 | 1996-11-26 | Leon Edward St. Pierre | Metal ion coordinated polyamine resins for the lowering of blood cholesterol |
| US5487888A (en) * | 1993-05-20 | 1996-01-30 | Geltex, Inc. | Iron-binding polymers for oral administration |
| JPH09500368A (ja) * | 1993-06-02 | 1997-01-14 | ジェルテックス ファーマシューティカルズ,インコーポレイテッド | 胆汁酸塩を除去するための組成物および方法 |
| US5496545A (en) * | 1993-08-11 | 1996-03-05 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| TW474813B (en) * | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
-
1993
- 1993-05-20 US US08/065,546 patent/US5487888A/en not_active Expired - Lifetime
-
1994
- 1994-05-16 DE DE69432559T patent/DE69432559T2/de not_active Expired - Lifetime
- 1994-05-16 EP EP94917977A patent/EP0699072B1/de not_active Expired - Lifetime
- 1994-05-16 JP JP50071295A patent/JP3645259B2/ja not_active Expired - Lifetime
- 1994-05-16 WO PCT/US1994/005359 patent/WO1994027621A1/en not_active Ceased
- 1994-05-16 AT AT94917977T patent/ATE238060T1/de not_active IP Right Cessation
- 1994-05-16 AU AU69489/94A patent/AU6948994A/en not_active Abandoned
-
1995
- 1995-12-06 US US08/567,933 patent/US5702696A/en not_active Expired - Lifetime
-
2000
- 2000-09-06 US US09/655,998 patent/US6605270B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0699072B1 (de) | 2003-04-23 |
| US5702696A (en) | 1997-12-30 |
| DE69432559D1 (de) | 2003-05-28 |
| JPH09501144A (ja) | 1997-02-04 |
| EP0699072A1 (de) | 1996-03-06 |
| DE69432559T2 (de) | 2003-11-20 |
| US6605270B1 (en) | 2003-08-12 |
| JP3645259B2 (ja) | 2005-05-11 |
| US5487888A (en) | 1996-01-30 |
| WO1994027621A1 (en) | 1994-12-08 |
| AU6948994A (en) | 1994-12-20 |
| EP0699072A4 (de) | 1998-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |