ATE238273T1 - Alpha-aminoamidderivate die als analgetische mittel nützlich sind - Google Patents

Alpha-aminoamidderivate die als analgetische mittel nützlich sind

Info

Publication number: ATE238273T1
Authority: AT; Austria
Prior art keywords: sub; hydrogen; alkyl; integer; present
Prior art date: 1997-12-31

Application number

AT98966617T

Other languages

English (en)

Inventor

Paolo Pevarello

Mario Varasi

Patricia Salvati

Claes Post

Original Assignee

Newron Pharm Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-31

Filing date

1998-12-12

Publication date

2003-05-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10824342&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE238273(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-12-12 Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE238273T1 publication Critical patent/ATE238273T1/de

Links

239000000730 antalgic agent Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
208000000094 Chronic Pain Diseases 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
208000004296 neuralgia Diseases 0.000 abstract 1
208000021722 neuropathic pain Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Pain & Pain Management (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Pyridine Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

AT98966617T 1997-12-31 1998-12-12 Alpha-aminoamidderivate die als analgetische mittel nützlich sind ATE238273T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9727523.4A GB9727523D0 (en)	1997-12-31	1997-12-31	Alpha-aminoamide derivatives useful as analgesic agents
PCT/EP1998/008157 WO1999035125A1 (en)	1997-12-31	1998-12-12	Alpha-aminoamide derivatives useful as analgesic agents

Publications (1)

Publication Number	Publication Date
ATE238273T1 true ATE238273T1 (de)	2003-05-15

Family

ID=10824342

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98966617T ATE238273T1 (de)	1997-12-31	1998-12-12	Alpha-aminoamidderivate die als analgetische mittel nützlich sind

Country Status (18)

Country	Link
US (2)	US6306903B1 (de)
EP (1)	EP1045830B1 (de)
JP (1)	JP4410930B2 (de)
KR (1)	KR100525587B1 (de)
AT (1)	ATE238273T1 (de)
BR (1)	BR9814548A (de)
CA (1)	CA2316902C (de)
DE (1)	DE69813896T2 (de)
DK (1)	DK1045830T3 (de)
EA (1)	EA002763B1 (de)
ES (1)	ES2194392T3 (de)
GB (1)	GB9727523D0 (de)
HU (1)	HU228995B1 (de)
IL (2)	IL136734A0 (de)
NO (1)	NO327453B1 (de)
NZ (1)	NZ505440A (de)
PT (1)	PT1045830E (de)
WO (1)	WO1999035125A1 (de)

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EP2201945B1 (de) *	1997-11-21	2013-03-06	Purdue Neuroscience Company	Verwendung von substituierten 2-Aminoacetamiden zur Behandlung oder Verbesserung von Angstzuständen
AU2002215053A1 (en) *	2000-11-27	2002-06-24	Pharmacia Italia S.P.A.	Phenylacetamido- pyrazole derivatives and their use as antitumor agents
CN1274306C (zh)	2001-09-03	2006-09-13	纽朗制药有限公司	包含加巴喷丁或其类似物和α－氨基酰胺的药物组合物及其止痛应用
US6476068B1 (en)	2001-12-06	2002-11-05	Pharmacia Italia, S.P.A.	Platinum derivative pharmaceutical formulations
EP1438956A1 (de)	2003-01-16	2004-07-21	Newron Pharmaceuticals S.p.A.	Alpha-Aminoamidderivate die als Antimigränemittel nützlich sind
WO2004087125A1 (en) *	2003-04-02	2004-10-14	Ionix Pharmaceuticals Limited	Amino acid derivatives as inhibitors of mammalian sodium channels
AR044007A1 (es)	2003-04-11	2005-08-24	Newron Pharmaceuticals Inc	Metodos para el tratamiento de la enfermedad de parkinson
WO2005000309A2 (en) *	2003-06-27	2005-01-06	Ionix Pharmaceuticals Limited	Chemical compounds
US20070276046A1 (en) *	2003-08-25	2007-11-29	Patricia Salvati	Alpha-Aminoamide Derivatives Useful as Anti-Inflammatory Agents
EP1524267A1 (de) *	2003-10-15	2005-04-20	Newron Pharmaceuticals S.p.A.	Substituierte Benzylaminoalkylen-Heterozyklen
EP1533302A1 (de) *	2003-11-21	2005-05-25	Newron Pharmaceuticals S.p.A.	Histidinderivate
EP1533298A1 (de)	2003-11-21	2005-05-25	Newron Pharmaceuticals S.p.A.	3-aminopyrrolidonederivate
EP1533295A1 (de)	2003-11-24	2005-05-25	Newron Pharmaceuticals S.p.A.	Cyclopentylderivate
EP1535908A1 (de) *	2003-11-24	2005-06-01	Newron Pharmaceuticals S.p.A.	N-Acyl-N'-Beznylalyklendiamin Derivate
EP1557166A1 (de) *	2004-01-21	2005-07-27	Newron Pharmaceuticals S.p.A.	Alpha-aminoamidderivate für die Behandlung von Funktionsstörungen der niedrigen Harnwege
EP1588704A1 (de)	2004-04-22	2005-10-26	Newron Pharmaceuticals S.p.A.	Alpha-aminoamidderivate zur Behandlung des Restless-Leg-Syndroms und der Suchterkrankungen
RS51411B (sr) *	2004-09-10	2011-02-28	Newron Pharmaceuticals S.P.A.	Upotreba (r)-(halobenziloksi) benzilamino-propanamida kao selektivnih modulatora natrijumovih i/ili kalcijumovih kanala
TW200728258A (en)	2005-10-10	2007-08-01	Glaxo Group Ltd	Novel compounds
EP1943216B1 (de) *	2005-10-10	2010-06-30	Glaxo Group Limited	Prolinamidderivate als natriumkanalmodulatoren
TW200730494A (en)	2005-10-10	2007-08-16	Glaxo Group Ltd	Novel compounds
IN266803B (de)	2005-12-22	2015-06-03	Newron Pharm Spa
EP1870097A1 (de) *	2006-06-15	2007-12-26	Newron Pharmaceuticals S.p.A.	Alpha-aminoamidederivate zur Behandlung von kognitiven Störungen
KR101491541B1 (ko)	2006-06-19	2015-02-09	뉴론 파마슈티칼즈 에스. 피. 에이.	2-［4-(3- 및 2-플루오로벤질옥시)벤질아미노)프로판 아미드의 제조방법
TR201802576T4 (tr)	2007-06-15	2018-03-21	Newron Pharm Spa	Sübsti̇tüe edi̇lmi̇ş 2-[2-(feni̇l)eti̇lami̇no]alkanami̇t türevleri̇ ve bunlarin sodyum ve/veya kalsi̇yum kanal modülatörleri̇ olarak kullanimi
EP3257842B1 (de)	2007-12-11	2020-11-18	Newron Pharmaceuticals S.p.A.	Therapeutische verwendung von 2-[4-(3- oder 2-fluorbenzyloxy)benzylamino]propanamiden mit hohem reinheitsgrad
EP2314569A1 (de)	2009-10-22	2011-04-27	Merck Patent GmbH	Neuartige polymorphe Formen von (S)-2-[4-(3-Fluor-benzyloxy)-benzylamino]-Propionamidmesylatsalz und Herstellungsverfahren dafür
LT2563355T (lt)	2010-04-27	2016-09-26	Newron Pharmaceuticals S.P.A.	Ralfinamido metansulfonato druskų arba jų r-enentiomerų gavimo būdas
CA2881322A1 (en)	2012-09-10	2014-03-13	F. Hoffmann-La Roche Ag	6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
KR101705718B1 (ko) *	2013-12-30	2017-02-14	이화여자대학교 산학협력단	신규한 아미드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 통증의 예방 또는 치료용 약학적 조성물
WO2016102967A1 (en)	2014-12-23	2016-06-30	Convergence Pharmaceuticals Limited	Process for preparing alpha-carboxamide pyrrolidine derivatives
CN107522654B (zh) *	2016-06-21	2020-09-01	中国人民解放军军事医学科学院毒物药物研究所	新的α-氨基酰胺衍生物及其医药用途
EP3691634A4 (de)	2017-10-05	2021-03-31	Biogen Inc.	Verfahren zur herstellung von alpha-carboxamid-pyrolidin-derivaten

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EP1438956A1 (de)	2003-01-16	2004-07-21	Newron Pharmaceuticals S.p.A.	Alpha-Aminoamidderivate die als Antimigränemittel nützlich sind
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1997
- 1997-12-31 GB GBGB9727523.4A patent/GB9727523D0/en not_active Ceased
1998
- 1998-12-12 DK DK98966617T patent/DK1045830T3/da active
- 1998-12-12 US US09/582,198 patent/US6306903B1/en not_active Ceased
- 1998-12-12 EP EP98966617A patent/EP1045830B1/de not_active Expired - Lifetime
- 1998-12-12 AT AT98966617T patent/ATE238273T1/de active
- 1998-12-12 BR BR9814548-7A patent/BR9814548A/pt not_active Application Discontinuation
- 1998-12-12 ES ES98966617T patent/ES2194392T3/es not_active Expired - Lifetime
- 1998-12-12 IL IL13673498A patent/IL136734A0/xx active IP Right Grant
- 1998-12-12 DE DE69813896T patent/DE69813896T2/de not_active Expired - Lifetime
- 1998-12-12 WO PCT/EP1998/008157 patent/WO1999035125A1/en not_active Ceased
- 1998-12-12 HU HU0100870A patent/HU228995B1/hu unknown
- 1998-12-12 EA EA200000731A patent/EA002763B1/ru not_active IP Right Cessation
- 1998-12-12 JP JP2000527527A patent/JP4410930B2/ja not_active Expired - Lifetime
- 1998-12-12 PT PT98966617T patent/PT1045830E/pt unknown
- 1998-12-12 US US11/359,982 patent/USRE40259E1/en not_active Expired - Lifetime
- 1998-12-12 NZ NZ505440A patent/NZ505440A/en not_active IP Right Cessation
- 1998-12-12 KR KR10-2000-7007229A patent/KR100525587B1/ko not_active Expired - Lifetime
- 1998-12-12 CA CA002316902A patent/CA2316902C/en not_active Expired - Lifetime
2000
- 2000-06-13 IL IL136734A patent/IL136734A/en not_active IP Right Cessation
- 2000-06-29 NO NO20003399A patent/NO327453B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
GB9727523D0 (en)	1998-02-25
JP2002508302A (ja)	2002-03-19
HUP0100870A3 (en)	2002-11-28
IL136734A (en)	2007-03-08
PT1045830E (pt)	2003-08-29
EA002763B1 (ru)	2002-08-29
JP4410930B2 (ja)	2010-02-10
NZ505440A (en)	2002-02-01
NO20003399L (no)	2000-08-02
KR100525587B1 (ko)	2005-11-03
CA2316902A1 (en)	1999-07-15
ES2194392T3 (es)	2003-11-16
BR9814548A (pt)	2000-10-10
EA200000731A1 (ru)	2001-02-26
NO20003399D0 (no)	2000-06-29
WO1999035125A1 (en)	1999-07-15
HUP0100870A2 (hu)	2001-07-30
US6306903B1 (en)	2001-10-23
DE69813896D1 (de)	2003-05-28
NO327453B1 (no)	2009-07-06
HU228995B1 (en)	2013-07-29
DK1045830T3 (da)	2003-08-04
EP1045830A1 (de)	2000-10-25
CA2316902C (en)	2006-06-06
EP1045830B1 (de)	2003-04-23
HK1028020A1 (en)	2001-02-02
USRE40259E1 (en)	2008-04-22
IL136734A0 (en)	2001-06-14
KR20010033706A (ko)	2001-04-25
DE69813896T2 (de)	2003-11-06

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2003-09-15

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