ATE238297T1 - Chinolinderivat - Google Patents
ChinolinderivatInfo
- Publication number
- ATE238297T1 ATE238297T1 AT95934864T AT95934864T ATE238297T1 AT E238297 T1 ATE238297 T1 AT E238297T1 AT 95934864 T AT95934864 T AT 95934864T AT 95934864 T AT95934864 T AT 95934864T AT E238297 T1 ATE238297 T1 AT E238297T1
- Authority
- AT
- Austria
- Prior art keywords
- carbon atoms
- group
- integer
- phenyl
- alkyl
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000005330 8 membered heterocyclic group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- -1 nitro, amino, phenyl Chemical group 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 235000001508 sulfur Nutrition 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28130194 | 1994-10-20 | ||
| JP21805695 | 1995-08-03 | ||
| PCT/JP1995/002167 WO1996012719A1 (en) | 1994-10-20 | 1995-10-20 | Quinoline derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE238297T1 true ATE238297T1 (de) | 2003-05-15 |
Family
ID=26522365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95934864T ATE238297T1 (de) | 1994-10-20 | 1995-10-20 | Chinolinderivat |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5693651A (de) |
| EP (1) | EP0787725B1 (de) |
| KR (1) | KR100356551B1 (de) |
| CN (1) | CN1071333C (de) |
| AT (1) | ATE238297T1 (de) |
| AU (1) | AU712802B2 (de) |
| CA (1) | CA2201113A1 (de) |
| DE (1) | DE69530501D1 (de) |
| RU (1) | RU2137770C1 (de) |
| WO (1) | WO1996012719A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6121288A (en) * | 1996-11-08 | 2000-09-19 | Nippon Chemiphar Co., Ltd. | Visceral fat lowering agent |
| AU3455100A (en) * | 1999-05-28 | 2000-12-18 | Nippon Chemiphar Co. Ltd. | Process for the preparation of 2-halo-3-(3-quinolyl)propionic acid derivatives |
| EP1695716A2 (de) * | 2000-12-26 | 2006-08-30 | Sankyo Company, Limited | Medizinische Zusammensetzungen enthaltend ein Diuretikum und einen Insulin-Sensibilisator |
| US7015345B2 (en) * | 2002-02-21 | 2006-03-21 | Asahi Kasei Pharma Corporation | Propionic acid derivatives |
| US20050119314A1 (en) * | 2002-04-05 | 2005-06-02 | Sankyo Company, Limited | Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent |
| US7232828B2 (en) | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
| PA8594401A1 (es) * | 2003-02-21 | 2004-09-16 | Pfizer | Acidos carboxilicos de heteroarilo condensado como agonista del ppar |
| US7241893B2 (en) * | 2004-09-17 | 2007-07-10 | Hoffman-La Roche Inc. | Thiazolinone 2-substituted quinolines |
| US7253285B2 (en) * | 2004-09-17 | 2007-08-07 | Hoffmann-La Roche Inc. | Thiazolinone 4-monosubstituted quinolines |
| WO2008020302A2 (en) * | 2006-08-17 | 2008-02-21 | Pfizer Products Inc. | Heteroaromatic quinoline-based compounds as phosphodiesterase (pde) inhibitors |
| CN102702082B (zh) * | 2006-11-30 | 2014-12-17 | 陶氏益农公司 | 2-取代的-5-((1-烷硫基)烷基)吡啶的制备方法 |
| WO2011079274A1 (en) | 2009-12-23 | 2011-06-30 | Jasco Pharmaceuticals, LLC | Aminopyrimidine kinase inhibitors |
| WO2012145617A2 (en) * | 2011-04-22 | 2012-10-26 | Jasco Pharmaceuticals, LLC | Aminopyrimidine kinase inhibitors |
| BR112014010563B1 (pt) | 2011-11-04 | 2021-01-12 | Jasco Pharmaceuticals, LLC | compostos inibidores da aminopirimidina quinase |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR240698A1 (es) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
| CZ181493A3 (en) * | 1992-09-10 | 1994-03-16 | Lilly Co Eli | The use of rhodanine derivative for the preparation of a pharmaceutical composition reducing level of sugar in blood and for treating alzheimer's disease |
| FR2696743B1 (fr) * | 1992-10-12 | 1994-12-23 | Adir | Nouveaux composés de thiazolidine dione, leur procédé de préparation et les compositions pharmaceutiques les contenant. |
-
1995
- 1995-10-20 WO PCT/JP1995/002167 patent/WO1996012719A1/ja not_active Ceased
- 1995-10-20 CA CA002201113A patent/CA2201113A1/en not_active Abandoned
- 1995-10-20 DE DE69530501T patent/DE69530501D1/de not_active Expired - Lifetime
- 1995-10-20 AT AT95934864T patent/ATE238297T1/de not_active IP Right Cessation
- 1995-10-20 KR KR1019970702575A patent/KR100356551B1/ko not_active Expired - Fee Related
- 1995-10-20 EP EP95934864A patent/EP0787725B1/de not_active Expired - Lifetime
- 1995-10-20 RU RU97107992/04A patent/RU2137770C1/ru not_active IP Right Cessation
- 1995-10-20 AU AU37098/95A patent/AU712802B2/en not_active Ceased
- 1995-10-20 CN CN95196871A patent/CN1071333C/zh not_active Expired - Fee Related
- 1995-10-20 US US08/809,592 patent/US5693651A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2201113A1 (en) | 1996-05-02 |
| DE69530501D1 (de) | 2003-05-28 |
| EP0787725A4 (de) | 1998-01-07 |
| EP0787725B1 (de) | 2003-04-23 |
| KR970707122A (ko) | 1997-12-01 |
| CN1170411A (zh) | 1998-01-14 |
| AU712802B2 (en) | 1999-11-18 |
| RU2137770C1 (ru) | 1999-09-20 |
| CN1071333C (zh) | 2001-09-19 |
| KR100356551B1 (ko) | 2002-12-18 |
| US5693651A (en) | 1997-12-02 |
| WO1996012719A1 (en) | 1996-05-02 |
| EP0787725A1 (de) | 1997-08-06 |
| AU3709895A (en) | 1996-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |