ATE238421T1 - Interleukin-3 (il-3)-polypeptide mith mehreren mutationen - Google Patents

Interleukin-3 (il-3)-polypeptide mith mehreren mutationen

Info

Publication number
ATE238421T1
ATE238421T1 AT94901584T AT94901584T ATE238421T1 AT E238421 T1 ATE238421 T1 AT E238421T1 AT 94901584 T AT94901584 T AT 94901584T AT 94901584 T AT94901584 T AT 94901584T AT E238421 T1 ATE238421 T1 AT E238421T1
Authority
AT
Austria
Prior art keywords
hil
muteins
amino acid
relates
present
Prior art date
Application number
AT94901584T
Other languages
English (en)
Inventor
S Christopher Bauer
Mark Allen Abrams
Sarah Ruth Braford-Goldberg
Maire Helena Caparon
Alan Michael Easton
Barbara Kure Klein
John Patrick Mckearn
Peter O Olins
Kumnan Paik
John Warren Thomas
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE238421T1 publication Critical patent/ATE238421T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT94901584T 1992-11-24 1993-11-22 Interleukin-3 (il-3)-polypeptide mith mehreren mutationen ATE238421T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98104492A 1992-11-24 1992-11-24
PCT/US1993/011197 WO1994012638A2 (en) 1992-11-24 1993-11-22 Interleukin-3 (il-3) multiple mutation polypeptides

Publications (1)

Publication Number Publication Date
ATE238421T1 true ATE238421T1 (de) 2003-05-15

Family

ID=25528061

Family Applications (2)

Application Number Title Priority Date Filing Date
AT94902293T ATE251669T1 (de) 1992-11-24 1993-11-22 Mutierte polypeptide des interleukin-3(il-3)
AT94901584T ATE238421T1 (de) 1992-11-24 1993-11-22 Interleukin-3 (il-3)-polypeptide mith mehreren mutationen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT94902293T ATE251669T1 (de) 1992-11-24 1993-11-22 Mutierte polypeptide des interleukin-3(il-3)

Country Status (12)

Country Link
US (11) US5604116A (de)
EP (4) EP0672145B1 (de)
JP (3) JPH08503706A (de)
KR (1) KR100332139B1 (de)
AT (2) ATE251669T1 (de)
AU (3) AU5670994A (de)
CA (2) CA2150116A1 (de)
DE (2) DE69333243T2 (de)
DK (2) DK0670898T3 (de)
ES (2) ES2198416T3 (de)
PT (2) PT670898E (de)
WO (2) WO1994012638A2 (de)

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US6361976B1 (en) * 1992-11-24 2002-03-26 S. Christopher Bauer Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production
US5772992A (en) * 1992-11-24 1998-06-30 G.D. Searle & Co. Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors
US6403076B1 (en) * 1992-11-24 2002-06-11 S. Christopher Bauer Compositions for increasing hematopoiesis with interleukin-3 mutants
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US6436387B1 (en) * 1992-11-24 2002-08-20 G.D. Searle & Co. Methods of ex-vivo expansion of hematopoietic cells using multivariant IL-3 hematopoiesis chimera proteins
US6057133A (en) * 1992-11-24 2000-05-02 G. D. Searle Multivariant human IL-3 fusion proteins and their recombinant production
CA2150116A1 (en) * 1992-11-24 1994-06-09 S. Christopher Bauer Interleukin-3 (il-3) multiple mutation polypeptides
US6413509B1 (en) * 1992-11-24 2002-07-02 S. Christopher Bauer Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 mutant polypeptides with other hematopoietic growth factors
US7091319B1 (en) 1992-11-24 2006-08-15 Bauer S Christopher IL-3 variant hematopoiesis fusion protein
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
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Also Published As

Publication number Publication date
EP1361273A2 (de) 2003-11-12
PT670898E (pt) 2004-02-27
DE69333243D1 (de) 2003-11-13
DK0670898T3 (da) 2004-02-09
AU690088B2 (en) 1998-04-23
JPH08503706A (ja) 1996-04-23
US6051217A (en) 2000-04-18
AU6078398A (en) 1998-06-18
JPH08503489A (ja) 1996-04-16
US5604116A (en) 1997-02-18
US20030103936A1 (en) 2003-06-05
US5817486A (en) 1998-10-06
WO1994012639A2 (en) 1994-06-09
DK0672145T3 (da) 2003-08-11
US20030220472A1 (en) 2003-11-27
US6440407B1 (en) 2002-08-27
CA2150116A1 (en) 1994-06-09
EP0672145B1 (de) 2003-04-23
US5677149A (en) 1997-10-14
EP1283264A3 (de) 2004-03-10
EP1283264A2 (de) 2003-02-12
AU5612594A (en) 1994-06-22
US20040018618A1 (en) 2004-01-29
DE69333243T2 (de) 2004-08-19
WO1994012639A3 (en) 1994-07-21
DE69332908D1 (de) 2003-05-28
EP0670898B1 (de) 2003-10-08
ATE251669T1 (de) 2003-10-15
AU5670994A (en) 1994-06-22
US6479261B1 (en) 2002-11-12
EP0672145A1 (de) 1995-09-20
US6458931B1 (en) 2002-10-01
KR950704490A (ko) 1995-11-20
EP1361273A3 (de) 2004-02-11
CA2150117A1 (en) 1994-06-09
WO1994012638A3 (en) 1994-09-01
WO1994012638A2 (en) 1994-06-09
ES2198416T3 (es) 2004-02-01
JP2003259886A (ja) 2003-09-16
US20050244372A1 (en) 2005-11-03
ES2211875T3 (es) 2004-07-16
KR100332139B1 (ko) 2002-11-30
PT672145E (pt) 2003-08-29
DE69332908T2 (de) 2003-12-24
EP0670898A1 (de) 1995-09-13

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