ATE238811T1 - Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften - Google Patents

Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften

Info

Publication number
ATE238811T1
ATE238811T1 AT99931229T AT99931229T ATE238811T1 AT E238811 T1 ATE238811 T1 AT E238811T1 AT 99931229 T AT99931229 T AT 99931229T AT 99931229 T AT99931229 T AT 99931229T AT E238811 T1 ATE238811 T1 AT E238811T1
Authority
AT
Austria
Prior art keywords
protein transferase
transferase inhibitors
farnesyl protein
radiosensitizing properties
radiosensitizing
Prior art date
Application number
AT99931229T
Other languages
English (en)
Inventor
Ginckel Robert Franciscus Van
Wim Joanna Floren
David William End
Walter Boudewijn Leopo Wouters
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE238811T1 publication Critical patent/ATE238811T1/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
AT99931229T 1998-07-06 1999-06-30 Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften ATE238811T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98202257 1998-07-06
EP98204330 1998-12-18
PCT/EP1999/004545 WO2000001411A1 (en) 1998-07-06 1999-06-30 Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties

Publications (1)

Publication Number Publication Date
ATE238811T1 true ATE238811T1 (de) 2003-05-15

Family

ID=26150503

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99931229T ATE238811T1 (de) 1998-07-06 1999-06-30 Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften

Country Status (30)

Country Link
US (1) US6545020B1 (de)
EP (1) EP1094839B1 (de)
JP (1) JP4530537B2 (de)
KR (1) KR100591603B1 (de)
CN (1) CN1152716C (de)
AP (1) AP1599A (de)
AT (1) ATE238811T1 (de)
AU (1) AU762423B2 (de)
BG (1) BG64941B1 (de)
BR (1) BR9911861A (de)
CA (1) CA2336624C (de)
CZ (1) CZ300968B6 (de)
DE (1) DE69907461T2 (de)
DK (1) DK1094839T3 (de)
EA (1) EA003877B1 (de)
EE (1) EE04582B1 (de)
ES (1) ES2199579T3 (de)
HR (1) HRP20000903A2 (de)
HU (1) HU229076B1 (de)
ID (1) ID26987A (de)
IL (2) IL140721A0 (de)
MY (1) MY126519A (de)
NO (1) NO328178B1 (de)
PL (1) PL193464B1 (de)
PT (1) PT1094839E (de)
SI (1) SI1094839T1 (de)
SK (1) SK284723B6 (de)
TR (1) TR200003879T2 (de)
TW (1) TW586937B (de)
WO (1) WO2000001411A1 (de)

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US7173040B2 (en) 2000-09-25 2007-02-06 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derinazoline derivatives
JP4348080B2 (ja) 2000-11-21 2009-10-21 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ファルネシルトランスフェラーゼを阻害するベンゾ複素環誘導体
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WO2009151683A2 (en) * 2008-03-12 2009-12-17 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
ATE555384T1 (de) 2008-06-26 2012-05-15 Spherotec Gmbh Verfahren zum testen der reaktion von zellen auf die einwirkung von therapeutika
US20100331363A1 (en) * 2008-11-13 2010-12-30 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
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US20110060005A1 (en) * 2008-11-13 2011-03-10 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
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CN104884448A (zh) 2012-10-16 2015-09-02 詹森药业有限公司 Rorγt的杂芳基连接的喹啉基调节剂
CN105073729A (zh) 2012-10-16 2015-11-18 詹森药业有限公司 RORγt的苯基连接的喹啉基调节剂
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
BR112016008258A2 (pt) 2013-10-15 2017-10-10 Janssen Pharmaceutica Nv moduladores de ror?t de quinolinila
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
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TW201818965A (zh) 2016-11-03 2018-06-01 美商庫拉腫瘤技術股份有限公司 以法呢基轉移酶（ｆａｒｎｅｓｙｌ ｔｒａｎｓｆｅｒａｓｅ）抑制劑治療癌症病患之方法
US10137121B2 (en) 2017-02-21 2018-11-27 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
TWI738314B (zh) 2017-02-21 2021-09-01 美商庫拉腫瘤技術股份有限公司 以法呢基轉移酶(farnesyltransferase)抑制劑治療癌症之方法
US10806730B2 (en) 2017-08-07 2020-10-20 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
MX2020001207A (es) 2017-08-07 2020-03-20 Kura Oncology Inc Metodos de tratamiento del cancer con inhibidores de farnesiltransferasa.
WO2019113269A1 (en) 2017-12-08 2019-06-13 Kura Oncology, Inc. Methods of treating cancer patients with farnesyltransferase inhibitors
EP3873469A2 (de) 2018-11-01 2021-09-08 Kura Oncology, Inc. Verfahren zur behandlung von krebs mit farnesyltransferase-inhibitoren
WO2020180663A1 (en) 2019-03-01 2020-09-10 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
US20220143006A1 (en) 2019-03-15 2022-05-12 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
CA3134825A1 (en) 2019-03-29 2020-10-08 Kura Oncology, Inc. Methods of treating squamous cell carcinomas with farnesyltransferase inhibitors
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Also Published As

Publication number Publication date
BG105108A (en) 2001-11-30
EE04582B1 (et) 2006-02-15
HU229076B1 (en) 2013-07-29
US6545020B1 (en) 2003-04-08
TR200003879T2 (tr) 2007-01-22
HRP20000903A2 (en) 2001-12-31
MY126519A (en) 2006-10-31
IL140721A (en) 2008-11-26
ID26987A (id) 2001-02-22
KR20010052770A (ko) 2001-06-25
EE200000794A (et) 2002-06-17
KR100591603B1 (ko) 2006-06-20
CA2336624C (en) 2008-10-21
SK284723B6 (sk) 2005-10-06
SI1094839T1 (en) 2003-12-31
HUP0103689A3 (en) 2003-01-28
PT1094839E (pt) 2003-09-30
WO2000001411A1 (en) 2000-01-13
PL347979A1 (en) 2002-05-06
BR9911861A (pt) 2001-03-20
NO20010082L (no) 2001-01-05
IL140721A0 (en) 2002-02-10
DE69907461D1 (de) 2003-06-05
EA003877B1 (ru) 2003-10-30
DE69907461T2 (de) 2004-02-19
NO328178B1 (no) 2009-12-28
EP1094839B1 (de) 2003-05-02
AU4780599A (en) 2000-01-24
CZ20004777A3 (en) 2001-05-16
ES2199579T3 (es) 2004-02-16
AP1599A (en) 2006-04-27
JP2002519389A (ja) 2002-07-02
BG64941B1 (bg) 2006-10-31
DK1094839T3 (da) 2003-08-18
HK1034451A1 (en) 2001-10-26
PL193464B1 (pl) 2007-02-28
HUP0103689A2 (hu) 2002-02-28
EP1094839A1 (de) 2001-05-02
CN1152716C (zh) 2004-06-09
NO20010082D0 (no) 2001-01-05
JP4530537B2 (ja) 2010-08-25
EA200100111A1 (ru) 2001-06-25
CN1311692A (zh) 2001-09-05
AP2001002057A0 (en) 2001-03-31
AU762423B2 (en) 2003-06-26
SK19862000A3 (sk) 2001-12-03
CZ300968B6 (cs) 2009-09-30
TW586937B (en) 2004-05-11
CA2336624A1 (en) 2000-01-13

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