ATE238811T1 - Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften - Google Patents

Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften

Info

Publication number: ATE238811T1
Authority: AT; Austria
Prior art keywords: protein transferase; transferase inhibitors; farnesyl protein; radiosensitizing properties; radiosensitizing
Prior art date: 1998-07-06

Application number

AT99931229T

Other languages

English (en)

Inventor

Ginckel Robert Franciscus Van

Wim Joanna Floren

David William End

Walter Boudewijn Leopo Wouters

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-06

Filing date

1999-06-30

Publication date

2003-05-15

1999-06-30 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE238811T1 publication Critical patent/ATE238811T1/de

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)

AT99931229T 1998-07-06 1999-06-30 Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften ATE238811T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP98202257		1998-07-06
EP98204330		1998-12-18
PCT/EP1999/004545 WO2000001411A1 (en)	1998-07-06	1999-06-30	Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties

Publications (1)

Publication Number	Publication Date
ATE238811T1 true ATE238811T1 (de)	2003-05-15

Family

ID=26150503

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99931229T ATE238811T1 (de)	1998-07-06	1999-06-30	Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften

Country Status (30)

Country	Link
US (1)	US6545020B1 (de)
EP (1)	EP1094839B1 (de)
JP (1)	JP4530537B2 (de)
KR (1)	KR100591603B1 (de)
CN (1)	CN1152716C (de)
AP (1)	AP1599A (de)
AT (1)	ATE238811T1 (de)
AU (1)	AU762423B2 (de)
BG (1)	BG64941B1 (de)
BR (1)	BR9911861A (de)
CA (1)	CA2336624C (de)
CZ (1)	CZ300968B6 (de)
DE (1)	DE69907461T2 (de)
DK (1)	DK1094839T3 (de)
EA (1)	EA003877B1 (de)
EE (1)	EE04582B1 (de)
ES (1)	ES2199579T3 (de)
HR (1)	HRP20000903A2 (de)
HU (1)	HU229076B1 (de)
ID (1)	ID26987A (de)
IL (2)	IL140721A0 (de)
MY (1)	MY126519A (de)
NO (1)	NO328178B1 (de)
PL (1)	PL193464B1 (de)
PT (1)	PT1094839E (de)
SI (1)	SI1094839T1 (de)
SK (1)	SK284723B6 (de)
TR (1)	TR200003879T2 (de)
TW (1)	TW586937B (de)
WO (1)	WO2000001411A1 (de)

Families Citing this family (59)

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HRP20000904A2 (en)	1998-07-06	2001-12-31	Janssen Pharmaceutica Nv	Farnesyl protein transferase inhibitors for treating arthropathies
PL193464B1 (pl)	1998-07-06	2007-02-28	Janssen Pharmaceutica Nv	Zastosowanie inhibitora białkowej transferazy farnezylowej
SI1255537T1 (sl) *	2000-02-04	2006-10-31	Janssen Pharmaceutica Nv	Inhibitorji farnezil protein transferaze za zdravljenje raka dojk
JO2361B1 (en) *	2000-06-22	2006-12-12	جانسين فارماسيوتيكا ان. في	Enaniumer 1,2-anylated quinoline inhibitor for the transporter - farnesyl
JP4974437B2 (ja)	2000-09-25	2012-07-11	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ファルネシルトランスフェラーゼを阻害する６−［（置換フェニル）メチル］−キノリンおよびキナゾリン誘導体
WO2002024686A2 (en)	2000-09-25	2002-03-28	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives
DE60118225T2 (de)	2000-09-25	2007-05-03	Janssen Pharmaceutica N.V.	Chinolin- und chinazolinderivate und deren verwendung als farnesyl transferase inhibitoren
US7067531B2 (en)	2000-09-25	2006-06-27	Angibaud Patrick Rene	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
AU2002214056A1 (en)	2000-11-21	2002-06-03	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting benzoheterocyclic derivatives
JP4351445B2 (ja)	2000-12-27	2009-10-28	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ファルネシルトランスフェラーゼを阻害する４−置換−キノリンおよびキナゾリン誘導体
US20040067968A1 (en) *	2000-12-27	2004-04-08	Angibaud Patrick Rene	Farnesyl transferase inhibiting 4-heterocyclyl quinoline and quinazoline
EP1408971A4 (de)	2001-06-21	2006-01-25	Ariad Pharma Inc	Neue chinoline und ihre verwendungszwecke
EP1458720B1 (de)	2001-12-19	2009-03-18	Janssen Pharmaceutica N.V.	Durch c-verbundene imidazole substituierte 1,8-annellierten chinolon-derivate als farnesyl transferase inhibitoren
EP1490065B1 (de)	2002-03-22	2007-06-13	Janssen Pharmaceutica N.V.	Benzylimidazolyl substituierte 2-chinolon und chinazolinon derivate zur verwendung als farnesyl transferase inhibitoren
DE60307616T2 (de)	2002-04-15	2007-10-04	Janssen Pharmaceutica N.V.	Farnesyl transferase hemmende tricyclische quinazolinederivate substitutiert mit kohlenstoff-gebundenen imidazolen oder triazolen
EA009875B1 (ru) *	2003-11-20	2008-04-28	Янссен Фармацевтика Н.В.	6-алкенил и 6-фенилалкил замещенные 2-хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(адф-рибоза) полимеразы
JP4691041B2 (ja)	2003-11-20	2011-06-01	チルドレンズホスピタルメディカルセンター	Ｇｔｐアーゼ阻害剤および使用方法
US20070293539A1 (en) *	2004-03-18	2007-12-20	Lansbury Peter T	Methods for the treatment of synucleinopathies
US20060106060A1 (en) *	2004-03-18	2006-05-18	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies (Lansbury)
CA2559285A1 (en) *	2004-03-18	2005-09-29	Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
CA2559282A1 (en) *	2004-03-18	2005-09-29	Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
US20050272722A1 (en) *	2004-03-18	2005-12-08	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
WO2005089518A2 (en) *	2004-03-18	2005-09-29	The Brigham And Women's Hospital, Inc.	Uch-l1 expression and cancer therapy
US20060194821A1 (en) *	2005-02-18	2006-08-31	The Brigham And Women's Hospital, Inc.	Compounds inhibiting the aggregation of superoxide dismutase-1
WO2007016539A2 (en)	2005-07-29	2007-02-08	Children's Hospital Medical Center	Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase
EP1968591A4 (de)	2005-12-23	2010-02-17	Link Medicine Corp	Behandlung von synucleinopathien
AU2008256928A1 (en) *	2007-05-23	2008-12-04	Allergan, Inc.	Therapeutic ((phenyl)imidazolyl)methylquinolinyl compounds
WO2009151683A2 (en) *	2008-03-12	2009-12-17	Link Medicine Corporation	Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
EP2138844B1 (de)	2008-06-26	2012-04-25	SpheroTec GmbH	Verfahren zum Testen der Reaktion von Zellen auf die Einwirkung von Therapeutika
US20110060005A1 (en) *	2008-11-13	2011-03-10	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
US20100331363A1 (en) *	2008-11-13	2010-12-30	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
JP2012508768A (ja) *	2008-11-13	2012-04-12	リンク・メディスン・コーポレーション	アザキノリノン誘導体及びその使用
US9980942B2 (en)	2012-05-02	2018-05-29	Children's Hospital Medical Center	Rejuvenation of precursor cells
MY189505A (en)	2012-10-16	2022-02-16	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of roryt
ES2619610T3 (es)	2012-10-16	2017-06-26	Janssen Pharmaceutica Nv	Moduladores de ROR-gamma-t de quinolinilo enlazado con heteroarilo
CA2888485C (en)	2012-10-16	2021-01-26	Janssen Pharmaceutica Nv	Phenyl linked quinolinyl modulators of ror.gamma.t
US9284308B2 (en)	2013-10-15	2016-03-15	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of RORγt
US9221804B2 (en)	2013-10-15	2015-12-29	Janssen Pharmaceutica Nv	Secondary alcohol quinolinyl modulators of RORγt
US9328095B2 (en)	2013-10-15	2016-05-03	Janssen Pharmaceutica Nv	Heteroaryl linked quinolinyl modulators of RORgammat
US10555941B2 (en)	2013-10-15	2020-02-11	Janssen Pharmaceutica Nv	Alkyl linked quinolinyl modulators of RORγt
ES2742843T3 (es)	2013-10-15	2020-02-17	Janssen Pharmaceutica Nv	Moduladores de quinolinilo de ROR(gamma)t
US9403816B2 (en)	2013-10-15	2016-08-02	Janssen Pharmaceutica Nv	Phenyl linked quinolinyl modulators of RORγt
BR112016008215A2 (pt)	2013-10-15	2017-09-26	Janssen Pharmaceutica Nv	moduladores de quinolinila ligados por alquila de roryt
US10028503B2 (en)	2014-06-18	2018-07-24	Children's Hospital Medical Center	Platelet storage methods and compositions for same
HUE044698T2 (hu)	2015-08-17	2019-11-28	Kura Oncology Inc	Kezelési módszer rákos páciensek kezelésére farnezil-transzferáz inhibitorokkal
WO2017184968A1 (en)	2016-04-22	2017-10-26	Kura Oncology, Inc.	Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
JP2019534290A (ja)	2016-11-03	2019-11-28	クラオンコロジー，インコーポレイテッド	癌の治療方法において使用するためのファルネシルトランスフェラーゼ阻害剤
US9956215B1 (en)	2017-02-21	2018-05-01	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
EP4119142A1 (de)	2017-02-21	2023-01-18	Kura Oncology, Inc.	Verfahren zur behandlung von krebs mit farnesyltransferase-inhibitoren
US10806730B2 (en)	2017-08-07	2020-10-20	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
MY200746A (en)	2017-08-07	2024-01-13	Kura Oncology Inc	Methods of treating cancer with farnesyltransferase inhibitors
WO2019113269A1 (en)	2017-12-08	2019-06-13	Kura Oncology, Inc.	Methods of treating cancer patients with farnesyltransferase inhibitors
TW202031259A (zh)	2018-11-01	2020-09-01	美商庫拉腫瘤技術股份有限公司	以法尼基轉移酶(farnesyltransferase)抑制劑治療癌症之方法
WO2020180663A1 (en)	2019-03-01	2020-09-10	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
WO2020190604A1 (en)	2019-03-15	2020-09-24	Kura Oncology, Inc.	Methods of treating cancer patients with farnesyltransferase inhibitors
AU2020254492A1 (en)	2019-03-29	2021-11-11	Kura Oncology, Inc.	Methods of treating Squamous Cell Carcinomas with farnesyltransferase inhibitors
WO2020205387A1 (en)	2019-04-01	2020-10-08	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
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1999
- 1999-06-30 PL PL99347979A patent/PL193464B1/pl unknown
- 1999-06-30 US US09/743,130 patent/US6545020B1/en not_active Expired - Lifetime
- 1999-06-30 BR BR9911861-0A patent/BR9911861A/pt not_active Application Discontinuation
- 1999-06-30 CZ CZ20004777A patent/CZ300968B6/cs not_active IP Right Cessation
- 1999-06-30 HU HU0103689A patent/HU229076B1/hu unknown
- 1999-06-30 KR KR1020007014066A patent/KR100591603B1/ko not_active Expired - Lifetime
- 1999-06-30 DE DE69907461T patent/DE69907461T2/de not_active Expired - Lifetime
- 1999-06-30 TR TR2000/03879T patent/TR200003879T2/xx unknown
- 1999-06-30 ID IDW20010020A patent/ID26987A/id unknown
- 1999-06-30 HR HR20000903A patent/HRP20000903A2/hr not_active Application Discontinuation
- 1999-06-30 CA CA002336624A patent/CA2336624C/en not_active Expired - Lifetime
- 1999-06-30 EE EEP200000794A patent/EE04582B1/xx unknown
- 1999-06-30 WO PCT/EP1999/004545 patent/WO2000001411A1/en not_active Ceased
- 1999-06-30 ES ES99931229T patent/ES2199579T3/es not_active Expired - Lifetime
- 1999-06-30 DK DK99931229T patent/DK1094839T3/da active
- 1999-06-30 AT AT99931229T patent/ATE238811T1/de active
- 1999-06-30 AU AU47805/99A patent/AU762423B2/en not_active Expired
- 1999-06-30 AP APAP/P/2001/002057A patent/AP1599A/en active
- 1999-06-30 SK SK1986-2000A patent/SK284723B6/sk not_active IP Right Cessation
- 1999-06-30 PT PT99931229T patent/PT1094839E/pt unknown
- 1999-06-30 EP EP99931229A patent/EP1094839B1/de not_active Expired - Lifetime
- 1999-06-30 EA EA200100111A patent/EA003877B1/ru not_active IP Right Cessation
- 1999-06-30 IL IL14072199A patent/IL140721A0/xx active IP Right Grant
- 1999-06-30 JP JP2000557857A patent/JP4530537B2/ja not_active Expired - Lifetime
- 1999-06-30 CN CNB998082678A patent/CN1152716C/zh not_active Expired - Lifetime
- 1999-06-30 SI SI9930332T patent/SI1094839T1/xx unknown
- 1999-07-01 MY MYPI99002794A patent/MY126519A/en unknown
- 1999-07-05 TW TW088111346A patent/TW586937B/zh not_active IP Right Cessation
2001
- 2001-01-03 BG BG105108A patent/BG64941B1/bg unknown
- 2001-01-04 IL IL140721A patent/IL140721A/en not_active IP Right Cessation
- 2001-01-05 NO NO20010082A patent/NO328178B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO20010082D0 (no)	2001-01-05
CN1152716C (zh)	2004-06-09
KR100591603B1 (ko)	2006-06-20
IL140721A (en)	2008-11-26
AU4780599A (en)	2000-01-24
JP2002519389A (ja)	2002-07-02
HUP0103689A2 (hu)	2002-02-28
CA2336624C (en)	2008-10-21
DE69907461D1 (de)	2003-06-05
CN1311692A (zh)	2001-09-05
BG64941B1 (bg)	2006-10-31
HK1034451A1 (en)	2001-10-26
HU229076B1 (en)	2013-07-29
TW586937B (en)	2004-05-11
CA2336624A1 (en)	2000-01-13
MY126519A (en)	2006-10-31
AU762423B2 (en)	2003-06-26
EP1094839B1 (de)	2003-05-02
SK19862000A3 (sk)	2001-12-03
EP1094839A1 (de)	2001-05-02
WO2000001411A1 (en)	2000-01-13
AP1599A (en)	2006-04-27
EA200100111A1 (ru)	2001-06-25
CZ20004777A3 (en)	2001-05-16
PT1094839E (pt)	2003-09-30
BR9911861A (pt)	2001-03-20
DK1094839T3 (da)	2003-08-18
ES2199579T3 (es)	2004-02-16
SK284723B6 (sk)	2005-10-06
US6545020B1 (en)	2003-04-08
HRP20000903A2 (en)	2001-12-31
NO328178B1 (no)	2009-12-28
DE69907461T2 (de)	2004-02-19
CZ300968B6 (cs)	2009-09-30
KR20010052770A (ko)	2001-06-25
AP2001002057A0 (en)	2001-03-31
PL347979A1 (en)	2002-05-06
EE200000794A (et)	2002-06-17
HUP0103689A3 (en)	2003-01-28
BG105108A (en)	2001-11-30
EA003877B1 (ru)	2003-10-30
TR200003879T2 (tr)	2007-01-22
EE04582B1 (et)	2006-02-15
ID26987A (id)	2001-02-22
SI1094839T1 (en)	2003-12-31
IL140721A0 (en)	2002-02-10
NO20010082L (no)	2001-01-05
PL193464B1 (pl)	2007-02-28
JP4530537B2 (ja)	2010-08-25

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2003-12-15

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Publication	Publication Date	Title
ATE238811T1 (de)	2003-05-15	Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften
EE9800262A (et)	1999-02-15	Farnesüül-proteiini transferaasi inhibiitorid
EE9800408A (et)	1999-06-15	Proteiinfarnesüültransferaasi inhibiitorid
EP0944388A4 (de)	2001-08-16	Hemmern von farnesyl protein transferase
EP1011669A4 (de)	2001-09-12	Farnesyl-protein transferase inhibitoren
DE69924876D1 (de)	2005-05-25	Farnesyl protein transferase inhibitoren
NO996571D0 (no)	1999-12-30	Inhibitorer for farnesyl-protein-transferase
LTPA2014028I1 (lt)	2014-08-25	Pakeistieji 3-cianochinolinai kaip proteintirozinkinazės inhibitoriai
EE9700314A (et)	1998-06-15	Farnesüül-proteiini transferaasi inhibiitorid
EP0891350A4 (de)	2001-01-17	Inhibioten der farnesylprotein-transferase
FI951554A0 (fi)	1995-03-31	Imidatsolipitoisia farnesyyliproteiinitransferaasi-inhibiittoreita
FI952010A7 (fi)	1995-04-27	Farnesyyliproteiinitransferaasin estäjät
FI952011L (fi)	1995-04-27	Farnesyyliproteiinitransferaasin estäjät
EP0891360A4 (de)	2002-05-15	Inhibitoren der farnesyl-protein transferase
EP0777475A4 (de)	1997-12-03	Inhibitoren der farnesyl-protein-transferase
EP1165082A4 (de)	2002-06-12	Inhibitoren der prenyl-protein-transferase
EP0904080A4 (de)	2001-08-01	Inhibitoren der farnesyl-protein transferase
EP0880320A4 (de)	1999-06-16	Inhibitoren der farnesyl-protein transferase
EP0812203A4 (de)	1999-04-14	Inhibitoren der geranylgeranyl-protein transferase
EP1090011A4 (de)	2005-04-06	Inhibitoren von prenyl-protein-transferase
EP0891352A4 (de)	2001-08-16	Inhibitoren der farnesyl-protein transferase
EP1158982A4 (de)	2002-06-12	Inhibitoren der Prenyl-Protein Transferase
DE69825589D1 (de)	2004-09-16	Benzpyrido cycloheptan derivate mit farnesyl protein transferase inhibierender wirkung
EP1035850A4 (de)	2001-09-12	Inhibitoren der farnesyl-protein transferase
EP1035852A4 (de)	2001-09-12	Hemmer von farnesyl-protein transferase