ATE238811T1 - Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften - Google Patents

Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften

Info

Publication number: ATE238811T1
Authority: AT; Austria
Prior art keywords: protein transferase; transferase inhibitors; farnesyl protein; radiosensitizing properties; radiosensitizing
Prior art date: 1998-07-06

Application number

AT99931229T

Other languages

English (en)

Inventor

Ginckel Robert Franciscus Van

Wim Joanna Floren

David William End

Walter Boudewijn Leopo Wouters

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-06

Filing date

1999-06-30

Publication date

2003-05-15

1999-06-30 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE238811T1 publication Critical patent/ATE238811T1/de

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)

AT99931229T 1998-07-06 1999-06-30 Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften ATE238811T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP98202257		1998-07-06
EP98204330		1998-12-18
PCT/EP1999/004545 WO2000001411A1 (en)	1998-07-06	1999-06-30	Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties

Publications (1)

Publication Number	Publication Date
ATE238811T1 true ATE238811T1 (de)	2003-05-15

Family

ID=26150503

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99931229T ATE238811T1 (de)	1998-07-06	1999-06-30	Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften

Country Status (30)

Country	Link
US (1)	US6545020B1 (de)
EP (1)	EP1094839B1 (de)
JP (1)	JP4530537B2 (de)
KR (1)	KR100591603B1 (de)
CN (1)	CN1152716C (de)
AP (1)	AP1599A (de)
AT (1)	ATE238811T1 (de)
AU (1)	AU762423B2 (de)
BG (1)	BG64941B1 (de)
BR (1)	BR9911861A (de)
CA (1)	CA2336624C (de)
CZ (1)	CZ300968B6 (de)
DE (1)	DE69907461T2 (de)
DK (1)	DK1094839T3 (de)
EA (1)	EA003877B1 (de)
EE (1)	EE04582B1 (de)
ES (1)	ES2199579T3 (de)
HR (1)	HRP20000903A2 (de)
HU (1)	HU229076B1 (de)
ID (1)	ID26987A (de)
IL (2)	IL140721A0 (de)
MY (1)	MY126519A (de)
NO (1)	NO328178B1 (de)
PL (1)	PL193464B1 (de)
PT (1)	PT1094839E (de)
SI (1)	SI1094839T1 (de)
SK (1)	SK284723B6 (de)
TR (1)	TR200003879T2 (de)
TW (1)	TW586937B (de)
WO (1)	WO2000001411A1 (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ID26987A (id)	1998-07-06	2001-02-22	Janssen Pharmaceutica Nv	Inhibitor-inhibitor transferase protein farnesil dengan sifat-sifat peka terhadap sinar radiasi in vivo
HRP20000904A2 (en)	1998-07-06	2001-12-31	Janssen Pharmaceutica Nv	Farnesyl protein transferase inhibitors for treating arthropathies
PT1255537E (pt) *	2000-02-04	2006-09-29	Janssen Pharmaceutica Nv	Inibidores da proteina farnesil transferase para tratar cancro da mama
JO2361B1 (en) *	2000-06-22	2006-12-12	جانسين فارماسيوتيكا ان. في	Enaniumer 1,2-anylated quinoline inhibitor for the transporter - farnesyl
WO2002024683A1 (en)	2000-09-25	2002-03-28	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derivatives
US7053105B2 (en)	2000-09-25	2006-05-30	Janssen Pharmaceutica, N.V.	Farnesyl transferase inhibiting quinoline and quinazoline derivatives as farnesyl transferase inhibitors
ATE409189T1 (de)	2000-09-25	2008-10-15	Janssen Pharmaceutica Nv	Farnesyl transferase-hemmende 6- heterocyclylmethyl-chinolin und chinazol-derivate
JP4974439B2 (ja)	2000-09-25	2012-07-11	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ファルネシルトランスフェラーゼを阻害する６−ヘテロシクリルメチルキノリノン誘導体
ES2328225T3 (es)	2000-11-21	2009-11-11	Janssen Pharmaceutica Nv	Derivados benzoheterociclicos inhibidores de la farnesil-transferasa.
ATE319704T1 (de)	2000-12-27	2006-03-15	Janssen Pharmaceutica Nv	Farnesyltransferase hemmende, in der 4-stellung substituierte chinolin- und chinazolinderivate
EP1351954B1 (de) *	2000-12-27	2006-05-03	Janssen Pharmaceutica N.V.	Farnesyltransferasehemmende 4-heterocyclylchinolin- und chinazolinderivate
WO2003000266A1 (en)	2001-06-21	2003-01-03	Ariad Pharmaceuticals, Inc.	Novel quinolines and uses thereof
CA2469275C (en)	2001-12-19	2011-09-06	Janssen Pharmaceutica N.V.	1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors
ES2287466T3 (es)	2002-03-22	2007-12-16	Janssen Pharmaceutica N.V.	Derivados de 2-quinolinona y quinazolina de bencilimidazolil sustituidas como inhibidores de la farnesil transferasa.
CA2481480C (en)	2002-04-15	2011-04-12	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting tricyclic quinazoline derivatives substituted with carbon-linked imidazoles or triazoles
NZ546991A (en) *	2003-11-20	2010-01-29	Janssen Pharmaceutica Nv	6-Alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as PARP inhibitors
JP4691041B2 (ja)	2003-11-20	2011-06-01	チルドレンズホスピタルメディカルセンター	Ｇｔｐアーゼ阻害剤および使用方法
US20070293539A1 (en) *	2004-03-18	2007-12-20	Lansbury Peter T	Methods for the treatment of synucleinopathies
WO2005089515A2 (en) *	2004-03-18	2005-09-29	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
CA2559221A1 (en) *	2004-03-18	2005-09-29	Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
US20050288298A1 (en) *	2004-03-18	2005-12-29	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
CA2559285A1 (en) *	2004-03-18	2005-09-29	Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
US20050272068A1 (en) *	2004-03-18	2005-12-08	The Brigham And Women's Hospital, Inc.	UCH-L1 expression and cancer therapy
US20060194821A1 (en) *	2005-02-18	2006-08-31	The Brigham And Women's Hospital, Inc.	Compounds inhibiting the aggregation of superoxide dismutase-1
WO2007016539A2 (en)	2005-07-29	2007-02-08	Children's Hospital Medical Center	Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase
AU2006331542A1 (en)	2005-12-23	2007-07-05	Link Medicine Corporation	Treatment of synucleinopathies
US8124774B2 (en) *	2007-05-23	2012-02-28	Allergan, Inc.	Therapeutic ((phenyl)imidazolyl)methylquinolinyl compounds
WO2009151683A2 (en) *	2008-03-12	2009-12-17	Link Medicine Corporation	Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
ATE555384T1 (de)	2008-06-26	2012-05-15	Spherotec Gmbh	Verfahren zum testen der reaktion von zellen auf die einwirkung von therapeutika
US20110060005A1 (en) *	2008-11-13	2011-03-10	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
US20100331363A1 (en) *	2008-11-13	2010-12-30	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
AU2009313927A1 (en) *	2008-11-13	2010-05-20	Astrazeneca Ab	Azaquinolinone derivatives and uses thereof
US9980942B2 (en)	2012-05-02	2018-05-29	Children's Hospital Medical Center	Rejuvenation of precursor cells
HK1213887A1 (zh)	2012-10-16	2016-07-15	Janssen Pharmaceutica N.V.	RORγt的苯基连接的喹啉基调节剂
MY189505A (en)	2012-10-16	2022-02-16	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of roryt
WO2014062655A1 (en)	2012-10-16	2014-04-24	Janssen Pharmaceutica Nv	HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt
US9284308B2 (en)	2013-10-15	2016-03-15	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of RORγt
US9403816B2 (en)	2013-10-15	2016-08-02	Janssen Pharmaceutica Nv	Phenyl linked quinolinyl modulators of RORγt
CA2927182A1 (en)	2013-10-15	2015-04-23	Janssen Pharmaceutica Nv	Quinolinyl modulators of ror.gamma.t
CA2926339A1 (en)	2013-10-15	2015-04-23	Janssen Pharmaceutica Nv	Alkyl linked quinolinyl modulators of roryt
US9221804B2 (en)	2013-10-15	2015-12-29	Janssen Pharmaceutica Nv	Secondary alcohol quinolinyl modulators of RORγt
US10555941B2 (en)	2013-10-15	2020-02-11	Janssen Pharmaceutica Nv	Alkyl linked quinolinyl modulators of RORγt
US9328095B2 (en)	2013-10-15	2016-05-03	Janssen Pharmaceutica Nv	Heteroaryl linked quinolinyl modulators of RORgammat
US10028503B2 (en)	2014-06-18	2018-07-24	Children's Hospital Medical Center	Platelet storage methods and compositions for same
US10471055B2 (en)	2015-08-17	2019-11-12	Kura Oncology, Inc.	Methods of treating cancer patients with farnesyltransferase inhibitors
US20190119758A1 (en)	2016-04-22	2019-04-25	Kura Oncology, Inc.	Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
HRP20210544T1 (hr)	2016-11-03	2021-08-20	Kura Oncology, Inc.	Inhibitori farneziltransferaze za uporabu u liječenju raka
WO2018156609A1 (en)	2017-02-21	2018-08-30	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
US10137121B2 (en)	2017-02-21	2018-11-27	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
US10806730B2 (en)	2017-08-07	2020-10-20	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
CA3071854A1 (en)	2017-08-07	2019-02-14	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
WO2019113269A1 (en)	2017-12-08	2019-06-13	Kura Oncology, Inc.	Methods of treating cancer patients with farnesyltransferase inhibitors
AU2019372141A1 (en)	2018-11-01	2021-05-27	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
WO2020180663A1 (en)	2019-03-01	2020-09-10	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
US20220143006A1 (en)	2019-03-15	2022-05-12	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
WO2020205486A1 (en)	2019-03-29	2020-10-08	Kura Oncology, Inc.	Methods of treating squamous cell carcinomas with farnesyltransferase inhibitors
TW202102218A (zh)	2019-04-01	2021-01-16	美商庫拉腫瘤技術股份有限公司	以法呢基(farnesyl)轉移酶抑制劑治療癌症的方法
US20220305001A1 (en)	2019-05-02	2022-09-29	Kura Oncology, Inc.	Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors
CN114450027A (zh)	2019-08-16	2022-05-06	儿童医院医疗中心	用cdc42特异性抑制剂治疗受试者的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5141851A (en) *	1990-04-18	1992-08-25	Board Of Regents, The University Of Texas System	Isolated farnesyl protein transferase enzyme
US6083917A (en) *	1990-04-18	2000-07-04	Board Of Regents, The University Of Texas System	Methods and compositions for the identification, characterization and inhibition of farnesyltransferase
US5602184A (en) *	1993-03-03	1997-02-11	The United States Of America As Represented By Department Of Health And Human Services	Monoterpenes, sesquiterpenes and diterpenes as cancer therapy
TW349948B (en) *	1995-10-31	1999-01-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 2-quinolone derivatives
DE69635966T2 (de)	1995-12-08	2006-11-30	Janssen Pharmaceutica N.V.	(Imidazol-5-yl)Methyl-2-Chinolinonderivate als Farnesyl Protein transferase Inhibitoren
EP0910385A4 (de) *	1996-04-15	1999-12-22	Univ Pennsylvania	Sensibilisierung von zellen zur strahlen- und chemotherapie
CA2260216A1 (en) *	1996-07-15	1998-01-22	Bristol-Myers Squibb Company	Thiadioxobenzodiazepine inhibitors of farnesyl protein transferase
TW591030B (en)	1997-03-10	2004-06-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
ID26987A (id)	1998-07-06	2001-02-22	Janssen Pharmaceutica Nv	Inhibitor-inhibitor transferase protein farnesil dengan sifat-sifat peka terhadap sinar radiasi in vivo
TR200201296T2 (tr) *	1999-02-11	2002-07-22	Pfizer Products Inc.	Antikanser maddeleri olarak faydalı heteroaril-ikame edilmiş kinolin-2-on türevleri

1999
- 1999-06-30 ID IDW20010020A patent/ID26987A/id unknown
- 1999-06-30 AT AT99931229T patent/ATE238811T1/de active
- 1999-06-30 PT PT99931229T patent/PT1094839E/pt unknown
- 1999-06-30 BR BR9911861-0A patent/BR9911861A/pt not_active Application Discontinuation
- 1999-06-30 TR TR2000/03879T patent/TR200003879T2/xx unknown
- 1999-06-30 EP EP99931229A patent/EP1094839B1/de not_active Expired - Lifetime
- 1999-06-30 PL PL99347979A patent/PL193464B1/pl unknown
- 1999-06-30 SI SI9930332T patent/SI1094839T1/xx unknown
- 1999-06-30 SK SK1986-2000A patent/SK284723B6/sk not_active IP Right Cessation
- 1999-06-30 EA EA200100111A patent/EA003877B1/ru not_active IP Right Cessation
- 1999-06-30 CN CNB998082678A patent/CN1152716C/zh not_active Expired - Lifetime
- 1999-06-30 WO PCT/EP1999/004545 patent/WO2000001411A1/en not_active Ceased
- 1999-06-30 DK DK99931229T patent/DK1094839T3/da active
- 1999-06-30 CA CA002336624A patent/CA2336624C/en not_active Expired - Lifetime
- 1999-06-30 EE EEP200000794A patent/EE04582B1/xx unknown
- 1999-06-30 CZ CZ20004777A patent/CZ300968B6/cs not_active IP Right Cessation
- 1999-06-30 DE DE69907461T patent/DE69907461T2/de not_active Expired - Lifetime
- 1999-06-30 HU HU0103689A patent/HU229076B1/hu unknown
- 1999-06-30 ES ES99931229T patent/ES2199579T3/es not_active Expired - Lifetime
- 1999-06-30 JP JP2000557857A patent/JP4530537B2/ja not_active Expired - Lifetime
- 1999-06-30 AU AU47805/99A patent/AU762423B2/en not_active Expired
- 1999-06-30 US US09/743,130 patent/US6545020B1/en not_active Expired - Lifetime
- 1999-06-30 HR HR20000903A patent/HRP20000903A2/hr not_active Application Discontinuation
- 1999-06-30 AP APAP/P/2001/002057A patent/AP1599A/en active
- 1999-06-30 IL IL14072199A patent/IL140721A0/xx active IP Right Grant
- 1999-06-30 KR KR1020007014066A patent/KR100591603B1/ko not_active Expired - Lifetime
- 1999-07-01 MY MYPI99002794A patent/MY126519A/en unknown
- 1999-07-05 TW TW088111346A patent/TW586937B/zh not_active IP Right Cessation
2001
- 2001-01-03 BG BG105108A patent/BG64941B1/bg unknown
- 2001-01-04 IL IL140721A patent/IL140721A/en not_active IP Right Cessation
- 2001-01-05 NO NO20010082A patent/NO328178B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EE04582B1 (et)	2006-02-15
BG64941B1 (bg)	2006-10-31
CN1152716C (zh)	2004-06-09
IL140721A0 (en)	2002-02-10
PT1094839E (pt)	2003-09-30
NO20010082L (no)	2001-01-05
MY126519A (en)	2006-10-31
CN1311692A (zh)	2001-09-05
ID26987A (id)	2001-02-22
EE200000794A (et)	2002-06-17
EA003877B1 (ru)	2003-10-30
EP1094839B1 (de)	2003-05-02
DK1094839T3 (da)	2003-08-18
HK1034451A1 (en)	2001-10-26
HUP0103689A2 (hu)	2002-02-28
SK284723B6 (sk)	2005-10-06
JP4530537B2 (ja)	2010-08-25
CZ300968B6 (cs)	2009-09-30
JP2002519389A (ja)	2002-07-02
HRP20000903A2 (en)	2001-12-31
NO20010082D0 (no)	2001-01-05
PL347979A1 (en)	2002-05-06
WO2000001411A1 (en)	2000-01-13
CZ20004777A3 (en)	2001-05-16
BG105108A (en)	2001-11-30
TR200003879T2 (tr)	2007-01-22
HU229076B1 (en)	2013-07-29
CA2336624C (en)	2008-10-21
AU4780599A (en)	2000-01-24
CA2336624A1 (en)	2000-01-13
DE69907461D1 (de)	2003-06-05
KR100591603B1 (ko)	2006-06-20
EA200100111A1 (ru)	2001-06-25
NO328178B1 (no)	2009-12-28
US6545020B1 (en)	2003-04-08
HUP0103689A3 (en)	2003-01-28
BR9911861A (pt)	2001-03-20
DE69907461T2 (de)	2004-02-19
KR20010052770A (ko)	2001-06-25
SI1094839T1 (en)	2003-12-31
TW586937B (en)	2004-05-11
AP1599A (en)	2006-04-27
IL140721A (en)	2008-11-26
ES2199579T3 (es)	2004-02-16
AU762423B2 (en)	2003-06-26
EP1094839A1 (de)	2001-05-02
PL193464B1 (pl)	2007-02-28
AP2001002057A0 (en)	2001-03-31
SK19862000A3 (sk)	2001-12-03

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2003-12-15

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Publication	Publication Date	Title
DE69907461D1 (de)	2003-06-05	Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften
EE04309B1 (et)	2004-06-15	Farnesüül-proteiini transferaasi inhibiitorid
EE9800408A (et)	1999-06-15	Proteiinfarnesüültransferaasi inhibiitorid
DE69924876D1 (de)	2005-05-25	Farnesyl protein transferase inhibitoren
NO996571D0 (no)	1999-12-30	Inhibitorer for farnesyl-protein-transferase
LTPA2014028I1 (lt)	2014-08-25	Pakeistieji 3-cianochinolinai kaip proteintirozinkinazės inhibitoriai
EE9700314A (et)	1998-06-15	Farnesüül-proteiini transferaasi inhibiitorid
EP0891350A4 (de)	2001-01-17	Inhibioten der farnesylprotein-transferase
FI952010A7 (fi)	1995-04-27	Farnesyyliproteiinitransferaasin estäjät
FI952011A7 (fi)	1995-04-27	Farnesyyliproteiinitransferaasin estäjät
EP0986384A4 (de)	2004-09-15	Isoprentransferase proteine inhibitoren
EP0891360A4 (de)	2002-05-15	Inhibitoren der farnesyl-protein transferase
EP0777475A4 (de)	1997-12-03	Inhibitoren der farnesyl-protein-transferase
EP1165084A4 (de)	2002-05-15	Inhibitoren der prenyl-proteintransferasen
EP0904080A4 (de)	2001-08-01	Inhibitoren der farnesyl-protein transferase
EP0880320A4 (de)	1999-06-16	Inhibitoren der farnesyl-protein transferase
EP0812203A4 (de)	1999-04-14	Inhibitoren der geranylgeranyl-protein transferase
EP1090011A4 (de)	2005-04-06	Inhibitoren von prenyl-protein-transferase
EP0891352A4 (de)	2001-08-16	Inhibitoren der farnesyl-protein transferase
DE69825589D1 (de)	2004-09-16	Benzpyrido cycloheptan derivate mit farnesyl protein transferase inhibierender wirkung
EP1035850A4 (de)	2001-09-12	Inhibitoren der farnesyl-protein transferase
EP1035852A4 (de)	2001-09-12	Hemmer von farnesyl-protein transferase
NO20012961D0 (no)	2001-06-15	Trisykliske farnesylproteintransferase-inhibitorer
EP0891353A4 (de)	2001-08-08	Farnesyl-protein transferase inhibitoren
EP0787123A4 (de)	1999-10-13	Farnesyl-protein transferase inhibitoren