ATE239009T1 - Benzothiophene, deren zusammensetzungen und verfahren - Google Patents

Benzothiophene, deren zusammensetzungen und verfahren

Info

Publication number: ATE239009T1
Authority: AT; Austria
Prior art keywords: estrogen; compositions; benzothiophenes; methods; benzoä
Prior art date: 1996-02-21

Application number

AT97301058T

Other languages

English (en)

Inventor

George Joseph Cullinan

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-21

Filing date

1997-02-19

Publication date

2003-05-15

1997-02-19 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE239009T1 publication Critical patent/ATE239009T1/de

Links

239000000203 mixture Substances 0.000 title 1
239000000262 estrogen Substances 0.000 abstract 2
229940011871 estrogen Drugs 0.000 abstract 2
206010027304 Menopausal symptoms Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
230000001575 pathological effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000583 progesterone congener Substances 0.000 abstract 1
238000002636 symptomatic treatment Methods 0.000 abstract 1
150000003577 thiophenes Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

AT97301058T 1996-02-21 1997-02-19 Benzothiophene, deren zusammensetzungen und verfahren ATE239009T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US1199096P	1996-02-21	1996-02-21

Publications (1)

Publication Number	Publication Date
ATE239009T1 true ATE239009T1 (de)	2003-05-15

Family

ID=21752855

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97301058T ATE239009T1 (de)	1996-02-21	1997-02-19	Benzothiophene, deren zusammensetzungen und verfahren

Country Status (9)

Country	Link
US (1)	US6432982B1 (de)
EP (1)	EP0791590B1 (de)
JP (1)	JP2000505453A (de)
AT (1)	ATE239009T1 (de)
AU (1)	AU1959697A (de)
CA (1)	CA2247130A1 (de)
DE (1)	DE69721358T2 (de)
ES (1)	ES2197301T3 (de)
WO (1)	WO1997030985A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6465445B1 (en)	1998-06-11	2002-10-15	Endorecherche, Inc.	Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
JP2004531559A (ja)	2001-05-22	2004-10-14	イーライ・リリー・アンド・カンパニー	エストロゲン欠乏または内因性エストロゲンに対する異常な生理反応に関連する疾患を抑制するためのテトラヒドロキノリン誘導体
EP1395563B1 (de)	2001-05-22	2006-03-29	Eli Lilly And Company	2-substituierte 1,2,3,4-tetrahydrochinoline und derivate davon, zusammensetzungen und verfahren

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3862232A (en)	1963-07-03	1975-01-21	Upjohn Co	1-(p-hydroxyphenyl)-2-phenyl-6-(2-diethylaminoethoxy)-3,4-dihydronaphthalene and the salts thereof
US3293263A (en)	1963-12-09	1966-12-20	Upjohn Co	Diphenylbenzocycloalkenes
US3320271A (en)	1964-06-01	1967-05-16	Upjohn Co	1, 2-diphenyl-3, 4-dihydronaphthalenes and 2, 3-diphenylindenes
DE1300575B (de)	1965-05-21	1969-08-07	Bristol Myers Co	Benzo[b]thiophene
US4133814A (en)	1975-10-28	1979-01-09	Eli Lilly And Company	2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4380635A (en)	1981-04-03	1983-04-19	Eli Lilly And Company	Synthesis of acylated benzothiophenes
US4418068A (en)	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes
US4358593A (en)	1981-04-03	1982-11-09	Eli Lilly And Company	Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
GB2097788B (en)	1981-04-03	1985-04-24	Lilly Co Eli	Benzothiophene compounds and process for preparing them
FR2665444B1 (fr)	1990-08-06	1992-11-27	Sanofi Sa	Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
DE4117512A1 (de)	1991-05-25	1992-11-26	Schering Ag	2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
JP3157882B2 (ja)	1991-11-15	2001-04-16	帝国臓器製薬株式会社	新規なベンゾチオフエン誘導体
TW366342B (en)	1992-07-28	1999-08-11	Lilly Co Eli	The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5482949A (en)	1993-03-19	1996-01-09	Eli Lilly And Company	Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US6756388B1 (en)	1993-10-12	2004-06-29	Pfizer Inc.	Benzothiophenes and related compounds as estrogen agonists
US6399634B1 (en)	1994-09-20	2002-06-04	Eli Lilly And Company	Benzothiophene compounds, compositions, and methods
US5510357A (en)	1995-02-28	1996-04-23	Eli Lilly And Company	Benzothiophene compounds as anti-estrogenic agents
US6479517B1 (en) *	1995-02-28	2002-11-12	Eli Lilly And Company	Phosphorous-containing benzothiophenes
US6417199B1 (en) *	1995-03-10	2002-07-09	Eli Lilly And Company	3-benzyl-benzothiophenes
US6395755B1 (en) *	1995-03-10	2002-05-28	Eli Lilly And Company	Benzothiophene pharmaceutical compounds
US5532382A (en)	1995-03-13	1996-07-02	Eli Lilly And Company	Benzothiophenes substituted at the 3-carbonyl
CA2223595C (en) *	1995-06-07	2008-08-05	Neorx Corporation	Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
US6444688B1 (en) *	1995-06-07	2002-09-03	Eli Lilly And Company	Compounds and compositions with nitrogen-containing non-basic side chains

1997
- 1997-01-14 US US08/783,160 patent/US6432982B1/en not_active Expired - Fee Related
- 1997-02-13 CA CA002247130A patent/CA2247130A1/en not_active Abandoned
- 1997-02-13 AU AU19596/97A patent/AU1959697A/en not_active Abandoned
- 1997-02-13 JP JP9530246A patent/JP2000505453A/ja active Pending
- 1997-02-13 WO PCT/US1997/002373 patent/WO1997030985A1/en not_active Ceased
- 1997-02-19 EP EP97301058A patent/EP0791590B1/de not_active Expired - Lifetime
- 1997-02-19 AT AT97301058T patent/ATE239009T1/de not_active IP Right Cessation
- 1997-02-19 DE DE69721358T patent/DE69721358T2/de not_active Expired - Fee Related
- 1997-02-19 ES ES97301058T patent/ES2197301T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO1997030985A1 (en)	1997-08-28
CA2247130A1 (en)	1997-08-28
US6432982B1 (en)	2002-08-13
DE69721358T2 (de)	2004-04-08
EP0791590A1 (de)	1997-08-27
JP2000505453A (ja)	2000-05-09
DE69721358D1 (de)	2003-06-05
ES2197301T3 (es)	2004-01-01
EP0791590B1 (de)	2003-05-02
AU1959697A (en)	1997-09-10

Legal Events

Date	Code	Title	Description
2003-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
NO20014607L (no)	2001-11-20	Sammensetninger til forbedring av fertilitet
MXPA00007681A (es)	2003-07-14	Composiciones de epotilona.
ID22562A (id)	1999-11-11	Komposisi untuk pembasmi artropoda berbahaya
DE69509359D1 (de)	1999-06-02	Arylsubstituierte 5,5 kondensierte aromatische stickstoffverbindungen als entzuendungshemmende mittel
DE69711686D1 (de)	2002-05-08	Molybdänkomplexe enthaltende schmiermittelzusammensetzungen
FR2776187B1 (fr)	2000-05-05	Composition solide deodorante
NO20006630D0 (no)	2000-12-22	Farmasöytisk sammensetning for behandlingen av diabetes
NO20022048D0 (no)	2002-04-30	Brönnfôring for reparasjoner
DE69940721D1 (de)	2009-05-28	Quecksilberfreie metallhalogenidlampe
DE69626422D1 (de)	2003-04-03	Verbesserte zusammensetzungen mit organischen verbindungen
DE69829097D1 (de)	2005-03-31	Cholesterinsenkende Zusammensetzung enthaltend Coenzym Q
GB9814234D0 (en)	1998-09-02	Organic composition
PH31265A (en)	1998-06-18	Aqueous solution inclusion complexes of benzo-thiophene compounds with water soluble cyclodextrins, and pharmaceutical formulations and methods thereof.
TR199900853A3 (tr)	1999-11-22	Sübstitüe edilmis trisiklik bilesikler.
MA24869A1 (fr)	1999-12-31	Compositions de blanchiment liquide
FI900041A0 (fi)	1990-01-04	Substituerade indol-, benzofuran- och benzotiopenderivat saosom 5-lipoxigenasinhibitorer,
DE69501086D1 (de)	1998-01-08	Graphitstahlzusammensetzungen
ZA9810214B (en)	2000-05-09	2-arylbenzo(b)thiophenes useful for the treatment of estrogen deprivation syndrome.
ATE239009T1 (de)	2003-05-15	Benzothiophene, deren zusammensetzungen und verfahren
ZA9810215B (en)	2000-05-09	2-Aryl-3-Aroylbenzo[b]thiophenes useful for the treatment of estrogen deprivation syndrome.
DE69820919D1 (de)	2004-02-12	Mit Wasser quellbare Zusammensetzungen und Dichtungsmassen
DE69917297D1 (de)	2004-06-17	Vernetzbare fluorelastomerzusammensetzungen
ATE247101T1 (de)	2003-08-15	Benzothiophenderivate, zwischenprodukte, verfahren, zubereitungen und methoden
ZA979898B (en)	1998-06-01	Organic compositions.
NO995081D0 (no)	1999-10-18	Anordning for H.323 proxy