ATE239460T1 - 1-(1-(4-chlorphenyl)cyclobutyl)-3-methylbutyl amin derivate zur senkung von harnsäurespiegeln beim menschen - Google Patents

1-(1-(4-chlorphenyl)cyclobutyl)-3-methylbutyl amin derivate zur senkung von harnsäurespiegeln beim menschen

Info

Publication number: ATE239460T1
Authority: AT; Austria
Prior art keywords: cyclobutyl; pct; uric acid; chlorphenyl; human beings
Prior art date: 1996-09-25

Application number

AT97942030T

Other languages

English (en)

Inventor

Peter Finian Kelly

Stephen Paul Jones

Original Assignee

Abbott Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-25

Filing date

1997-09-15

Publication date

2003-05-15

1997-09-15 Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE239460T1 publication Critical patent/ATE239460T1/de

Links

LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 title abstract 2
TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 title abstract 2
229940116269 uric acid Drugs 0.000 title abstract 2
-1 1-(1-(4-CHLORPHENYL)CYCLOBUTYL)-3-METHYLBUTYL Chemical class 0.000 title 1
201000005569 Gout Diseases 0.000 abstract 1
201000001431 Hyperuricemia Diseases 0.000 abstract 1
UWAOJIWUVCMBAZ-UHFFFAOYSA-N [1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl]-dimethylazanium;chloride Chemical compound Cl.C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UWAOJIWUVCMBAZ-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000029078 coronary artery disease Diseases 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000004682 monohydrates Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Hematology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Materials For Medical Uses (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Crystals, And After-Treatments Of Crystals (AREA)

AT97942030T 1996-09-25 1997-09-15 1-(1-(4-chlorphenyl)cyclobutyl)-3-methylbutyl amin derivate zur senkung von harnsäurespiegeln beim menschen ATE239460T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9619962.5A GB9619962D0 (en)	1996-09-25	1996-09-25	Medical treatment
PCT/EP1997/005034 WO1998013033A1 (en)	1996-09-25	1997-09-15	Medical treatment

Publications (1)

Publication Number	Publication Date
ATE239460T1 true ATE239460T1 (de)	2003-05-15

Family

ID=10800448

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97942030T ATE239460T1 (de)	1996-09-25	1997-09-15	1-(1-(4-chlorphenyl)cyclobutyl)-3-methylbutyl amin derivate zur senkung von harnsäurespiegeln beim menschen

Country Status (26)

Country	Link
US (1)	US6162831A (de)
EP (1)	EP1007023B1 (de)
JP (1)	JP2001501608A (de)
KR (1)	KR20000048568A (de)
CN (1)	CN1231604A (de)
AT (1)	ATE239460T1 (de)
AU (1)	AU722129B2 (de)
BG (1)	BG103278A (de)
BR (1)	BR9711414A (de)
CA (1)	CA2266438A1 (de)
DE (1)	DE69721838T2 (de)
DK (1)	DK1007023T3 (de)
ES (1)	ES2199374T3 (de)
GB (1)	GB9619962D0 (de)
HR (1)	HRP970519A2 (de)
HU (1)	HUP9904545A3 (de)
IL (1)	IL128851A (de)
NO (1)	NO991425D0 (de)
NZ (1)	NZ334668A (de)
PL (1)	PL332423A1 (de)
PT (1)	PT1007023E (de)
SK (1)	SK32199A3 (de)
TR (1)	TR199900649T2 (de)
TW (1)	TW415842B (de)
WO (1)	WO1998013033A1 (de)
ZA (1)	ZA978573B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6331571B1 (en)	1998-08-24	2001-12-18	Sepracor, Inc.	Methods of treating and preventing attention deficit disorders
US6476078B2 (en)	1999-08-11	2002-11-05	Sepracor, Inc.	Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
US6974838B2 (en)	1998-08-24	2005-12-13	Sepracor Inc.	Methods of treating or preventing pain using sibutramine metabolites
US6339106B1 (en)	1999-08-11	2002-01-15	Sepracor, Inc.	Methods and compositions for the treatment and prevention of sexual dysfunction
US6552087B1 (en)	1999-03-19	2003-04-22	Abbott Gmbh & Co. Kg	Therapeutic agent comprising (+)-sibutramine
WO2000056306A1 (en) *	1999-03-19	2000-09-28	Knoll Gmbh	Treatment of osteoarthritis
US6399826B1 (en)	1999-08-11	2002-06-04	Sepracor Inc.	Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
US6610887B2 (en)	2001-04-13	2003-08-26	Sepracor Inc.	Methods of preparing didesmethylsibutramine and other sibutramine derivatives
US11103542B2 (en)	2002-03-13	2021-08-31	Kibow Biotech, Inc.	Composition and method for maintaining healthy kidney function
US9655932B2 (en) *	2002-03-13	2017-05-23	Kibow Biotech, Inc.	Composition and method for preventing or treating gout or hyperuricemia
NZ538966A (en) *	2002-10-05	2006-11-30	Hanmi Pharm	Pharmaceutical composition comprising crystalline sibutramine methanesulfonate hemihydrate
US20050131074A1 (en) *	2003-08-04	2005-06-16	Beckman Kristen M.	Methods for treating metabolic syndrome
WO2006012438A2 (en) *	2004-07-21	2006-02-02	University Of Florida Research Foundation, Inc.	Compositions and methods for treatment and prevention of insulin resistance
KR100627687B1 (ko) *	2005-04-20	2006-09-25	주식회사 씨티씨바이오	시부트라민 유리염기 함유 조성물 및 이의 제조방법
BRPI0716002A2 (pt) *	2006-11-22	2013-07-30	Sk Chemicals Co Ltd	complexo de inclusço, processo de preparaÇço de um complexo de inclusço e composiÇço de tratamento e prevenÇço de hipocondria e obesidade
WO2018125735A1 (en)	2016-12-29	2018-07-05	Kibow Biotech, Inc.	Composition and method for maintaining healthy kidney function
KR20210124958A (ko) *	2018-11-02	2021-10-15	앰퍼샌드 바이오파마슈티컬스, 인코포레이티드	국소적으로 적용되는 완충제(buffers)를 사용하는 양이온 과부하 및 전해질 불균형의 위험 가능성 관리를 위한 제형 및 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE52768B1 (en) *	1981-04-06	1988-02-17	Boots Co Ltd	1-arylcyclobutylalkylamine compounds useful as therapeutic agents
GB8531071D0 (en) *	1985-12-17	1986-01-29	Boots Co Plc	Therapeutic compound
GB8704777D0 (en) *	1987-02-28	1987-04-01	Boots Co Plc	Medical treatment
JP2675573B2 (ja) *	1988-03-31	1997-11-12	科研製薬株式会社	脳機能改善剤
IE61928B1 (en) *	1988-11-29	1994-11-30	Boots Co Plc	Treatment of obesity
AU4542993A (en) *	1992-06-23	1994-01-24	Sepracor, Inc.	Methods and compositions for treating depression and other disorders using optically pure (+) sibutramine
AU4542893A (en) *	1992-06-23	1994-01-24	Sepracor, Inc.	Methods and compositions for treating depression and other disorders using optically pure (-) sibutramine
US5459164A (en) *	1994-02-03	1995-10-17	Boots Pharmaceuticals, Inc.	Medical treatment

1996
- 1996-09-25 GB GBGB9619962.5A patent/GB9619962D0/en active Pending
1997
- 1997-09-15 DE DE69721838T patent/DE69721838T2/de not_active Expired - Fee Related
- 1997-09-15 CN CN97198232A patent/CN1231604A/zh active Pending
- 1997-09-15 DK DK97942030T patent/DK1007023T3/da active
- 1997-09-15 PT PT97942030T patent/PT1007023E/pt unknown
- 1997-09-15 PL PL97332423A patent/PL332423A1/xx unknown
- 1997-09-15 WO PCT/EP1997/005034 patent/WO1998013033A1/en not_active Ceased
- 1997-09-15 AT AT97942030T patent/ATE239460T1/de not_active IP Right Cessation
- 1997-09-15 CA CA002266438A patent/CA2266438A1/en not_active Abandoned
- 1997-09-15 SK SK321-99A patent/SK32199A3/sk unknown
- 1997-09-15 ES ES97942030T patent/ES2199374T3/es not_active Expired - Lifetime
- 1997-09-15 NZ NZ334668A patent/NZ334668A/xx unknown
- 1997-09-15 HU HU9904545A patent/HUP9904545A3/hu unknown
- 1997-09-15 US US09/269,339 patent/US6162831A/en not_active Expired - Fee Related
- 1997-09-15 TR TR1999/00649T patent/TR199900649T2/xx unknown
- 1997-09-15 BR BR9711414-6A patent/BR9711414A/pt not_active Application Discontinuation
- 1997-09-15 AU AU43851/97A patent/AU722129B2/en not_active Ceased
- 1997-09-15 KR KR1019990702491A patent/KR20000048568A/ko not_active Ceased
- 1997-09-15 EP EP97942030A patent/EP1007023B1/de not_active Expired - Lifetime
- 1997-09-15 JP JP10515217A patent/JP2001501608A/ja active Pending
- 1997-09-15 IL IL12885197A patent/IL128851A/xx not_active IP Right Cessation
- 1997-09-25 HR HR9619962.5A patent/HRP970519A2/hr not_active Application Discontinuation
- 1997-09-25 ZA ZA978573A patent/ZA978573B/xx unknown
- 1997-09-25 TW TW086113992A patent/TW415842B/zh not_active IP Right Cessation
1999
- 1999-03-24 NO NO991425A patent/NO991425D0/no unknown
- 1999-03-24 BG BG103278A patent/BG103278A/xx unknown

Also Published As

Publication number	Publication date
BR9711414A (pt)	2000-04-25
IL128851A (en)	2001-08-26
HRP970519A2 (en)	1998-08-31
PT1007023E (pt)	2003-08-29
AU722129B2 (en)	2000-07-20
CN1231604A (zh)	1999-10-13
ZA978573B (en)	1999-03-25
ES2199374T3 (es)	2004-02-16
HUP9904545A3 (en)	2000-12-28
NZ334668A (en)	2000-07-28
KR20000048568A (ko)	2000-07-25
NO991425L (no)	1999-03-24
DE69721838D1 (de)	2003-06-12
NO991425D0 (no)	1999-03-24
EP1007023A1 (de)	2000-06-14
GB9619962D0 (en)	1996-11-13
WO1998013033A1 (en)	1998-04-02
TW415842B (en)	2000-12-21
US6162831A (en)	2000-12-19
CA2266438A1 (en)	1998-04-02
AU4385197A (en)	1998-04-17
IL128851A0 (en)	2000-01-31
BG103278A (en)	2000-01-31
HUP9904545A2 (hu)	2000-11-28
DK1007023T3 (da)	2003-08-25
PL332423A1 (en)	1999-09-13
EP1007023B1 (de)	2003-05-07
DE69721838T2 (de)	2004-01-22
TR199900649T2 (xx)	1999-07-21
SK32199A3 (en)	1999-12-10
JP2001501608A (ja)	2001-02-06

Legal Events

Date

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Description

2003-12-15

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Publication of translation of european patent specification

Ref document number: 1007023

Country of ref document: EP

2004-12-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE239460T1 (de)	2003-05-15	1-(1-(4-chlorphenyl)cyclobutyl)-3-methylbutyl amin derivate zur senkung von harnsäurespiegeln beim menschen
DE60039508D1 (de)	2008-08-28	Methoden zur behandlung der essstörungen
RU94017851A (ru)	1996-01-10	Ингибиторы протеолитических ферментов на основе производных сахарина, фармацевтическая композиция для лечения дегеративных заболеваний
KR950016725A (ko)	1995-07-20	폐 고혈압성 질병을 억제하는 방법
DK555089A (da)	1990-10-05	Farmaceutiske praeparater indeholdende n-(3,4-dimethoxycinnamoyl)anthranilsyre
IT1250749B (it)	1995-04-21	Composti eterociclici ad attivita' a ii antagonista
DE60220055D1 (de)	2007-06-21	4-(4-methoxybenzyl)-n'-(5-nitro-1,3-thiazol-2-yl)harnstoff und dessen verwendung bei der behandlung von mit glycogensynthasekinase-3 (gsk3) assoziierten leiden
ATE169225T1 (de)	1998-08-15	Anwendung von urodilatin bei lungen- und bronchialerkrankungen
WO2000056315A8 (en)	2001-06-21	Treatment of pain
DK0583271T3 (da)	1999-07-26	Arylmorpholin, fremstilling og anvendelse
DK1169029T3 (da)	2005-08-29	Anvendelse af sibutramin eller et derivat deraf til behandling af sövnforstyrrelser
TR200103561T2 (tr)	2002-04-22	Rodanin türevleri ve amiloidlerin önlenmesi ve görüntülenmesinde kullanımları
DE3778642D1 (de)	1992-06-04	Therapeutikum zur behandlung von magengeschwueren.
DE3575920D1 (de)	1990-03-15	Gegen mikroben wirkende n-(1-(alkyl oder arylmethyl)-4(1h)-pyridinyliden)-alkanamine, ihre saeureadditionssalze und verfahren zur herstellung, verfahren zur verwendung und zusammensetzungen daraus.
NO872812D0 (no)	1987-07-06	4-nitrogensubstituerte isokinolinolforbindelser med terapeutisk aktivitet og fremgangsmaate for deres fremstilling.
KR950016739A (ko)	1995-07-20	강박관념 질환 및 소모성 질환을 억제하는 방법
DE60026559D1 (de)	2006-05-04	Arzneimittel gegen essstörungen
BG106000A (en)	2002-06-28	Treatment of hiatial hernia
ATE111462T1 (de)	1994-09-15	1,4-dihydropyridin-derivate.
RU92004439A (ru)	1995-10-27	Азотсодержащие тетрациклические соединения, способ их получения, применение и фармацевтическая композиция
BG105995A (en)	2002-06-28	Weight loss after pregnancy
TH18470A (th)	1996-05-09	อนุพันธ์เมลาโทนินสำหรับใช้ในการรักษาความผิดปกติของการหลับ