ATE239472T1 - Trycyclische derivate zur inhibierung der g- protein funktion und für die behandlung von proliferativen erkrankungen - Google Patents

Trycyclische derivate zur inhibierung der g- protein funktion und für die behandlung von proliferativen erkrankungen

Info

Publication number
ATE239472T1
ATE239472T1 AT96909646T AT96909646T ATE239472T1 AT E239472 T1 ATE239472 T1 AT E239472T1 AT 96909646 T AT96909646 T AT 96909646T AT 96909646 T AT96909646 T AT 96909646T AT E239472 T1 ATE239472 T1 AT E239472T1
Authority
AT
Austria
Prior art keywords
trycyclic
inhibiting
derivatives
treatment
proliferative diseases
Prior art date
Application number
AT96909646T
Other languages
English (en)
Inventor
Adriano Afonso
Joseph M Kelly
Ronald L Wolin
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE239472T1 publication Critical patent/ATE239472T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT96909646T 1995-03-24 1996-03-20 Trycyclische derivate zur inhibierung der g- protein funktion und für die behandlung von proliferativen erkrankungen ATE239472T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/410,442 US5684013A (en) 1995-03-24 1995-03-24 Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
PCT/US1996/003306 WO1996030017A1 (en) 1995-03-24 1996-03-20 Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Publications (1)

Publication Number Publication Date
ATE239472T1 true ATE239472T1 (de) 2003-05-15

Family

ID=23624752

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96909646T ATE239472T1 (de) 1995-03-24 1996-03-20 Trycyclische derivate zur inhibierung der g- protein funktion und für die behandlung von proliferativen erkrankungen

Country Status (15)

Country Link
US (3) US5684013A (de)
EP (1) EP0814807B1 (de)
JP (1) JP3001982B2 (de)
KR (1) KR19980703257A (de)
AR (1) AR003936A1 (de)
AT (1) ATE239472T1 (de)
AU (1) AU708244B2 (de)
CA (1) CA2216291C (de)
DE (1) DE69627993T2 (de)
ES (1) ES2198481T3 (de)
HU (1) HUP9801396A3 (de)
IL (1) IL117603A (de)
NZ (1) NZ305133A (de)
TW (1) TW473477B (de)
WO (1) WO1996030017A1 (de)

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Also Published As

Publication number Publication date
MX9707191A (es) 1997-11-29
KR19980703257A (ko) 1998-10-15
US5958939A (en) 1999-09-28
EP0814807B1 (de) 2003-05-07
CA2216291C (en) 2001-06-05
IL117603A (en) 2001-01-28
CA2216291A1 (en) 1996-10-03
HUP9801396A2 (hu) 1999-05-28
JPH10505102A (ja) 1998-05-19
ES2198481T3 (es) 2004-02-01
DE69627993D1 (de) 2003-06-12
AU5307296A (en) 1996-10-16
HUP9801396A3 (en) 2000-03-28
WO1996030017A1 (en) 1996-10-03
DE69627993T2 (de) 2004-02-26
AU708244B2 (en) 1999-07-29
IL117603A0 (en) 1996-07-23
JP3001982B2 (ja) 2000-01-24
TW473477B (en) 2002-01-21
NZ305133A (en) 1999-11-29
US5684013A (en) 1997-11-04
EP0814807A1 (de) 1998-01-07
US5703090A (en) 1997-12-30
AR003936A1 (es) 1998-09-30

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