ATE240408T1 - Verfahren und verbindungen zur analysierung von nukleinsaeuren durch massenspektrometrie - Google Patents

Verfahren und verbindungen zur analysierung von nukleinsaeuren durch massenspektrometrie

Info

Publication number
ATE240408T1
ATE240408T1 AT98936928T AT98936928T ATE240408T1 AT E240408 T1 ATE240408 T1 AT E240408T1 AT 98936928 T AT98936928 T AT 98936928T AT 98936928 T AT98936928 T AT 98936928T AT E240408 T1 ATE240408 T1 AT E240408T1
Authority
AT
Austria
Prior art keywords
compounds
nucleic acids
mass spectrometry
analyzing nucleic
nucleic acid
Prior art date
Application number
AT98936928T
Other languages
English (en)
Inventor
Ness Jeffrey Van
John C Tabone
Jeffry Howbert
John T Mulligan
Original Assignee
Qiagen Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/898,564 external-priority patent/US6613508B1/en
Priority claimed from US08/898,501 external-priority patent/US6027890A/en
Priority claimed from US08/898,180 external-priority patent/US6312893B1/en
Application filed by Qiagen Genomics Inc filed Critical Qiagen Genomics Inc
Application granted granted Critical
Publication of ATE240408T1 publication Critical patent/ATE240408T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B80/00—Linkers or spacers specially adapted for combinatorial chemistry or libraries, e.g. traceless linkers or safety-catch linkers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00581—Mass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Structural Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Saccharide Compounds (AREA)
  • Polyamides (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT98936928T 1997-07-22 1998-07-22 Verfahren und verbindungen zur analysierung von nukleinsaeuren durch massenspektrometrie ATE240408T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/898,564 US6613508B1 (en) 1996-01-23 1997-07-22 Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US08/898,501 US6027890A (en) 1996-01-23 1997-07-22 Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US08/898,180 US6312893B1 (en) 1996-01-23 1997-07-22 Methods and compositions for determining the sequence of nucleic acid molecules
PCT/US1998/015008 WO1999005319A2 (en) 1997-07-22 1998-07-22 Methods and compounds for analyzing nucleic acids by mass spectrometry

Publications (1)

Publication Number Publication Date
ATE240408T1 true ATE240408T1 (de) 2003-05-15

Family

ID=27420575

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98936928T ATE240408T1 (de) 1997-07-22 1998-07-22 Verfahren und verbindungen zur analysierung von nukleinsaeuren durch massenspektrometrie

Country Status (12)

Country Link
EP (1) EP0990047B1 (de)
JP (2) JP4414086B2 (de)
CN (1) CN1270598A (de)
AT (1) ATE240408T1 (de)
AU (1) AU738237B2 (de)
CA (1) CA2297158C (de)
DE (1) DE69814629T2 (de)
DK (1) DK0990047T3 (de)
ES (1) ES2200355T3 (de)
NZ (1) NZ501919A (de)
PT (1) PT990047E (de)
WO (1) WO1999005319A2 (de)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2274587A1 (en) 1996-12-10 1998-06-18 Genetrace Systems Inc. Releasable nonvolatile mass-label molecules
EP1056528A4 (de) * 1997-10-30 2002-02-20 Transgenomic Inc Verfahren zur trennung von polynukleotiden mit hochauflösender flüssigkeitschromatographie
GB9815164D0 (en) * 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds for mass spectrometry
US7225079B2 (en) 1998-08-04 2007-05-29 Transgenomic, Inc. System and method for automated matched ion polynucleotide chromatography
BR0013024A (pt) * 1999-08-31 2002-06-18 Qiagen Genomics Inc Comtostos enantiomiericamente enriquecidos tendo ligação( ões ) fotoclivável( is ) e métodos relacionados aos mesmos
WO2001046687A2 (en) * 1999-12-22 2001-06-28 Transgenomic, Inc. System and method for automated matched ion polynucleotide chromatography
AU2001234893A1 (en) * 2000-02-08 2001-08-20 The Regents Of The University Of Michigan Protein mapping
JP2001218598A (ja) * 2000-02-09 2001-08-14 Asahi Breweries Ltd ペクチネータス属菌の特異的ならびに定量的検出方法
US6713258B2 (en) 2000-03-29 2004-03-30 Center For The Application Of Molecular Biology To International Agriculture (Cambia) Methods for genotyping by hybridization analysis
US7537938B2 (en) 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US7771929B2 (en) 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
US7160735B2 (en) 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
WO2002014867A2 (en) * 2000-08-11 2002-02-21 Agilix Corporation Ultra-sensitive detection systems
WO2004060278A2 (en) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Methods for rapid identification of pathogens in humans and animals
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
EP1950305A1 (de) 2001-05-09 2008-07-30 Monsanto Technology, LLC Tyr-A-Gene und ihre Verwendung
WO2002095356A2 (en) 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
HUP0501021A3 (en) 2001-05-21 2006-06-28 Aclara Biosciences Inc Mountai Methods and compositions for analyzing proteins
US7358052B2 (en) 2001-05-26 2008-04-15 Monogram Biosciences, Inc. Catalytic amplification of multiplexed assay signals
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
WO2003033741A1 (en) * 2001-10-16 2003-04-24 Aclara Biosciences, Inc. Universal e-tag primer and probe compositions and methods
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US7402397B2 (en) 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US20040219685A1 (en) 2003-01-30 2004-11-04 Applera Corporation Methods and mixtures pertaining to analyte determination using electrophilic labeling reagents
US6997031B2 (en) 2003-05-01 2006-02-14 Waters Corporation Fraction collector for composition analysis
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8242254B2 (en) 2003-09-11 2012-08-14 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
WO2005054871A2 (en) * 2003-11-26 2005-06-16 Applera Corporation Analysis of mass spectral data in the quiet zones
US8163895B2 (en) 2003-12-05 2012-04-24 Ibis Biosciences, Inc. Compositions for use in identification of orthopoxviruses
DE10350484B4 (de) * 2003-12-20 2006-02-02 Ehrfeld Mikrotechnik Bts Gmbh Verfahren und Vorrichtung zur Markierung von Proteinen
US7355045B2 (en) 2004-01-05 2008-04-08 Applera Corporation Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
US20050148771A1 (en) 2004-01-05 2005-07-07 Applera Corporation. Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof
US20050148087A1 (en) 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
ES2641832T3 (es) 2004-05-24 2017-11-14 Ibis Biosciences, Inc. Espectrometría de masas con filtración de iones selectiva por establecimiento de umbrales digitales
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
US20060205040A1 (en) 2005-03-03 2006-09-14 Rangarajan Sampath Compositions for use in identification of adventitious viruses
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
EP1904655A2 (de) 2005-07-21 2008-04-02 Isis Pharmaceuticals, Inc. Verfahren zur raschen identifizierung und quantifizierung von nukleinsäurevarianten
EP2010679A2 (de) 2006-04-06 2009-01-07 Ibis Biosciences, Inc. Zusammensetzungen für die identifizierung von pilzen
AU2007353877B2 (en) * 2006-09-14 2012-07-19 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
JP5680304B2 (ja) 2007-02-23 2015-03-04 アイビス バイオサイエンシズ インコーポレイティッド 迅速な法医学的ｄｎａ分析法
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
KR101322624B1 (ko) * 2007-06-13 2013-10-29 삼성전자주식회사 흡착 매개체를 이용하는 전계 효과 트랜지스터 기반 생분자검출 장치와 그 방법
US7888127B2 (en) 2008-01-15 2011-02-15 Sequenom, Inc. Methods for reducing adduct formation for mass spectrometry analysis
CN101251510B (zh) * 2008-03-14 2012-06-06 毅新兴业（北京）科技有限公司 一种联合限制性酶切法和质谱法以检测snp的方法
CN101251511B (zh) * 2008-03-14 2012-06-06 毅新兴业（北京）科技有限公司 一种利用限制性内切酶双酶切检测snp的方法
CN101246142B (zh) * 2008-04-03 2012-06-20 毅新兴业（北京）科技有限公司 一种检测单核苷酸多态性的方法
WO2010033627A2 (en) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
US8534447B2 (en) 2008-09-16 2013-09-17 Ibis Biosciences, Inc. Microplate handling systems and related computer program products and methods
EP2349549B1 (de) 2008-09-16 2012-07-18 Ibis Biosciences, Inc. Mischpatronen, mischstationen und verwandte ausrüstungen, und system
EP2396803A4 (de) 2009-02-12 2016-10-26 Ibis Biosciences Inc Ionisationssondenanordnungen
US9719083B2 (en) 2009-03-08 2017-08-01 Ibis Biosciences, Inc. Bioagent detection methods
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
EP2454000A4 (de) 2009-07-17 2016-08-10 Ibis Biosciences Inc Systeme zur identifizierung von biowirkstoffen
WO2011014811A1 (en) 2009-07-31 2011-02-03 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
EP3098325A1 (de) 2009-08-06 2016-11-30 Ibis Biosciences, Inc. Basenzusammensetzungen ohne massenbestimmung zur nukleinsäureerkennung
US20110200995A1 (en) 2009-09-04 2011-08-18 Intelligent Medical Devices, Inc. Optimized probes and primers and methods of using same for the detection, screening, isolation and sequencing of vancomycin resistance genes and vancomycin resistant enterococci
EP2957641B1 (de) 2009-10-15 2017-05-17 Ibis Biosciences, Inc. Multiple-displacement-amplifikation
US9758840B2 (en) 2010-03-14 2017-09-12 Ibis Biosciences, Inc. Parasite detection via endosymbiont detection
TWI510781B (zh) * 2010-10-29 2015-12-01 Scinopharm Taiwan Ltd 即時監測固相胜肽合成反應之質譜系統
ES2881535T3 (es) * 2011-03-15 2021-11-29 Massachusetts Inst Technology Detección multiplexada con indicadores codificados con isótopos
US8877909B2 (en) 2011-04-04 2014-11-04 Intelligent Medical Devices, Inc. Optimized oligonucleotides and methods of using same for the detection, isolation, amplification, quantitation, monitoring, screening, and sequencing of group B Streptococcus
US10345281B2 (en) 2014-04-04 2019-07-09 Massachusetts Institute Of Technology Reagents for enhanced detection of low volatility analytes
US9891193B2 (en) 2012-07-24 2018-02-13 Massachusetts Institute Of Technology Reagent impregnated swipe for chemical detection
WO2014058508A2 (en) * 2012-07-24 2014-04-17 Massachusetts Institute Of Technology Reagents for oxidizer-based chemical detection
US9588095B2 (en) 2012-07-24 2017-03-07 Massachusetts Institute Of Technology Reagents for oxidizer-based chemical detection
US20140127674A1 (en) 2012-10-25 2014-05-08 Intelligent Medical Devices, Inc. Optimized probes and primers and methods of using same for the binding, detection, differentiation, isolation and sequencing of influenza a; influenza b and respiratory syncytial virus
US20140256582A1 (en) 2013-03-05 2014-09-11 Intelligent Medical Devices, Inc. Optimized probes and primers and methods of using same for the detection, screening, isolation and sequencing of mrsa, mssa, staphylococcus markers, and the antibiotic resistance gene mec a
US9305756B2 (en) 2013-03-13 2016-04-05 Agena Bioscience, Inc. Preparation enhancements and methods of use for MALDI mass spectrometry
WO2014197840A1 (en) 2013-06-07 2014-12-11 Massachusetts Institute Of Technology Affinity-based detection of ligand-encoded synthetic biomarkers
US10816530B2 (en) 2013-07-23 2020-10-27 Massachusetts Institute Of Technology Substrate containing latent vaporization reagents
CN113016623A (zh) 2014-09-26 2021-06-25 谱赛科美国股份有限公司 用于甜菊的单核苷酸多态性(snp)标志物
KR101701998B1 (ko) * 2014-10-23 2017-02-03 한국과학기술연구원 기체크로마토그래피-전기분무/고분해능 질량분석기와 이를 이용한 기체상태 유기화합물의 이온화 방법
JP6560336B2 (ja) * 2015-02-26 2019-08-14 株式会社日立ハイテクノロジーズ 核酸分子の構築方法
US20180265887A1 (en) 2017-03-16 2018-09-20 Jacobs Farm Del Cabo Basil Plants With High Tolerance to Downy Mildew
AU2018248327B2 (en) 2017-04-07 2024-10-10 Massachusetts Institute Of Technology Methods to spatially profile protease activity in tissue and sections
CN106979942B (zh) * 2017-05-04 2020-07-07 华中师范大学 一种对固相合成化合物组合库个体定量的拉曼光谱分析方法及其用途
US20210198734A1 (en) * 2018-05-25 2021-07-01 New York Institute Of Technology Direct nucleic acid sequencing method
WO2020068920A2 (en) 2018-09-25 2020-04-02 Massachusetts Institute Of Technology Lung protease nanosensors and uses thereof
CN111208300B (zh) * 2018-11-21 2021-10-29 中国科学院大连化学物理研究所 一种赖氨酸氮连接磷酸化翻译后修饰富集和鉴定的方法
CN111239402B (zh) * 2018-11-29 2021-07-09 北京大学 一种可用于疾病标志物检测的质谱免疫分析方法及应用
CN113075114B (zh) * 2019-12-17 2022-07-01 北京大学 一种用于单细胞分析的有机质谱流式分析方法
US12240813B2 (en) 2020-05-19 2025-03-04 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
CN114984032B (zh) * 2022-06-27 2023-07-07 四川大学 Dna四面体框架核酸-绿原酸复合物及其在制备治疗肝纤维化的药物中的用途
CN115356411B (zh) * 2022-08-09 2023-07-28 河北一品生物医药有限公司 一种高效液相色谱法检测l-哌啶甲酸盐酸盐有关物质的方法
CN118515851B (zh) * 2024-07-23 2024-10-22 苏州大学 一种生物质可重塑三重形状记忆环氧树脂及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
CA2153387A1 (en) * 1993-01-07 1994-07-21 Hubert Koester Dna sequencing by mass spectrometry
GB9315847D0 (en) * 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
EP0765401B1 (de) * 1993-11-17 2001-02-21 Amersham Pharmacia Biotech UK Limited Verfahren zur massenspektroskopischen sequenzanalyse einer nukleinsäure mittels primerverlängerung
US5834195A (en) * 1994-03-23 1998-11-10 The Penn State Research Foundation Method for identifying members of combinatorial libraries
EP0868535B9 (de) * 1996-01-23 2007-05-09 Qiagen Genomics, Inc. Verfahren und zusammenstellungen zur sequenzbestimmung von nukleinsäuremolekulen
NZ331042A (en) * 1996-01-23 1999-10-28 Rapigene Inc Methods and compositions for detecting binding of ligand pair using non-fluorescent label
DE69739465D1 (de) * 1996-01-23 2009-07-30 Operon Biotechnologies Inc Methoden zur Analyse von Nukleinsäure-Molekülen mittels Techniken zur Grössen-bestimmung
CA2274587A1 (en) * 1996-12-10 1998-06-18 Genetrace Systems Inc. Releasable nonvolatile mass-label molecules
WO1998031830A1 (en) * 1997-01-15 1998-07-23 Brax Group Limited Mass label linked hybridisation probes
AU734636B2 (en) * 1997-07-11 2001-06-21 Xzillion Gmbh & Co. Kg Characterising nucleic acids

Also Published As

Publication number Publication date
CA2297158A1 (en) 1999-02-04
CN1270598A (zh) 2000-10-18
DE69814629T2 (de) 2004-03-25
CA2297158C (en) 2009-12-22
AU738237B2 (en) 2001-09-13
WO1999005319A2 (en) 1999-02-04
AU8576598A (en) 1999-02-16
WO1999005319A9 (en) 1999-06-17
JP4870791B2 (ja) 2012-02-08
JP4414086B2 (ja) 2010-02-10
DK0990047T3 (da) 2003-09-15
DE69814629D1 (de) 2003-06-18
NZ501919A (en) 2001-11-30
JP2009159985A (ja) 2009-07-23
EP0990047B1 (de) 2003-05-14
JP2001511359A (ja) 2001-08-14
PT990047E (pt) 2003-10-31
ES2200355T3 (es) 2004-03-01
WO1999005319A3 (en) 1999-05-14
EP0990047A2 (de) 2000-04-05

Similar Documents

Publication Publication Date Title
DE69814629D1 (de) Verfahren und verbindungen zur analysierung von nukleinsaeuren durch massenspektrometrie
DE69701612D1 (de) Verfahren und zusammensetzungen zum analysieren von nukleinsäuremolekulen mittels bemessungstechniken
ATE191934T1 (de) Verfahren zur isothermer amplifikation von nukleinsäure molekülen
ATE191750T1 (de) Verfahren und zusammenstellungen zur sequenzbestimmung von nukleinsäuremolekulen
DE69432419D1 (de) Ein elektrochemiluminescenter nachweis von nukleinsäuren auf basis der selbsttragenden sequenzreplikation
EP1961826A3 (de) Verfahren zur direkten Sequenzierung von Nukleinsäuren
DE59804008D1 (de) Verfahren zur identifikation von nucleinsäuren durch matrix-assistierte laser desorptions/ionisations massenspektrometrie
DE69937223D1 (de) Verfahren zur synthese von nukleinsäuren
Collins et al. Isotopically labeled crosslinking reagents: resolution of mass degeneracy in the identification of crosslinked peptides
DE69710077D1 (de) Verfahren zur erkennung von verbindungen, die die interaktion von rna und rna-bindeproteinen beeinflussen
EP0777750A4 (de) Verfahren mit einer hohen umsatzrate für das auffinden von sequenzen oder genetischen veränderungen in nukleinsäuren
DE69900462D1 (de) Konjugate von dns und pns und verfahren zu deren herstellung
ATE314385T1 (de) Verfahren zur gewinnung von nukleinsäuren mit hilfe chaotroper-und ammoniumreagentien
EA200100160A1 (ru) Новые способы идентификации биомолекул лигандов и мишеней
ATE290076T1 (de) Ein verfahren zur trennung und reinigung von rna
ATE229081T1 (de) Verfahren zur analyse von nukleinsäure- wiederholungssequenzen
EP0950115A4 (de) Verfahren zur quantifizierung von nukleinsäuremolekülen
DE50013477D1 (de) Verfahren zur analyse von nukleinsäuresequenzen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0990047

Country of ref document: EP

REN Ceased due to non-payment of the annual fee