DK0990047T3 - Fremgangsmåder og sammensætninger til analyse af nukleinsyrer ved hjælp af massespektrometri - Google Patents
Fremgangsmåder og sammensætninger til analyse af nukleinsyrer ved hjælp af massespektrometriInfo
- Publication number
- DK0990047T3 DK0990047T3 DK98936928T DK98936928T DK0990047T3 DK 0990047 T3 DK0990047 T3 DK 0990047T3 DK 98936928 T DK98936928 T DK 98936928T DK 98936928 T DK98936928 T DK 98936928T DK 0990047 T3 DK0990047 T3 DK 0990047T3
- Authority
- DK
- Denmark
- Prior art keywords
- compositions
- methods
- nucleic acids
- mass spectrometry
- analyzing nucleic
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 4
- 102000039446 nucleic acids Human genes 0.000 title abstract 4
- 108020004707 nucleic acids Proteins 0.000 title abstract 4
- 238000004949 mass spectrometry Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
- C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B80/00—Linkers or spacers specially adapted for combinatorial chemistry or libraries, e.g. traceless linkers or safety-catch linkers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00572—Chemical means
- B01J2219/00581—Mass
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00608—DNA chips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/00626—Covalent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Structural Engineering (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Saccharide Compounds (AREA)
- Polyamides (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/898,564 US6613508B1 (en) | 1996-01-23 | 1997-07-22 | Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques |
| US08/898,501 US6027890A (en) | 1996-01-23 | 1997-07-22 | Methods and compositions for enhancing sensitivity in the analysis of biological-based assays |
| US08/898,180 US6312893B1 (en) | 1996-01-23 | 1997-07-22 | Methods and compositions for determining the sequence of nucleic acid molecules |
| PCT/US1998/015008 WO1999005319A2 (en) | 1997-07-22 | 1998-07-22 | Methods and compounds for analyzing nucleic acids by mass spectrometry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0990047T3 true DK0990047T3 (da) | 2003-09-15 |
Family
ID=27420575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98936928T DK0990047T3 (da) | 1997-07-22 | 1998-07-22 | Fremgangsmåder og sammensætninger til analyse af nukleinsyrer ved hjælp af massespektrometri |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0990047B1 (da) |
| JP (2) | JP4414086B2 (da) |
| CN (1) | CN1270598A (da) |
| AT (1) | ATE240408T1 (da) |
| AU (1) | AU738237B2 (da) |
| CA (1) | CA2297158C (da) |
| DE (1) | DE69814629T2 (da) |
| DK (1) | DK0990047T3 (da) |
| ES (1) | ES2200355T3 (da) |
| NZ (1) | NZ501919A (da) |
| PT (1) | PT990047E (da) |
| WO (1) | WO1999005319A2 (da) |
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| CN106979942B (zh) * | 2017-05-04 | 2020-07-07 | 华中师范大学 | 一种对固相合成化合物组合库个体定量的拉曼光谱分析方法及其用途 |
| US20210198734A1 (en) * | 2018-05-25 | 2021-07-01 | New York Institute Of Technology | Direct nucleic acid sequencing method |
| WO2020068920A2 (en) | 2018-09-25 | 2020-04-02 | Massachusetts Institute Of Technology | Lung protease nanosensors and uses thereof |
| CN111208300B (zh) * | 2018-11-21 | 2021-10-29 | 中国科学院大连化学物理研究所 | 一种赖氨酸氮连接磷酸化翻译后修饰富集和鉴定的方法 |
| CN111239402B (zh) * | 2018-11-29 | 2021-07-09 | 北京大学 | 一种可用于疾病标志物检测的质谱免疫分析方法及应用 |
| CN113075114B (zh) * | 2019-12-17 | 2022-07-01 | 北京大学 | 一种用于单细胞分析的有机质谱流式分析方法 |
| US12240813B2 (en) | 2020-05-19 | 2025-03-04 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
| CN114984032B (zh) * | 2022-06-27 | 2023-07-07 | 四川大学 | Dna四面体框架核酸-绿原酸复合物及其在制备治疗肝纤维化的药物中的用途 |
| CN115356411B (zh) * | 2022-08-09 | 2023-07-28 | 河北一品生物医药有限公司 | 一种高效液相色谱法检测l-哌啶甲酸盐酸盐有关物质的方法 |
| CN118515851B (zh) * | 2024-07-23 | 2024-10-22 | 苏州大学 | 一种生物质可重塑三重形状记忆环氧树脂及其制备方法 |
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| US5118605A (en) * | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
| US5565324A (en) * | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| CA2153387A1 (en) * | 1993-01-07 | 1994-07-21 | Hubert Koester | Dna sequencing by mass spectrometry |
| GB9315847D0 (en) * | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
| EP0765401B1 (en) * | 1993-11-17 | 2001-02-21 | Amersham Pharmacia Biotech UK Limited | Primer extension mass spectroscopy nucleic acid sequencing method |
| US5834195A (en) * | 1994-03-23 | 1998-11-10 | The Penn State Research Foundation | Method for identifying members of combinatorial libraries |
| EP0868535B9 (en) * | 1996-01-23 | 2007-05-09 | Qiagen Genomics, Inc. | Methods and compositions for determining the sequence of nucleic acid molecules |
| NZ331042A (en) * | 1996-01-23 | 1999-10-28 | Rapigene Inc | Methods and compositions for detecting binding of ligand pair using non-fluorescent label |
| DE69739465D1 (de) * | 1996-01-23 | 2009-07-30 | Operon Biotechnologies Inc | Methoden zur Analyse von Nukleinsäure-Molekülen mittels Techniken zur Grössen-bestimmung |
| CA2274587A1 (en) * | 1996-12-10 | 1998-06-18 | Genetrace Systems Inc. | Releasable nonvolatile mass-label molecules |
| WO1998031830A1 (en) * | 1997-01-15 | 1998-07-23 | Brax Group Limited | Mass label linked hybridisation probes |
| AU734636B2 (en) * | 1997-07-11 | 2001-06-21 | Xzillion Gmbh & Co. Kg | Characterising nucleic acids |
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- 1998-07-22 CN CN98809047A patent/CN1270598A/zh active Pending
- 1998-07-22 AT AT98936928T patent/ATE240408T1/de not_active IP Right Cessation
- 1998-07-22 AU AU85765/98A patent/AU738237B2/en not_active Ceased
- 1998-07-22 EP EP98936928A patent/EP0990047B1/en not_active Expired - Lifetime
- 1998-07-22 NZ NZ501919A patent/NZ501919A/en unknown
- 1998-07-22 PT PT98936928T patent/PT990047E/pt unknown
- 1998-07-22 JP JP2000504286A patent/JP4414086B2/ja not_active Expired - Lifetime
- 1998-07-22 ES ES98936928T patent/ES2200355T3/es not_active Expired - Lifetime
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- 1998-07-22 CA CA002297158A patent/CA2297158C/en not_active Expired - Fee Related
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2009
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| CA2297158A1 (en) | 1999-02-04 |
| CN1270598A (zh) | 2000-10-18 |
| DE69814629T2 (de) | 2004-03-25 |
| CA2297158C (en) | 2009-12-22 |
| AU738237B2 (en) | 2001-09-13 |
| WO1999005319A2 (en) | 1999-02-04 |
| AU8576598A (en) | 1999-02-16 |
| WO1999005319A9 (en) | 1999-06-17 |
| JP4870791B2 (ja) | 2012-02-08 |
| JP4414086B2 (ja) | 2010-02-10 |
| ATE240408T1 (de) | 2003-05-15 |
| DE69814629D1 (de) | 2003-06-18 |
| NZ501919A (en) | 2001-11-30 |
| JP2009159985A (ja) | 2009-07-23 |
| EP0990047B1 (en) | 2003-05-14 |
| JP2001511359A (ja) | 2001-08-14 |
| PT990047E (pt) | 2003-10-31 |
| ES2200355T3 (es) | 2004-03-01 |
| WO1999005319A3 (en) | 1999-05-14 |
| EP0990047A2 (en) | 2000-04-05 |
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