ATE240923T1 - Herstellung von arylethern sowie damit verbundene reagentien und verfahren - Google Patents
Herstellung von arylethern sowie damit verbundene reagentien und verfahrenInfo
- Publication number
- ATE240923T1 ATE240923T1 AT97910139T AT97910139T ATE240923T1 AT E240923 T1 ATE240923 T1 AT E240923T1 AT 97910139 T AT97910139 T AT 97910139T AT 97910139 T AT97910139 T AT 97910139T AT E240923 T1 ATE240923 T1 AT E240923T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- methods
- aryl ethers
- associated reagents
- reagents
- Prior art date
Links
- 150000008378 aryl ethers Chemical class 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 abstract 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 2
- -1 vinyl ether compound Chemical class 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001336 alkenes Chemical class 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 229910052759 nickel Inorganic materials 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
- 229910052697 platinum Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/24—Anthracenes; Hydrogenated anthracenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/728,449 US5847166A (en) | 1996-10-10 | 1996-10-10 | Synthesis of aryl ethers |
| PCT/US1997/018719 WO1998015515A1 (en) | 1996-10-10 | 1997-10-10 | Synthesis of aryl ethers, methods and reagents related thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE240923T1 true ATE240923T1 (de) | 2003-06-15 |
Family
ID=24926897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97910139T ATE240923T1 (de) | 1996-10-10 | 1997-10-10 | Herstellung von arylethern sowie damit verbundene reagentien und verfahren |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5847166A (de) |
| EP (3) | EP1254884A3 (de) |
| JP (1) | JP2001501954A (de) |
| AT (1) | ATE240923T1 (de) |
| AU (1) | AU4759297A (de) |
| CA (1) | CA2267153C (de) |
| DE (1) | DE69722271T2 (de) |
| DK (1) | DK1027316T3 (de) |
| ES (1) | ES2200162T3 (de) |
| PT (1) | PT1027316E (de) |
| WO (1) | WO1998015515A1 (de) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5847166A (en) * | 1996-10-10 | 1998-12-08 | Massachusetts Institute Of Technology | Synthesis of aryl ethers |
| DE19725872A1 (de) * | 1997-06-18 | 1998-12-24 | Basf Ag | Verfahren zur Herstellung von Butenylethern |
| US6323366B1 (en) | 1997-07-29 | 2001-11-27 | Massachusetts Institute Of Technology | Arylamine synthesis |
| US5977361A (en) * | 1997-10-16 | 1999-11-02 | Yale University | Transition metal-catalyzed process for preparing N-aryl compounds |
| US6057456A (en) * | 1997-10-16 | 2000-05-02 | Yale University | Transition metal-catalyzed process for preparing alpha-arylated carbonyl-containing compounds |
| US6414173B1 (en) | 1998-07-02 | 2002-07-02 | University Of Maryland | Hypervalent silane and siloxane derivatives and the use thereof |
| ATE360634T1 (de) * | 1998-07-10 | 2007-05-15 | Massachusetts Inst Technology | Ligande für metalle und verbesserte metall- katalysierte verfahren, die darauf basieren |
| US6395916B1 (en) | 1998-07-10 | 2002-05-28 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
| US6307087B1 (en) | 1998-07-10 | 2001-10-23 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
| EP1354887B1 (de) * | 1998-07-10 | 2007-04-25 | Massachussetts Institute of Technology | Ligande für Metalle und verbesserte Metall-katalysierte Verfahren, die darauf basieren |
| US7223879B2 (en) | 1998-07-10 | 2007-05-29 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
| US6100398A (en) * | 1998-10-14 | 2000-08-08 | Yale University | Transition metal-catalyzed process for preparing N-aryl amine compounds |
| CA2391966A1 (en) | 1999-11-24 | 2001-05-31 | Massachusetts Institute Of Technology | Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries |
| US6562989B2 (en) | 2000-08-07 | 2003-05-13 | Yale University | Catalyst for aromatic C—O, C—N, and C—C bond formation |
| DE10222330A1 (de) * | 2002-05-17 | 2003-11-27 | Degussa | Verfahren zur katalysatorfreien Herstellung von Alkoxybenzonitrilen |
| US6489512B1 (en) | 2002-06-21 | 2002-12-03 | Rhodia Chirex Inc. | Method for making aryl hydrazines and substituted indoles |
| CA2554696C (en) | 2004-02-13 | 2009-06-30 | Warner-Lambert Company Llc | Androgen receptor modulators |
| EP1737813A1 (de) * | 2004-04-13 | 2007-01-03 | Warner-Lambert Company LLC | Androgenmodulatoren |
| US7138555B2 (en) | 2004-04-20 | 2006-11-21 | Xerox Corporation | Process for preparing iodoaromatic compounds and using the same |
| WO2005102990A1 (en) * | 2004-04-22 | 2005-11-03 | Warner-Lambert Company Llc | Androgen modulators |
| CA2570047C (en) * | 2004-07-08 | 2010-09-28 | Warner-Lambert Company Llc | 4-cycloalkoxy benzonitriles as androgen modulators |
| US20080064745A1 (en) * | 2004-08-18 | 2008-03-13 | Warner-Lambert Company Llc | Androgen Modulators |
| TW200724139A (en) * | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
| US20090170886A1 (en) * | 2005-08-08 | 2009-07-02 | Pfizer Inc | Androgen modulators |
| CA2679754C (en) | 2007-03-12 | 2018-08-07 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines synthesis |
| EP2231680B1 (de) | 2007-12-12 | 2018-03-28 | Massachusetts Institute of Technology | Liganden für übergangsmetallkatalysierte kreuzkupplungen und verfahren zu deren anwendung |
| US20090326280A1 (en) * | 2008-06-27 | 2009-12-31 | Todd Coleman | Systems and Methods for the Preparation of Alkyl Aryl Ethers |
| JP2010202589A (ja) * | 2009-03-04 | 2010-09-16 | Kuraray Co Ltd | ２，３−ジヒドロ−チエノ［３，４−ｂ］フラン誘導体の製造方法、及びそれに用いられる新規化合物 |
| WO2011100438A2 (en) | 2010-02-10 | 2011-08-18 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Molecular thermoelectric device |
| ES2645725T3 (es) | 2010-06-11 | 2017-12-07 | Rhodes Technologies | Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos |
| BR112013001138A2 (pt) | 2010-07-16 | 2016-07-05 | Abbvie Inc | ligantes de fosfina para reações catalíticas |
| US9255074B2 (en) | 2010-07-16 | 2016-02-09 | Abbvie Inc. | Process for preparing antiviral compounds |
| US8975443B2 (en) | 2010-07-16 | 2015-03-10 | Abbvie Inc. | Phosphine ligands for catalytic reactions |
| WO2012009699A2 (en) | 2010-07-16 | 2012-01-19 | Abbott Laboratories | Process for preparing antiviral compounds |
| JP2015514135A (ja) | 2012-04-14 | 2015-05-18 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 新規組成物および方法 |
| CA2903281C (en) | 2013-03-08 | 2022-11-29 | The University Of British Columbia | Substituted organofluoroborates as imaging agents |
| CA3148303C (en) | 2013-12-03 | 2024-02-27 | Intra-Cellular Therapies, Inc. | Heterocycle fused gamma-carboline compounds for use in treatment of bipolar disorders |
| CA2944512C (en) | 2014-04-04 | 2018-04-24 | Intra-Cellular Therapies, Inc. | Heterocycle fused gamma-carbolines for treatment of central nervous system disorders |
| CA2944755A1 (en) | 2014-04-04 | 2015-10-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
| JP6476396B2 (ja) * | 2015-03-10 | 2019-03-06 | 国立大学法人名古屋大学 | 環化触媒、クロマン類の製法及びピロリジン類の製法 |
| PT3407888T (pt) | 2016-01-26 | 2021-03-19 | Intra Cellular Therapies Inc | Compostos de piridopirroloquinoxalina, suas composições e utilizações |
| SI3407889T1 (sl) | 2016-03-25 | 2021-09-30 | Intra-Cellular Therapies, Inc. | Organske spojine in njihova uporaba v zdravljenju ali preprečevanju motenj centralnega živčnega sistema |
| EP3436016B1 (de) | 2016-03-28 | 2022-04-27 | Intra-Cellular Therapies, Inc. | Neuartige co-kristalle |
| US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| EP3436455A4 (de) | 2016-03-28 | 2019-09-04 | Intra-Cellular Therapies, Inc. | Neuartige salze und kristalle |
| JP7013454B2 (ja) | 2016-10-12 | 2022-02-15 | イントラ－セルラー・セラピーズ・インコーポレイテッド | アモルファス固体分散体 |
| WO2018126140A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2018126143A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| IL304026B2 (en) | 2017-03-24 | 2024-11-01 | Intra Cellular Therapies Inc | A pharmaceutical preparation containing 1-(4-fluoro-phenyl)-4-((Sa10,Rb6)-3-D2-2,2-methyl-2, 3, a10, 10, 9, b6- hexahydro-H7, H1- Pyrido[3',4',:4,5]pyrrolo[3,2,1-de]quioxalin-8-yl)-butan-1-one and its uses |
| US11427587B2 (en) | 2017-07-26 | 2022-08-30 | Intra-Cellular Therapies, Inc. | Organic compounds |
| JP7223742B2 (ja) | 2017-07-26 | 2023-02-16 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| IL277504B1 (en) | 2018-03-23 | 2026-02-01 | Intra Cellular Therapies Inc | Deuterium-converted ((sa10,rb6)-8-(3-(4-fluorophenoxy)propyl 6b, 7, 8, 9, 10, 10a-hexahydro-1h-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-82(h3)-one compounds, pharmaceutical composition containing them and their uses |
| JP7476115B2 (ja) | 2018-06-06 | 2024-04-30 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 新規の塩および結晶 |
| WO2019237037A1 (en) | 2018-06-08 | 2019-12-12 | Intra-Cellular Therapies, Inc. | Novel methods |
| DK3609891T3 (da) | 2018-06-11 | 2026-02-23 | Intra Cellular Therapies Inc | Syntese af substituerede heterocykliske fusionerede gamma-carboliner |
| WO2020004502A1 (ja) | 2018-06-26 | 2020-01-02 | ダイキン工業株式会社 | フルオロビニルエーテル化合物の製造方法 |
| US12144808B2 (en) | 2018-08-29 | 2024-11-19 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| AU2019328528B2 (en) | 2018-08-31 | 2025-01-23 | Intra-Cellular Therapies, Inc. | Novel methods |
| MX2021002321A (es) | 2018-08-31 | 2021-04-28 | Intra Cellular Therapies Inc | Nuevos metodos. |
| ES3047409T3 (en) | 2018-12-17 | 2025-12-03 | Intra Cellular Therapies Inc | Substituted heterocycle fused gamma-carbolines synthesis |
| EP3898580A4 (de) | 2018-12-17 | 2022-08-10 | Intra-Cellular Therapies, Inc. | Synthese kondensierter gamma-carboline mit substituiertem heterozyklus |
| KR20210110834A (ko) | 2018-12-18 | 2021-09-09 | 프로빈셜 헬스 서비시즈 오쏘리티 | 이중 방식의 18f-표지된 테라노스틱 화합물 및 그 용도 |
| IL301342A (en) | 2020-10-21 | 2023-05-01 | Provincial Health Services Authority | Novel CXCR4-targeting compounds |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE734904A (de) * | 1969-04-10 | 1969-12-22 | ||
| US5847166A (en) * | 1996-10-10 | 1998-12-08 | Massachusetts Institute Of Technology | Synthesis of aryl ethers |
-
1996
- 1996-10-10 US US08/728,449 patent/US5847166A/en not_active Expired - Lifetime
-
1997
- 1997-10-10 AU AU47592/97A patent/AU4759297A/en not_active Abandoned
- 1997-10-10 CA CA002267153A patent/CA2267153C/en not_active Expired - Fee Related
- 1997-10-10 PT PT97910139T patent/PT1027316E/pt unknown
- 1997-10-10 DK DK97910139T patent/DK1027316T3/da active
- 1997-10-10 ES ES97910139T patent/ES2200162T3/es not_active Expired - Lifetime
- 1997-10-10 WO PCT/US1997/018719 patent/WO1998015515A1/en not_active Ceased
- 1997-10-10 JP JP10517804A patent/JP2001501954A/ja not_active Ceased
- 1997-10-10 EP EP02012284A patent/EP1254884A3/de not_active Withdrawn
- 1997-10-10 DE DE69722271T patent/DE69722271T2/de not_active Expired - Lifetime
- 1997-10-10 AT AT97910139T patent/ATE240923T1/de active
- 1997-10-10 EP EP97910139A patent/EP1027316B1/de not_active Expired - Lifetime
- 1997-10-10 EP EP02012164A patent/EP1245553A3/de not_active Withdrawn
-
1998
- 1998-12-08 US US09/206,820 patent/US6166226A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PT1027316E (pt) | 2003-10-31 |
| CA2267153A1 (en) | 1998-04-16 |
| CA2267153C (en) | 2004-07-20 |
| US6166226A (en) | 2000-12-26 |
| EP1245553A3 (de) | 2003-12-10 |
| DK1027316T3 (da) | 2003-09-15 |
| EP1254884A3 (de) | 2003-12-10 |
| EP1027316B1 (de) | 2003-05-21 |
| ES2200162T3 (es) | 2004-03-01 |
| DE69722271D1 (de) | 2003-06-26 |
| EP1027316A1 (de) | 2000-08-16 |
| EP1245553A2 (de) | 2002-10-02 |
| JP2001501954A (ja) | 2001-02-13 |
| EP1254884A2 (de) | 2002-11-06 |
| DE69722271T2 (de) | 2004-04-01 |
| US5847166A (en) | 1998-12-08 |
| AU4759297A (en) | 1998-05-05 |
| WO1998015515A1 (en) | 1998-04-16 |
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