ATE242246T1 - (1,2,3)-triazolo(4,5-d)pyrimidin-derivate als antithrombotische mittel - Google Patents

(1,2,3)-triazolo(4,5-d)pyrimidin-derivate als antithrombotische mittel

Info

Publication number
ATE242246T1
ATE242246T1 AT00976525T AT00976525T ATE242246T1 AT E242246 T1 ATE242246 T1 AT E242246T1 AT 00976525 T AT00976525 T AT 00976525T AT 00976525 T AT00976525 T AT 00976525T AT E242246 T1 ATE242246 T1 AT E242246T1
Authority
AT
Austria
Prior art keywords
triazolo
antithrbotic
agents
pyrimidine derivatives
compounds
Prior art date
Application number
AT00976525T
Other languages
English (en)
Inventor
Simon Guile
Brian Springthorpe
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE242246T1 publication Critical patent/ATE242246T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT00976525T 1999-11-15 2000-11-14 (1,2,3)-triazolo(4,5-d)pyrimidin-derivate als antithrombotische mittel ATE242246T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9904129A SE9904129D0 (sv) 1999-11-15 1999-11-15 Novel compounds
PCT/SE2000/002229 WO2001036421A1 (en) 1999-11-15 2000-11-14 Novel [1,2,3]-triazolo[4,5-d]pyrimidine compounds

Publications (1)

Publication Number Publication Date
ATE242246T1 true ATE242246T1 (de) 2003-06-15

Family

ID=20417726

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00976525T ATE242246T1 (de) 1999-11-15 2000-11-14 (1,2,3)-triazolo(4,5-d)pyrimidin-derivate als antithrombotische mittel

Country Status (8)

Country Link
US (1) US6713483B1 (de)
EP (1) EP1232156B1 (de)
JP (1) JP4859321B2 (de)
AT (1) ATE242246T1 (de)
AU (1) AU1428801A (de)
DE (1) DE60003220T2 (de)
SE (1) SE9904129D0 (de)
WO (1) WO2001036421A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0013407D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
GB0013488D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Chemical compound
US7018985B1 (en) 2000-08-21 2006-03-28 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US7132408B2 (en) 2000-08-21 2006-11-07 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US7452870B2 (en) 2000-08-21 2008-11-18 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with P2Y12 receptor antagonist compound
US6897201B2 (en) 2000-08-21 2005-05-24 Inspire Pharmaceuticals, Inc. Compositions and methods for the treatment of glaucoma or ocular hypertension
US7115585B2 (en) 2000-08-21 2006-10-03 Inspire Pharmaceuticals, Inc. Compositions for treating epithelial and retinal tissue diseases
US7435724B2 (en) 2002-02-27 2008-10-14 Inspire Pharmaceutical, Inc. Degradation-resistant mononucleoside phosphate compounds
EP1598354A1 (de) * 2004-05-18 2005-11-23 Vasopharm Biotech GmbH Durch kondensierten zyklus verbundenen n-heteroaryl verbindungen und ihre verwendung als nad(p)h oxidase und blutplättchen-aggregation hemmer
GB0512844D0 (en) * 2005-06-23 2005-08-03 Novartis Ag Organic compounds
JPWO2007020935A1 (ja) * 2005-08-17 2009-02-26 小野薬品工業株式会社 Ｐ２ｙ１２受容体および／またはｐ２ｙ１４受容体ブロッカーを含有してなる疼痛治療剤
TWI482772B (zh) * 2006-08-21 2015-05-01 Astrazeneca Ab 適合口服且包含三唑并[4,5-d]嘧啶衍生物之組合物
JP2010508350A (ja) * 2006-10-31 2010-03-18 ヤンセン ファーマシューティカ エヌ．ベー． Ａｄｐｐ２ｙ１２レセプターアンタゴニストとしてのトリアゾロピリミジン誘導体
WO2012063126A2 (en) * 2010-11-09 2012-05-18 Actavis Group Ptc Ehf Improved processes for preparing pure (3ar,4s,6r,6as)-6-amino-2,2-dimethyltetrahdro-3ah-cyclopenta[d] [1,3]-dioxol-4-ol and its key starting material
PL2755957T4 (pl) * 2011-09-14 2017-05-31 Lek Pharmaceuticals D.D. Synteza związków triazolopirymidynowych
EP2570405A1 (de) * 2011-09-14 2013-03-20 LEK Pharmaceuticals d.d. Synthese von Triazolpyrimidin-Verbindungen
CN102603751A (zh) * 2012-02-24 2012-07-25 中国药科大学 三唑并(4,5-d)嘧啶衍生物及其制备方法与在制药中的用途
WO2014206187A1 (zh) 2013-06-24 2014-12-31 苏州明锐医药科技有限公司 替卡格雷及其中间体的制备方法
WO2014206188A1 (zh) * 2013-06-27 2014-12-31 苏州明锐医药科技有限公司 替格瑞洛的制备方法
CN105272985B (zh) * 2014-06-24 2017-11-21 珠海联邦制药股份有限公司 三唑并[4,5‑d]嘧啶化合物及其合成方法、用途、组合物
CN112915063B (zh) * 2021-01-25 2022-12-20 刘红枚 一种用于治疗子宫平滑肌高频率强直性收缩相关疾病的化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997003084A1 (en) 1995-07-11 1997-01-30 Astra Pharmaceuticals Ltd. New inhibitors of platelet aggregation
US6297232B1 (en) 1996-12-20 2001-10-02 Astrazeneca Ab Triazolo[4,5-D]pyrimidinyl derivatives and their use as medicaments
AR017014A1 (es) 1997-07-22 2001-08-22 Astrazeneca Ab Compuestos de triazolo [4,5-d]pirimidina, composiciones farmaceuticas, uso de los mismos para preparar medicamentos y procesos para la preparacionde dichos compuestos
SE9702774D0 (sv) * 1997-07-22 1997-07-22 Astra Pharma Prod Novel compounds
SE9702772D0 (sv) 1997-07-22 1997-07-22 Astra Pharma Prod Novel compounds
MXPA00007634A (es) * 1998-02-17 2003-09-10 Astrazeneca Uk Ltd Nuevos compuestos de triazol (4,5-d) pirimidina.
SE9802574D0 (sv) * 1998-07-17 1998-07-17 Astra Pharma Prod Novel compounds
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses

Also Published As

Publication number Publication date
US6713483B1 (en) 2004-03-30
EP1232156A1 (de) 2002-08-21
AU1428801A (en) 2001-05-30
DE60003220D1 (de) 2003-07-10
EP1232156B1 (de) 2003-06-04
WO2001036421A1 (en) 2001-05-25
JP4859321B2 (ja) 2012-01-25
SE9904129D0 (sv) 1999-11-15
DE60003220T2 (de) 2004-07-15
JP2003514819A (ja) 2003-04-22

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties