ATE242316T1 - Neurale transplantation durch verwendung von pluripotenten neuroepithelzellen - Google Patents

Neurale transplantation durch verwendung von pluripotenten neuroepithelzellen

Info

Publication number: ATE242316T1
Authority: AT; Austria
Prior art keywords: cells; pluripotent; neuropepithelial; neural transplantation; cell lines
Prior art date: 1995-09-12

Application number

AT96930260T

Other languages

English (en)

Inventor

John Sinden

Jeffrey Alan Gray

Helen Hodges

Timothy Kershaw

Rashid-Doubell

Original Assignee

Reneuron Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-12

Filing date

1996-09-12

Publication date

2003-06-15

1996-09-12 Application filed by Reneuron Ltd filed Critical Reneuron Ltd

2003-06-15 Application granted granted Critical

2003-06-15 Publication of ATE242316T1 publication Critical patent/ATE242316T1/de

Links

238000002054 transplantation Methods 0.000 title abstract 2
230000001537 neural effect Effects 0.000 title 1
210000004027 cell Anatomy 0.000 abstract 3
238000000034 method Methods 0.000 abstract 3
230000003542 behavioural effect Effects 0.000 abstract 1
230000006735 deficit Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000012423 maintenance Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
210000000461 neuroepithelial cell Anatomy 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
- C12N2501/392—Sexual steroids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/395—Thyroid hormones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Developmental Biology & Embryology (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Ophthalmology & Optometry (AREA)
Virology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Urology & Nephrology (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Food Science & Technology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
General Physics & Mathematics (AREA)

AT96930260T 1995-09-12 1996-09-12 Neurale transplantation durch verwendung von pluripotenten neuroepithelzellen ATE242316T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9518606.0A GB9518606D0 (en)	1995-09-12	1995-09-12	Neural transplantation
PCT/GB1996/002251 WO1997010329A1 (en)	1995-09-12	1996-09-12	Neural transplantation using pluripotent neuroepithelial cells

Publications (1)

Publication Number	Publication Date
ATE242316T1 true ATE242316T1 (de)	2003-06-15

Family

ID=10780583

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96930260T ATE242316T1 (de)	1995-09-12	1996-09-12	Neurale transplantation durch verwendung von pluripotenten neuroepithelzellen

Country Status (20)

Country	Link
US (3)	US7048921B2 (de)
EP (1)	EP0850298B1 (de)
JP (1)	JP4280872B2 (de)
KR (1)	KR19990044606A (de)
CN (1)	CN1193345A (de)
AT (1)	ATE242316T1 (de)
AU (1)	AU711563B2 (de)
CA (1)	CA2231436C (de)
CZ (1)	CZ296669B6 (de)
DE (1)	DE69628566T2 (de)
DK (1)	DK0850298T3 (de)
ES (1)	ES2196172T3 (de)
GB (1)	GB9518606D0 (de)
HU (1)	HUP9802091A3 (de)
NO (1)	NO981072L (de)
PL (1)	PL186777B1 (de)
PT (1)	PT850298E (de)
RU (1)	RU2185833C2 (de)
SK (1)	SK285816B6 (de)
WO (1)	WO1997010329A1 (de)

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WO1996014400A1 (en)	1994-11-08	1996-05-17	Bradley Michael John Stringer	Human cell-lines
GB9518606D0 (en) *	1995-09-12	1995-11-15	Inst Of Psychiatry	Neural transplantation
GB9904281D0 (en) *	1999-02-24	1999-04-21	Reneuron Ltd	Transplantation
GB9907243D0 (en) *	1999-03-29	1999-05-26	Reneuron Ltd	Therapy
KR100801764B1 (ko) *	1999-09-17	2008-02-05	레뉴런 리미티드	세포의 조건부 불멸화
US6399384B1 (en) *	1999-09-17	2002-06-04	Reneuron Limited	Conditional immortalization of cells
US6465215B1 (en)	1999-12-14	2002-10-15	Reneuron Limited	Identification of cells for transplantation
GB0005856D0 (en) *	2000-03-10	2000-05-03	Reneuron Ltd	Genetic constructs
GB0125773D0 (en) *	2001-10-26	2001-12-19	Reneuron Ltd	Constructs
RU2219937C2 (ru) *	2002-02-26	2003-12-27	Санкт-Петербургский научно-исследовательский психоневрологический институт им. В.М. Бехтерева	Способ лечения задержки психоречевого и интеллектуального развития различного происхождения
RU2219936C2 (ru) *	2002-02-26	2003-12-27	Санкт-Петербургский научно-исследовательский психоневрологический институт им. В.М.Бехтерева	Способ лечения хронического слухового галлюциноза, резистентного к терапии
DE602005002430T2 (de)	2004-09-30	2008-06-19	Reneuron Ltd., Guildford	Zelllinie
BRPI0810949A2 (pt) *	2007-05-29	2015-10-27	Christopher B Reid	"método de preparação de células multipotentes, auto-renovadoras, diferenciadoras ou resistentes a doenças, célula e vetor pra uso do método"
GB0822246D0 (en)	2008-12-05	2009-01-14	Reneuron Ltd	Composition
GB0902034D0 (en)	2009-02-06	2009-03-11	Reneuron Ltd	Method
GB201011589D0 (en) *	2010-07-09	2010-08-25	Reneuron Ltd	Therapeutic cells
US20150232662A1 (en) *	2014-02-20	2015-08-20	Sabic Innovative Plastics Ip B.V.	Thermoplastic composition and article
US20170173114A1 (en) *	2014-05-07	2017-06-22	Joslin Diabetes Center, Inc.	Methods and compositions for induction of ucp1 expression
CN116590345B (zh) *	2023-05-06	2024-01-30	北京中医药大学	永生化小鼠足细胞系及其制备方法、分化方法和应用

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GB9518606D0 (en) *	1995-09-12	1995-11-15	Inst Of Psychiatry	Neural transplantation
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CA2262817A1 (en)	1996-08-19	1998-02-26	James Robl	Embryonic or stem-like cell lines produced by cross species nuclear transplantation
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AU3888699A (en) *	1998-05-07	1999-11-23	University Of South Florida	Bone marrow cells as a source of neurons for brain and spinal cord repair
US5958767A (en) *	1998-08-14	1999-09-28	The Children's Medical Center Corp.	Engraftable human neural stem cells
GB9904281D0 (en)	1999-02-24	1999-04-21	Reneuron Ltd	Transplantation
GB9907243D0 (en) *	1999-03-29	1999-05-26	Reneuron Ltd	Therapy
US6399384B1 (en) *	1999-09-17	2002-06-04	Reneuron Limited	Conditional immortalization of cells
US6465215B1 (en)	1999-12-14	2002-10-15	Reneuron Limited	Identification of cells for transplantation
US7160724B2 (en)	2000-03-09	2007-01-09	University Of South Florida	Human cord blood as a source of neural tissue for repair of the brain and spinal cord
US7250294B2 (en)	2000-05-17	2007-07-31	Geron Corporation	Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
WO2001094541A2 (en)	2000-06-05	2001-12-13	University Of South Florida	Human mesenchymal progenitor cell
US7049072B2 (en)	2000-06-05	2006-05-23	University Of South Florida	Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state
WO2003029432A2 (en)	2001-10-03	2003-04-10	University Of South Florida	Human mesenchymal progenitor cell
GB0125773D0 (en)	2001-10-26	2001-12-19	Reneuron Ltd	Constructs
DE602005002430T2 (de) *	2004-09-30	2008-06-19	Reneuron Ltd., Guildford	Zelllinie

1995
- 1995-09-12 GB GBGB9518606.0A patent/GB9518606D0/en active Pending
1996
- 1996-09-12 EP EP96930260A patent/EP0850298B1/de not_active Expired - Lifetime
- 1996-09-12 JP JP51175697A patent/JP4280872B2/ja not_active Expired - Lifetime
- 1996-09-12 CA CA002231436A patent/CA2231436C/en not_active Expired - Lifetime
- 1996-09-12 SK SK306-98A patent/SK285816B6/sk unknown
- 1996-09-12 KR KR1019980701856A patent/KR19990044606A/ko not_active Ceased
- 1996-09-12 HU HU9802091A patent/HUP9802091A3/hu unknown
- 1996-09-12 PT PT96930260T patent/PT850298E/pt unknown
- 1996-09-12 DK DK96930260T patent/DK0850298T3/da active
- 1996-09-12 WO PCT/GB1996/002251 patent/WO1997010329A1/en not_active Ceased
- 1996-09-12 ES ES96930260T patent/ES2196172T3/es not_active Expired - Lifetime
- 1996-09-12 CN CN96196376A patent/CN1193345A/zh active Pending
- 1996-09-12 DE DE69628566T patent/DE69628566T2/de not_active Expired - Lifetime
- 1996-09-12 AT AT96930260T patent/ATE242316T1/de not_active IP Right Cessation
- 1996-09-12 RU RU98107327/14A patent/RU2185833C2/ru not_active IP Right Cessation
- 1996-09-12 CZ CZ0055898A patent/CZ296669B6/cs not_active IP Right Cessation
- 1996-09-12 AU AU69375/96A patent/AU711563B2/en not_active Expired
- 1996-09-12 PL PL96325646A patent/PL186777B1/pl unknown
1998
- 1998-03-11 NO NO981072A patent/NO981072L/no not_active Application Discontinuation
2001
- 2001-01-12 US US09/760,274 patent/US7048921B2/en not_active Expired - Fee Related
2003
- 2003-02-28 US US10/376,119 patent/US20030147873A1/en not_active Abandoned
2005
- 2005-07-08 US US11/178,216 patent/US7371374B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CZ296669B6 (cs)	2006-05-17
US7371374B2 (en)	2008-05-13
US7048921B2 (en)	2006-05-23
JP4280872B2 (ja)	2009-06-17
PL325646A1 (en)	1998-08-03
HK1009154A1 (en)	1999-05-28
PT850298E (pt)	2003-09-30
KR19990044606A (ko)	1999-06-25
ES2196172T3 (es)	2003-12-16
EP0850298B1 (de)	2003-06-04
JPH11513242A (ja)	1999-11-16
CA2231436A1 (en)	1997-03-20
WO1997010329A1 (en)	1997-03-20
RU2185833C2 (ru)	2002-07-27
EP0850298A1 (de)	1998-07-01
NO981072L (no)	1998-05-12
CA2231436C (en)	2007-07-17
AU6937596A (en)	1997-04-01
AU711563B2 (en)	1999-10-14
US20060051326A1 (en)	2006-03-09
SK285816B6 (sk)	2007-09-06
CZ55898A3 (cs)	1998-06-17
HUP9802091A3 (en)	2001-01-29
HUP9802091A2 (hu)	1998-12-28
DE69628566T2 (de)	2004-05-06
US20030147873A1 (en)	2003-08-07
PL186777B1 (pl)	2004-02-27
GB9518606D0 (en)	1995-11-15
DE69628566D1 (de)	2003-07-10
NO981072D0 (no)	1998-03-11
US20010001662A1 (en)	2001-05-24
DK0850298T3 (da)	2003-09-15
CN1193345A (zh)	1998-09-16
SK30698A3 (en)	1999-01-11

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2003-10-15

UEP

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2009-06-15

REN

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Publication	Publication Date	Title
ATE242316T1 (de)	2003-06-15	Neurale transplantation durch verwendung von pluripotenten neuroepithelzellen
DE69609222D1 (de)	2000-08-17	Partikel auf Polyaminosäure(n)basis zur Verwendung als Wirkstoffträger sowie deren Herstellungsverfahren
MY113045A (en)	2001-11-30	Waste treatment plant and process
EP0832203A4 (de)	2002-07-17	Verwendung von neuronalen fötalen zellinien für die transplantationstherapie
WO2001036589A3 (en)	2002-02-14	Human ex vivo immune system
HUT64595A (en)	1994-01-28	Method for producing mammalian cytokine, il-11
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