ES2196172T3 - Transplante neuronal utilizando celulas neuroepiteliales pluripotentes. - Google Patents

Transplante neuronal utilizando celulas neuroepiteliales pluripotentes.

Info

Publication number
ES2196172T3
ES2196172T3 ES96930260T ES96930260T ES2196172T3 ES 2196172 T3 ES2196172 T3 ES 2196172T3 ES 96930260 T ES96930260 T ES 96930260T ES 96930260 T ES96930260 T ES 96930260T ES 2196172 T3 ES2196172 T3 ES 2196172T3
Authority
ES
Spain
Prior art keywords
cells
neuroepitelial
pluripotent
neuronal
transplant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96930260T
Other languages
English (en)
Inventor
John Sinden
Jeffrey Alan Gray
Helen Hodges
Timothy Kershaw
Fiza Rashid-Doubell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reneuron Ltd
Original Assignee
Reneuron Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reneuron Ltd filed Critical Reneuron Ltd
Application granted granted Critical
Publication of ES2196172T3 publication Critical patent/ES2196172T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C12N2501/392—Sexual steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/395—Thyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90—Polysaccharides
    • C12N2501/91—Heparin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Psychiatry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)

Abstract

UN NUEVO METODO PARA LA CORRECCION DE DEFICITS DE CONDUCTA Y/O PSICOLOGICOS SE HACE POSIBLE MEDIANTE EL TRASPLANTE INTRACEREBRAL DE CELULAS NEUROEPITELIALES PLURIPOTENCIALES. LA INVENCION ABARCA CELULAS, LINEAS CELULARES, PREPARACIONES FARMACEUTICAS, MEDICAMENTOS, METODOS PARA LA PRODUCCION Y MANTENIMIENTO DE LAS LINEAS CELULARES PARA SU USO EN EL METODO DE LA INVENCION.
ES96930260T 1995-09-12 1996-09-12 Transplante neuronal utilizando celulas neuroepiteliales pluripotentes. Expired - Lifetime ES2196172T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9518606.0A GB9518606D0 (en) 1995-09-12 1995-09-12 Neural transplantation

Publications (1)

Publication Number Publication Date
ES2196172T3 true ES2196172T3 (es) 2003-12-16

Family

ID=10780583

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96930260T Expired - Lifetime ES2196172T3 (es) 1995-09-12 1996-09-12 Transplante neuronal utilizando celulas neuroepiteliales pluripotentes.

Country Status (20)

Country Link
US (3) US7048921B2 (es)
EP (1) EP0850298B1 (es)
JP (1) JP4280872B2 (es)
KR (1) KR19990044606A (es)
CN (1) CN1193345A (es)
AT (1) ATE242316T1 (es)
AU (1) AU711563B2 (es)
CA (1) CA2231436C (es)
CZ (1) CZ296669B6 (es)
DE (1) DE69628566T2 (es)
DK (1) DK0850298T3 (es)
ES (1) ES2196172T3 (es)
GB (1) GB9518606D0 (es)
HU (1) HUP9802091A3 (es)
NO (1) NO981072L (es)
PL (1) PL186777B1 (es)
PT (1) PT850298E (es)
RU (1) RU2185833C2 (es)
SK (1) SK285816B6 (es)
WO (1) WO1997010329A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014400A1 (en) 1994-11-08 1996-05-17 Bradley Michael John Stringer Human cell-lines
GB9518606D0 (en) * 1995-09-12 1995-11-15 Inst Of Psychiatry Neural transplantation
GB9904281D0 (en) * 1999-02-24 1999-04-21 Reneuron Ltd Transplantation
GB9907243D0 (en) * 1999-03-29 1999-05-26 Reneuron Ltd Therapy
KR100801764B1 (ko) * 1999-09-17 2008-02-05 레뉴런 리미티드 세포의 조건부 불멸화
US6399384B1 (en) 1999-09-17 2002-06-04 Reneuron Limited Conditional immortalization of cells
US6465215B1 (en) 1999-12-14 2002-10-15 Reneuron Limited Identification of cells for transplantation
GB0005856D0 (en) * 2000-03-10 2000-05-03 Reneuron Ltd Genetic constructs
GB0125773D0 (en) * 2001-10-26 2001-12-19 Reneuron Ltd Constructs
RU2219936C2 (ru) * 2002-02-26 2003-12-27 Санкт-Петербургский научно-исследовательский психоневрологический институт им. В.М.Бехтерева Способ лечения хронического слухового галлюциноза, резистентного к терапии
RU2219937C2 (ru) * 2002-02-26 2003-12-27 Санкт-Петербургский научно-исследовательский психоневрологический институт им. В.М. Бехтерева Способ лечения задержки психоречевого и интеллектуального развития различного происхождения
DE602005002430T2 (de) 2004-09-30 2008-06-19 Reneuron Ltd., Guildford Zelllinie
PT2164993T (pt) * 2007-05-29 2017-01-12 Reid Christopher B Métodos para produção e usos de populações de células multipotentes, populações de células pluripotentes, populações de célula diferenciadas e populações de células resistentes a vih
GB0822246D0 (en) 2008-12-05 2009-01-14 Reneuron Ltd Composition
GB0902034D0 (en) 2009-02-06 2009-03-11 Reneuron Ltd Method
GB201011589D0 (en) * 2010-07-09 2010-08-25 Reneuron Ltd Therapeutic cells
US20150232662A1 (en) * 2014-02-20 2015-08-20 Sabic Innovative Plastics Ip B.V. Thermoplastic composition and article
US20170173114A1 (en) * 2014-05-07 2017-06-22 Joslin Diabetes Center, Inc. Methods and compositions for induction of ucp1 expression
CN116590345B (zh) * 2023-05-06 2024-01-30 北京中医药大学 永生化小鼠足细胞系及其制备方法、分化方法和应用

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US147873A (en) * 1874-02-24 Improvement in nasal yokes for animals
US1662A (en) * 1840-06-27 ariel nobris
US28510A (en) * 1860-05-29 John e
US146821A (en) * 1874-01-27 Improvement in nose-pieces of nail-plate feeders
US203483A (en) * 1878-05-07 Improvement in honey-boxes
US913443A (en) * 1908-08-13 1909-02-23 Webster Full Expansion Rotary Engine Company Rotary engine.
NZ226750A (en) * 1987-10-29 1990-09-26 Amrad Corp Ltd Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene
JPH03504799A (ja) 1988-04-12 1991-10-24 マサチューセッツ・インスティチュート・オブ・テクノロジー 真核細胞の細胞型を操作する方法
US5270191A (en) 1988-04-12 1993-12-14 Massachusetts Institute Of Technology Method for manipulation of the cell types of eukaryotes
DE69010388T2 (de) * 1989-04-27 1994-10-20 Ajinomoto Kk Demethylallosamidin und ein Verfahren zu seiner Herstellung.
US5399493A (en) 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
WO1991009936A1 (en) * 1989-12-26 1991-07-11 Hana Biologics, Inc. Proliferated neuron progenitor cell product and process
US5612211A (en) 1990-06-08 1997-03-18 New York University Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
RU2028089C1 (ru) * 1990-10-16 1995-02-09 Украинский научно-исследовательский институт нейрохирургии Способ лечения апаллического синдрома
EP0594669B9 (en) * 1991-07-08 2008-03-19 NeuroSpheres Holdings Ltd. Growth factor-responsive neural progenitor cells which can be proliferated in vitro.
US5851832A (en) 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
JPH07504331A (ja) 1992-03-04 1995-05-18 システミックス，インコーポレイティド 造血幹細胞の培養およびその遺伝子工学
US5753491A (en) 1993-04-13 1998-05-19 Us Health Use of neuro-derived fetal cell lines for transplantation therapy
PT696205E (pt) 1993-04-13 2002-07-31 Us Gov Health & Human Serv Utilizacao de linhas celulares fetais nauro-derivadas para terapia de transplantacao
WO1996014400A1 (en) 1994-11-08 1996-05-17 Bradley Michael John Stringer Human cell-lines
WO1996015226A1 (en) * 1994-11-14 1996-05-23 Neurospheres Holdings Ltd. Regulation of neural stem cell proliferation
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
GB9517263D0 (en) * 1995-08-23 1995-10-25 Cancer Res Campaign Tech Expression systems
GB9518606D0 (en) * 1995-09-12 1995-11-15 Inst Of Psychiatry Neural transplantation
US5588692A (en) * 1995-10-11 1996-12-31 General Motors Corporation Push-out vehicle side door
JP2001500725A (ja) 1996-08-19 2001-01-23 ユニヴァーシティー オヴ マサチューセッツ 種間核移植により製造される胚性または幹細胞様細胞株
SE9604322D0 (sv) * 1996-11-25 1996-11-25 Astra Ab Bacterial antigens and vaccine compositions II
US20020123143A1 (en) 1997-08-22 2002-09-05 Jean Toma Multipotent stem cells from peripheral tissues and uses thereof
ES2246085T3 (es) * 1998-05-07 2006-02-01 University Of South Florida Celulas de medula osea como fuente de neuronas util para reparar la medula espinal y el cerebro.
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
GB9904281D0 (en) 1999-02-24 1999-04-21 Reneuron Ltd Transplantation
GB9907243D0 (en) * 1999-03-29 1999-05-26 Reneuron Ltd Therapy
US6399384B1 (en) 1999-09-17 2002-06-04 Reneuron Limited Conditional immortalization of cells
US6465215B1 (en) * 1999-12-14 2002-10-15 Reneuron Limited Identification of cells for transplantation
EP1263930A4 (en) 2000-03-09 2004-07-21 Saneron Ccel Therapeutics Inc HUMAN CORD BLOOD BLOOD AS A SOURCE FOR NEURAL TISSUE FOR HEALING THE BRAIN AND BACK MARK
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
WO2001094541A2 (en) 2000-06-05 2001-12-13 University Of South Florida Human mesenchymal progenitor cell
US7049072B2 (en) * 2000-06-05 2006-05-23 University Of South Florida Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state
WO2003029432A2 (en) 2001-10-03 2003-04-10 University Of South Florida Human mesenchymal progenitor cell
GB0125773D0 (en) * 2001-10-26 2001-12-19 Reneuron Ltd Constructs
DE602005002430T2 (de) * 2004-09-30 2008-06-19 Reneuron Ltd., Guildford Zelllinie

Also Published As

Publication number Publication date
AU6937596A (en) 1997-04-01
US20060051326A1 (en) 2006-03-09
NO981072D0 (no) 1998-03-11
HUP9802091A2 (hu) 1998-12-28
CN1193345A (zh) 1998-09-16
AU711563B2 (en) 1999-10-14
SK30698A3 (en) 1999-01-11
DE69628566T2 (de) 2004-05-06
PL325646A1 (en) 1998-08-03
KR19990044606A (ko) 1999-06-25
PT850298E (pt) 2003-09-30
HUP9802091A3 (en) 2001-01-29
RU2185833C2 (ru) 2002-07-27
ATE242316T1 (de) 2003-06-15
US20030147873A1 (en) 2003-08-07
EP0850298B1 (en) 2003-06-04
CZ296669B6 (cs) 2006-05-17
US20010001662A1 (en) 2001-05-24
DE69628566D1 (de) 2003-07-10
HK1009154A1 (en) 1999-05-28
CZ55898A3 (cs) 1998-06-17
US7371374B2 (en) 2008-05-13
NO981072L (no) 1998-05-12
SK285816B6 (sk) 2007-09-06
US7048921B2 (en) 2006-05-23
CA2231436C (en) 2007-07-17
CA2231436A1 (en) 1997-03-20
EP0850298A1 (en) 1998-07-01
WO1997010329A1 (en) 1997-03-20
DK0850298T3 (da) 2003-09-15
GB9518606D0 (en) 1995-11-15
PL186777B1 (pl) 2004-02-27
JP4280872B2 (ja) 2009-06-17
JPH11513242A (ja) 1999-11-16

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