DK0850298T3 - Nervetransplantation under anvendelse af pluripotente neuroepitelceller - Google Patents

Nervetransplantation under anvendelse af pluripotente neuroepitelceller

Info

Publication number: DK0850298T3
Authority: DK; Denmark
Prior art keywords: neuroepithelial cells; pluripotent neuroepithelial; nerve transplantation; cells; pluripotent
Prior art date: 1995-09-12

Application number

DK96930260T

Other languages

Danish (da)

English (en)

Inventor

John Institute Of Psych Sinden

Alan Institute Of Psyc Jeffrey

Helen Institute Of Psyc Hodges

Timothy C O Inst Of Ps Kershaw

Fiza University Rashid-Doubell

Original Assignee

Reneuron Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-12

Filing date

1996-09-12

Publication date

2003-09-15

1996-09-12 Application filed by Reneuron Ltd filed Critical Reneuron Ltd

2003-09-15 Application granted granted Critical

2003-09-15 Publication of DK0850298T3 publication Critical patent/DK0850298T3/da

Links

210000000461 neuroepithelial cell Anatomy 0.000 title abstract 2
238000002054 transplantation Methods 0.000 title abstract 2
210000005036 nerve Anatomy 0.000 title 1
210000004027 cell Anatomy 0.000 abstract 3
238000000034 method Methods 0.000 abstract 3
230000003542 behavioural effect Effects 0.000 abstract 1
230000006735 deficit Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000012423 maintenance Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
- C12N2501/392—Sexual steroids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/395—Thyroid hormones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Organic Chemistry (AREA)
Developmental Biology & Embryology (AREA)
Neurology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Virology (AREA)
Epidemiology (AREA)
General Engineering & Computer Science (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Urology & Nephrology (AREA)
Physics & Mathematics (AREA)
Hospice & Palliative Care (AREA)
Food Science & Technology (AREA)
Psychiatry (AREA)
Analytical Chemistry (AREA)
General Physics & Mathematics (AREA)

DK96930260T 1995-09-12 1996-09-12 Nervetransplantation under anvendelse af pluripotente neuroepitelceller DK0850298T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9518606.0A GB9518606D0 (en)	1995-09-12	1995-09-12	Neural transplantation
PCT/GB1996/002251 WO1997010329A1 (en)	1995-09-12	1996-09-12	Neural transplantation using pluripotent neuroepithelial cells

Publications (1)

Publication Number	Publication Date
DK0850298T3 true DK0850298T3 (da)	2003-09-15

Family

ID=10780583

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96930260T DK0850298T3 (da)	1995-09-12	1996-09-12	Nervetransplantation under anvendelse af pluripotente neuroepitelceller

Country Status (20)

Country	Link
US (3)	US7048921B2 (de)
EP (1)	EP0850298B1 (de)
JP (1)	JP4280872B2 (de)
KR (1)	KR19990044606A (de)
CN (1)	CN1193345A (de)
AT (1)	ATE242316T1 (de)
AU (1)	AU711563B2 (de)
CA (1)	CA2231436C (de)
CZ (1)	CZ296669B6 (de)
DE (1)	DE69628566T2 (de)
DK (1)	DK0850298T3 (de)
ES (1)	ES2196172T3 (de)
GB (1)	GB9518606D0 (de)
HU (1)	HUP9802091A3 (de)
NO (1)	NO981072L (de)
PL (1)	PL186777B1 (de)
PT (1)	PT850298E (de)
RU (1)	RU2185833C2 (de)
SK (1)	SK285816B6 (de)
WO (1)	WO1997010329A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996014400A1 (en)	1994-11-08	1996-05-17	Bradley Michael John Stringer	Human cell-lines
GB9518606D0 (en) *	1995-09-12	1995-11-15	Inst Of Psychiatry	Neural transplantation
GB9904281D0 (en) *	1999-02-24	1999-04-21	Reneuron Ltd	Transplantation
GB9907243D0 (en) *	1999-03-29	1999-05-26	Reneuron Ltd	Therapy
KR100801764B1 (ko) *	1999-09-17	2008-02-05	레뉴런 리미티드	세포의 조건부 불멸화
US6399384B1 (en)	1999-09-17	2002-06-04	Reneuron Limited	Conditional immortalization of cells
US6465215B1 (en)	1999-12-14	2002-10-15	Reneuron Limited	Identification of cells for transplantation
GB0005856D0 (en) *	2000-03-10	2000-05-03	Reneuron Ltd	Genetic constructs
GB0125773D0 (en) *	2001-10-26	2001-12-19	Reneuron Ltd	Constructs
RU2219936C2 (ru) *	2002-02-26	2003-12-27	Санкт-Петербургский научно-исследовательский психоневрологический институт им. В.М.Бехтерева	Способ лечения хронического слухового галлюциноза, резистентного к терапии
RU2219937C2 (ru) *	2002-02-26	2003-12-27	Санкт-Петербургский научно-исследовательский психоневрологический институт им. В.М. Бехтерева	Способ лечения задержки психоречевого и интеллектуального развития различного происхождения
DE602005002430T2 (de)	2004-09-30	2008-06-19	Reneuron Ltd., Guildford	Zelllinie
PT2164993T (pt) *	2007-05-29	2017-01-12	Reid Christopher B	Métodos para produção e usos de populações de células multipotentes, populações de células pluripotentes, populações de célula diferenciadas e populações de células resistentes a vih
GB0822246D0 (en)	2008-12-05	2009-01-14	Reneuron Ltd	Composition
GB0902034D0 (en)	2009-02-06	2009-03-11	Reneuron Ltd	Method
GB201011589D0 (en) *	2010-07-09	2010-08-25	Reneuron Ltd	Therapeutic cells
US20150232662A1 (en) *	2014-02-20	2015-08-20	Sabic Innovative Plastics Ip B.V.	Thermoplastic composition and article
US20170173114A1 (en) *	2014-05-07	2017-06-22	Joslin Diabetes Center, Inc.	Methods and compositions for induction of ucp1 expression
CN116590345B (zh) *	2023-05-06	2024-01-30	北京中医药大学	永生化小鼠足细胞系及其制备方法、分化方法和应用

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US147873A (en) *		1874-02-24		Improvement in nasal yokes for animals
US1662A (en) *		1840-06-27		ariel nobris
US28510A (en) *		1860-05-29		John e
US146821A (en) *		1874-01-27		Improvement in nose-pieces of nail-plate feeders
US203483A (en) *		1878-05-07		Improvement in honey-boxes
US913443A (en) *	1908-08-13	1909-02-23	Webster Full Expansion Rotary Engine Company	Rotary engine.
NZ226750A (en) *	1987-10-29	1990-09-26	Amrad Corp Ltd	Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene
JPH03504799A (ja)	1988-04-12	1991-10-24	マサチューセッツ・インスティチュート・オブ・テクノロジー	真核細胞の細胞型を操作する方法
US5270191A (en)	1988-04-12	1993-12-14	Massachusetts Institute Of Technology	Method for manipulation of the cell types of eukaryotes
DE69010388T2 (de) *	1989-04-27	1994-10-20	Ajinomoto Kk	Demethylallosamidin und ein Verfahren zu seiner Herstellung.
US5399493A (en)	1989-06-15	1995-03-21	The Regents Of The University Of Michigan	Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
WO1991009936A1 (en) *	1989-12-26	1991-07-11	Hana Biologics, Inc.	Proliferated neuron progenitor cell product and process
US5612211A (en)	1990-06-08	1997-03-18	New York University	Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
RU2028089C1 (ru) *	1990-10-16	1995-02-09	Украинский научно-исследовательский институт нейрохирургии	Способ лечения апаллического синдрома
EP0594669B9 (de) *	1991-07-08	2008-03-19	NeuroSpheres Holdings Ltd.	Auf Wachstumsfaktoren reagierende neurale Vorläuferzellen, die in vitro vermehrt werden können.
US5851832A (en)	1991-07-08	1998-12-22	Neurospheres, Ltd.	In vitro growth and proliferation of multipotent neural stem cells and their progeny
JPH07504331A (ja)	1992-03-04	1995-05-18	システミックス，インコーポレイティド	造血幹細胞の培養およびその遺伝子工学
US5753491A (en)	1993-04-13	1998-05-19	Us Health	Use of neuro-derived fetal cell lines for transplantation therapy
PT696205E (pt)	1993-04-13	2002-07-31	Us Gov Health & Human Serv	Utilizacao de linhas celulares fetais nauro-derivadas para terapia de transplantacao
WO1996014400A1 (en)	1994-11-08	1996-05-17	Bradley Michael John Stringer	Human cell-lines
WO1996015226A1 (en) *	1994-11-14	1996-05-23	Neurospheres Holdings Ltd.	Regulation of neural stem cell proliferation
US5843780A (en)	1995-01-20	1998-12-01	Wisconsin Alumni Research Foundation	Primate embryonic stem cells
GB9517263D0 (en) *	1995-08-23	1995-10-25	Cancer Res Campaign Tech	Expression systems
GB9518606D0 (en) *	1995-09-12	1995-11-15	Inst Of Psychiatry	Neural transplantation
US5588692A (en) *	1995-10-11	1996-12-31	General Motors Corporation	Push-out vehicle side door
JP2001500725A (ja)	1996-08-19	2001-01-23	ユニヴァーシティーオヴマサチューセッツ	種間核移植により製造される胚性または幹細胞様細胞株
SE9604322D0 (sv) *	1996-11-25	1996-11-25	Astra Ab	Bacterial antigens and vaccine compositions II
US20020123143A1 (en)	1997-08-22	2002-09-05	Jean Toma	Multipotent stem cells from peripheral tissues and uses thereof
ES2246085T3 (es) *	1998-05-07	2006-02-01	University Of South Florida	Celulas de medula osea como fuente de neuronas util para reparar la medula espinal y el cerebro.
US5958767A (en)	1998-08-14	1999-09-28	The Children's Medical Center Corp.	Engraftable human neural stem cells
GB9904281D0 (en)	1999-02-24	1999-04-21	Reneuron Ltd	Transplantation
GB9907243D0 (en) *	1999-03-29	1999-05-26	Reneuron Ltd	Therapy
US6399384B1 (en)	1999-09-17	2002-06-04	Reneuron Limited	Conditional immortalization of cells
US6465215B1 (en) *	1999-12-14	2002-10-15	Reneuron Limited	Identification of cells for transplantation
EP1263930A4 (de)	2000-03-09	2004-07-21	Saneron Ccel Therapeutics Inc	Menschliches nabelschnurblut als quelle für neurales gewebe zur heilung von gehirn und rückenmark
US7250294B2 (en)	2000-05-17	2007-07-31	Geron Corporation	Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
WO2001094541A2 (en)	2000-06-05	2001-12-13	University Of South Florida	Human mesenchymal progenitor cell
US7049072B2 (en) *	2000-06-05	2006-05-23	University Of South Florida	Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state
WO2003029432A2 (en)	2001-10-03	2003-04-10	University Of South Florida	Human mesenchymal progenitor cell
GB0125773D0 (en) *	2001-10-26	2001-12-19	Reneuron Ltd	Constructs
DE602005002430T2 (de) *	2004-09-30	2008-06-19	Reneuron Ltd., Guildford	Zelllinie

1995
- 1995-09-12 GB GBGB9518606.0A patent/GB9518606D0/en active Pending
1996
- 1996-09-12 EP EP96930260A patent/EP0850298B1/de not_active Expired - Lifetime
- 1996-09-12 DK DK96930260T patent/DK0850298T3/da active
- 1996-09-12 CN CN96196376A patent/CN1193345A/zh active Pending
- 1996-09-12 JP JP51175697A patent/JP4280872B2/ja not_active Expired - Lifetime
- 1996-09-12 ES ES96930260T patent/ES2196172T3/es not_active Expired - Lifetime
- 1996-09-12 HU HU9802091A patent/HUP9802091A3/hu unknown
- 1996-09-12 SK SK306-98A patent/SK285816B6/sk unknown
- 1996-09-12 PL PL96325646A patent/PL186777B1/pl unknown
- 1996-09-12 RU RU98107327/14A patent/RU2185833C2/ru not_active IP Right Cessation
- 1996-09-12 PT PT96930260T patent/PT850298E/pt unknown
- 1996-09-12 AU AU69375/96A patent/AU711563B2/en not_active Expired
- 1996-09-12 CA CA002231436A patent/CA2231436C/en not_active Expired - Lifetime
- 1996-09-12 CZ CZ0055898A patent/CZ296669B6/cs not_active IP Right Cessation
- 1996-09-12 KR KR1019980701856A patent/KR19990044606A/ko not_active Ceased
- 1996-09-12 AT AT96930260T patent/ATE242316T1/de not_active IP Right Cessation
- 1996-09-12 WO PCT/GB1996/002251 patent/WO1997010329A1/en not_active Ceased
- 1996-09-12 DE DE69628566T patent/DE69628566T2/de not_active Expired - Lifetime
1998
- 1998-03-11 NO NO981072A patent/NO981072L/no not_active Application Discontinuation
2001
- 2001-01-12 US US09/760,274 patent/US7048921B2/en not_active Expired - Fee Related
2003
- 2003-02-28 US US10/376,119 patent/US20030147873A1/en not_active Abandoned
2005
- 2005-07-08 US US11/178,216 patent/US7371374B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU6937596A (en)	1997-04-01
US20060051326A1 (en)	2006-03-09
NO981072D0 (no)	1998-03-11
HUP9802091A2 (hu)	1998-12-28
CN1193345A (zh)	1998-09-16
AU711563B2 (en)	1999-10-14
SK30698A3 (en)	1999-01-11
DE69628566T2 (de)	2004-05-06
PL325646A1 (en)	1998-08-03
KR19990044606A (ko)	1999-06-25
PT850298E (pt)	2003-09-30
HUP9802091A3 (en)	2001-01-29
RU2185833C2 (ru)	2002-07-27
ATE242316T1 (de)	2003-06-15
US20030147873A1 (en)	2003-08-07
EP0850298B1 (de)	2003-06-04
CZ296669B6 (cs)	2006-05-17
US20010001662A1 (en)	2001-05-24
DE69628566D1 (de)	2003-07-10
HK1009154A1 (en)	1999-05-28
CZ55898A3 (cs)	1998-06-17
US7371374B2 (en)	2008-05-13
NO981072L (no)	1998-05-12
SK285816B6 (sk)	2007-09-06
US7048921B2 (en)	2006-05-23
CA2231436C (en)	2007-07-17
ES2196172T3 (es)	2003-12-16
CA2231436A1 (en)	1997-03-20
EP0850298A1 (de)	1998-07-01
WO1997010329A1 (en)	1997-03-20
GB9518606D0 (en)	1995-11-15
PL186777B1 (pl)	2004-02-27
JP4280872B2 (ja)	2009-06-17
JPH11513242A (ja)	1999-11-16

Publication	Publication Date	Title
PT850298E (pt)	2003-09-30	Transplante neural utilizando celulas neuroepiteliais pluripotenciais
ATE514772T1 (de)	2011-07-15	Multipotente erwachsene stammzellen und verfahren zu deren isolierung
WO2001036589A3 (en)	2002-02-14	Human ex vivo immune system
WO1997012960A3 (en)	2001-12-20	Solid support for use in cell cultivation, especially for the cultivation of liver cells, biological reactor containing said solid support and the use thereof in a bio-artificial liver system
DE69609222D1 (de)	2000-08-17	Partikel auf Polyaminosäure(n)basis zur Verwendung als Wirkstoffträger sowie deren Herstellungsverfahren
SE0000305D0 (sv)	2000-01-31	Förfarande och anordning vid superstruktur till implantat
GB9308271D0 (en)	1993-06-02	Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method
IL121790A0 (en)	1998-02-22	Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor (GDNF) protein product
PT785948E (pt)	2003-09-30	Analogos do factor de crescimento de queratinocitos
DE69635924D1 (de)	2006-05-11	Isolierung und züchtung von schwannzellen
ATE464910T1 (de)	2010-05-15	Humane cd80-mutante und zusammensetzungen und methoden zu deren herstellung und verwendung
DK0952772T3 (da)	2005-07-18	Fremgangsmåder til anvendelse af mononukleare phagocytter til at fremme axonal regeneration
DK1554374T3 (da)	2007-05-07	Fremgangsmåde til storskala T-lymfocytdyrkning i et homogent system
ATE98130T1 (de)	1993-12-15	Kombination von angiotensin-converting-enzymehemmern mit kaliumkanal-modulatoren sowie deren verwendung in arzneimitteln.
HUP9802531A2 (hu)	1999-02-01	Eljárás haematopoeticus stem sejtek mobilizálására
DE69817180D1 (de)	2003-09-18	Zns neuroregenerative zusammensetzungen und deren verwendungen
DE3666458D1 (en)	1989-11-23	Method and device for the _i(in vitro) culture of plant cells and organs, as well as for the micropropagation and regeneration of complete plants
DE69725100D1 (de)	2003-10-30	Verfahren und Satz zur Prüfung der Drogenempfindlichkeit von Mikroben, sowie Verfahren und Satz zur Missung der minimumhemmenden Konzentration von Mikroorganismen
DK0883406T3 (da)	2004-08-02	Anvendelse af IL-7 til behandling af autoimmune sygdomme og især insulinafhængig diabe-tesmellitus i særdeleshed
EP0673259A4 (de)	1995-12-06	Methode zur transplantation von zellen ins gehirn und therapeutische verwendungen davon.
ES2132027A1 (es)	1999-08-01	Desarrollo de una piel artificial mediante cultivo de queratinocitos sobre una base de fibrina y fibroblastos humanos y metodo de preparacion de esta piel para trasplante.
ATE384121T1 (de)	2008-02-15	Verfahren zur kultivierung von menschlichen lungenmastzellen und deren anwendungen
ATE269090T1 (de)	2004-07-15	Tiermodell zum testen von arzneistoffen zur behandlung von leukämie oder hiv
EP0142109A3 (en)	1987-01-21	Macromolecules extracted from cultured mesenchymal cells for the treatment of degenerative diseases
DE69636412D1 (de)	2006-09-14	Ginkolide zur hemmung der membranexpression