ATE242326T1 - Rekombinante humanisierte antikörper gegen lewis y - Google Patents

Rekombinante humanisierte antikörper gegen lewis y

Info

Publication number
ATE242326T1
ATE242326T1 AT95912894T AT95912894T ATE242326T1 AT E242326 T1 ATE242326 T1 AT E242326T1 AT 95912894 T AT95912894 T AT 95912894T AT 95912894 T AT95912894 T AT 95912894T AT E242326 T1 ATE242326 T1 AT E242326T1
Authority
AT
Austria
Prior art keywords
lewis
humanized
specific antibodies
antibodies
antigen
Prior art date
Application number
AT95912894T
Other languages
English (en)
Inventor
Francis J Carr
Lloyd J Old
Elisabeth Stockert
Sydney Welt
Kunio Kitamura
Pilar Garin-Chesa
Dr Kathryn Armour
Original Assignee
Sloan Kettering Inst Cancer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Inst Cancer filed Critical Sloan Kettering Inst Cancer
Application granted granted Critical
Publication of ATE242326T1 publication Critical patent/ATE242326T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/34—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95912894T 1994-03-08 1995-03-08 Rekombinante humanisierte antikörper gegen lewis y ATE242326T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/207,861 US6310185B1 (en) 1994-03-08 1994-03-08 Recombinant human anti-Lewis Y antibodies
PCT/US1995/003096 WO1995024484A1 (en) 1994-03-08 1995-03-08 Recombinant humanized anti-lewis y antibodies

Publications (1)

Publication Number Publication Date
ATE242326T1 true ATE242326T1 (de) 2003-06-15

Family

ID=22772277

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95912894T ATE242326T1 (de) 1994-03-08 1995-03-08 Rekombinante humanisierte antikörper gegen lewis y

Country Status (10)

Country Link
US (3) US6310185B1 (de)
EP (1) EP0749482B1 (de)
AT (1) ATE242326T1 (de)
AU (1) AU696286B2 (de)
CA (1) CA2185114C (de)
DE (1) DE69530975T2 (de)
DK (1) DK0749482T3 (de)
ES (1) ES2199985T3 (de)
PT (1) PT749482E (de)
WO (1) WO1995024484A1 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6310185B1 (en) * 1994-03-08 2001-10-30 Memorial Sloan Kettering Cancer Center Recombinant human anti-Lewis Y antibodies
RU2162101C1 (ru) * 1999-06-10 2001-01-20 Институт биоорганической химии им. М.М. Шемякина и Ю.А. Овчинникова РАН Тест-система для изучения клеток новообразований (неоплазии)
US6582323B2 (en) 1999-11-01 2003-06-24 Callaway Golf Company Multiple material golf club head
US6491592B2 (en) 1999-11-01 2002-12-10 Callaway Golf Company Multiple material golf club head
TW577761B (en) 1999-11-01 2004-03-01 Callaway Golf Co Multiple material golf club head
US6565452B2 (en) 1999-11-01 2003-05-20 Callaway Golf Company Multiple material golf club head with face insert
US7128661B2 (en) * 1999-11-01 2006-10-31 Callaway Golf Company Multiple material golf club head
US7118493B2 (en) * 1999-11-01 2006-10-10 Callaway Golf Company Multiple material golf club head
US6739983B2 (en) * 1999-11-01 2004-05-25 Callaway Golf Company Golf club head with customizable center of gravity
US7125344B2 (en) * 1999-11-01 2006-10-24 Callaway Golf Company Multiple material golf club head
US6663504B2 (en) 1999-11-01 2003-12-16 Callaway Golf Company Multiple material golf club head
IL157446A0 (en) * 2001-02-23 2004-03-28 Immunex Corp Immunex Corp Increased recovery of active proteins
USD479294S1 (en) 2002-03-14 2003-09-02 Callaway Golf Company Golf club head
USD472592S1 (en) 2002-03-27 2003-04-01 Callaway Golf Company Golf club head
USD472593S1 (en) 2002-03-27 2003-04-01 Callaway Golf Company Golf club head
SG187991A1 (en) 2002-05-02 2013-03-28 Wyeth Corp Calicheamicin derivative-carrier conjugates
EP2322209A3 (de) 2002-08-20 2012-02-01 Glykos Finland Oy Tumorspezifische Oligosaccharid-Epitope und deren Verwendung
US6984181B2 (en) * 2002-09-25 2006-01-10 Callaway Golf Company Multiple material golf putter head
JP4206915B2 (ja) * 2002-12-27 2009-01-14 三菱マテリアル株式会社 パワーモジュール用基板
US6929079B2 (en) * 2003-02-21 2005-08-16 Smith International, Inc. Drill bit cutter element having multiple cusps
US6883624B2 (en) * 2003-01-31 2005-04-26 Smith International, Inc. Multi-lobed cutter element for drill bit
US20060011388A1 (en) * 2003-01-31 2006-01-19 Mohammed Boudrare Drill bit and cutter element having multiple extensions
USD491243S1 (en) 2003-06-30 2004-06-08 Callaway Golf Company Golf club head
JP2007528868A (ja) * 2003-08-14 2007-10-18 ワイス 抗ルイスｙ抗イディオタイプ抗体およびその使用
AR048098A1 (es) * 2004-03-15 2006-03-29 Wyeth Corp Conjugados de caliqueamicina
TWI384069B (zh) * 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
US7335491B2 (en) * 2004-08-27 2008-02-26 Wyeth Research Ireland Limited Production of anti-abeta
TWI364458B (en) * 2004-08-27 2012-05-21 Wyeth Res Ireland Ltd Production of tnfr-lg
RU2451082C2 (ru) * 2004-08-27 2012-05-20 Вайет Рисёрч Айрлэнд Лимитед Производство полипептидов
USD523103S1 (en) 2004-09-09 2006-06-13 Callaway Golf Company Golf club head
US7166038B2 (en) * 2005-01-03 2007-01-23 Callaway Golf Company Golf club head
US7549935B2 (en) * 2005-01-03 2009-06-23 Callaway Golf Company Golf club head
US7488261B2 (en) * 2005-01-03 2009-02-10 Callaway Golf Company Golf club with high moment of inertia
US7169060B2 (en) 2005-01-03 2007-01-30 Callaway Golf Company Golf club head
US7163468B2 (en) 2005-01-03 2007-01-16 Callaway Golf Company Golf club head
US7311613B2 (en) * 2005-01-03 2007-12-25 Callaway Golf Company Golf club head
US7559851B2 (en) * 2005-01-03 2009-07-14 Callaway Golf Company Golf club with high moment of inertia
US7591737B2 (en) * 2005-01-03 2009-09-22 Callaway Golf Company Golf club head
US7568982B2 (en) * 2005-01-03 2009-08-04 Callaway Golf Company Golf club with high moment of inertia
AU2006210724A1 (en) 2005-02-03 2006-08-10 Antitope Limited Human antibodies and proteins
GB2427633B (en) * 2005-05-17 2007-08-15 Smith International Drill bit and method of designing a drill bit
US7757789B2 (en) * 2005-06-21 2010-07-20 Smith International, Inc. Drill bit and insert having bladed interface between substrate and coating
FI20055417A0 (fi) 2005-07-20 2005-07-20 Glykos Finland Oy Syöpäpesifiset glykaanit ja niiden käyttö
US20100226884A1 (en) * 2009-01-20 2010-09-09 Immunomedics, Inc. Novel Class of Monospecific and Bispecific Humanized Antibodies that Target the Insulin-like Growth Factor Type I Receptor (IGF-1R)
US9862770B2 (en) 2005-10-19 2018-01-09 Ibc Pharmaceuticals, Inc. Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors
US8883162B2 (en) 2005-10-19 2014-11-11 Ibc Pharmaceuticals, Inc. Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors
EP1957097A1 (de) * 2005-12-06 2008-08-20 Wyeth a Corporation of the State of Delaware Interleukin-11-zusammensetzungen und anwendungsverfahren
DK2368914T3 (en) 2006-03-10 2019-03-04 Wyeth Llc Anti-5T4 antibodies and uses thereof
WO2007120626A2 (en) * 2006-04-10 2007-10-25 Abbott Biotechnology Ltd. Uses and compositions for treatment of ankylosing spondylitis
US20100021451A1 (en) 2006-06-08 2010-01-28 Wong Robert L Uses and compositions for treatment of ankylosing spondylitis
US7743855B2 (en) * 2006-09-05 2010-06-29 Smith International, Inc. Drill bit with cutter element having multifaceted, slanted top cutting surface
US7798258B2 (en) * 2007-01-03 2010-09-21 Smith International, Inc. Drill bit with cutter element having crossing chisel crests
US8205692B2 (en) * 2007-01-03 2012-06-26 Smith International, Inc. Rock bit and inserts with a chisel crest having a broadened region
US7686106B2 (en) * 2007-01-03 2010-03-30 Smith International, Inc. Rock bit and inserts with wear relief grooves
US7631709B2 (en) 2007-01-03 2009-12-15 Smith International, Inc. Drill bit and cutter element having chisel crest with protruding pilot portion
US7819754B2 (en) * 2007-09-13 2010-10-26 Callaway Golf Company Golf club with removable components
US7753809B2 (en) * 2007-12-19 2010-07-13 Cackett Matthew T Driver with deep AFT cavity
US8414422B2 (en) * 2009-12-16 2013-04-09 Callaway Golf Company External weight for golf club head
WO2011090492A1 (en) * 2010-01-19 2011-07-28 Immunomedics, Inc. Novel class of monospecific and bispecific humanized antibodies that target the insulin-like growth factor type i receptor (igf-1r)
JP2013535981A (ja) 2010-08-20 2013-09-19 ワイス・エルエルシー 成長因子不含適合細胞の細胞培養
US8607899B2 (en) 2011-02-18 2013-12-17 National Oilwell Varco, L.P. Rock bit and cutter teeth geometries
PT2837680T (pt) 2011-07-01 2020-04-17 Amgen Inc Cultura celular de mamífero
RU2663794C2 (ru) 2011-10-21 2018-08-09 Пфайзер Инк. Добавление железа для улучшения культивирования клеток
IL307155B2 (en) 2018-05-01 2025-11-01 Amgen Inc Antibodies with modulated glycan profiles
KR102835308B1 (ko) 2018-08-08 2025-07-21 드래곤플라이 쎄라퓨틱스, 인크. Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질
GB201910899D0 (en) * 2019-07-31 2019-09-11 Scancell Ltd Binding members
AU2021298824A1 (en) * 2020-06-30 2023-01-19 Pentixapharm Ag Humanized antibodies against lewis Y
US12551584B1 (en) * 2020-12-07 2026-02-17 Actinium Pharmaceuticals, Inc. Lewis Y radioimmunotherapy for the treatment of cancer
CN113214402B (zh) * 2021-06-03 2022-06-07 上海交通大学 分离的抗原结合蛋白及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) * 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5242824A (en) * 1988-12-22 1993-09-07 Oncogen Monoclonal antibody to human carcinomas
IL94872A (en) * 1989-06-30 1995-03-30 Oncogen Monoclonal or chimeric antibodies reactive with human carcinomas, recombinant proteins comprising their antigen binding region, pharmaceutical compositions and kits comprising said antibodies and methods for imaging human carcinoma using same
GB9019812D0 (en) * 1990-09-11 1990-10-24 Scotgen Ltd Novel antibodies for treatment and prevention of infection in animals and man
DK0528767T3 (da) * 1991-08-21 2000-04-17 Novartis Ag antistofderivater
US6310185B1 (en) * 1994-03-08 2001-10-30 Memorial Sloan Kettering Cancer Center Recombinant human anti-Lewis Y antibodies

Also Published As

Publication number Publication date
CA2185114A1 (en) 1995-09-14
CA2185114C (en) 2008-01-22
DE69530975D1 (de) 2003-07-10
EP0749482B1 (de) 2003-06-04
AU696286B2 (en) 1998-09-03
DE69530975T2 (de) 2004-05-19
DK0749482T3 (da) 2003-09-29
AU1990795A (en) 1995-09-25
PT749482E (pt) 2003-10-31
ES2199985T3 (es) 2004-03-01
US6310185B1 (en) 2001-10-30
EP0749482A1 (de) 1996-12-27
US5874060A (en) 1999-02-23
WO1995024484A1 (en) 1995-09-14
US6518415B1 (en) 2003-02-11

Similar Documents

Publication Publication Date Title
DE69530975D1 (de) Rekombinante humanisierte antikörper gegen lewis y
ATE327330T1 (de) Rekombinante humanisierte antikörper gegen fb5
AU1726199A (en) Metastatic cancer regulated gene
Takahashi et al. Significance of vessel count and vascular endothelial growth factor and its receptor (KDR) in intestinal-type gastric cancer.
DE60134178D1 (de) Trp8 krebsmarker
IL149046A (en) Composition comprising a polynucleotide encoding a 36p6d5 polypeptide for use in diagnosing cancer and diagnostic method related to 36p6d5
NZ596317A (en) Antibodies directed to her-3 and uses thereof
HRP20141158T1 (hr) Postupak za dijagnosticiranje raka koji izražava skraä†enu varijantu her2-receptora
ATE524196T1 (de) An das krebsassoziierte antigen cd46 bindende antikörper und verwendungsverfahren dafür
NZ523206A (en) Antibodies that bind to tumor gene sequences
WO2003024191A3 (en) Antibodies that bind to cancer-associated antigen cytokeratin 8 and methods of use thereof
NZ298554A (en) A tumour suppressor gene (Hypermethylated in Cancer) HIC-1 and its use
Homma et al. Production of CA125 by human lung cancer cell lines
ES8900247A1 (es) Un metodo de detecion y diagnostico de cancer empleando un nuevo antigeno asociado a un tumor.
ATE187463T1 (de) Monoklonale antikörper gegen tumorassoziierte antigene, verfahren zu ihrer herstellung und ihre verwendung
WO2002072008A3 (en) Method for treating cancer using a33 specific antibodies and chemotherapeutic agents
WO2004094612A3 (en) Cancer specific monoclonal antibodies
ATE288960T1 (de) Humanisierte monoklonale antikörper mit hoher affinität gegen tag-72
NO20004251L (no) Humaniserte anti-CEA monoklonale antistoffer med høy affinitet
Plebani et al. Is CA 242 really a new tumour marker for pancreatic adenocarcinoma?
IT1264083B1 (it) Procedimento per la produzione in piante di anticorpi ingegnerizzati, anticorpi prodotti e loro uso in diagnosi e terapia.
Kim et al. Prognostic significance of HER2 gene amplification according to stage of breast cancer
WO2006114245A3 (en) Identification of human gene sequences of cancer antigens expressed in metastatic carcinoma and involved in metastasis formation, and their use in cancer diagnosis, prognosis and therapy
Gagliardi et al. Immunolocalization of criptoregulin and amphiregulin in rectal-cancer-correlation with prognosis
Madhloom et al. ANALYSIS OF THE IMMUNOHISTOCHEMICAL EXPRESSIONS OF C-MYC IN COLORECTAL CARCINOMA AND THEIR CORRELATIONS WITH OTHER CLINICAL PATHOLOGICAL PARAMETERS.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0749482

Country of ref document: EP