ATE242774T1 - Heterozyklische verbindungen die als oxido- squalen-zyklase-inhibitoren anwendung finden - Google Patents

Heterozyklische verbindungen die als oxido- squalen-zyklase-inhibitoren anwendung finden

Info

Publication number
ATE242774T1
ATE242774T1 AT98903175T AT98903175T ATE242774T1 AT E242774 T1 ATE242774 T1 AT E242774T1 AT 98903175 T AT98903175 T AT 98903175T AT 98903175 T AT98903175 T AT 98903175T AT E242774 T1 ATE242774 T1 AT E242774T1
Authority
AT
Austria
Prior art keywords
heterocyclic compounds
heterocyclic derivatives
cyclase inhibitors
oxidosqualene cyclase
present
Prior art date
Application number
AT98903175T
Other languages
English (en)
Inventor
George Robert Brown
Nicholas John Newcombe
Alan John Foubister
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9702945.8A external-priority patent/GB9702945D0/en
Priority claimed from GBGB9715735.8A external-priority patent/GB9715735D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE242774T1 publication Critical patent/ATE242774T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT98903175T 1997-02-13 1998-02-09 Heterozyklische verbindungen die als oxido- squalen-zyklase-inhibitoren anwendung finden ATE242774T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9702945.8A GB9702945D0 (en) 1997-02-13 1997-02-13 Heterocyclic compounds
GBGB9715735.8A GB9715735D0 (en) 1997-07-26 1997-07-26 Heterocyclic compounds
PCT/GB1998/000406 WO1998035959A1 (en) 1997-02-13 1998-02-09 Heterocyclic compounds useful as oxido-squalene cyclase inhibitors

Publications (1)

Publication Number Publication Date
ATE242774T1 true ATE242774T1 (de) 2003-06-15

Family

ID=26310985

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98903175T ATE242774T1 (de) 1997-02-13 1998-02-09 Heterozyklische verbindungen die als oxido- squalen-zyklase-inhibitoren anwendung finden

Country Status (10)

Country Link
US (1) US6391880B1 (de)
EP (1) EP0966462B1 (de)
JP (1) JP2001511799A (de)
AT (1) ATE242774T1 (de)
AU (1) AU5999798A (de)
DE (1) DE69815509T2 (de)
DK (1) DK0966462T3 (de)
ES (1) ES2201438T3 (de)
PT (1) PT966462E (de)
WO (1) WO1998035959A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
GB9715892D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
WO2000078317A1 (en) * 1999-06-23 2000-12-28 Merck & Co., Inc. Integrin receptor antagonists
JP4564713B2 (ja) 2000-11-01 2010-10-20 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 窒素性複素環式化合物、ならびに窒素性複素環式化合物およびその中間体を作製するための方法
JP2008545010A (ja) * 2005-06-30 2008-12-11 プロシディオン・リミテッド Ｇタンパク質共役受容体アゴニスト
AU2008234017B2 (en) * 2007-03-30 2011-09-22 F. Hoffmann-La Roche Ag Imidazolidinone derivatives
US10752588B2 (en) 2014-12-19 2020-08-25 The Broad Institute, Inc. Dopamine D2 receptor ligands
WO2016100940A1 (en) 2014-12-19 2016-06-23 The Broad Institute, Inc. Dopamine d2 receptor ligands

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT340933B (de) 1973-08-20 1978-01-10 Thomae Gmbh Dr K Verfahren zur herstellung neuer pyrimidinderivate und ihrer saureadditionssalze
US4167567A (en) 1978-05-05 1979-09-11 The Upjohn Company Antihypertensive 4-aminoquinolines
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
SE8203887D0 (sv) 1982-06-23 1982-06-23 Kabivitrum Ab Nya trombininhiberande foreningar
DE3246932A1 (de) 1982-12-16 1984-06-20 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte 5h-pyrimido(5,4-b)indole
FR2557570B1 (fr) 1984-01-04 1986-04-18 Adir Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant
US4840963A (en) 1984-03-14 1989-06-20 Merck & Co., Inc. 2-Sulfamoyl-1H-indole derivatives for the treatment of elevated intraocular pressure
GB8601160D0 (en) 1986-01-17 1986-02-19 Fujisawa Pharmaceutical Co Heterocyclic compounds
GB8603120D0 (en) 1986-02-07 1986-03-12 Pfizer Ltd Anti-dysrhythmia agents
GB8609630D0 (en) 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
GB8710494D0 (en) 1987-05-02 1987-06-03 Pfizer Ltd Antiarrhythmic agents
JPH0696575B2 (ja) 1987-09-17 1994-11-30 三菱化成株式会社 ４−アミノピリジン誘導体及びその酸付加塩
US4871721A (en) 1988-01-11 1989-10-03 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors
GB8817315D0 (en) 1988-07-20 1988-08-24 Pfizer Ltd Triazole antifungal agents
GB8819307D0 (en) 1988-08-13 1988-09-14 Pfizer Ltd Antiarrhythmic agents
DE3943226C2 (de) 1989-01-13 1995-01-05 Mannesmann Ag Verfahren und Vorrichtung zur Erfassung von Ungänzen an langgestreckten Werkstücken
DE3905364A1 (de) 1989-02-22 1990-08-23 Hoechst Ag Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool
IE64358B1 (en) 1989-07-18 1995-07-26 Ici Plc Diaryl ether heterocycles
US5032604A (en) 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
DE3943225A1 (de) 1989-12-23 1991-06-27 Schering Ag Neue ss-carboline, verfahren zu deren herstellung und deren verwendung in arzneimitteln
AU8868991A (en) 1990-11-15 1992-06-11 Pentapharm Ag Meta-substituted phenyl alanine derivatives
EP0495750A3 (en) 1991-01-14 1992-09-16 Ciba-Geigy Ag Heterocyclic hydroxylamine
IT1245712B (it) 1991-04-09 1994-10-14 Boehringer Mannheim Italia Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree
FR2676054B1 (fr) 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
WO1993000342A1 (en) 1991-06-21 1993-01-07 Boehringer Mannheim Italia S.P.A. 2-amino-4-aryl-thiazoles with antiasthmatic and anti-inflammatory activities on the respiratory tract
JPH06510786A (ja) 1991-09-19 1994-12-01 スミスクライン・ビーチャム・コーポレイション ロイコトリエン関連疾患治療用ピリジン化合物
PH31294A (en) 1992-02-13 1998-07-06 Thomae Gmbh Dr K Benzimidazolyl derivatives, pharmaceutical compositions containing these compounds and process for preparing them.
HU211995B (en) 1992-06-30 1996-01-29 Gyogyszerkutato Intezet Process to prepare novel benzoyl amino acid derivs. and pharmaceutical compns. contg.them
US5371091A (en) 1992-08-31 1994-12-06 Bristol-Myers Squibb Company Heteroaromatic amine thrombin inhibitors
FR2697252B1 (fr) 1992-10-28 1994-12-09 Fournier Ind & Sante Dérivés de 1,2,3,5,6,7,8,8a-octahydro-5,5,8a-triméthyl-(8abeta)-6-isoquinolineamine, leur procédé de préparation et leur utilisation en thérapeutique.
DE4243858A1 (de) 1992-12-23 1994-06-30 Thomae Gmbh Dr K Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5332822A (en) 1992-12-24 1994-07-26 Bristol-Myers Squibb Company Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors
US5364865A (en) 1992-12-30 1994-11-15 Sterling Winthrop Inc. Phenoxy- and phenoxyalkyl-piperidines as antiviral agents
DE4302485A1 (de) 1993-01-29 1994-08-04 Merck Patent Gmbh Piperazinderivate
JPH07509731A (ja) 1993-02-10 1995-10-26 ペンタファルム　アクチェンゲゼルシャフト トロンビン阻害剤としての置換されたフェニルアラニン誘導体のピペラジド
TW257757B (de) 1993-03-03 1995-09-21 Boehringer Mannheim Gmbh
DE4306506A1 (de) 1993-03-03 1994-09-08 Boehringer Mannheim Gmbh Neue 4-Alkylaminopyridine - Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
AU692438B2 (en) 1993-03-29 1998-06-11 Astrazeneca Ab Heterocyclic derivatives as platelet aggregation inhibitors
EP0690847A1 (de) 1993-03-29 1996-01-10 Zeneca Limited Heterozyklische derivate als plätchenaggregationsinhibitoren
US5681954A (en) 1993-05-14 1997-10-28 Daiichi Pharmaceutical Co., Ltd. Piperazine derivatives
JPH07145060A (ja) 1993-11-25 1995-06-06 Teijin Ltd 細胞遊走阻害剤
AU3107795A (en) 1994-08-09 1996-03-07 Pentapharm Ag Inhibitors of the benzamidine type
IL115420A0 (en) * 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
EP0801650A4 (de) 1994-12-22 1998-05-06 Smithkline Beecham Corp Fibrinogenrezeptor-antagonisten
JPH10511359A (ja) 1994-12-22 1998-11-04 スミスクライン・ビーチャム・コーポレイション フィブリノゲン受容体拮抗物質
IL117149A0 (en) 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
IL117580A0 (en) 1995-03-29 1996-07-23 Merck & Co Inc Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them
IT1282797B1 (it) 1995-04-21 1998-03-31 Colla Paolo Pirril-(indolil)-aril-sulfoni e relativo processo di produzione ed impiego nella terapia delle infezioni da virus dell'aids
GB9516709D0 (en) * 1995-08-15 1995-10-18 Zeneca Ltd Medicament
US6313127B1 (en) * 1996-02-02 2001-11-06 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
GB9602166D0 (en) 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
GB9602294D0 (en) 1996-02-05 1996-04-03 Zeneca Ltd Heterocyclic compounds
PT892780E (pt) 1996-02-22 2003-02-28 Bristol Myers Squibb Pharma Co Analogos de m-amidino fenilo como inibidores do factor xa
CN1228087A (zh) 1996-08-14 1999-09-08 曾尼卡有限公司 取代的嘧啶衍生物和它们的药物用途
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
GB9715892D0 (en) * 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
WO1998035959A1 (en) 1998-08-20
EP0966462A1 (de) 1999-12-29
AU5999798A (en) 1998-09-08
EP0966462B1 (de) 2003-06-11
JP2001511799A (ja) 2001-08-14
DE69815509T2 (de) 2004-05-13
US6391880B1 (en) 2002-05-21
ES2201438T3 (es) 2004-03-16
DK0966462T3 (da) 2003-09-22
DE69815509D1 (de) 2003-07-17
PT966462E (pt) 2003-10-31

Similar Documents

Publication Publication Date Title
DE69718177D1 (de) Substituierte pyrimidinderivate und ihre pharmazeutische anwendung
PL326203A1 (en) (methylsulphonyl)phenyl-2-(5)-furanones as cox-2 inhibitors
ATE177420T1 (de) Cyclobutan-derivate als inhibitoren der squalen- synthetase und der protein-farnesyltransferase
EA200400073A1 (ru) Пирролопиримидины как ингибиторы протеинкиназы
HUP0401740A2 (hu) N-szubsztituált hidroxipirimidinon-karboxamid HIV-integráz inhibitorok és ezeket tartalmazó gyógyszerkészítmények
NO20053645L (no) (4R)- og (4S)-diastereoisomerer av (2S)-2-[ 2-oksy-4-propylpyrrolidinyl]butanamid og farmasoytisk preparat inneholdende disse
ATE232856T1 (de) Diaryl-2(5h)-fuaranone als cox-2-inhibitoren
MA26697A1 (fr) Composes nouveaux inhibiteurs de gsk-3 et compositions pharmaceutiques les contenant
DK0778834T3 (da) Bicykliske, heterocykliske diarylforbindelser som inhibitorer af cyclooxygenase-2
TNSN07022A1 (fr) Derives de pyridine
YU59198A (sh) Supstituisani piridini kao selektivni inhibitori ciklooksigenaze-2
IL152845A0 (en) Fused heterocyclic compounds and pharmaceutical compositions containing the same
DE60005502D1 (de) 4'-c-ethynyl-purin-nukleoside
DE69618820D1 (de) 3,4-diaryl-2-hydroxy-2,5-dihydrofurane als wirkstoffvorstufen von cox-2 inhibitoren
DE69825603D1 (de) 2,3,5-trisubstituierte pyridine als inhibitoren von cyclooxygenase-2
ATE242774T1 (de) Heterozyklische verbindungen die als oxido- squalen-zyklase-inhibitoren anwendung finden
DE69703791D1 (de) Diphenylstibene als prodrugs zu cox-2-inhibitoren
DE69829861D1 (de) 2-aminopyridine als inhibitoren von cyclooxygenase-2
SG146685A1 (en) Dihydroporphine derivatives, processes for their preparation, and pharmaceutical compositions containing them
NO996183L (no) Fremgangsmåte for fremstilling av medikamenter som innbefatter HMG-CoA-reduktaseinhibitorer
GEP20033130B (en) Inhibitors of IMPDH Enzyme

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0966462

Country of ref document: EP

REN Ceased due to non-payment of the annual fee