ATE243681T1 - Benzamidinderivate als faktor xa-inhibitoren - Google Patents

Benzamidinderivate als faktor xa-inhibitoren

Info

Publication number
ATE243681T1
ATE243681T1 AT98948982T AT98948982T ATE243681T1 AT E243681 T1 ATE243681 T1 AT E243681T1 AT 98948982 T AT98948982 T AT 98948982T AT 98948982 T AT98948982 T AT 98948982T AT E243681 T1 ATE243681 T1 AT E243681T1
Authority
AT
Austria
Prior art keywords
inhibitors
factor
benzamidine derivatives
benzamidine
derivatives
Prior art date
Application number
AT98948982T
Other languages
German (de)
English (en)
Inventor
Dieter Dorsch
Horst Juraszyk
Hanns Wurziger
Sabine Bernotat-Danielowski
Guido Melzer
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE243681T1 publication Critical patent/ATE243681T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT98948982T 1997-10-01 1998-09-16 Benzamidinderivate als faktor xa-inhibitoren ATE243681T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19743435A DE19743435A1 (de) 1997-10-01 1997-10-01 Benzamidinderivate
PCT/EP1998/005898 WO1999016751A1 (fr) 1997-10-01 1998-09-16 DERIVES DE BENZAMIDINE UTILISES COMME INHIBITEURS DU FACTEUR Xa

Publications (1)

Publication Number Publication Date
ATE243681T1 true ATE243681T1 (de) 2003-07-15

Family

ID=7844313

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98948982T ATE243681T1 (de) 1997-10-01 1998-09-16 Benzamidinderivate als faktor xa-inhibitoren

Country Status (19)

Country Link
US (1) US6492368B1 (fr)
EP (1) EP1025086B1 (fr)
JP (1) JP2001518467A (fr)
KR (1) KR20010024386A (fr)
CN (1) CN1272107A (fr)
AR (1) AR017164A1 (fr)
AT (1) ATE243681T1 (fr)
AU (1) AU736080B2 (fr)
BR (1) BR9812699A (fr)
CA (1) CA2305568A1 (fr)
DE (2) DE19743435A1 (fr)
HU (1) HUP0004306A3 (fr)
ID (1) ID24430A (fr)
NO (1) NO20001687D0 (fr)
PL (1) PL339173A1 (fr)
RU (1) RU2194044C2 (fr)
SK (1) SK282799B6 (fr)
WO (1) WO1999016751A1 (fr)
ZA (1) ZA988937B (fr)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6525042B1 (en) 1997-09-30 2003-02-25 Daiichi Pharmaceutical Co., Ltd. Sulfonyl derivatives
ES2232131T3 (es) * 1998-05-02 2005-05-16 Astrazeneca Ab Derivados heterociclicos que inhiben el factor xa.
GB9809349D0 (en) * 1998-05-02 1998-07-01 Zeneca Ltd Heterocyclic derivatives
AU5196399A (en) * 1998-08-11 2000-03-06 Daiichi Pharmaceutical Co., Ltd. Novel sulfonyl derivatives
EP1088821A1 (fr) * 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Derives des sulfamides pharmaceutiquement actifs
US6608066B1 (en) * 1999-10-27 2003-08-19 Sunol Molecular Corporation Tissue factor antagonists and methods of use thereof
EP1829535A3 (fr) * 1999-10-27 2007-10-24 Tanox, Inc. Antagonistes de facteur de tissus et leurs procédés d'utilisation
DE10035927A1 (de) 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
DE10035928A1 (de) 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
EP1193268A1 (fr) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Dérivés de sulfonamide pharmaceutiquement actifs comportant des groupes lipophiles ainsi que ionisables comme inhibiteurs de protéine junkinases
EP1193267A1 (fr) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Composés de sulfonamides hydrophiles pharmaceutiquement actifs
EP1193256A1 (fr) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Derivés de benzénesulphonamide pharmaceutiquemant actifs comme inhibiteurs de protéines JNK
DE60144284D1 (de) 2000-11-01 2011-05-05 Millennium Pharm Inc Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung
DE10102322A1 (de) 2001-01-19 2002-07-25 Merck Patent Gmbh Phenylderivate
DE10130718A1 (de) * 2001-06-26 2003-01-02 Merck Patent Gmbh Kohlenhydratderivate
EP1569912B1 (fr) 2002-12-03 2015-04-29 Pharmacyclics, Inc. Derives de 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine utilises en tant qu'inhibiteurs du facteur viia
MXPA04007775A (es) 2002-03-13 2004-10-15 Janssen Pharmaceutica Nv Derivados de sulfonilo como novedosos inhibidores de la histona desacetilasa.
KR20040090979A (ko) 2002-03-13 2004-10-27 얀센 파마슈티카 엔.브이. 히스톤 데아세틸레이즈의 신규한 억제제
RU2337099C2 (ru) * 2003-04-03 2008-10-27 Мерк Патент Гмбх Карбонильные соединения
DE10336716A1 (de) * 2003-08-11 2005-03-10 Merck Patent Gmbh Verfahren zur Herstellung von N-Aryl-morpholinonen
JP5096157B2 (ja) * 2004-10-14 2012-12-12 ヴィレックス アクチェンゲゼルシャフト 芳香族スルホン酸を用いて塩を沈殿および再結晶させることによって３−ヒドロキシ−アミジノ−フェニルアラニン誘導体を精製する方法
TW200633990A (en) 2004-11-18 2006-10-01 Takeda Pharmaceuticals Co Amide compound
US7906645B2 (en) * 2004-12-24 2011-03-15 Astrazeneca Ab Heterocyclic compounds as ccr2b antagonists
WO2007007588A1 (fr) * 2005-07-08 2007-01-18 Ono Pharmaceutical Co., Ltd. Compose comportant un groupe cyclique ayant un noyau plan
AU2006326540A1 (en) * 2005-12-14 2007-06-21 Amgen Inc. Diaza heterocyclic sulfonamide derivatives and their uses
WO2007078335A2 (fr) * 2005-12-21 2007-07-12 Decode Genetics, Ehf. Inhibiteurs de biaryl-azote-heterocycle de lta4h pour traiter l'inflammation
GB0525957D0 (en) * 2005-12-21 2006-02-01 Astrazeneca Ab Methods
DE102005061624A1 (de) * 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verbessertes Verfahren zur Herstellung von Salzen von 4-(Benzimidazolylmethylamino)-Benzamidinen
PL1976828T3 (pl) 2005-12-29 2017-07-31 Celtaxsys, Inc. Pochodne diaminy jako inhibitory hydrolazy leukotrienu a4
WO2008019139A2 (fr) 2006-08-04 2008-02-14 Beth Israel Deaconess Medical Center Inhibiteurs de la pyruvate kinase et procédés de traitement de maladie
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
CA2687918C (fr) 2007-06-08 2016-11-08 Janssen Pharmaceutica N.V. Derives de piperidine/piperazine
AU2008258487B2 (en) 2007-06-08 2012-11-15 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
EP2152271B1 (fr) 2007-06-08 2015-10-21 Janssen Pharmaceutica, N.V. Dérivés de piperidine/piperazine
CA2696609C (fr) 2007-08-27 2017-09-05 Helicon Therapeutics, Inc. Composes isoxazole therapeutiques
JP5656288B2 (ja) * 2007-09-07 2015-01-21 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ムスカリン受容体アンタゴニストとして有用なグアジニン含有化合物
US8163898B2 (en) 2007-09-21 2012-04-24 Msd K. K. 4-sulfonylpiperidine derivatives
JP5579170B2 (ja) * 2008-06-05 2014-08-27 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｄｇａｔ阻害剤とｐｐａｒ作動薬を含有する薬剤組み合わせ物
US20100152197A1 (en) * 2008-12-15 2010-06-17 Astrazeneca Ab (4-tert-butylpiperazin-2-yl)(piperazin-1-yl)methanone-n-carboxamide derivatives
EP2400968B1 (fr) * 2009-02-26 2016-09-28 Reviva Pharmaceuticals, Inc. Composition, synthèses et procédés d'utilisation des dérivés d'arylpipérazine
EP2417123A2 (fr) 2009-04-06 2012-02-15 Agios Pharmaceuticals, Inc. Compositions thérapeutiques et procédés d'utilisation associés
CR20170071A (es) 2009-06-29 2017-03-28 Agios Pharmaceuticals Inc Compuestos terapeuticos y composiciones
EP2448581B1 (fr) * 2009-06-29 2016-12-07 Agios Pharmaceuticals, Inc. Compositions thérapeutiques et procédés d'utilisation associés
EP2651898B1 (fr) 2010-12-17 2015-12-09 Agios Pharmaceuticals, Inc. Nouveaux dérivés de n-(4-(azétidine- 1 - carbonyl) phényl)-(hétéro-) arylsulfonamide en tant que modulateurs de la pyruvate kinase m2 (pmk2)
WO2012088314A1 (fr) 2010-12-21 2012-06-28 Agios Pharmaceuticals, Inc. Activateurs bicycliques de pkm2
TWI549947B (zh) 2010-12-29 2016-09-21 阿吉歐斯製藥公司 治療化合物及組成物
ME03074B (fr) 2011-05-03 2019-01-20 Agios Pharmaceuticals Inc Activateurs de la pyruvate kinase destinés à être utilisés en thérapie
WO2012151440A1 (fr) 2011-05-03 2012-11-08 Agios Pharmaceuticals, Inc. Procédés d'utilisation d'activateurs de pyruvate kinase
FR2976943B1 (fr) * 2011-06-23 2013-07-12 Metabolys Derives de piperazine, leurs procedes de preparation et leurs utilisations dans le traitement de l'insulinoresistance
EP3587406B1 (fr) 2013-03-13 2021-01-27 Forma Therapeutics, Inc. Dérivés de 2-hydroxy-1-{4-[(4-phénylphényl)carbonyl]pipérazin-1-yl}éthan-1-one et composés similaires en tant qu'inhibiteurs de la synthase d'acide gras (fasn) pour le traitement du cancer
EP2968264A4 (fr) 2013-03-14 2016-11-02 Celtaxsys Inc Inhibiteurs de la leucotriène a4 hydrolase
WO2014139144A1 (fr) 2013-03-15 2014-09-18 Agios Pharmaceuticals, Inc. Composés et compositions thérapeutiques
CN105008329B (zh) 2013-03-21 2018-01-05 默克专利股份公司 作为fasn抑制剂的哌嗪衍生物
MA44392B1 (fr) 2015-06-11 2023-10-31 Agios Pharmaceuticals Inc Procédés d'utilisation d'activateurs de la pyruvate kinase
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
CN113382633A (zh) 2018-10-29 2021-09-10 福马治疗股份有限公司 (4-(2-氟-4-(1-甲基-1H-苯并[d]咪唑-5-基)苯甲酰基)哌嗪-1-基)(1-羟基环丙基)甲酮的固体形式

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ233503A (en) * 1989-05-15 1991-06-25 Janssen Pharmaceutica Nv Substituted (thio)morpholinyl and piperazinyl alkylphenol ethers
KR920703558A (ko) * 1990-11-15 1992-12-18 원본미기재 메타-치환 페닐알라닌 유도체
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
GB9208740D0 (en) * 1992-04-23 1992-06-10 Glaxo Group Ltd Chemical compounds
DE4234295A1 (de) * 1992-10-12 1994-04-14 Thomae Gmbh Dr K Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4302485A1 (de) 1993-01-29 1994-08-04 Merck Patent Gmbh Piperazinderivate
DE69522717T2 (de) 1995-03-30 2002-02-14 Pfizer Inc., New York Chinazolinderivate
AU6318896A (en) * 1995-07-06 1997-02-05 Japan Tobacco Inc. Benzamidoxime derivatives and medicinal use thereof
CA2197364A1 (fr) * 1996-02-15 1997-08-16 Toshikazu Suzuki Compose phenolique et methode de preparation
DE69835430T2 (de) * 1997-05-30 2007-03-08 Takeda Pharmaceutical Co. Ltd. Sulfonamidderivate, ihre herstellung und verwendung

Also Published As

Publication number Publication date
BR9812699A (pt) 2000-08-22
EP1025086A1 (fr) 2000-08-09
RU2194044C2 (ru) 2002-12-10
DE19743435A1 (de) 1999-04-08
ZA988937B (en) 1999-03-31
US6492368B1 (en) 2002-12-10
PL339173A1 (en) 2000-12-04
SK282799B6 (sk) 2002-12-03
SK4472000A3 (en) 2000-11-07
KR20010024386A (ko) 2001-03-26
EP1025086B1 (fr) 2003-06-25
CA2305568A1 (fr) 1999-04-08
WO1999016751A1 (fr) 1999-04-08
CN1272107A (zh) 2000-11-01
HUP0004306A3 (en) 2001-12-28
AU736080B2 (en) 2001-07-26
AR017164A1 (es) 2001-08-22
DE59808842D1 (de) 2003-07-31
JP2001518467A (ja) 2001-10-16
NO20001687L (no) 2000-03-31
ID24430A (id) 2000-07-20
NO20001687D0 (no) 2000-03-31
AU9540798A (en) 1999-04-23
HUP0004306A2 (hu) 2001-11-28

Similar Documents

Publication Publication Date Title
ATE243681T1 (de) Benzamidinderivate als faktor xa-inhibitoren
ATE302198T1 (de) Guanidine imitatoren als faktor xa inhibitoren
ATE293599T1 (de) Indolderivate als faktor xa inhibitoren
NO20021230L (no) Faktor Xa inhibitorer
NO20002958D0 (no) Benzamidinderivater som koagulasjonsfaktor Xa-hemmere
ATE443698T1 (de) Stickstoffhaltige heterocyclen als faktor xa- hemmer
ATE346050T1 (de) Substituierte oxoazaheterocyclyl faktor xa hemmer
NO20013072L (no) Nitrogenholdige heterocykler som faktor Xa-inhibitorer
FI964317A7 (fi) Tekijän-Xa-inhibiittoreita
PT1526132E (pt) Derivados de oxazolidinona substituídos e sua utilização enquanto inibidores do factor xa
NO20011293L (no) Faktor VIIa-inhibitorer
ATE278680T1 (de) Glukokinase aktivatoren
NO20022863L (no) Trans-olefiniske glycokinase aktivatorer
ATE251612T1 (de) 6-phenylpyridyl-2-amin-derivate verwendbar als nos-inhibitoren
HUP0002528A3 (en) Heterocyclic derivatives which inhibit factor xa
DE60008527D1 (de) Zellproliferation inhibitoren
ATE234276T1 (de) Diacylhydrazinderivate als integrin-inhibitoren
DE69702751D1 (de) Dipeptidische benzamidine als kininogenasen-inhibitoren
DK1189929T3 (da) Faktor VIIa-inhibitorer
PL350941A1 (en) Pyrazole-3-on-derivative as factor xa inhibitors
DE50016096D1 (de) Versorgungseinheit
FI4008U1 (fi) Tuloilmalaite

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee