ATE243681T1 - Benzamidinderivate als faktor xa-inhibitoren - Google Patents

Benzamidinderivate als faktor xa-inhibitoren

Info

Publication number
ATE243681T1
ATE243681T1 AT98948982T AT98948982T ATE243681T1 AT E243681 T1 ATE243681 T1 AT E243681T1 AT 98948982 T AT98948982 T AT 98948982T AT 98948982 T AT98948982 T AT 98948982T AT E243681 T1 ATE243681 T1 AT E243681T1
Authority
AT
Austria
Prior art keywords
inhibitors
factor
benzamidine derivatives
benzamidine
derivatives
Prior art date
Application number
AT98948982T
Other languages
German (de)
English (en)
Inventor
Dieter Dorsch
Horst Juraszyk
Hanns Wurziger
Sabine Bernotat-Danielowski
Guido Melzer
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE243681T1 publication Critical patent/ATE243681T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98948982T 1997-10-01 1998-09-16 Benzamidinderivate als faktor xa-inhibitoren ATE243681T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19743435A DE19743435A1 (de) 1997-10-01 1997-10-01 Benzamidinderivate
PCT/EP1998/005898 WO1999016751A1 (fr) 1997-10-01 1998-09-16 DERIVES DE BENZAMIDINE UTILISES COMME INHIBITEURS DU FACTEUR Xa

Publications (1)

Publication Number Publication Date
ATE243681T1 true ATE243681T1 (de) 2003-07-15

Family

ID=7844313

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98948982T ATE243681T1 (de) 1997-10-01 1998-09-16 Benzamidinderivate als faktor xa-inhibitoren

Country Status (19)

Country Link
US (1) US6492368B1 (fr)
EP (1) EP1025086B1 (fr)
JP (1) JP2001518467A (fr)
KR (1) KR20010024386A (fr)
CN (1) CN1272107A (fr)
AR (1) AR017164A1 (fr)
AT (1) ATE243681T1 (fr)
AU (1) AU736080B2 (fr)
BR (1) BR9812699A (fr)
CA (1) CA2305568A1 (fr)
DE (2) DE19743435A1 (fr)
HU (1) HUP0004306A3 (fr)
ID (1) ID24430A (fr)
NO (1) NO20001687L (fr)
PL (1) PL339173A1 (fr)
RU (1) RU2194044C2 (fr)
SK (1) SK282799B6 (fr)
WO (1) WO1999016751A1 (fr)
ZA (1) ZA988937B (fr)

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EP1976828B1 (fr) 2005-12-29 2016-12-21 Celtaxsys, Inc. Dérivés de la diamine utilisés en tant qu'inhibiteurs de la leucotriene a4 hydrolase
ES2614931T3 (es) 2006-08-04 2017-06-02 Beth Israel Deaconess Medical Center Inhibidores de la piruvato cinasa y métodos de tratamiento de enfermedad
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ES2663517T3 (es) 2007-08-27 2018-04-13 Dart Neuroscience (Cayman) Ltd Compuestos terapéuticos de isoxazol
JP5656288B2 (ja) * 2007-09-07 2015-01-21 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ムスカリン受容体アンタゴニストとして有用なグアジニン含有化合物
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Also Published As

Publication number Publication date
BR9812699A (pt) 2000-08-22
RU2194044C2 (ru) 2002-12-10
AU736080B2 (en) 2001-07-26
HUP0004306A2 (hu) 2001-11-28
KR20010024386A (ko) 2001-03-26
US6492368B1 (en) 2002-12-10
JP2001518467A (ja) 2001-10-16
NO20001687D0 (no) 2000-03-31
AR017164A1 (es) 2001-08-22
SK4472000A3 (en) 2000-11-07
EP1025086A1 (fr) 2000-08-09
HUP0004306A3 (en) 2001-12-28
DE59808842D1 (de) 2003-07-31
AU9540798A (en) 1999-04-23
CA2305568A1 (fr) 1999-04-08
ZA988937B (en) 1999-03-31
NO20001687L (no) 2000-03-31
PL339173A1 (en) 2000-12-04
DE19743435A1 (de) 1999-04-08
SK282799B6 (sk) 2002-12-03
CN1272107A (zh) 2000-11-01
WO1999016751A1 (fr) 1999-04-08
EP1025086B1 (fr) 2003-06-25
ID24430A (id) 2000-07-20

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