ATE244023T1 - Ternäre radiopharmazeutische komplexe - Google Patents

Ternäre radiopharmazeutische komplexe

Info

Publication number
ATE244023T1
ATE244023T1 AT97915928T AT97915928T ATE244023T1 AT E244023 T1 ATE244023 T1 AT E244023T1 AT 97915928 T AT97915928 T AT 97915928T AT 97915928 T AT97915928 T AT 97915928T AT E244023 T1 ATE244023 T1 AT E244023T1
Authority
AT
Austria
Prior art keywords
chelator
radiopharmaceuticals
transition metal
biologically active
ancillary ligand
Prior art date
Application number
AT97915928T
Other languages
English (en)
Inventor
David Scott Edwards
Shuang Liu
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/808,699 external-priority patent/US5879659A/en
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Application granted granted Critical
Publication of ATE244023T1 publication Critical patent/ATE244023T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97915928T 1996-03-13 1997-03-12 Ternäre radiopharmazeutische komplexe ATE244023T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1336096P 1996-03-13 1996-03-13
US64686696A 1996-05-08 1996-05-08
US08/808,699 US5879659A (en) 1996-03-13 1997-02-28 Ternary radiopharmaceutical complexes
PCT/US1997/003915 WO1997033627A2 (en) 1996-03-13 1997-03-12 New ternary radiopharmaceutical complexes

Publications (1)

Publication Number Publication Date
ATE244023T1 true ATE244023T1 (de) 2003-07-15

Family

ID=27359839

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97915928T ATE244023T1 (de) 1996-03-13 1997-03-12 Ternäre radiopharmazeutische komplexe

Country Status (8)

Country Link
EP (1) EP0888130B1 (de)
JP (1) JP2000507233A (de)
AT (1) ATE244023T1 (de)
AU (1) AU2323197A (de)
CA (1) CA2249025A1 (de)
DE (1) DE69723242T2 (de)
ES (1) ES2201284T3 (de)
WO (1) WO1997033627A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739313A (en) 1995-11-13 1998-04-14 Regents Of The University Of Minnesota Radionuclide labeling of vitamin B12 and coenzymes thereof
US6251364B1 (en) 1999-03-29 2001-06-26 Dupont Pharmaceuticals Company Ternary ligand complexes useful as radiopharmaceuticals
US6806363B1 (en) 1999-04-16 2004-10-19 Mayo Foundation For Medical Education & Research Cobalamin conjugates useful as antitumor agents
JP2003531105A (ja) 1999-10-15 2003-10-21 メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ 造影剤および治療薬として有用なコバラミン結合体
US7591995B2 (en) 1999-10-15 2009-09-22 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging and therapeutic agents
CA2427146A1 (en) 2000-10-25 2002-07-18 Mayo Foundation For Medical Education And Research Transcobalamin binding conjugates useful for treating abnormal cellular proliferation
GB0031592D0 (en) * 2000-12-28 2001-02-07 Nycomed Amersham Plc Stabilised radiopharmaceutical compositions
US6838074B2 (en) 2001-08-08 2005-01-04 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
US7138104B2 (en) 2001-08-08 2006-11-21 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
CN102088991A (zh) 2008-05-13 2011-06-08 堪萨斯大学 金属提取肽标签和相关方法
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992005154A1 (en) * 1990-09-14 1992-04-02 Mallinckrodt Medical, Inc. Novel nitrogen-sulfur ligands useful in radiographic imaging agents
AU3610593A (en) * 1992-02-06 1993-09-03 Mallinckrodt Medical, Inc. Ligands for improving metal chelate formation kinetics
GB9209641D0 (en) * 1992-05-02 1992-06-17 Johnson Matthey Plc Improvements in radiolabelling
EP0681484A1 (de) * 1993-01-28 1995-11-15 The Wellcome Foundation Limited Immunreaktive reagenzien unter verwendung von heterodimeren
US5750088A (en) * 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
US5744120A (en) * 1993-03-30 1998-04-28 The Dupont Merick Pharmaceutical Company Ternary radiopharmaceutical complexes
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
ES2114209T3 (es) * 1993-07-19 1998-05-16 Resolution Pharm Inc Queladores de radionuclidos de tipo hidrazino que tienen una configuracion n3s.

Also Published As

Publication number Publication date
EP0888130A2 (de) 1999-01-07
DE69723242T2 (de) 2004-06-03
JP2000507233A (ja) 2000-06-13
DE69723242D1 (de) 2003-08-07
WO1997033627A3 (en) 1998-02-26
ES2201284T3 (es) 2004-03-16
EP0888130B1 (de) 2003-07-02
CA2249025A1 (en) 1997-09-18
AU2323197A (en) 1997-10-01
WO1997033627A2 (en) 1997-09-18

Similar Documents

Publication Publication Date Title
EP1195168A3 (de) Ternäre radiopharmazeutische Komplexe
UA32577C2 (uk) Радіомічена сполука для утворення зображення тромбів при радіонуклідній діагностиці, радіофармацевтичний препарат та радіофармацевтична композиція на їх основі та комплект для приготування радіофармацевтичних препаратів
TR200200416T2 (tr) İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler.
CA2278201A1 (en) Novel modifications to 2-amino-4-(4-fluorobenzylamino)-1-ethoxycarbonyl-aminobenzene, and processes for their preparation
ATE244023T1 (de) Ternäre radiopharmazeutische komplexe
BG103485A (en) Ketobanzamides as calpain inhibitors
MY133974A (en) Stable reagents for the preparation of radiopharmaceutiocals
TR200100075T2 (tr) 2-Kuinolon ihtiva eden farmasötik bileşimler
ATE85619T1 (de) Herstellung von als radiopharmazeutische produkte verwendbare nitruroverbindungen.
BG103310A (en) Benzonaphthyridins as bronchial therapeutical means
NO20032007L (no) Radiofarmasöytika for diagnostisering av Alzheimers sykdom
CA2046654A1 (en) Radiolabeled proteins for diagnostic or therapeutic use
EA199800998A2 (ru) Хелатные соединения металлов с макроциклическими полиаминокарбоновыми соединениями и их использование для диагностических исследований
DE69131850D1 (de) Technetium-99m-komplexe zur verwendung als radiopharmazeutische mittel
TR199800543A2 (xx) Benziloksi ikame edilen, aniliye edilmi� N-heterosiklik bile�ikler.
DE3862843D1 (de) Kationische komplexe des technetiums-99m.
WO1997010852A3 (de) Bifunktionelle sulfidhaltige sulfonamid-chelatbildner vom typ xsns für radioaktive isotope
WO1997012636A3 (de) Bifunktionelle sulfidhaltige sulfonamid-chelatbildner vom typ s2ny für radioaktive isotope
WO2001080906A3 (en) Radiometal complexes of 2-pyrrolylthiones for imaging a therapy
CA2255664A1 (en) Selenophene anti-tumor agents
CA2070961A1 (en) Thiol-reactive maleimido-based radiolabeling reagents
EP1048302A3 (de) Radiotracer zur Untersuchung von Acetylcholinesterase und Alzheimer Erkrankung
JPH1095733A5 (de)
ATE216267T1 (de) Cardiotropische radiopharmazeutika,die einen übergangsmetall-nitrid-komplex enthalten und die eine rasche myocardial-eliminierung aufweisen
CA2298639A1 (en) Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties