ATE244234T1 - Substituierte imidazole zur behandlung von entzündlichen krankheiten - Google Patents

Substituierte imidazole zur behandlung von entzündlichen krankheiten

Info

Publication number
ATE244234T1
ATE244234T1 AT98918463T AT98918463T ATE244234T1 AT E244234 T1 ATE244234 T1 AT E244234T1 AT 98918463 T AT98918463 T AT 98918463T AT 98918463 T AT98918463 T AT 98918463T AT E244234 T1 ATE244234 T1 AT E244234T1
Authority
AT
Austria
Prior art keywords
treatment
inflammatory diseases
substituted imidazoles
imidazoles
substituted
Prior art date
Application number
AT98918463T
Other languages
English (en)
Inventor
Scott A Beers
Elizabeth Malloy
Michael P Wachter
Wei Wu
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Application granted granted Critical
Publication of ATE244234T1 publication Critical patent/ATE244234T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98918463T 1997-04-24 1998-04-17 Substituierte imidazole zur behandlung von entzündlichen krankheiten ATE244234T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4425297P 1997-04-24 1997-04-24
PCT/US1998/007910 WO1998047892A1 (en) 1997-04-24 1998-04-17 Substituted imidazoles useful in the treatment of inflammatory diseases

Publications (1)

Publication Number Publication Date
ATE244234T1 true ATE244234T1 (de) 2003-07-15

Family

ID=21931339

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98918463T ATE244234T1 (de) 1997-04-24 1998-04-17 Substituierte imidazole zur behandlung von entzündlichen krankheiten

Country Status (24)

Country Link
US (3) US5965583A (de)
EP (1) EP1028954B1 (de)
JP (1) JP2001522357A (de)
KR (1) KR100568438B1 (de)
CN (1) CN1211381C (de)
AR (1) AR012594A1 (de)
AT (1) ATE244234T1 (de)
AU (1) AU7138298A (de)
BR (1) BR9808998A (de)
CA (1) CA2297176A1 (de)
DE (1) DE69816109T2 (de)
DK (1) DK1028954T3 (de)
ES (1) ES2202840T3 (de)
HU (1) HUP0002842A3 (de)
IL (1) IL132318A0 (de)
NO (1) NO318937B1 (de)
NZ (1) NZ500447A (de)
PL (1) PL191111B1 (de)
PT (1) PT1028954E (de)
RU (1) RU2222534C2 (de)
TR (1) TR199902622T2 (de)
UA (1) UA65572C2 (de)
WO (1) WO1998047892A1 (de)
ZA (1) ZA983451B (de)

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CA2297176A1 (en) 1998-10-29
KR100568438B1 (ko) 2006-04-07
US6214830B1 (en) 2001-04-10
PL191111B1 (pl) 2006-03-31
NO995095D0 (no) 1999-10-19
NO995095L (no) 1999-12-09
NZ500447A (en) 2001-09-28
HUP0002842A3 (en) 2002-01-28
IL132318A0 (en) 2001-03-19
RU2222534C2 (ru) 2004-01-27
AU7138298A (en) 1998-11-13
CN1253558A (zh) 2000-05-17
ZA983451B (en) 1999-10-25
UA65572C2 (en) 2004-04-15
CN1211381C (zh) 2005-07-20
EP1028954B1 (de) 2003-07-02
US6521655B1 (en) 2003-02-18
BR9808998A (pt) 2000-08-08
NO318937B1 (no) 2005-05-30
AR012594A1 (es) 2000-11-08
DK1028954T3 (da) 2003-10-27
DE69816109T2 (de) 2004-04-22
JP2001522357A (ja) 2001-11-13
US5965583A (en) 1999-10-12
KR20010020204A (ko) 2001-03-15
DE69816109D1 (de) 2003-08-07
PT1028954E (pt) 2003-11-28
WO1998047892A1 (en) 1998-10-29
ES2202840T3 (es) 2004-04-01
PL336758A1 (en) 2000-07-17
EP1028954A1 (de) 2000-08-23
HUP0002842A2 (hu) 2001-06-28

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