ATE245622T1 - Antidiabetische mittel - Google Patents

Antidiabetische mittel

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Publication number
ATE245622T1
ATE245622T1 AT97906471T AT97906471T ATE245622T1 AT E245622 T1 ATE245622 T1 AT E245622T1 AT 97906471 T AT97906471 T AT 97906471T AT 97906471 T AT97906471 T AT 97906471T AT E245622 T1 ATE245622 T1 AT E245622T1
Authority
AT
Austria
Prior art keywords
levels
antidiabetic agents
compounds
acetylphenols
antiobesity
Prior art date
Application number
AT97906471T
Other languages
English (en)
Inventor
Alan D Adams
Thomas W Doebber
Joel P Berger
Gregory D Berger
Anthony B Jones
Langen Derek Von
Mark D Leibowitz
David E Moller
John T Olson
Arthur A Patchett
Soumya P Sahoo
Richard L Tolman
Richard B Toupence
Thomas F Walsh
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9604231.2A external-priority patent/GB9604231D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE245622T1 publication Critical patent/ATE245622T1/de

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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  • Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
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  • Obesity (AREA)
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  • Nutrition Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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AT97906471T 1996-02-02 1997-01-31 Antidiabetische mittel ATE245622T1 (de)

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US1109396P 1996-02-02 1996-02-02
GBGB9604231.2A GB9604231D0 (en) 1996-02-28 1996-02-28 Antidiabetic agents
US3443596P 1996-12-23 1996-12-23
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WO1997028115A1 (en) 1997-08-07
CA2245529A1 (en) 1997-08-07
DE69723680T9 (de) 2004-11-04
EP0888278B1 (de) 2003-07-23
AU2115997A (en) 1997-08-22
ES2202582T3 (es) 2004-04-01
JP2002503202A (ja) 2002-01-29
AU721452B2 (en) 2000-07-06
EP0888278A4 (de) 1999-06-30
EP0888278A1 (de) 1999-01-07
DE69723680D1 (de) 2003-08-28
DE69723680T2 (de) 2004-04-15

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