ATE245628T1 - Verfahren zur stereoselektiven synthese von prostacyclin-derivaten - Google Patents

Verfahren zur stereoselektiven synthese von prostacyclin-derivaten

Info

Publication number
ATE245628T1
ATE245628T1 AT98953972T AT98953972T ATE245628T1 AT E245628 T1 ATE245628 T1 AT E245628T1 AT 98953972 T AT98953972 T AT 98953972T AT 98953972 T AT98953972 T AT 98953972T AT E245628 T1 ATE245628 T1 AT E245628T1
Authority
AT
Austria
Prior art keywords
stereoselective synthesis
prostacyclin derivatives
making
stereoselective
prostacyclin
Prior art date
Application number
AT98953972T
Other languages
English (en)
Inventor
Robert M Moriarty
Raju Penmasta
Liang Guo
Munagala S Rao
James P Staszewski
Original Assignee
United Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United Therapeutics Corp filed Critical United Therapeutics Corp
Application granted granted Critical
Publication of ATE245628T1 publication Critical patent/ATE245628T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
AT98953972T 1997-10-24 1998-10-26 Verfahren zur stereoselektiven synthese von prostacyclin-derivaten ATE245628T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95773697A 1997-10-24 1997-10-24
PCT/US1998/022585 WO1999021830A1 (en) 1997-10-24 1998-10-26 Process for stereoselective synthesis of prostacyclin derivatives

Publications (1)

Publication Number Publication Date
ATE245628T1 true ATE245628T1 (de) 2003-08-15

Family

ID=25500067

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98953972T ATE245628T1 (de) 1997-10-24 1998-10-26 Verfahren zur stereoselektiven synthese von prostacyclin-derivaten

Country Status (11)

Country Link
EP (1) EP1025083B1 (de)
JP (1) JP3717053B2 (de)
KR (1) KR100447022B1 (de)
CN (1) CN1264819C (de)
AT (1) ATE245628T1 (de)
CA (2) CA2307163C (de)
DE (1) DE69816642T2 (de)
DK (1) DK1025083T3 (de)
ES (1) ES2198760T3 (de)
PT (1) PT1025083E (de)
WO (1) WO1999021830A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6700025B2 (en) * 2001-01-05 2004-03-02 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
ES2670872T3 (es) 2003-05-22 2018-06-01 United Therapeutics Corporation Polimorfo de una sal de dietanolamina de treprostinil
EP2711024B1 (de) 2007-09-07 2019-03-06 United Therapeutics Corporation Pufferlösungen mit selektiver bakteriziden Wirkung gegen gramnegative Bakterien und Verfahren zur Verwendung davon
WO2009078965A1 (en) 2007-12-17 2009-06-25 United Therapeutics Corporation An improved process to prepare treprostinil, the active ingredient in remodulin
CN101891596B (zh) * 2009-05-22 2013-12-11 上海天伟生物制药有限公司 一种化合物及其制备方法和用途
US8481782B2 (en) 2010-06-03 2013-07-09 United Therapeutics Corporation Treprostinil production
CA2710725C (en) 2010-07-22 2017-08-01 Alphora Research Inc. Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation
CA2726599C (en) 2010-12-30 2017-07-25 Alphora Research Inc. Process for treprostinil salt preparation
KR101454571B1 (ko) * 2011-03-02 2014-10-23 유나이티드 세러퓨틱스 코오포레이션 트레프로스티닐 생산을 위한 중간체 합성
US8524939B2 (en) * 2011-08-24 2013-09-03 Chirogate International Inc. Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
CN103193626B (zh) * 2012-01-10 2016-05-11 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
CN103193627B (zh) * 2012-01-10 2016-04-20 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
CA3125504C (en) 2013-03-14 2023-10-24 United Therapeutics Corporation Solid forms of treprostinil
HU231184B1 (hu) 2014-10-08 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Treprostinil-nátrium-monohidrát és eljárás ennek előállítására
US9593061B2 (en) 2014-10-20 2017-03-14 United Therapeutics Corporation Synthesis of intermediates for producing prostacyclin derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4306075A (en) * 1980-03-28 1981-12-15 The Upjohn Company Composition and process
US4486598A (en) * 1982-02-22 1984-12-04 The Upjohn Company Carbacyclin analogs
DE19708496A1 (de) * 1997-03-03 1998-09-10 Hoechst Ag Verfahren zur enantionmerenreinen Anthracylin-Synthese

Also Published As

Publication number Publication date
KR100447022B1 (ko) 2004-09-07
CA2847985C (en) 2015-02-03
JP3717053B2 (ja) 2005-11-16
CA2847985A1 (en) 1999-05-06
ES2198760T3 (es) 2004-02-01
KR20010031309A (ko) 2001-04-16
WO1999021830A1 (en) 1999-05-06
DE69816642D1 (de) 2003-08-28
JP2004500303A (ja) 2004-01-08
PT1025083E (pt) 2003-10-31
CN1264819C (zh) 2006-07-19
EP1025083A1 (de) 2000-08-09
EP1025083B1 (de) 2003-07-23
WO1999021830A8 (en) 1999-07-22
CA2307163C (en) 2014-05-06
CN1283184A (zh) 2001-02-07
DE69816642T2 (de) 2004-06-09
DK1025083T3 (da) 2004-03-01
CA2307163A1 (en) 1999-05-06

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