ATE275565T1 - Verfahren zur herstellung von n6-substituierten deaza-adenosinderivaten - Google Patents

Verfahren zur herstellung von n6-substituierten deaza-adenosinderivaten

Info

Publication number: ATE275565T1
Authority: AT; Austria
Prior art keywords: producing; adenosine derivatives; substituted; deaza adenosine; substituted deaza
Prior art date: 1998-12-31

Application number

AT99966299T

Other languages

English (en)

Inventor

Adam W Sledeski

Luc Grondard

Matthew R Powers

Tory H Powner

Michael K O'brien

Ching T Tsuei

Patrick Leon

Gregory G Kubiak

Laurence Pailleres-Hubert

Benoit Viguier

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-31

Filing date

1999-12-15

Publication date

2004-09-15

1999-12-15 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2004-09-15 Application granted granted Critical

2004-09-15 Publication of ATE275565T1 publication Critical patent/ATE275565T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
150000003835 adenosine derivatives Chemical class 0.000 title 1
239000000543 intermediate Substances 0.000 abstract 2
-1 N6-substituted adenosine Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT99966299T 1998-12-31 1999-12-15 Verfahren zur herstellung von n6-substituierten deaza-adenosinderivaten ATE275565T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US11448698P	1998-12-31	1998-12-31
US11602899P	1999-01-15	1999-01-15
PCT/US1999/029841 WO2000040584A2 (en)	1998-12-31	1999-12-15	Process for preparing n6-substituted deaza-adenosine derivatives

Publications (1)

Publication Number	Publication Date
ATE275565T1 true ATE275565T1 (de)	2004-09-15

Family

ID=26812247

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99966299T ATE275565T1 (de)	1998-12-31	1999-12-15	Verfahren zur herstellung von n6-substituierten deaza-adenosinderivaten

Country Status (15)

Country	Link
US (1)	US6429315B1 (de)
EP (1)	EP1140933B1 (de)
JP (1)	JP2002534430A (de)
KR (1)	KR20010089751A (de)
CN (1)	CN1383427A (de)
AT (1)	ATE275565T1 (de)
AU (1)	AU2187100A (de)
BR (1)	BR9917000A (de)
CA (1)	CA2358962A1 (de)
DE (1)	DE69920045T2 (de)
DK (1)	DK1140933T3 (de)
ES (1)	ES2228163T3 (de)
PT (1)	PT1140933E (de)
SI (1)	SI1140933T1 (de)
WO (1)	WO2000040584A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1140933E (pt)	1998-12-31	2004-12-31	Aventis Pharma Inc	Processo para preparar derivados n6-substituidos de desaza-adenosina
GT200500281A (es) *	2004-10-22	2006-04-24	Novartis Ag	Compuestos organicos.
GB0500785D0 (en) *	2005-01-14	2005-02-23	Novartis Ag	Organic compounds
GB0607944D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
PE20080361A1 (es)	2006-04-21	2008-06-03	Novartis Ag	Compuestos derivados de purina como activadores del receptor de adenosina a2a
GB0607948D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
GB0607953D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
GB0607950D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
EP1889846A1 (de)	2006-07-13	2008-02-20	Novartis AG	Purinderivate als A2a Agonisten
EP1903044A1 (de) *	2006-09-14	2008-03-26	Novartis AG	Adenosinderivate als Agonisten des A2A-Rezeptors
WO2008055874A1 (en) *	2006-11-10	2008-05-15	Novartis Ag	Cyclopentene diol monoacetate derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG80526A1 (en)	1990-09-25	2001-05-22	Rhone Poulenc Rorer Int	Compounds having antihypertensive and anti- ischemic properies
US5561134A (en)	1990-09-25	1996-10-01	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
US5652366A (en)	1990-09-25	1997-07-29	Rhone-Poulenc Rorer Pharmaceuticals Inc.	DI (1R)-(-)camphosulfonic acid) salt, preparation thereof and use thereof
US5545769A (en)	1994-09-29	1996-08-13	E. I. Du Pont De Nemours And Company	Process for the manufacture of selected halogenated hydrocarbons containing fluorine and hydrogen and compositions provided therein
US5684159A (en)	1995-05-30	1997-11-04	Rhone-Poulenc Rorer S.A.	L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds
FR2734822B1 (fr)	1995-05-30	1997-07-04	Rhone Poulenc Rorer Sa	Nouveaux derives du 2-azabicyclo(2.2.1)heptane, leur preparation et leur application
EA000884B1 (ru)	1996-01-02	2000-06-26	Рон-Пуленк Рорер Фармасьютикалз Инк.	Способ получения 2,4-дигидроксипиридина и 2,4-дигидрокси-3-нитропиридина
UA51716C2 (uk) *	1996-07-08	2002-12-16	Авентіс Фармасьютікалз Продактс Інк.	Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування
JP2001501922A (ja)	1996-09-12	2001-02-13	ローヌ―プーランローラーファーマシューティカルズインコーポレイテッド	キラルな１―アリール―及び１―ヘテロアリール―２―置換エチル―２―アミンの立体特異的な製造
DK0946550T3 (da)	1996-12-11	2005-08-29	Aventis Pharma Inc	Fremstilling af [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-chlor-2-thienyl)methyl]propyl]amino]-3H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2,3-dihydroxycyclopentancarboxamid
PT1140933E (pt)	1998-12-31	2004-12-31	Aventis Pharma Inc	Processo para preparar derivados n6-substituidos de desaza-adenosina

1999
- 1999-12-15 PT PT99966299T patent/PT1140933E/pt unknown
- 1999-12-15 KR KR1020017008416A patent/KR20010089751A/ko not_active Ceased
- 1999-12-15 SI SI9930688T patent/SI1140933T1/xx unknown
- 1999-12-15 AT AT99966299T patent/ATE275565T1/de not_active IP Right Cessation
- 1999-12-15 JP JP2000592292A patent/JP2002534430A/ja active Pending
- 1999-12-15 BR BR9917000-0A patent/BR9917000A/pt not_active IP Right Cessation
- 1999-12-15 CA CA002358962A patent/CA2358962A1/en not_active Abandoned
- 1999-12-15 AU AU21871/00A patent/AU2187100A/en not_active Abandoned
- 1999-12-15 EP EP99966299A patent/EP1140933B1/de not_active Expired - Lifetime
- 1999-12-15 CN CN99815953A patent/CN1383427A/zh active Pending
- 1999-12-15 DK DK99966299T patent/DK1140933T3/da active
- 1999-12-15 DE DE69920045T patent/DE69920045T2/de not_active Expired - Fee Related
- 1999-12-15 ES ES99966299T patent/ES2228163T3/es not_active Expired - Lifetime
- 1999-12-15 WO PCT/US1999/029841 patent/WO2000040584A2/en not_active Ceased
2000
- 2000-01-21 US US09/489,276 patent/US6429315B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK1140933T3 (da)	2004-12-20
EP1140933B1 (de)	2004-09-08
CA2358962A1 (en)	2000-07-13
PT1140933E (pt)	2004-12-31
KR20010089751A (ko)	2001-10-08
WO2000040584A2 (en)	2000-07-13
DE69920045D1 (de)	2004-10-14
WO2000040584A3 (en)	2000-11-02
JP2002534430A (ja)	2002-10-15
EP1140933A2 (de)	2001-10-10
HK1040239A1 (en)	2002-05-31
CN1383427A (zh)	2002-12-04
AU2187100A (en)	2000-07-24
DE69920045T2 (de)	2005-09-29
BR9917000A (pt)	2001-12-11
ES2228163T3 (es)	2005-04-01
US6429315B1 (en)	2002-08-06
SI1140933T1 (en)	2005-02-28

Legal Events

Date

Code

Title

Description

2005-03-15

UEP

Publication of translation of european patent specification

Ref document number: 1140933

Country of ref document: EP

2007-09-15

REN

Ceased due to non-payment of the annual fee

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