ATE275565T1 - Verfahren zur herstellung von n6-substituierten deaza-adenosinderivaten - Google Patents

Verfahren zur herstellung von n6-substituierten deaza-adenosinderivaten

Info

Publication number
ATE275565T1
ATE275565T1 AT99966299T AT99966299T ATE275565T1 AT E275565 T1 ATE275565 T1 AT E275565T1 AT 99966299 T AT99966299 T AT 99966299T AT 99966299 T AT99966299 T AT 99966299T AT E275565 T1 ATE275565 T1 AT E275565T1
Authority
AT
Austria
Prior art keywords
producing
adenosine derivatives
substituted
deaza adenosine
substituted deaza
Prior art date
Application number
AT99966299T
Other languages
English (en)
Inventor
Adam W Sledeski
Luc Grondard
Matthew R Powers
Tory H Powner
Michael K O'brien
Ching T Tsuei
Patrick Leon
Gregory G Kubiak
Laurence Pailleres-Hubert
Benoit Viguier
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of ATE275565T1 publication Critical patent/ATE275565T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT99966299T 1998-12-31 1999-12-15 Verfahren zur herstellung von n6-substituierten deaza-adenosinderivaten ATE275565T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11448698P 1998-12-31 1998-12-31
US11602899P 1999-01-15 1999-01-15
PCT/US1999/029841 WO2000040584A2 (en) 1998-12-31 1999-12-15 Process for preparing n6-substituted deaza-adenosine derivatives

Publications (1)

Publication Number Publication Date
ATE275565T1 true ATE275565T1 (de) 2004-09-15

Family

ID=26812247

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99966299T ATE275565T1 (de) 1998-12-31 1999-12-15 Verfahren zur herstellung von n6-substituierten deaza-adenosinderivaten

Country Status (15)

Country Link
US (1) US6429315B1 (de)
EP (1) EP1140933B1 (de)
JP (1) JP2002534430A (de)
KR (1) KR20010089751A (de)
CN (1) CN1383427A (de)
AT (1) ATE275565T1 (de)
AU (1) AU2187100A (de)
BR (1) BR9917000A (de)
CA (1) CA2358962A1 (de)
DE (1) DE69920045T2 (de)
DK (1) DK1140933T3 (de)
ES (1) ES2228163T3 (de)
PT (1) PT1140933E (de)
SI (1) SI1140933T1 (de)
WO (1) WO2000040584A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1383427A (zh) 1998-12-31 2002-12-04 阿温蒂斯药物公司 制备n6－取代的脱氮杂一腺苷衍生物的方法
GT200500281A (es) * 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0500785D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
GB0607953D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
HRP20120494T1 (hr) 2006-04-21 2012-08-31 Novartis Ag Derivati purina za uporabu kao agonista adenozin a2a receptora
GB0607950D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607948D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607944D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
EP1889846A1 (de) 2006-07-13 2008-02-20 Novartis AG Purinderivate als A2a Agonisten
EP1903044A1 (de) * 2006-09-14 2008-03-26 Novartis AG Adenosinderivate als Agonisten des A2A-Rezeptors
JP2010508835A (ja) * 2006-11-10 2010-03-25 ノバルティス アーゲー シクロペンテンジオールモノアセテート誘導体

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5561134A (en) 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
US5652366A (en) 1990-09-25 1997-07-29 Rhone-Poulenc Rorer Pharmaceuticals Inc. DI (1R)-(-)camphosulfonic acid) salt, preparation thereof and use thereof
ES2095960T3 (es) 1990-09-25 1997-03-01 Rhone Poulenc Rorer Int Compuestos que tienen propiedades antihipertensivas y antiisquemicas.
US5545769A (en) 1994-09-29 1996-08-13 E. I. Du Pont De Nemours And Company Process for the manufacture of selected halogenated hydrocarbons containing fluorine and hydrogen and compositions provided therein
US5684159A (en) 1995-05-30 1997-11-04 Rhone-Poulenc Rorer S.A. L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds
FR2734822B1 (fr) 1995-05-30 1997-07-04 Rhone Poulenc Rorer Sa Nouveaux derives du 2-azabicyclo(2.2.1)heptane, leur preparation et leur application
JP2000502709A (ja) 1996-01-02 2000-03-07 ローヌ―プーラン ローラー ファーマシューティカルズ インコーポレイテッド ２，４―ジヒドロキシピリジン及び２，４―ジヒドロキシ―３―ニトロピリジンの製造方法
UA51716C2 (uk) * 1996-07-08 2002-12-16 Авентіс Фармасьютікалз Продактс Інк. Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування
JP2001501922A (ja) 1996-09-12 2001-02-13 ローヌ―プーラン ローラー ファーマシューティカルズ インコーポレイテッド キラルな１―アリール―及び１―ヘテロアリール―２―置換エチル―２―アミンの立体特異的な製造
EP1609791A1 (de) 1996-12-11 2005-12-28 Aventis Pharmaceuticals Inc. Herstellung von [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-Chlor-2-thienyl)methy]propy]amino]-3H-imidazo[4,5-b]pyridin-3-y]-N-ethyl-2,3-dihydroxycyclopentancarboxamid
CN1383427A (zh) 1998-12-31 2002-12-04 阿温蒂斯药物公司 制备n6－取代的脱氮杂一腺苷衍生物的方法

Also Published As

Publication number Publication date
WO2000040584A3 (en) 2000-11-02
SI1140933T1 (en) 2005-02-28
EP1140933A2 (de) 2001-10-10
EP1140933B1 (de) 2004-09-08
ES2228163T3 (es) 2005-04-01
DE69920045D1 (de) 2004-10-14
WO2000040584A2 (en) 2000-07-13
CA2358962A1 (en) 2000-07-13
AU2187100A (en) 2000-07-24
US6429315B1 (en) 2002-08-06
KR20010089751A (ko) 2001-10-08
DK1140933T3 (da) 2004-12-20
HK1040239A1 (en) 2002-05-31
CN1383427A (zh) 2002-12-04
BR9917000A (pt) 2001-12-11
DE69920045T2 (de) 2005-09-29
PT1140933E (pt) 2004-12-31
JP2002534430A (ja) 2002-10-15

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