ATE246172T1 - Verfahren zur herstellung von hydroxy-25-ene vitamin d verbindungen - Google Patents
Verfahren zur herstellung von hydroxy-25-ene vitamin d verbindungenInfo
- Publication number
- ATE246172T1 ATE246172T1 AT99953335T AT99953335T ATE246172T1 AT E246172 T1 ATE246172 T1 AT E246172T1 AT 99953335 T AT99953335 T AT 99953335T AT 99953335 T AT99953335 T AT 99953335T AT E246172 T1 ATE246172 T1 AT E246172T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- vitamin
- producing hydroxy
- ene vitamin
- present
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 150000003722 vitamin derivatives Chemical class 0.000 title 1
- 229930003316 Vitamin D Natural products 0.000 abstract 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 2
- 235000019166 vitamin D Nutrition 0.000 abstract 2
- 239000011710 vitamin D Substances 0.000 abstract 2
- -1 vitamin D compounds Chemical class 0.000 abstract 2
- 229940046008 vitamin d Drugs 0.000 abstract 2
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8722298P | 1998-05-29 | 1998-05-29 | |
| PCT/US1999/011950 WO1999061417A2 (en) | 1998-05-29 | 1999-05-28 | Method for making hydroxy-25-ene-vitamin d compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE246172T1 true ATE246172T1 (de) | 2003-08-15 |
Family
ID=22203846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99953335T ATE246172T1 (de) | 1998-05-29 | 1999-05-28 | Verfahren zur herstellung von hydroxy-25-ene vitamin d verbindungen |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6441207B1 (de) |
| EP (1) | EP1091936B1 (de) |
| JP (1) | JP2002516306A (de) |
| CN (1) | CN1148347C (de) |
| AT (1) | ATE246172T1 (de) |
| AU (1) | AU755701B2 (de) |
| CA (1) | CA2333256A1 (de) |
| DE (1) | DE69910031T2 (de) |
| ES (1) | ES2204165T3 (de) |
| IL (1) | IL139354A (de) |
| WO (1) | WO1999061417A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1048979A1 (en) * | 2000-03-30 | 2003-04-25 | Teijin Limited | Vitamin D intermediate and its manufacturing method |
| KR100679115B1 (ko) | 2004-11-12 | 2007-02-05 | (주)유케이케미팜 | 1-알파-히드록시콜레칼시페롤 유도체의 제조방법 |
| BRPI0708128A2 (pt) * | 2006-03-02 | 2011-05-17 | Novozymes Biopolymer As | derivado de ácido hialurÈnico, processo para produção de um derivado de ácido hialurÈnico, composição, artigo cosmético, artigo sanitário, médico ou cirúrgico, cápsula ou microcápsula de medicamento, métodos para realizar procedimentos em oftalmologia, no tratamento de osteoartrite, e no tratamento de cáncer, para realizar administração transdérmica e dérmica de um agente farmacologicamente ativo, e administração dérmica de um cosmético, e para realizar procedimentos no tratamento de perda de cabelo ou calvìcie, métodos oftalmológico, de tratamento de osteoartrite, de uma ferida, e de perda de cabelo ou calvìcie, e, uso de um derivado de ácido hialurÈnico |
| CN102131773B (zh) * | 2008-07-22 | 2014-09-24 | Azad药物成分股份公司 | 生产帕立骨化醇的方法 |
| SG2014006324A (en) | 2009-01-27 | 2014-03-28 | Berg Llc | Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy |
| PL216135B1 (pl) * | 2009-08-07 | 2014-03-31 | Inst Farmaceutyczny | Nowe syntony i ich zastosowanie do otrzymywania pochodnych 19-nor witamin D |
| CN102655869B (zh) | 2009-08-14 | 2016-08-10 | 博格有限责任公司 | 用于治疗脱发的维生素d3及其类似物 |
| WO2012033703A1 (en) * | 2010-09-10 | 2012-03-15 | Genzyme Corporation | Continuous photolytic process for the preparation of vitamin d related substances |
| ES2472241B1 (es) * | 2012-12-27 | 2015-03-09 | Vinas Lab | Procedimiento para obtener compuestos diénicos de configuración trans útiles como intermedios para la síntesis de análogos de vitamina D y uso de un microrreactor correspondiente |
| HK1222819A1 (zh) | 2013-05-29 | 2017-07-14 | 博格有限责任公司 | 使用维生素d预防或减轻化疗诱发的脱发 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4225596A (en) * | 1978-10-13 | 1980-09-30 | Wisconsin Alumni Research Foundation | Method for treating calcium imbalance and improving calcium absorption in mammals |
| CA1160217A (en) | 1979-10-23 | 1984-01-10 | Osamu Nishikawa | Process for the preparation of active-type vitamin d.sub.3 compounds |
| US4310511A (en) | 1980-10-02 | 1982-01-12 | Massachusetts General Hospital | Sunscreen compositions containing Δ5,7 steroidal dienes |
| JPS57149224A (en) | 1981-03-13 | 1982-09-14 | Chugai Pharmaceut Co Ltd | Tumor-suppressing agent |
| US4749710A (en) | 1985-05-01 | 1988-06-07 | Hoffmann-La Roche Inc. | Immunosuppressive agents |
| ES2055019T3 (es) | 1988-12-12 | 1994-08-16 | Duphar Int Res | Metodo para la conversion fotoquimica de compuestos de taquisterol en compuestos de previtamina d y de compuestos de trans-vitamina d en compuestos de cis-vitamina d. |
| CA1333616C (en) | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| DK0494224T3 (da) | 1989-09-25 | 2000-08-07 | Univ Utah Res Found | Anvendelse af steroidhormoner i sammensætninger til induktion af T-cellelymfokinproduktion |
| US5518725A (en) | 1989-09-25 | 1996-05-21 | University Of Utah Research Foundation | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination |
| US5562910A (en) | 1989-09-25 | 1996-10-08 | University Of Utah Research Foundation | Vaccine compositions and method for enhancing an immune response |
| US5030772A (en) * | 1990-02-14 | 1991-07-09 | Deluca Hector F | Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives |
| EP0454204B1 (de) | 1990-04-27 | 1995-06-28 | Duphar International Research B.V | Verfahren zur photochemischen Isomerisierung von organischen Verbindungen unter dem Einfluss eines Photosensibilisators |
| DE69233074T2 (de) * | 1991-01-08 | 2004-03-18 | Bone Care International Inc., Madison | Verfahren zur Herstellung von 1-alpha-24-dihydroxy-Vitamin D2 |
| IT1247175B (it) | 1991-04-19 | 1994-12-12 | Fidia Spa | Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico. |
| GB9220439D0 (en) | 1992-09-28 | 1992-11-11 | Leo Pharm Prod Ltd | Chemical compounds |
| US5880114A (en) | 1993-06-16 | 1999-03-09 | Wisconsin Alumni Research Foundation | Treatment of immune deficiency with vitamin D compounds |
| US5716946A (en) | 1996-02-13 | 1998-02-10 | Wisconsin Alumni Research Foundation | Multiple sclerosis treatment |
-
1999
- 1999-05-28 IL IL13935499A patent/IL139354A/xx not_active IP Right Cessation
- 1999-05-28 CN CNB998067881A patent/CN1148347C/zh not_active Expired - Fee Related
- 1999-05-28 AU AU43209/99A patent/AU755701B2/en not_active Ceased
- 1999-05-28 AT AT99953335T patent/ATE246172T1/de not_active IP Right Cessation
- 1999-05-28 DE DE69910031T patent/DE69910031T2/de not_active Expired - Lifetime
- 1999-05-28 CA CA002333256A patent/CA2333256A1/en not_active Abandoned
- 1999-05-28 JP JP2000550823A patent/JP2002516306A/ja active Pending
- 1999-05-28 ES ES99953335T patent/ES2204165T3/es not_active Expired - Lifetime
- 1999-05-28 EP EP99953335A patent/EP1091936B1/de not_active Expired - Lifetime
- 1999-05-28 WO PCT/US1999/011950 patent/WO1999061417A2/en not_active Ceased
-
2000
- 2000-11-20 US US09/716,316 patent/US6441207B1/en not_active Expired - Lifetime
-
2002
- 2002-08-26 US US10/228,002 patent/US20030009042A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2333256A1 (en) | 1999-12-02 |
| IL139354A (en) | 2005-08-31 |
| AU755701B2 (en) | 2002-12-19 |
| WO1999061417A3 (en) | 2000-01-13 |
| DE69910031D1 (de) | 2003-09-04 |
| ES2204165T3 (es) | 2004-04-16 |
| CN1303369A (zh) | 2001-07-11 |
| JP2002516306A (ja) | 2002-06-04 |
| EP1091936A2 (de) | 2001-04-18 |
| AU4320999A (en) | 1999-12-13 |
| EP1091936B1 (de) | 2003-07-30 |
| CN1148347C (zh) | 2004-05-05 |
| DE69910031T2 (de) | 2004-04-29 |
| IL139354A0 (en) | 2001-11-25 |
| US20030009042A1 (en) | 2003-01-09 |
| WO1999061417A2 (en) | 1999-12-02 |
| US6441207B1 (en) | 2002-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |