ATE247472T1 - Acylbenzoxazine zur erhöhung der synaptischen reaktion(en) - Google Patents

Acylbenzoxazine zur erhöhung der synaptischen reaktion(en)

Info

Publication number: ATE247472T1
Authority: AT; Austria
Prior art keywords: ampa receptors; treatment; methods; acylbenzoxazines; increase
Prior art date: 1998-04-03

Application number

AT99915240T

Other languages

English (en)

Inventor

Gary A Rogers

Peter Johnstroem

Original Assignee

Univ California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-03

Filing date

1999-04-02

Publication date

2003-09-15

1999-04-02 Application filed by Univ California filed Critical Univ California

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE247472T1 publication Critical patent/ATE247472T1/de

Links

230000009782 synaptic response Effects 0.000 title abstract 2
102000003678 AMPA Receptors Human genes 0.000 abstract 3
108090000078 AMPA Receptors Proteins 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
230000002708 enhancing effect Effects 0.000 abstract 2
230000001771 impaired effect Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
YXTROGRGRSPWKL-UHFFFAOYSA-N 1-benzoylpiperidine Chemical class C=1C=CC=CC=1C(=O)N1CCCCC1 YXTROGRGRSPWKL-UHFFFAOYSA-N 0.000 abstract 1
CMLFRMDBDNHMRA-UHFFFAOYSA-N 2h-1,2-benzoxazine Chemical group C1=CC=C2C=CNOC2=C1 CMLFRMDBDNHMRA-UHFFFAOYSA-N 0.000 abstract 1
210000004556 brain Anatomy 0.000 abstract 1
230000036992 cognitive tasks Effects 0.000 abstract 1
230000007812 deficiency Effects 0.000 abstract 1
230000002964 excitative effect Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
210000000225 synapse Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT99915240T 1998-04-03 1999-04-02 Acylbenzoxazine zur erhöhung der synaptischen reaktion(en) ATE247472T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/054,916 US6124278A (en)	1998-04-03	1998-04-03	Acylbenzoxazines for enhancing synaptic response
PCT/US1999/007325 WO1999051240A1 (en)	1998-04-03	1999-04-02	Acylbenzoxazines for enhancing synaptic response(s)

Publications (1)

Publication Number	Publication Date
ATE247472T1 true ATE247472T1 (de)	2003-09-15

Family

ID=21994357

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99915240T ATE247472T1 (de)	1998-04-03	1999-04-02	Acylbenzoxazine zur erhöhung der synaptischen reaktion(en)

Country Status (22)

Country	Link
US (1)	US6124278A (de)
EP (1)	EP1067935B1 (de)
JP (1)	JP4574846B2 (de)
KR (1)	KR100646753B1 (de)
CN (1)	CN1186020C (de)
AT (1)	ATE247472T1 (de)
BR (1)	BR9909378A (de)
CA (1)	CA2326764C (de)
CZ (1)	CZ292931B6 (de)
DE (1)	DE69910552T2 (de)
DK (1)	DK1067935T3 (de)
ES (1)	ES2207194T3 (de)
HK (1)	HK1039060B (de)
HU (1)	HUP0102321A3 (de)
IL (1)	IL138284A0 (de)
NO (1)	NO20004383L (de)
NZ (1)	NZ506712A (de)
PL (1)	PL195394B1 (de)
PT (1)	PT1067935E (de)
RU (1)	RU2246498C2 (de)
TR (1)	TR200002849T2 (de)
WO (1)	WO1999051240A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI232863B (en)	2001-06-11	2005-05-21	Akzo Nobel Nv	Benzoxazepine derivatives
AU2002320841B2 (en)	2001-06-14	2008-02-28	Merck Sharp & Dohme B.V.	(Pyrido/thieno)-[f]-oxazepin-5-one derivatives as positive modulators of the AMPA receptor
CZ2004632A3 (cs) *	2001-11-26	2004-08-18	Cortexápharmaceuticalsźáinc	Karbonylbenzoxazinové sloučeniny pro zvýšení glutamátergních synaptických odpovědí
EP2173369A2 (de) *	2003-08-08	2010-04-14	DSM IP Assets B.V.	Neues screening-verfahren für gehirnaktive verbindungen
TW200800959A (en)	2005-06-10	2008-01-01	Wyeth Corp	Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
CL2008000119A1 (es)	2007-01-16	2008-05-16	Wyeth Corp	Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia.
KR101673886B1 (ko) *	2008-06-06	2016-11-08	사노피	ＴＡＦＩａ의 억제제로서의 마크로사이클릭 우레아 및 술파미드 유도체
US20110218190A1 (en) *	2008-11-10	2011-09-08	The Regents Of The University Of California	Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
WO2014201411A1 (en)	2013-06-13	2014-12-18	Veroscience Llc	Compositions and methods for treating metabolic disorders
WO2018009256A1 (en)	2016-03-29	2018-01-11	Respirerx Pharmaceuticals, Inc.	Compositions and methods for treating attention deficit disorders
CN108689876B (zh) *	2018-06-28	2020-11-27	苏州东南药业股份有限公司	一种8-(2-羟基苯甲酰胺基)辛酸钠的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0475908A1 (de) *	1990-09-14	1992-03-18	Ciba-Geigy Ag	Chromogene Lactamverbindungen und ihre Herstellung und Verwendung
FI96313C (fi) *	1990-11-28	1996-06-10	Daiichi Seiyaku Co	Menetelmä terapeuttisesti käyttökelpoisten ja optisesti aktiivisten 10-(3-amino-4,4-dialkyyli-1-pyrrolidinyyli)-9-fluori-2,3-dihydro-3(S)-metyyli-7-okso-7H-pyrido/1,2,3-de//1,4/bentsoksatsiini-6-karboksyylihappojen valmistamiseksi
ES2174851T3 (es) *	1992-07-24	2002-11-16	Univ California	Farmacos que aumentan las respuestas sinapticas mediadas por receptores ampa.
DE4229396C2 (de) *	1992-09-03	1997-06-05	Glunz Ag	Verfahren zur Herstellung von Span- oder Faserplatten
US5650409A (en) *	1995-06-02	1997-07-22	Cortex Pharmaceuticals, Inc.	Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) *	1996-04-03	1998-04-07	The Regents Of The University Of California	Benzoxazines for enhancing synaptic response
US5985871A (en) *	1997-12-24	1999-11-16	Cortex Pharmaceuticals, Inc.	Benzoxazine compounds for enhancing synaptic response

1998
- 1998-04-03 US US09/054,916 patent/US6124278A/en not_active Expired - Lifetime
1999
- 1999-04-02 IL IL13828499A patent/IL138284A0/xx not_active IP Right Cessation
- 1999-04-02 WO PCT/US1999/007325 patent/WO1999051240A1/en not_active Ceased
- 1999-04-02 EP EP99915240A patent/EP1067935B1/de not_active Expired - Lifetime
- 1999-04-02 KR KR1020007010679A patent/KR100646753B1/ko not_active Expired - Fee Related
- 1999-04-02 AT AT99915240T patent/ATE247472T1/de active
- 1999-04-02 HK HK02100196.0A patent/HK1039060B/zh not_active IP Right Cessation
- 1999-04-02 TR TR2000/02849T patent/TR200002849T2/xx unknown
- 1999-04-02 CN CNB998046949A patent/CN1186020C/zh not_active Expired - Fee Related
- 1999-04-02 DK DK99915240T patent/DK1067935T3/da active
- 1999-04-02 ES ES99915240T patent/ES2207194T3/es not_active Expired - Lifetime
- 1999-04-02 BR BR9909378-2A patent/BR9909378A/pt not_active Application Discontinuation
- 1999-04-02 RU RU2000127738/04A patent/RU2246498C2/ru not_active IP Right Cessation
- 1999-04-02 JP JP2000542011A patent/JP4574846B2/ja not_active Expired - Fee Related
- 1999-04-02 DE DE69910552T patent/DE69910552T2/de not_active Expired - Lifetime
- 1999-04-02 NZ NZ506712A patent/NZ506712A/xx unknown
- 1999-04-02 PL PL99345687A patent/PL195394B1/pl not_active IP Right Cessation
- 1999-04-02 CA CA2326764A patent/CA2326764C/en not_active Expired - Fee Related
- 1999-04-02 PT PT99915240T patent/PT1067935E/pt unknown
- 1999-04-02 HU HU0102321A patent/HUP0102321A3/hu unknown
- 1999-04-02 CZ CZ20003614A patent/CZ292931B6/cs not_active IP Right Cessation
2000
- 2000-09-04 NO NO20004383A patent/NO20004383L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NZ506712A (en)	2002-11-26
KR100646753B1 (ko)	2006-11-17
EP1067935A1 (de)	2001-01-17
PL195394B1 (pl)	2007-09-28
JP2002510635A (ja)	2002-04-09
DE69910552T2 (de)	2004-06-17
CN1186020C (zh)	2005-01-26
US6124278A (en)	2000-09-26
NO20004383D0 (no)	2000-09-04
TR200002849T2 (tr)	2001-06-21
EP1067935A4 (de)	2001-10-04
CZ292931B6 (cs)	2004-01-14
EP1067935B1 (de)	2003-08-20
PL345687A1 (en)	2002-01-02
CN1306427A (zh)	2001-08-01
BR9909378A (pt)	2000-12-05
CA2326764A1 (en)	1999-10-14
JP4574846B2 (ja)	2010-11-04
DE69910552D1 (de)	2003-09-25
IL138284A0 (en)	2001-10-31
PT1067935E (pt)	2004-01-30
RU2246498C2 (ru)	2005-02-20
NO20004383L (no)	2000-10-09
KR20010042192A (ko)	2001-05-25
ES2207194T3 (es)	2004-05-16
WO1999051240A1 (en)	1999-10-14
CA2326764C (en)	2010-12-14
AU736376B2 (en)	2001-07-26
DK1067935T3 (da)	2003-11-24
HUP0102321A3 (en)	2002-01-28
WO1999051240A8 (en)	2001-03-22
HUP0102321A2 (hu)	2001-11-28
HK1039060B (zh)	2005-05-13
AU3379899A (en)	1999-10-25
HK1039060A1 (en)	2002-04-12
CZ20003614A3 (cs)	2001-01-17

Legal Events

Date

Code

Title

Description

2004-05-15

UEP

Publication of translation of european patent specification

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