NO993768L - Benzofuranforbindelser som forbedrer AMPA-reseptoraktivitet - Google Patents

Benzofuranforbindelser som forbedrer AMPA-reseptoraktivitet

Info

Publication number: NO993768L
Authority: NO; Norway
Prior art keywords: compounds; ampa receptor; improve; receptor activity; receptors
Prior art date: 1997-02-13

Application number

NO993768A

Other languages

English (en)

Other versions

NO993768D0 (no

NO318935B1 (no

Inventor

Gary A Rogers

Christopher M Marrs

Original Assignee

Univ California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-13

Filing date

1999-08-04

Publication date

1999-09-23

1999-08-04 Application filed by Univ California filed Critical Univ California

1999-08-04 Publication of NO993768D0 publication Critical patent/NO993768D0/no

1999-09-23 Publication of NO993768L publication Critical patent/NO993768L/no

2005-05-30 Publication of NO318935B1 publication Critical patent/NO318935B1/no

Links

102000003678 AMPA Receptors Human genes 0.000 title abstract 4
108090000078 AMPA Receptors Proteins 0.000 title abstract 4
150000001907 coumarones Chemical class 0.000 title 1
230000006399 behavior Effects 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
210000004556 brain Anatomy 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
230000002964 excitative effect Effects 0.000 abstract 1
206010027175 memory impairment Diseases 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1
210000000225 synapse Anatomy 0.000 abstract 1
230000000946 synaptic effect Effects 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Luminescent Compositions (AREA)
Furan Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

NO19993768A 1997-02-13 1999-08-04 Benzofuranforbindelser som forbedrer AMPA-reseptoraktivitet NO318935B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/800,108 US6110935A (en)	1997-02-13	1997-02-13	Benzofurazan compounds for enhancing glutamatergic synaptic responses
PCT/US1998/002713 WO1998035950A1 (en)	1997-02-13	1998-02-13	Benzofurazan compounds which enhance ampa receptor activity

Publications (3)

Publication Number	Publication Date
NO993768D0 NO993768D0 (no)	1999-08-04
NO993768L true NO993768L (no)	1999-09-23
NO318935B1 NO318935B1 (no)	2005-05-30

Family

ID=25177504

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19993768A NO318935B1 (no)	1997-02-13	1999-08-04	Benzofuranforbindelser som forbedrer AMPA-reseptoraktivitet

Country Status (24)

Country	Link
US (3)	US6110935A (no)
EP (2)	EP0960105B1 (no)
JP (1)	JP4446023B2 (no)
KR (1)	KR100544295B1 (no)
CN (1)	CN1085206C (no)
AT (2)	ATE266649T1 (no)
AU (1)	AU737802C (no)
BR (1)	BR9807333B1 (no)
CA (1)	CA2279319C (no)
CZ (1)	CZ299765B6 (no)
DE (2)	DE69823803T2 (no)
DK (2)	DK0960105T3 (no)
ES (2)	ES2264078T3 (no)
GB (1)	GB2325225B (no)
HU (1)	HUP0002303A3 (no)
ID (1)	ID22342A (no)
IL (1)	IL131200A (no)
NO (1)	NO318935B1 (no)
NZ (1)	NZ336980A (no)
PL (1)	PL199135B1 (no)
PT (2)	PT960105E (no)
RU (1)	RU2189984C2 (no)
TR (1)	TR199901941T2 (no)
WO (1)	WO1998035950A1 (no)

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* Cited by examiner, † Cited by third party
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IN188837B (no)	1998-05-22	2002-11-09	Torrent Pharmaceuticals Ltd
AU2002366756A1 (en) *	2001-12-20	2003-07-09	Alangudi Sankaranarayanan	Use of benzofuroxan derivatives as antiplatelet agents
KR20050094840A (ko) *	2003-01-13	2005-09-28	코텍스 파마슈티칼스, 인크.	수면 부족 및 스트레스로 인한 인식 저하의 치료방법
WO2004103994A1 (en) *	2003-05-23	2004-12-02	Basilea Pharmaceutica Ag	Furazanobenzimidazoles
US20050228019A1 (en) *	2004-01-26	2005-10-13	Cortex Pharmaceuticals, Inc.	Enhancement of ampakine-Induced facilitation of synaptic responses by cholinesterase inhibitors
CN101600436A (zh) *	2006-08-31	2009-12-09	艾伯塔大学校董	使用正变构ampa受体调节剂抑制呼吸抑制的方法
BRPI0720323A2 (pt) *	2007-01-03	2016-08-09	Cortex Pharma Inc	composto, método de tratamento, composição farmacêutica e uso do composto
GEP20125438B (en) *	2007-01-03	2012-03-26	Servier Lab	3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses
WO2008143963A1 (en) *	2007-05-17	2008-11-27	Cortex Pharmaceuticals, Inc.	Di-substituted amides for enhancing glutamatergic synaptic responses
CA2695742C (en)	2007-08-10	2012-11-27	Rudolf Mueller	Bicyclic amides for enhancing glutamatergic synaptic responses
US8119632B2 (en)	2007-08-10	2012-02-21	Cortex Pharmaceuticals, Inc.	Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
US8071914B2 (en) *	2007-12-26	2011-12-06	Noboru Oshima	Heating apparatus
WO2010054336A2 (en) *	2008-11-10	2010-05-14	The Regents Of The University Of California	Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
CA2751285A1 (en) *	2009-02-02	2010-08-05	Cortex Pharmaceuticals, Inc. Eveleth, Gary S. Lynch)	Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
US20130058915A1 (en)	2010-03-02	2013-03-07	Children's Medica Center Corporation	Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
US20110257186A1 (en) *	2010-04-15	2011-10-20	Staubli Ursula V	Compositions and methods for treating visual disorders
EP2801377B1 (en)	2011-03-04	2019-08-07	The Regents of The University of California	Hydrogel comprising cells for local release of growth factors to mediate motor recovery after stroke
CN102633731B (zh) *	2012-03-13	2014-04-30	四川大学华西医院	6-喹喔啉甲酸酰胺化合物、制备方法和应用
KR101421032B1 (ko) *	2012-12-28	2014-07-22	주식회사 레고켐 바이오사이언스	(2-메틸-1-(3-메틸벤질)-1Ｈ-벤조[d]이미다졸-5일)(피페리딘-5-일)메탄온의 제조방법
EP3008167A4 (en)	2013-06-13	2017-06-07	VeroScience LLC	Compositions and methods for treating metabolic disorders
EP3436021A4 (en)	2016-03-29	2019-11-06	RespireRx Pharmaceuticals Inc.	COMPOSITIONS AND METHODS FOR TREATING ATTENTION DEFICIT DISORDER
CN107286114B (zh)	2016-04-13	2020-08-18	中国人民解放军军事医学科学院毒物药物研究所	Ampa受体增效剂的脑靶向前药及其医药用途

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US3981864A (en) *	1973-09-08	1976-09-21	Eisai Co., Ltd.	1,3-Benzodioxol derivatives
FR2499991A1 (fr) *	1981-02-19	1982-08-20	Sandoz Sa	Nouveaux 2,1,3-benzothiadiazoles et 2,1,3-benzoxadiazoles, leur preparation et leur application comme medicaments
US4420485A (en) *	1982-09-29	1983-12-13	Hoechst-Roussel Pharmaceuticals Inc.	1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines]
SU1657189A1 (ru) *	1988-05-23	1991-06-23	Научно-Исследовательский Институт Экспериментальной Медицины Амн Ссср	Способ коррекции апато-абулических состо ний при шизофрении
SU1587050A1 (ru) *	1988-12-23	1990-08-23	Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского	Производные (7-бромбензо-2,1,3-тиадиазол-4-сульфонил)амина в качестве промежуточных продуктов в синтезе 2-[(7-бромбензо-2,1,3-тиадиазол-4-сульфонил)амино]-5-бром-N-(4-хлорфенил)бензамида, обладающего антигельминтной активностью
US5032604A (en) *	1989-12-08	1991-07-16	Merck & Co., Inc.	Class III antiarrhythmic agents
US5112824A (en) *	1989-12-08	1992-05-12	Merck & Co., Inc.	Benzofuran compounds as class III antiarrhythmic agents
IL96507A0 (en) *	1989-12-08	1991-08-16	Merck & Co Inc	Nitrogen-containing spirocycles and pharmaceutical compositions containing them
EP0651746B1 (en) *	1992-07-24	2002-03-27	The Regents of the University of California	Drugs that enhance synaptic responses mediated by ampa receptors
ATE174915T1 (de) *	1994-10-31	1999-01-15	Merck Patent Gmbh	Benzylpiperidinderivate mit hoher affinität zu bindungsstellen von aminosäure-rezeptoren
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US5985871A (en)	1997-12-24	1999-11-16	Cortex Pharmaceuticals, Inc.	Benzoxazine compounds for enhancing synaptic response

1997
- 1997-02-13 US US08/800,108 patent/US6110935A/en not_active Expired - Lifetime
1998
- 1998-02-13 RU RU99119488/04A patent/RU2189984C2/ru not_active IP Right Cessation
- 1998-02-13 EP EP98906358A patent/EP0960105B1/en not_active Expired - Lifetime
- 1998-02-13 BR BRPI9807333-8A patent/BR9807333B1/pt not_active IP Right Cessation
- 1998-02-13 IL IL13120098A patent/IL131200A/xx not_active IP Right Cessation
- 1998-02-13 ID IDW990855A patent/ID22342A/id unknown
- 1998-02-13 KR KR1019997007369A patent/KR100544295B1/ko not_active Expired - Fee Related
- 1998-02-13 CN CN98802541A patent/CN1085206C/zh not_active Expired - Fee Related
- 1998-02-13 DE DE69823803T patent/DE69823803T2/de not_active Expired - Lifetime
- 1998-02-13 CZ CZ0279599A patent/CZ299765B6/cs not_active IP Right Cessation
- 1998-02-13 ES ES04075259T patent/ES2264078T3/es not_active Expired - Lifetime
- 1998-02-13 DK DK98906358T patent/DK0960105T3/da active
- 1998-02-13 DE DE69834590T patent/DE69834590T2/de not_active Expired - Lifetime
- 1998-02-13 JP JP53589698A patent/JP4446023B2/ja not_active Expired - Fee Related
- 1998-02-13 EP EP04075259A patent/EP1428534B1/en not_active Expired - Lifetime
- 1998-02-13 DK DK04075259T patent/DK1428534T3/da active
- 1998-02-13 PL PL335058A patent/PL199135B1/pl not_active IP Right Cessation
- 1998-02-13 AT AT98906358T patent/ATE266649T1/de active
- 1998-02-13 WO PCT/US1998/002713 patent/WO1998035950A1/en not_active Ceased
- 1998-02-13 PT PT98906358T patent/PT960105E/pt unknown
- 1998-02-13 HU HU0002303A patent/HUP0002303A3/hu unknown
- 1998-02-13 ES ES98906358T patent/ES2221152T3/es not_active Expired - Lifetime
- 1998-02-13 US US09/355,139 patent/US6313115B1/en not_active Expired - Fee Related
- 1998-02-13 TR TR1999/01941T patent/TR199901941T2/xx unknown
- 1998-02-13 AU AU61599/98A patent/AU737802C/en not_active Ceased
- 1998-02-13 AT AT04075259T patent/ATE326221T1/de active
- 1998-02-13 PT PT04075259T patent/PT1428534E/pt unknown
- 1998-02-13 NZ NZ336980A patent/NZ336980A/xx not_active IP Right Cessation
- 1998-02-13 GB GB9809221A patent/GB2325225B/en not_active Expired - Fee Related
- 1998-02-13 CA CA002279319A patent/CA2279319C/en not_active Expired - Fee Related
1999
- 1999-08-04 NO NO19993768A patent/NO318935B1/no not_active IP Right Cessation
2001
- 2001-04-27 US US09/845,128 patent/US6730677B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1428534B1 (en)	2006-05-17
AU6159998A (en)	1998-09-08
DK1428534T3 (da)	2006-06-12
DE69834590D1 (de)	2006-06-22
EP1428534A1 (en)	2004-06-16
HUP0002303A2 (hu)	2001-04-28
ATE266649T1 (de)	2004-05-15
CZ279599A3 (cs)	2000-01-12
ES2264078T3 (es)	2006-12-16
BR9807333B1 (pt)	2011-10-18
IL131200A0 (en)	2001-01-28
DE69823803T2 (de)	2005-04-14
ATE326221T1 (de)	2006-06-15
CA2279319C (en)	2008-08-05
JP4446023B2 (ja)	2010-04-07
AU737802B2 (en)	2001-08-30
CN1247534A (zh)	2000-03-15
AU737802C (en)	2005-05-12
NZ336980A (en)	2000-08-25
ES2221152T3 (es)	2004-12-16
NO993768D0 (no)	1999-08-04
NO318935B1 (no)	2005-05-30
US6110935A (en)	2000-08-29
HUP0002303A3 (en)	2002-09-30
PL335058A1 (en)	2000-03-27
GB2325225B (en)	1999-03-03
GB9809221D0 (no)	1998-07-01
TR199901941T2 (xx)	1999-12-21
BR9807333A (pt)	2000-04-18
IL131200A (en)	2005-06-19
GB2325225A8 (en)	1999-02-17
WO1998035950A1 (en)	1998-08-20
CA2279319A1 (en)	1998-08-20
DE69823803D1 (de)	2004-06-17
US6730677B2 (en)	2004-05-04
CZ299765B6 (cs)	2008-11-19
DK0960105T3 (da)	2004-08-30
EP0960105B1 (en)	2004-05-12
GB2325225A (en)	1998-11-18
ID22342A (id)	1999-09-30
KR100544295B1 (ko)	2006-01-23
JP2001512459A (ja)	2001-08-21
CN1085206C (zh)	2002-05-22
US6313115B1 (en)	2001-11-06
PT960105E (pt)	2004-09-30
EP0960105A1 (en)	1999-12-01
DE69834590T2 (de)	2007-04-26
PL199135B1 (pl)	2008-08-29
US20020055508A1 (en)	2002-05-09
PT1428534E (pt)	2006-07-31
KR20000071082A (ko)	2000-11-25
RU2189984C2 (ru)	2002-09-27

Legal Events

Date	Code	Title	Description
2012-10-01	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO993768L (no)	1999-09-23	Benzofuranforbindelser som forbedrer AMPA-reseptoraktivitet
DK0891365T3 (da)	2003-02-10	Benzoxaziner til forstærkning af synaptiske responser
DE69811363D1 (de)	2003-03-20	Piperazin-derivate und ihre verwendung als entzündungshemmende mittel
PT839134E (pt)	2004-07-30	Benzoilpiperidinas/pirrolidinas para melhoramento da resposta sinaptica
DE60024588D1 (de)	2006-01-12	Substituierte porphyrine und deren therapeutische verwendungen
ES2155601T3 (es)	2001-05-16	Compuestos de benzolactama sustituidos como antagonistas de la sustancia p.
BR0015416A (pt)	2002-07-16	Composições contendo derivados do ácido hidroxieicosa tetraenóico e métodos de uso no tratamento de distúrbios de olhos secos
DK1054673T3 (da)	2004-07-05	Benzoxazinforbindelser til forstærkelse af synaptisk reaktion
MX232591B (es)	2005-12-02	Procedimiento para tratar infecciones oculares con azitromicina
PT1067935E (pt)	2004-01-30	Acilbenzoxazinas para melhorar resposta (s) sinaptica (s)
ATE215374T1 (de)	2002-04-15	Wässrige, haltbare suspension von mesalazin zum topischen gebrauch
BR9612074A (pt)	1999-03-30	Novos 4-(1h-benzimidazol-2-il)(1,4) diazepanos substituidos úteis para o tratamento de doenças alérgicas
EA200400584A1 (ru)	2005-02-24	Соединения карбонилбензоксазина для усиления глутаматергических синаптических ответов
BR0015402A (pt)	2002-06-25	Derivados de ácido 15-hidroxieicosatetraenóico de cadeia Èmega modificada e métodos de seu uso para o tratamento de olho seco