ATE247628T1 - Verfahren zur herstellung von gabapentin - Google Patents

Verfahren zur herstellung von gabapentin

Info

Publication number: ATE247628T1
Authority: AT; Austria
Prior art keywords: gabapentin; retentate; solution; unsalified; addition
Prior art date: 1999-03-26

Application number

AT00910850T

Other languages

English (en)

Inventor

Franco Tenconi

Cristiana Giordani

Nicola Caraccia

Original Assignee

Bioindustria Lab Italiano Medi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-26

Filing date

2000-03-16

Publication date

2003-09-15

2000-03-16 Application filed by Bioindustria Lab Italiano Medi filed Critical Bioindustria Lab Italiano Medi

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE247628T1 publication Critical patent/ATE247628T1/de

Links

UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 title abstract 12
229960002870 gabapentin Drugs 0.000 title abstract 6
238000004519 manufacturing process Methods 0.000 title 1
239000012465 retentate Substances 0.000 abstract 4
239000000243 solution Substances 0.000 abstract 3
XBUDZAQEMFGLEU-UHFFFAOYSA-N 2-[1-(aminomethyl)cyclohexyl]acetic acid;hydron;chloride Chemical compound Cl.OC(=O)CC1(CN)CCCCC1 XBUDZAQEMFGLEU-UHFFFAOYSA-N 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 2
239000012528 membrane Substances 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
150000007514 bases Chemical class 0.000 abstract 1
238000011026 diafiltration Methods 0.000 abstract 1
238000001704 evaporation Methods 0.000 abstract 1
150000002500 ions Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000002894 organic compounds Chemical class 0.000 abstract 1
239000012466 permeate Substances 0.000 abstract 1
230000001376 precipitating effect Effects 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Separation Using Semi-Permeable Membranes (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT00910850T 1999-03-26 2000-03-16 Verfahren zur herstellung von gabapentin ATE247628T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1999MI000625A IT1311984B1 (it)	1999-03-26	1999-03-26	Procedimento per la preparzione di gabapentin.
PCT/EP2000/002345 WO2000058268A1 (en)	1999-03-26	2000-03-16	A process for the preparation of gabapentin

Publications (1)

Publication Number	Publication Date
ATE247628T1 true ATE247628T1 (de)	2003-09-15

Family

ID=11382457

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00910850T ATE247628T1 (de)	1999-03-26	2000-03-16	Verfahren zur herstellung von gabapentin

Country Status (11)

Country	Link
US (1)	US6576790B1 (de)
EP (1)	EP1165489B1 (de)
AT (1)	ATE247628T1 (de)
AU (1)	AU3290400A (de)
CA (1)	CA2368476C (de)
DE (1)	DE60004652T2 (de)
DK (1)	DK1165489T3 (de)
ES (1)	ES2204533T3 (de)
IT (1)	IT1311984B1 (de)
PT (1)	PT1165489E (de)
WO (1)	WO2000058268A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU228771B1 (en) *	1998-05-15	2013-05-28	Warner Lambert Co	Stabilized pharmaceutical preparations of gamma-aminobutyric acid derivatives and process for preparing the same
ITMI20012750A1 (it)	2001-12-21	2003-06-21	Procos Spa	Processo per la produzione dell'acido 1-(amminometil)-cicloesil-acetico in forma pura
WO2003089403A1 (en) *	2002-04-16	2003-10-30	Taro Pharmaceutical Industries Ltd.	Process for preparing gabapentin
AU2002356424A1 (en)	2002-11-18	2004-06-15	Nicholas Piramal India Limited	Improved process for preparation of gabapentin
PT1603863E (pt) *	2002-11-20	2010-02-05	Hikal Ltd	Processo para a preparação de ácidos amino-metil-cicloalcano-acéticos
US20070043236A1 (en) *	2003-05-19	2007-02-22	Chandiran Thakashina M	Process for preparation of gabapentin
ITMI20031247A1 (it) *	2003-06-20	2004-12-21	Zambon Spa	Processo per la purificazione di gabapentina
US20050187295A1 (en) *	2004-02-19	2005-08-25	Surendra Kalyan	Processes for the preparation of gabapentin
ITMI20040579A1 (it)	2004-03-25	2004-06-25	Zambon Spa	Processo di preparazione di gabapentina
ES2246159B1 (es) *	2004-07-22	2007-03-16	Menadiona, S.L.	Procedimiento para la obtencion de aminoacidos ciclicos.
CN116693410B (zh) *	2023-06-08	2024-06-07	浙江竹子制药有限公司	一种粒径可控的加巴喷丁制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2460891C2 (de)	1974-12-21	1982-09-23	Gödecke AG, 1000 Berlin	1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4894476A (en) *	1988-05-02	1990-01-16	Warner-Lambert Company	Gabapentin monohydrate and a process for producing the same
US4960931A (en) *	1988-05-02	1990-10-02	Warner-Lambert Company	Gabapentin mohohydrate and a process for producing the same
DE3928184A1 (de) *	1989-08-25	1991-02-28	Goedecke Ag	Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte
US5491259A (en) *	1994-09-13	1996-02-13	The Dow Chemical Company	Process to produce aminocarboxylic acids containing low residual salt
IL119890A (en) *	1996-12-24	2002-03-10	Teva Pharma	Gabapentin form iii and preparation of gabapentin form ii

1999
- 1999-03-26 IT IT1999MI000625A patent/IT1311984B1/it active
2000
- 2000-03-16 DK DK00910850T patent/DK1165489T3/da active
- 2000-03-16 AT AT00910850T patent/ATE247628T1/de active
- 2000-03-16 WO PCT/EP2000/002345 patent/WO2000058268A1/en not_active Ceased
- 2000-03-16 PT PT00910850T patent/PT1165489E/pt unknown
- 2000-03-16 DE DE60004652T patent/DE60004652T2/de not_active Expired - Lifetime
- 2000-03-16 AU AU32904/00A patent/AU3290400A/en not_active Abandoned
- 2000-03-16 US US09/937,378 patent/US6576790B1/en not_active Expired - Lifetime
- 2000-03-16 ES ES00910850T patent/ES2204533T3/es not_active Expired - Lifetime
- 2000-03-16 CA CA002368476A patent/CA2368476C/en not_active Expired - Fee Related
- 2000-03-16 EP EP00910850A patent/EP1165489B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US6576790B1 (en)	2003-06-10
ES2204533T3 (es)	2004-05-01
IT1311984B1 (it)	2002-03-22
CA2368476A1 (en)	2000-10-05
EP1165489A1 (de)	2002-01-02
CA2368476C (en)	2009-12-08
AU3290400A (en)	2000-10-16
EP1165489B1 (de)	2003-08-20
PT1165489E (pt)	2003-12-31
WO2000058268A1 (en)	2000-10-05
ITMI990625A1 (it)	2000-09-26
DE60004652T2 (de)	2004-06-24
DK1165489T3 (da)	2003-12-15
DE60004652D1 (de)	2003-09-25

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2004-04-15

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