ATE247665T1 - Kombinierter prozess zur reinigung von vancomycin hydrochlorid - Google Patents

Kombinierter prozess zur reinigung von vancomycin hydrochlorid

Info

Publication number: ATE247665T1
Authority: AT; Austria
Prior art keywords: pct; vancomycin hydrochloride; sec; silica gel; product
Prior art date: 1995-02-07

Application number

AT96901183T

Other languages

English (en)

Inventor

Zlatko Pflaum

Robert Turkalj

Original Assignee

Lek Farmacevtska Druzba Dd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-07

Filing date

1996-02-06

Publication date

2003-09-15

1996-02-06 Application filed by Lek Farmacevtska Druzba Dd filed Critical Lek Farmacevtska Druzba Dd

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE247665T1 publication Critical patent/ATE247665T1/de

Links

108010059993 Vancomycin Proteins 0.000 title abstract 4
229960001572 vancomycin hydrochloride Drugs 0.000 title abstract 4
LCTORFDMHNKUSG-XTTLPDOESA-N vancomycin monohydrochloride Chemical compound Cl.O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 LCTORFDMHNKUSG-XTTLPDOESA-N 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
239000000741 silica gel Substances 0.000 abstract 2
229910002027 silica gel Inorganic materials 0.000 abstract 2
230000005526 G1 to G0 transition Effects 0.000 abstract 1
238000004587 chromatography analysis Methods 0.000 abstract 1
238000001914 filtration Methods 0.000 abstract 1
239000012535 impurity Substances 0.000 abstract 1
238000007911 parenteral administration Methods 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
238000004237 preparative chromatography Methods 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)

AT96901183T 1995-02-07 1996-02-06 Kombinierter prozess zur reinigung von vancomycin hydrochlorid ATE247665T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SI9500039A SI9500039B (sl)	1995-02-07	1995-02-07	Nov kombiniran postopek čiščenja Vankomicin hidroklorida
PCT/SI1996/000003 WO1996024615A1 (en)	1995-02-07	1996-02-06	New combined process for the purification of vancomycin hydrochloride

Publications (1)

Publication Number	Publication Date
ATE247665T1 true ATE247665T1 (de)	2003-09-15

Family

ID=20431542

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96901183T ATE247665T1 (de)	1995-02-07	1996-02-06	Kombinierter prozess zur reinigung von vancomycin hydrochlorid

Country Status (11)

Country	Link
US (1)	US5853720A (de)
EP (1)	EP0809652B1 (de)
JP (1)	JPH10513196A (de)
AT (1)	ATE247665T1 (de)
AU (1)	AU4500396A (de)
CA (1)	CA2210990C (de)
DE (1)	DE69629551T2 (de)
DK (1)	DK0809652T3 (de)
ES (1)	ES2205012T3 (de)
SI (1)	SI9500039B (de)
WO (1)	WO1996024615A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI233932B (en) *	2001-08-24	2005-06-11	Theravance Inc	Process for purifying glycopeptide phosphonate derivatives
MXPA05005338A (es) *	2002-11-18	2005-12-14	Vicuron Pharm Inc	Metodos para administrar dalbavancin para el tratamiento de infecciones bacterianas.
KR100554481B1 (ko) *	2004-06-30	2006-03-03	씨제이 주식회사	반코마이신 염산염의 정제방법
CN100408596C (zh) *	2005-11-30	2008-08-06	上海医药工业研究院	供hplc分析的万古霉素发酵液前处理方法
EP1798237A1 (de)	2005-12-16	2007-06-20	Pharmatex Italia Srl	Prozess zur Reinigung von Makrolid-Antibiotika
KR101101663B1 (ko) *	2009-01-13	2011-12-30	(주) 제노텍	반코마이신 습체의 정제방법
JP2011153119A (ja) *	2010-01-27	2011-08-11	Mylan Seiyaku Ltd	バンコマイシンまたはその塩を含有する錠剤
US8709310B2 (en) *	2011-01-05	2014-04-29	Hospira, Inc.	Spray drying vancomycin
CN104043104B (zh)	2013-03-15	2018-07-10	浙江创新生物有限公司	含盐酸万古霉素的喷雾干粉及其工业化制备方法
CN104610434B (zh) *	2013-11-01	2019-06-07	浙江医药股份有限公司新昌制药厂	一种盐酸万古霉素的分离纯化方法
CN104991028B (zh) *	2015-07-31	2017-10-31	北京市药品检验所	Lc‑ms测试物中不挥发性缓冲盐含量的降低方法
CN105461786B (zh) *	2016-01-23	2018-11-16	雅赛利(台州)制药有限公司	一种盐酸万古霉素的分离纯化工艺

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2577133B2 (ja) *	1989-11-27	1997-01-29	スティフティングフォールドテフニスヘウェッテンスハッペン	船舶のプロペラ
US5235037A (en) *	1991-08-15	1993-08-10	American Cyanamid Company	Vancomycin precipitation process

1995
- 1995-02-07 SI SI9500039A patent/SI9500039B/sl not_active IP Right Cessation
1996
- 1996-02-06 WO PCT/SI1996/000003 patent/WO1996024615A1/en not_active Ceased
- 1996-02-06 DK DK96901183T patent/DK0809652T3/da active
- 1996-02-06 AT AT96901183T patent/ATE247665T1/de not_active IP Right Cessation
- 1996-02-06 AU AU45003/96A patent/AU4500396A/en not_active Abandoned
- 1996-02-06 ES ES96901183T patent/ES2205012T3/es not_active Expired - Lifetime
- 1996-02-06 US US08/875,443 patent/US5853720A/en not_active Expired - Fee Related
- 1996-02-06 JP JP8524215A patent/JPH10513196A/ja not_active Withdrawn
- 1996-02-06 EP EP96901183A patent/EP0809652B1/de not_active Expired - Lifetime
- 1996-02-06 DE DE69629551T patent/DE69629551T2/de not_active Expired - Fee Related
- 1996-02-06 CA CA002210990A patent/CA2210990C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1996024615A1 (en)	1996-08-15
SI9500039A (en)	1996-08-31
AU4500396A (en)	1996-08-27
EP0809652B1 (de)	2003-08-20
JPH10513196A (ja)	1998-12-15
US5853720A (en)	1998-12-29
ES2205012T3 (es)	2004-05-01
CA2210990A1 (en)	1996-08-15
DE69629551T2 (de)	2004-06-17
CA2210990C (en)	2001-07-03
EP0809652A1 (de)	1997-12-03
DK0809652T3 (da)	2003-12-08
SI9500039B (sl)	2002-02-28
DE69629551D1 (de)	2003-09-25

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Legal Events

Date	Code	Title	Description
2004-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties