ATE247953T1 - Arzneimittel mit verzögerter wirkstoffabgabe enthaltend isoquercetin und ascorbinsäure - Google Patents

Arzneimittel mit verzögerter wirkstoffabgabe enthaltend isoquercetin und ascorbinsäure

Info

Publication number: ATE247953T1
Authority: AT; Austria
Prior art keywords: isoquercetin; ascorbic acid; delayed; products containing; medicinal products
Prior art date: 1999-03-16

Application number

AT00910786T

Other languages

English (en)

Inventor

Herwig Buchholz

Jerzy D Meduski

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-16

Filing date

2000-03-08

Publication date

2003-09-15

2000-03-08 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE247953T1 publication Critical patent/ATE247953T1/de

Links

CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title abstract 4
OVSQVDMCBVZWGM-IDRAQACASA-N Hirsutrin Natural products O([C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1)C1=C(c2cc(O)c(O)cc2)Oc2c(c(O)cc(O)c2)C1=O OVSQVDMCBVZWGM-IDRAQACASA-N 0.000 title abstract 2
FVQOMEDMFUMIMO-UHFFFAOYSA-N Hyperosid Natural products OC1C(O)C(O)C(CO)OC1OC1C(=O)C2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 FVQOMEDMFUMIMO-UHFFFAOYSA-N 0.000 title abstract 2
OVSQVDMCBVZWGM-QCKGUQPXSA-N isoquercetin Natural products OC[C@@H]1O[C@@H](OC2=C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)c(O)c4)[C@H](O)[C@@H](O)[C@@H]1O OVSQVDMCBVZWGM-QCKGUQPXSA-N 0.000 title abstract 2
OVSQVDMCBVZWGM-QSOFNFLRSA-N quercetin 3-O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-QSOFNFLRSA-N 0.000 title abstract 2
229960005070 ascorbic acid Drugs 0.000 title 1
235000010323 ascorbic acid Nutrition 0.000 title 1
239000011668 ascorbic acid Substances 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
239000000203 mixture Substances 0.000 abstract 2
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract 1
SXZYCXMUPBBULW-SKNVOMKLSA-N L-gulono-1,4-lactone Chemical compound OC[C@H](O)[C@H]1OC(=O)[C@@H](O)[C@H]1O SXZYCXMUPBBULW-SKNVOMKLSA-N 0.000 abstract 1
229930003268 Vitamin C Natural products 0.000 abstract 1
210000004556 brain Anatomy 0.000 abstract 1
230000007074 memory dysfunction Effects 0.000 abstract 1
239000004090 neuroprotective agent Substances 0.000 abstract 1
230000003449 preventive effect Effects 0.000 abstract 1
230000002035 prolonged effect Effects 0.000 abstract 1
239000012730 sustained-release form Substances 0.000 abstract 1
235000019154 vitamin C Nutrition 0.000 abstract 1
239000011718 vitamin C Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Organic Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Toxicology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

AT00910786T 1999-03-16 2000-03-08 Arzneimittel mit verzögerter wirkstoffabgabe enthaltend isoquercetin und ascorbinsäure ATE247953T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US12486399P	1999-03-16	1999-03-16
PCT/EP2000/002008 WO2000054754A2 (en)	1999-03-16	2000-03-08	Composition comprising isoquercetin and ascorbic acid in a sustained release form

Publications (1)

Publication Number	Publication Date
ATE247953T1 true ATE247953T1 (de)	2003-09-15

Family

ID=22417166

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00910786T ATE247953T1 (de)	1999-03-16	2000-03-08	Arzneimittel mit verzögerter wirkstoffabgabe enthaltend isoquercetin und ascorbinsäure

Country Status (10)

Country	Link
US (1)	US6491948B1 (de)
EP (1)	EP1161228B1 (de)
JP (1)	JP2003526619A (de)
AT (1)	ATE247953T1 (de)
AU (1)	AU3287200A (de)
CA (1)	CA2367387C (de)
DE (1)	DE60004797T2 (de)
DK (1)	DK1161228T3 (de)
ES (1)	ES2204531T3 (de)
WO (1)	WO2000054754A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19809304A1 (de) *	1998-03-05	1999-09-09	Merck Patent Gmbh	Formulierungen mit antiviraler Wirkung
CN1477958A (zh) *	2000-10-31	2004-02-25	高露洁-棕榄公司	组合物及方法
PL206379B1 (pl) *	2002-07-15	2010-08-31	Alcon	Ulegająca bioerozji kompozycja do wytwarzania błony do dostarczania leków oftalmicznych i zastosowanie
EP1817023A4 (de) *	2004-11-16	2010-08-18	Limerick Biopharma Inc	Verfahren und zusammensetzungen zur schmerzbehandlung
US20070087977A1 (en) *	2004-11-16	2007-04-19	Wendye Robbins	Methods and compositions for treating pain
JP2006160668A (ja) *	2004-12-08	2006-06-22	Sanei Gen Ffi Inc	過酸化脂質生成抑制剤
WO2008011364A2 (en) *	2006-07-17	2008-01-24	Thomas Christian Lines	Quercetin-containing compositions
WO2008011363A2 (en) *	2006-07-17	2008-01-24	Thomas Christian Lines	Quercetin-containing compositions
EP2200605A4 (de) *	2007-10-01	2011-03-23	Quercegen Pharma Llc	Verfahren zur stabilisierung von quercetin
US8044096B2 (en) *	2008-01-18	2011-10-25	Quercegen Pharmaceuticals Llc	Method for treating addiction using quercetin-containing compositions
US8574619B2 (en) *	2008-09-05	2013-11-05	Quercegen Pharmaceuticals, LLC	Reducing cholesterol levels with combined use of quercetin and statin
US8034363B2 (en) *	2008-12-11	2011-10-11	Advanced Technologies And Regenerative Medicine, Llc.	Sustained release systems of ascorbic acid phosphate
TWI660680B (zh)	2012-11-26	2019-06-01	美商通路實業集團國際公司	抗氧化膳食增補劑及其相關方法
JP6175048B2 (ja) *	2013-12-27	2017-08-02	花王株式会社	容器詰飲料
ES2743785T3 (es)	2014-12-23	2020-02-20	Hermes Arzneimittel Gmbh	Granulado directo con principio activo de liberación retardada
WO2017096049A1 (en)	2015-12-03	2017-06-08	The University Of North Carolina At Pembroke	Materials for cathepsin b enhancement and methods of use
TWI761672B (zh)	2018-04-23	2022-04-21	日商阿爾卑斯藥品工業股份有限公司	O-醣苷基類黃酮之組成物
EP3886838A4 (de)	2018-11-30	2022-08-10	Beth Israel Deaconess Medical Center, Inc.	Zusammensetzungen und verfahren zur verminderung von schweren thrombotischen ereignissen bei krebspatienten
US10617705B1 (en) *	2019-01-24	2020-04-14	Alps Pharmaceutical Ind. Co., Ltd.	Isoquercitrin compositions
US10918654B1 (en)	2019-09-23	2021-02-16	Alps Pharmaceutical Ind. Co., Ltd.	Rutin compositions
US11110109B2 (en)	2019-10-22	2021-09-07	Alps Pharmaceutical Ind. Co., Ltd.	Water soluble O-glycosyl flavonoid compositions and methods for preparing same
CN113712982B (zh) *	2021-09-13	2022-12-06	广东金骏康生物技术有限公司	一种预防或治疗非酒精性脂肪肝、肥胖症的组合物及制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5944327A (ja) *	1982-09-06	1984-03-12	Taiyo Kagaku Kk	Ｌ−アスコルビン酸およびその塩類の安定化法
JP2514201B2 (ja) *	1987-04-16	1996-07-10	横浜油脂工業株式会社	微粉状ｌ−アスコルビン酸被覆物の製造方法
JPH01296953A (ja) *	1988-05-24	1989-11-30	Freunt Ind Co Ltd	ビタミンｃ組成物、それを添加した飼料およびその製造方法
JP3016835B2 (ja) *	1990-08-19	2000-03-06	三栄源エフ・エフ・アイ株式会社	アスコルビン酸の褐変防止方法
JP2997303B2 (ja) *	1990-08-19	2000-01-11	三栄源エフ・エフ・アイ株式会社	褐変防止剤
JPH06199690A (ja) *	1992-03-06	1994-07-19	Yunie:Kk	脳代謝促進・脳機能改善剤
JPH06199693A (ja) *	1992-03-06	1994-07-19	Yunie:Kk	虚血性疾患改善治療剤
JPH0745402B2 (ja) *	1993-03-23	1995-05-17	信和薬品株式会社	持続性アスコルビン酸製剤
JPH07196523A (ja) *	1994-01-07	1995-08-01	Oomiya Yakugyo Kk	ケルセチン配糖体を含有する内用液剤
US5972995A (en) *	1997-10-16	1999-10-26	Children's Hospital Medical Center Of Northern California	Compositions and methods for cystic fibrosis therapy
US5972985A (en) *	1997-11-03	1999-10-26	Cytos Pharmaceuticals, Llc	Histidine containing nutriceutical compositions

2000
- 2000-03-08 DK DK00910786T patent/DK1161228T3/da active
- 2000-03-08 JP JP2000604830A patent/JP2003526619A/ja active Pending
- 2000-03-08 DE DE60004797T patent/DE60004797T2/de not_active Expired - Lifetime
- 2000-03-08 AU AU32872/00A patent/AU3287200A/en not_active Abandoned
- 2000-03-08 WO PCT/EP2000/002008 patent/WO2000054754A2/en not_active Ceased
- 2000-03-08 EP EP00910786A patent/EP1161228B1/de not_active Expired - Lifetime
- 2000-03-08 AT AT00910786T patent/ATE247953T1/de not_active IP Right Cessation
- 2000-03-08 ES ES00910786T patent/ES2204531T3/es not_active Expired - Lifetime
- 2000-03-08 CA CA002367387A patent/CA2367387C/en not_active Expired - Fee Related
- 2000-03-15 US US09/525,457 patent/US6491948B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2204531T3 (es)	2004-05-01
EP1161228A2 (de)	2001-12-12
JP2003526619A (ja)	2003-09-09
WO2000054754A3 (en)	2000-12-28
CA2367387A1 (en)	2000-09-21
WO2000054754A2 (en)	2000-09-21
AU3287200A (en)	2000-10-04
DK1161228T3 (da)	2003-11-24
DE60004797T2 (de)	2004-06-17
DE60004797D1 (de)	2003-10-02
EP1161228B1 (de)	2003-08-27
US6491948B1 (en)	2002-12-10
CA2367387C (en)	2009-06-23

Legal Events

Date	Code	Title	Description
2004-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60004797D1 (de)	2003-10-02	Arzneimittel mit verzögerter wirkstoffabgabe enthaltend isoquercetin und ascorbinsäure
EP1283054A4 (de)	2006-04-12	Medikamente zur behandlung von komplikationen des diabetes und neuropathien, und verwendung davon
AU2002218167A1 (en)	2002-03-26	N-phenyl-2-pyrimidine-amine derivatives
TR200500745T2 (tr)	2005-05-23	Damar gelişimi inhibitörleri olarak kuinazolin türevleri.
BG66093B1 (bg)	2011-04-29	Състави с контролирано освобождаване, съдържащи нимесулид
HUP0203451A2 (hu)	2003-02-28	Új, tuberkolózis elleni gyógyszerkészítmények és eljárás előállításukra
DE60001546D1 (de)	2003-04-10	Liponsaürederivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
DE602004022761D1 (de)	2009-10-08	Vitamine B3 und Vitamine C enthaltende Peelingzusammensetzung
DK1289517T3 (da)	2006-04-03	Farmaceutiske sammensætninger indeholdende cannabidiolderivater
TW200630123A (en)	2006-09-01	Oral medicinal product with modified release of at least one active principle in multimicrocapsular form
WO2005000232A3 (en)	2005-04-28	Six membered amino-amide derivatives as angiogenesis inhibitors
MXPA04001328A (es)	2004-05-05	Productos en combinacion de derivados de 1,4-benzotiepina-1,1-dioxido con otros ingredientes activos, y su uso.
DE69923336D1 (de)	2005-02-24	Oral anzuwendende buprenorphinhaltige arzneimittel
DE69006202D1 (de)	1994-03-03	Verbesserungen betreffend die Verabreichung pharmazeutischer Mittel.
TNSN07203A1 (en)	2008-11-21	Pharmaceutical compositions for the treatment of cellulite
ATE286894T1 (de)	2005-01-15	2h-1-benzopyran-derivate, prozesse zu ihrer herstellung und pharmazeutische zusammensetzungen
HUP0600084A2 (en)	2006-06-28	Pharmaceutical compositions containing ascorbic acid derivatives, methods of production of the active ingredient
ATE286893T1 (de)	2005-01-15	2h-1-benzopyran-derivative, prozesse zu ihrer herstellung und pharmazeutische zusammensetzungen
SE0001916D0 (sv)	2000-05-23	Novel formulation
ATE408619T1 (de)	2008-10-15	Lh-rh-antagonisten, deren herstellung und verwendung als arzneimittel
MXPA04001912A (es)	2004-07-23	Aminobenzofenonas novedosas.
MY133230A (en)	2007-10-31	Combination of no synthase inhibitor(s) and metabolic antioxidant(s)
ATE347886T1 (de)	2007-01-15	Arzneizubereitungen enthaltend paclitaxel eingeschlossen in nanopartikeln von polymerischen mizellen
MXPA02003731A (es)	2003-12-11	Derivados novedosos de acido fusidico.
WO2002070537A3 (en)	2002-11-07	Fusidic acid derivatives