ATE248854T1 - 16-hydroxy-11-(substituierte phenyl)-estra-4,9- dien derivate - Google Patents

16-hydroxy-11-(substituierte phenyl)-estra-4,9- dien derivate

Info

Publication number: ATE248854T1
Authority: AT; Austria
Prior art keywords: estra; hydroxy; substituted phenyl; diene derivatives; diene
Prior art date: 1997-01-15

Application number

AT98906887T

Other languages

English (en)

Inventor

Marinus Bernard Groen

Ronald Gebhard

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-15

Filing date

1998-01-13

Publication date

2003-09-15

1998-01-13 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE248854T1 publication Critical patent/ATE248854T1/de

Links

-1 16-HYDROXY-11-(SUBSTITUTED PHENYL)-ESTRA-4,9-DIENE Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Hematology (AREA)
Anesthesiology (AREA)
Child & Adolescent Psychology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT98906887T 1997-01-15 1998-01-13 16-hydroxy-11-(substituierte phenyl)-estra-4,9- dien derivate ATE248854T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97200098		1997-01-15
PCT/EP1998/000377 WO1998031702A1 (en)	1997-01-15	1998-01-13	16-hydroxy-11-(substituted phenyl)-estra-4,9-diene derivatives

Publications (1)

Publication Number	Publication Date
ATE248854T1 true ATE248854T1 (de)	2003-09-15

Family

ID=8227931

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98906887T ATE248854T1 (de)	1997-01-15	1998-01-13	16-hydroxy-11-(substituierte phenyl)-estra-4,9- dien derivate

Country Status (22)

Country	Link
US (1)	US6072068A (de)
EP (1)	EP0973792B1 (de)
JP (1)	JP2001508079A (de)
KR (1)	KR20000070149A (de)
CN (1)	CN1248262A (de)
AR (1)	AR011409A1 (de)
AT (1)	ATE248854T1 (de)
AU (1)	AU736064B2 (de)
BR (1)	BR9807079A (de)
CA (1)	CA2277924A1 (de)
DE (1)	DE69817792T2 (de)
HU (1)	HUP0000901A3 (de)
ID (1)	ID22228A (de)
IL (1)	IL122740A (de)
NO (1)	NO313386B1 (de)
NZ (1)	NZ336790A (de)
PL (1)	PL334518A1 (de)
RU (1)	RU2187510C2 (de)
TR (1)	TR199902367T2 (de)
TW (1)	TW518339B (de)
WO (1)	WO1998031702A1 (de)
ZA (1)	ZA9884B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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PL207610B1 (pl)	1999-04-30	2011-01-31	Pfizer Prod Inc	Związki modulujące receptory glukokortykoidowe, ich zastosowanie do wytwarzania leku i środek farmaceutyczny
US6740645B1 (en) *	1999-09-03	2004-05-25	Research Triangle Institute	17β-acyl-17α-propynyl-11β-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties
DE19961219A1 (de) *	1999-12-15	2001-07-19	Jenapharm Gmbh	11beta-Phenylestratrien-Derivate mit Fluoralkylgruppen in der aromatischen Seitenkette, deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US7713989B2 (en)	2000-04-27	2010-05-11	Dow Robert L	Glucocorticoid receptor modulators
IL146057A (en) *	2000-10-27	2007-09-20	Pfizer Prod Inc	A process for the preparation of modulators of a non-steroidal glucocorticoid receptor
EP1201649B1 (de) *	2000-10-28	2006-05-31	Pfizer Products Inc.	Modulatoren des Glucocorticoid-Rezeptors
ES2246292T3 (es)	2000-10-30	2006-02-16	Pfizer Products Inc.	Moduladores de receptor glucocorticoide.
US7250408B2 (en) *	2002-12-16	2007-07-31	Bayer Schering Pharma Ag	Glucocorticoid receptor antagonists for prophylaxis and therapy of glucocorticoid-mediated hypogonadism, of sexual dysfunction and/or infertility
DK2114970T3 (da)	2007-02-02	2011-09-19	Pfizer Prod Inc	Tricykliske forbindelser og deres anvendelse som glucocorticoidreceptormodulatorer
RU2326673C1 (ru) *	2007-02-27	2008-06-20	ФГУ Национальный научный центр наркологии Росздрава	ПРИМЕНЕНИЕ 17α-АЦЕТАТ-21-ПИВАЛОАТ 17α,21-ДИГИДРОКСИПРЕГН-4-ЕН-3,20-ДИОНА В КАЧЕСТВЕ СРЕДСТВА, СНИЖАЮЩЕГО ПАТОЛОГИЧЕСКОЕ ВЛЕЧЕНИЕ К КОКАИНУ
AU2013289344A1 (en)	2012-07-10	2015-02-05	Bayer Pharma Aktiengesellschaft	3-substituted estra-1,3,5(10),16-tetraene derivatives, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments
MA38349A1 (fr)	2013-02-21	2017-02-28	Bayer Pharma AG	Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3)
RU2017112748A (ru)	2014-11-17	2018-12-19	Арно Терапьютикс, Инк.	Композиции онапристона пролонгированного действия и способы
AU2016326657B2 (en)	2015-09-25	2019-10-24	Context Biopharma, Inc.	Methods of making onapristone intermediates
HK1255104A1 (zh)	2015-12-15	2019-08-02	Context Biopharma Inc.	无定形的奥那司酮组合物及其制备方法
JP6906525B2 (ja) *	2015-12-23	2021-07-21	オリックファーマシューティカルズ，インク．	グルココルチコイド受容体の阻害剤
WO2017112909A1 (en) *	2015-12-23	2017-06-29	Oric Pharmaceuticals, Inc.	Inhibitors of glucocorticoid receptor
US11110103B2 (en)	2015-12-23	2021-09-07	Oric Pharmaceuticals, Inc.	Inhibitors of glucocorticoid receptor
CN106397519A (zh) *	2016-08-30	2017-02-15	天津市中升挑战生物科技有限公司	一种烯丙孕素的制备方法
PT3523315T (pt)	2016-10-07	2021-04-29	Oric Pharmaceuticals Inc	Inibidor de recetor de glucocorticoide
WO2018102369A1 (en)	2016-11-30	2018-06-07	Arno Therapeutics, Inc.	Methods for onapristone synthesis dehydration and deprotection
CN113645979A (zh) *	2018-12-28	2021-11-12	熊猫咨询有限责任公司	短效选择性糖皮质激素受体调节剂
WO2023000135A1 (en) *	2021-07-19	2023-01-26	Context Biopharma Inc.	Processes of making onapristone and intermediates thereof
CN114456223B (zh) *	2022-01-24	2023-07-21	湖南科益新生物医药有限公司	3-缩酮的合成方法
CN119219724A (zh) *	2024-09-25	2024-12-31	浙江仙琚制药股份有限公司	一种α环氧甾体化合物新的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
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FR2522328B1 (fr) *	1982-03-01	1986-02-14	Roussel Uclaf	Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
AU580843B2 (en) *	1985-02-07	1989-02-02	Schering Aktiengesellschaft	11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them

1997
- 1997-12-24 IL IL12274097A patent/IL122740A/xx active IP Right Grant
1998
- 1998-01-06 ZA ZA9884A patent/ZA9884B/xx unknown
- 1998-01-12 TW TW087100392A patent/TW518339B/zh not_active IP Right Cessation
- 1998-01-13 JP JP53369598A patent/JP2001508079A/ja active Pending
- 1998-01-13 EP EP98906887A patent/EP0973792B1/de not_active Expired - Lifetime
- 1998-01-13 US US09/341,603 patent/US6072068A/en not_active Expired - Fee Related
- 1998-01-13 AT AT98906887T patent/ATE248854T1/de not_active IP Right Cessation
- 1998-01-13 TR TR1999/02367T patent/TR199902367T2/xx unknown
- 1998-01-13 CN CN98802618A patent/CN1248262A/zh active Pending
- 1998-01-13 WO PCT/EP1998/000377 patent/WO1998031702A1/en not_active Ceased
- 1998-01-13 HU HU0000901A patent/HUP0000901A3/hu unknown
- 1998-01-13 AU AU62935/98A patent/AU736064B2/en not_active Ceased
- 1998-01-13 BR BR9807079-7A patent/BR9807079A/pt not_active IP Right Cessation
- 1998-01-13 NZ NZ336790A patent/NZ336790A/en unknown
- 1998-01-13 RU RU99118008/04A patent/RU2187510C2/ru not_active IP Right Cessation
- 1998-01-13 ID IDW990700A patent/ID22228A/id unknown
- 1998-01-13 CA CA002277924A patent/CA2277924A1/en not_active Abandoned
- 1998-01-13 DE DE69817792T patent/DE69817792T2/de not_active Expired - Fee Related
- 1998-01-13 KR KR1019997006375A patent/KR20000070149A/ko not_active Ceased
- 1998-01-13 PL PL98334518A patent/PL334518A1/xx unknown
- 1998-01-14 AR ARP980100151A patent/AR011409A1/es not_active Application Discontinuation
1999
- 1999-07-14 NO NO19993459A patent/NO313386B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL334518A1 (en)	2000-02-28
HUP0000901A2 (hu)	2000-10-28
DE69817792T2 (de)	2004-07-01
IL122740A0 (en)	1998-08-16
DE69817792D1 (de)	2003-10-09
KR20000070149A (ko)	2000-11-25
JP2001508079A (ja)	2001-06-19
AU736064B2 (en)	2001-07-26
ZA9884B (en)	1998-07-08
RU2187510C2 (ru)	2002-08-20
AR011409A1 (es)	2000-08-16
AU6293598A (en)	1998-08-07
ID22228A (id)	1999-09-23
EP0973792A1 (de)	2000-01-26
NO993459L (no)	1999-09-07
NO313386B1 (no)	2002-09-23
IL122740A (en)	2003-09-17
CN1248262A (zh)	2000-03-22
BR9807079A (pt)	2000-04-18
NO993459D0 (no)	1999-07-14
TW518339B (en)	2003-01-21
NZ336790A (en)	2000-06-23
WO1998031702A1 (en)	1998-07-23
HUP0000901A3 (en)	2001-07-30
TR199902367T2 (xx)	2000-04-21
US6072068A (en)	2000-06-06
CA2277924A1 (en)	1998-07-23
EP0973792B1 (de)	2003-09-03

Legal Events

Date	Code	Title	Description
2004-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
NO993459L (no)	1999-09-07	16-hydroksy-11-(substituerte fenyl)-estra-4,9-dien-derivater
DK0763541T3 (da)	2000-02-28	11-(substitueret phenyl)-estra-4,9-dien-derivater
ATE228510T1 (de)	2002-12-15	Substituierte 1,2,3,4-tetrahydronaphthalin derivate
DE69706292D1 (de)	2001-09-27	Chinazoline derivate
FI972026A0 (fi)	1997-05-13	Foerfarande foer estimering av en terminalanordnings hastighet, foerfarande foer cellval och radiosystem
FI980427A0 (fi)	1998-02-25	Foerfarande, arrangemang och anordning foer verifiering
DE69728676D1 (de)	2004-05-19	Substituierte 6,6-heterobicyclische derivate
DE60009147T2 (de)	2005-04-21	Admantan derivate
EE04849B1 (et)	2007-06-15	Asendatud fenüülderivaadid, nende valmistamine jakasutamine
EE200000192A (et)	2001-04-16	Uus kombinatsioon
ATE273962T1 (de)	2004-09-15	5-phenyl-pyrimidine derivate
DE69730962D1 (de)	2004-11-04	Alkylaminobenzothiazole und -benzoxazole derivate
ATE298760T1 (de)	2005-07-15	2-halo-6-0-substituierte ketolide derivate
DE69928262D1 (de)	2005-12-15	Substituierte chinazoline derivate
ATE230405T1 (de)	2003-01-15	2-phenylpyran-4-one derivate
DE60025918D1 (de)	2006-04-20	4-phenyl-pyrimidine derivate
ATE219051T1 (de)	2002-06-15	5-aroylnaphthalin derivate
ATE241599T1 (de)	2003-06-15	25-hydroxy-16-ene-26,27-bishome-cholecalcerifer l derivate
DE59909590D1 (de)	2004-07-01	Azidfreie, gaserzeugende zusammensetzung
IT1304521B1 (it)	2001-03-19	Bigodino.
HK1023349A (en)	2000-09-08	16-hydroxy-11-(substituted phenyl)-estra-4,9-diene derivatives
FI971438A0 (fi)	1997-04-07	Koppling laemplig foer spaennings- eller spaenningsfri arbete, saerskilt koppling foer ljusbaogs- eller oeverstoemsskydd
FI971391A0 (fi)	1997-04-04	Koppling laemplig foer spaenningsarbete, saerskilt koppling foer ljusbaogs- eller oeverstoemsskydd
ID19473A (id)	1998-07-16	24-homo-26,27-heksafluoro-kolkalsiferol
FI972925A0 (fi)	1997-07-09	Radiopejlingssystem, radiopejlingssaendare och radiopejlingsmottagare