ATE248913T1 - Tcf mutante - Google Patents

Tcf mutante

Info

Publication number: ATE248913T1
Authority: AT; Austria
Prior art keywords: tcf; amino acid; present; mutant; activity
Prior art date: 1994-12-27

Application number

AT95942271T

Other languages

English (en)

Inventor

Masahiko Kinosaki

Kyoji Yamaguchi

Fumie Kobayashi

Masaaki Goto

Akihiko Murakami

Masatsugu Ueda

Kanji Higashio

Yasushi Yamashita

Original Assignee

Daiichi Seiyaku Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-27

Filing date

1995-12-27

Publication date

2003-09-15

1995-12-27 Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE248913T1 publication Critical patent/ATE248913T1/de

Links

125000003275 alpha amino acid group Chemical group 0.000 abstract 2
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
230000009286 beneficial effect Effects 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229960002897 heparin Drugs 0.000 abstract 1
229920000669 heparin Polymers 0.000 abstract 1
210000003494 hepatocyte Anatomy 0.000 abstract 1
208000019423 liver disease Diseases 0.000 abstract 1
238000002703 mutagenesis Methods 0.000 abstract 1
231100000350 mutagenesis Toxicity 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT95942271T 1994-12-27 1995-12-27 Tcf mutante ATE248913T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP33788594		1994-12-27
PCT/JP1995/002708 WO1996020214A1 (en)	1994-12-27	1995-12-27	Tcf mutant

Publications (1)

Publication Number	Publication Date
ATE248913T1 true ATE248913T1 (de)	2003-09-15

Family

ID=18312917

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95942271T ATE248913T1 (de)	1994-12-27	1995-12-27	Tcf mutante

Country Status (16)

Country	Link
US (2)	US6399744B1 (de)
EP (2)	EP1275718A3 (de)
JP (1)	JP3699482B2 (de)
KR (1)	KR100294328B1 (de)
AT (1)	ATE248913T1 (de)
AU (1)	AU698221B2 (de)
CA (1)	CA2183856C (de)
DE (1)	DE69531673T2 (de)
DK (1)	DK0757994T3 (de)
ES (1)	ES2206523T3 (de)
FI (1)	FI116223B (de)
HU (1)	HU220167B (de)
NO (1)	NO319022B1 (de)
NZ (1)	NZ298142A (de)
WO (1)	WO1996020214A1 (de)
ZA (1)	ZA9510982B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3699482B2 (ja) *	1994-12-27	2005-09-28	第一製薬株式会社	Ｔｃｆ変異体
JP4006058B2 (ja)	1997-03-11	2007-11-14	第一三共株式会社	多臓器不全予防及び／又は治療剤
US20020041863A1 (en)	1997-03-14	2002-04-11	Masamichi Kojiro	Preventive and/or therapeutic agent for cachexia
KR100552434B1 (ko) *	1997-03-28	2006-05-16	다이이치세이야꾸 가부시끼가이샤	신질환 예방 및/또는 치료제_
JP3961064B2 (ja) *	1997-03-28	2007-08-15	第一製薬株式会社	腎疾患予防及び／又は治療剤
GB9709453D0 (en) *	1997-05-10	1997-07-02	Imp Cancer Res Tech	Polypedtides and their use in therapy
DE19909251A1 (de)	1998-02-21	1999-08-26	Max Delbrueck Centrum	Mittel zur Therapie von menschlichen Erkrankungen, ausgehend von beta-Catenin, seine Herstellung und seine Verwendung

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ232813A (en) *	1989-03-10	1992-08-26	Snow Brand Milk Products Co Ltd	Human fibroblast glycoprotein, cell differentiation, blood vessel endothelial cell growth factor, cellular immunology inforcing factor of 78 or 74 thousand daltons plus or minus two thousand daltons
JP2634323B2 (ja) *	1990-07-13	1997-07-23	雪印乳業株式会社	Ｔｃｆ‐▲ｉｉ▼のアミノ酸配列をコードするｄｎａを含むプラスミド，形質転換細胞及びこれを用いて生理活性物質を生産する方法
DK0642580T3 (da) *	1992-05-18	2002-12-23	Genentech Inc	Hepactocytvækstfaktorvarianter
KR100260964B1 (ko) *	1992-07-16	2000-07-01	쇼노 카츄야	Tcf-ii를 유효성분으로 하는 혈액응고 정상화제
HUT68170A (en) *	1992-12-28	1995-03-21	Snow Brand Milk Products Co Ltd	Modified tumor cytotoxic factor /tcf/
JP3699482B2 (ja) *	1994-12-27	2005-09-28	第一製薬株式会社	Ｔｃｆ変異体
JP3961064B2 (ja) *	1997-03-28	2007-08-15	第一製薬株式会社	腎疾患予防及び／又は治療剤
JPH1129493A (ja) *	1997-07-14	1999-02-02	Snow Brand Milk Prod Co Ltd	放射線障害予防及び／又は治療剤

1995
- 1995-12-27 JP JP52036596A patent/JP3699482B2/ja not_active Expired - Lifetime
- 1995-12-27 HU HU9602174A patent/HU220167B/hu not_active IP Right Cessation
- 1995-12-27 AU AU43551/96A patent/AU698221B2/en not_active Ceased
- 1995-12-27 CA CA002183856A patent/CA2183856C/en not_active Expired - Fee Related
- 1995-12-27 EP EP02077639A patent/EP1275718A3/de not_active Withdrawn
- 1995-12-27 NZ NZ298142A patent/NZ298142A/xx not_active IP Right Cessation
- 1995-12-27 WO PCT/JP1995/002708 patent/WO1996020214A1/ja not_active Ceased
- 1995-12-27 DK DK95942271T patent/DK0757994T3/da active
- 1995-12-27 EP EP95942271A patent/EP0757994B1/de not_active Expired - Lifetime
- 1995-12-27 AT AT95942271T patent/ATE248913T1/de not_active IP Right Cessation
- 1995-12-27 DE DE69531673T patent/DE69531673T2/de not_active Expired - Fee Related
- 1995-12-27 US US08/700,519 patent/US6399744B1/en not_active Expired - Fee Related
- 1995-12-27 ZA ZA9510982A patent/ZA9510982B/xx unknown
- 1995-12-27 KR KR1019960704673A patent/KR100294328B1/ko not_active Expired - Fee Related
- 1995-12-27 ES ES95942271T patent/ES2206523T3/es not_active Expired - Lifetime
1996
- 1996-08-26 FI FI963313A patent/FI116223B/fi active IP Right Grant
- 1996-08-26 NO NO19963552A patent/NO319022B1/no not_active IP Right Cessation
2002
- 2002-04-25 US US10/133,912 patent/US20020165358A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0757994A1 (de)	1997-02-12
WO1996020214A1 (en)	1996-07-04
KR970701206A (ko)	1997-03-17
ES2206523T3 (es)	2004-05-16
NZ298142A (en)	1997-08-22
DE69531673D1 (de)	2003-10-09
KR100294328B1 (ko)	2001-09-17
NO963552D0 (no)	1996-08-26
FI963313A0 (fi)	1996-08-26
US6399744B1 (en)	2002-06-04
NO319022B1 (no)	2005-06-06
EP1275718A2 (de)	2003-01-15
CA2183856C (en)	2006-11-07
ZA9510982B (en)	1996-08-22
JP3699482B2 (ja)	2005-09-28
EP0757994B1 (de)	2003-09-03
DK0757994T3 (da)	2004-01-19
HU9602174D0 (en)	1996-10-28
CA2183856A1 (en)	1996-06-28
AU698221B2 (en)	1998-10-29
HU220167B (hu)	2001-11-28
FI116223B (fi)	2005-10-14
DE69531673T2 (de)	2004-07-08
HUT75236A (en)	1997-04-28
NO963552L (no)	1996-10-28
US20020165358A1 (en)	2002-11-07
FI963313L (fi)	1996-08-26
AU4355196A (en)	1996-07-19
EP0757994A4 (de)	1998-10-21
EP1275718A3 (de)	2003-03-19

Legal Events

Date

Code

Title

Description

2004-05-15

UEP

Publication of translation of european patent specification

Ref document number: 0757994

Country of ref document: EP

2010-01-15

EEIH

Change in the person of patent owner

2010-09-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DK0733067T3 (da)	1999-11-01	N-terminalt kemisk modificerede proteinpræparater og fremgangsmåder
PH24783A (en)	1990-10-30	Preparation of functional human urokinase proteins
DK0642580T3 (da)	2002-12-23	Hepactocytvækstfaktorvarianter
AU8502198A (en)	1999-02-10	Method for treating vascular proliferative diseases with p27 and fusions thereof
AU698221B2 (en)	1998-10-29	TCF mutant
DK0667872T3 (da)	2000-09-18	Mutantinterleukin 6 med forbedret biologisk aktivitet i forhold til vildtype-interleukin 6
CA2509508A1 (en)	1996-07-04	Tcf mutant
DE69032471D1 (de)	1998-08-13	Proteine mit onkostatin-m-aktivität und verfahren zu ihrer herstellung
EP0386240A4 (en)	1990-10-24	Novel polypeptide compounds