ATE250048T1 - Katalytische asymmetrische epoxidierung - Google Patents

Katalytische asymmetrische epoxidierung

Info

Publication number
ATE250048T1
ATE250048T1 AT97911672T AT97911672T ATE250048T1 AT E250048 T1 ATE250048 T1 AT E250048T1 AT 97911672 T AT97911672 T AT 97911672T AT 97911672 T AT97911672 T AT 97911672T AT E250048 T1 ATE250048 T1 AT E250048T1
Authority
AT
Austria
Prior art keywords
catalytic asymmetric
asymmetric epoxidation
epoxidation
catalytic
olefin
Prior art date
Application number
AT97911672T
Other languages
English (en)
Inventor
Yian Shi
Original Assignee
Univ Colorado State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Colorado State Res Found filed Critical Univ Colorado State Res Found
Application granted granted Critical
Publication of ATE250048T1 publication Critical patent/ATE250048T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/12—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with hydrogen peroxide or inorganic peroxides or peracids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
    • C07D303/42—Acyclic compounds having a chain of seven or more carbon atoms, e.g. epoxidised fats
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
    • C07F7/083—Syntheses without formation of a Si-C bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97911672T 1996-10-08 1997-10-08 Katalytische asymmetrische epoxidierung ATE250048T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2800996P 1996-10-08 1996-10-08
PCT/US1997/018310 WO1998015544A1 (en) 1996-10-08 1997-10-08 Catalytic asymmetric epoxidation

Publications (1)

Publication Number Publication Date
ATE250048T1 true ATE250048T1 (de) 2003-10-15

Family

ID=21841037

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97911672T ATE250048T1 (de) 1996-10-08 1997-10-08 Katalytische asymmetrische epoxidierung

Country Status (9)

Country Link
US (1) US6348608B1 (de)
EP (1) EP1021426B1 (de)
JP (1) JP2001502316A (de)
AT (1) ATE250048T1 (de)
AU (1) AU4898797A (de)
CA (1) CA2268255A1 (de)
DE (1) DE69725023T2 (de)
ES (1) ES2207721T3 (de)
WO (1) WO1998015544A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686483B2 (en) 1996-10-08 2004-02-03 Colorado State University Research Foundation Catalytic asymmetric epoxidation
US6613918B1 (en) 2000-10-20 2003-09-02 Bioavailability Systems, Llc Synthesis of spiro ortho esters, spiro ortho carbonates, and intermediates
CZ298749B6 (cs) 1996-10-18 2008-01-16 Vertex Pharmaceuticals Incorporated Inhibitory serinových proteáz a farmaceutické prostředky s jejich obsahem
AU3567399A (en) * 1998-04-16 1999-11-01 Colorado State University Research Foundation Kinetic resolution of olefins
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
WO2004037827A1 (en) 2000-10-20 2004-05-06 Bioavailability Systems, Llc Synthesis of spiro ortho esters, spiro ortho carbonates, and intermediates
EP1386918B1 (de) * 2001-05-11 2005-11-09 Kaneka Corporation Verfahren zur herstellung optisch aktiver epoxide
DE10136485C1 (de) * 2001-07-27 2003-03-06 Bayer Ag Polyaminosäure-katalysiertes Verfahren zur enantioselektiven Epoxidierung von alpha,ß-ungesättigten Eonen und alpha,ß-ungesättigten Sulfonen
AU2003219702A1 (en) * 2002-02-04 2003-09-02 Colorado State University Research Foundation Asymmetric epoxidation of electron deficient olefins
TW201127828A (en) 2003-09-05 2011-08-16 Vertex Pharma Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
CN101277950B (zh) * 2005-08-02 2013-03-27 弗特克斯药品有限公司 丝氨酸蛋白酶抑制剂
AR055395A1 (es) * 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
EP1770095A1 (de) * 2005-09-26 2007-04-04 Institut Catala D'Investigacio Quimica Effiziente Katalysatoren zur asymmetrischen Epoxidierung von mit Elektronenmangel sowie ohne Elektronenmangel Alkenen
EP1770094A1 (de) * 2005-09-26 2007-04-04 Institut Catala D'Investigacio Quimica Effiziente Synthese von asymmetrischem Epoxidierungs-Katalysator I
CA2643688A1 (en) 2006-02-27 2007-08-30 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
US20070225297A1 (en) 2006-03-16 2007-09-27 Perni Robert B Deuterated hepatitis C protease inhibitors
EP1993993A1 (de) 2006-03-16 2008-11-26 Vertex Pharmaceuticals Incorporated Verfahren und zwischenprodukte zur herstellung von sterischen verbindungen
EP2134717A2 (de) * 2007-02-27 2009-12-23 Vertex Pharmceuticals Incorporated Serinprotease-hemmer
MX2009009182A (es) * 2007-02-27 2009-09-04 Vertex Pharma Co-cristales y composiciones farmaceuticas que los comprenden.
NZ583699A (en) * 2007-08-30 2012-04-27 Vertex Pharma Co-crystals of vx-950 (telaprevir) other components and pharmaceutical compositions comprising the same
CN110128439B (zh) * 2018-02-08 2020-12-01 凯特立斯（深圳）科技有限公司 一种氧杂螺环化合物及其合成与拆分方法
CN113227113A (zh) * 2018-12-20 2021-08-06 帝斯曼知识产权资产管理有限公司 环氧化催化剂的改进合成

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5414078A (en) * 1991-04-05 1995-05-09 Emory University Preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-deoxynucleosides from acyclic, achiral precursors
US5403549A (en) 1993-11-04 1995-04-04 Cyclo3 pss Medical Systems, Inc. Method for sterilization using a fluid chemical biocide

Also Published As

Publication number Publication date
DE69725023D1 (de) 2003-10-23
EP1021426B1 (de) 2003-09-17
WO1998015544A1 (en) 1998-04-16
CA2268255A1 (en) 1998-04-16
JP2001502316A (ja) 2001-02-20
US6348608B1 (en) 2002-02-19
EP1021426A1 (de) 2000-07-26
AU4898797A (en) 1998-05-05
ES2207721T3 (es) 2004-06-01
DE69725023T2 (de) 2004-08-05
EP1021426A4 (de) 2000-07-26

Similar Documents

Publication Publication Date Title
ATE250048T1 (de) Katalytische asymmetrische epoxidierung
ES2113374T3 (es) Catalizadores quirales y reacciones de epoxidacion catalizadas por los mismos.
NO953617L (no) Fremgangsmåte for rensing av taxoider
PT1042314E (pt) Metodo de preparacao de oxidos de tetra-hidrobenzotiepina enantiomericamente enriquecidos
DK0643626T3 (da) Fremgangsmåde til fremstilling af epoxychromaner med en chiral katalysator
DE3681641D1 (de) Verfahren zur herstellung von amagnetischen bohrstrangteilen.
ID16522A (id) Katalis hidrogenasi untuk produksi hidrogen peroksida, dan metoda pembuatannya
NO963247L (no) Fremgangsmåte for epoksydering av prochirale olefiner og en katalysator for dette, samt mellomprodukter for fremstilling av katalysatoren
DE60122505D1 (de) Enzymatische umsetzung von epoxiden
ATE341645T1 (de) Verfahren für die reverse transkription
NO20023150L (no) Fremgangsmate for fremstilling av citalopram
HUP9802369A3 (en) Dinaphtazepinium salts useful as enantioselective epoxidation catalysts
FR2785831B1 (fr) Support monolithe poreux d'un element de filtration et element de filtration
EA199900772A1 (ru) Способ селективного эпоксидирования для получения лекарственных соединений
ATE236141T1 (de) Verfahren zur epoxidierung von substituierten cyclohexanonen
DE3765651D1 (de) Verfahren zur herstellung einer synthesefaser und einer orientierten synthesefaser sowie nach diesem verfahren hergestellte orientierte synthesefaser.
ES2180155T3 (es) Procedimiento en una etapa para la fabricacion de alfa-hidroxieteres mediante oxidacion de compuestos c=c insaturados con hidroperoxidos.
WO1999045671A3 (en) System for editing entertainment information by producers
DE69833198D1 (de) Mehrkanalverbindung mit reduzierter spitzen- zu durchschnittamplitude
DE3578066D1 (de) Verfahren zur herstellung von alpha, beta-diaminoacrylnitrilen.
EP0629702A3 (de) Verfahren zur Herstellung von chiralen Epoxy- oder Hydroxy-Verbindungen durch stereoselektive Epoxidierung oder Hydroxylierung.
DK0688737T3 (da) Fremgangsmåde til fremstilling af hvidt carbon
BG102535A (en) Dihydrate of (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate of 4,10 beta-diacetoxy-2 alpha-benzoyloxy-5 beta, 20-epoxy-1-hydroxy-9-oxo-19-nor-cyclopropa[g]tax-11-ene 13-alpha -yl and method for its preparaton
HUP9803009A1 (hu) Önmagából energiát előállítani és ezáltal önmagát üzemeltetni képes berendezés és energia-előállítási eljárás
IT1282954B1 (it) Processo di racemizzazione di 3-dialchilamino-1,2-propandioli chirali.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1021426

Country of ref document: EP

REN Ceased due to non-payment of the annual fee