ATE250059T1 - 8-substituierte purine als selektive adenosine- rezeptor antagonisten - Google Patents

8-substituierte purine als selektive adenosine- rezeptor antagonisten

Info

Publication number: ATE250059T1
Authority: AT; Austria
Prior art keywords: receptor antagonists; adenosine receptor; substituted purines; selective adenosine; selective
Prior art date: 1991-03-12

Application number

AT92104089T

Other languages

English (en)

Inventor

Norton P Peet

Mark W Dudley

Nelsen L Lentz

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-03-12

Filing date

1992-03-10

Publication date

2003-10-15

1992-03-10 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

2003-10-15 Application granted granted Critical

2003-10-15 Publication of ATE250059T1 publication Critical patent/ATE250059T1/de

Links

229940121359 adenosine receptor antagonist Drugs 0.000 title abstract 2
239000000296 purinergic P1 receptor antagonist Substances 0.000 title abstract 2
150000003212 purines Chemical class 0.000 title 1
-1 8-substituted purines Chemical class 0.000 abstract 1
101150007969 ADORA1 gene Proteins 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
206010006482 Bronchospasm Diseases 0.000 abstract 1
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
230000007885 bronchoconstriction Effects 0.000 abstract 1
230000002685 pulmonary effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Cephalosporin Compounds (AREA)

AT92104089T 1991-03-12 1992-03-10 8-substituierte purine als selektive adenosine- rezeptor antagonisten ATE250059T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/667,943 US5208240A (en)	1991-03-12	1991-03-12	8-substituted purines as selective adenosine receptor agents

Publications (1)

Publication Number	Publication Date
ATE250059T1 true ATE250059T1 (de)	2003-10-15

Family

ID=24680310

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92104089T ATE250059T1 (de)	1991-03-12	1992-03-10	8-substituierte purine als selektive adenosine- rezeptor antagonisten

Country Status (18)

Country	Link
US (1)	US5208240A (de)
EP (1)	EP0503563B1 (de)
JP (1)	JP3131275B2 (de)
KR (1)	KR100220887B1 (de)
AT (1)	ATE250059T1 (de)
AU (1)	AU643599B2 (de)
CA (1)	CA2062837C (de)
DE (1)	DE69233202T2 (de)
DK (1)	DK0503563T3 (de)
ES (1)	ES2207631T3 (de)
FI (1)	FI108721B (de)
HU (1)	HU215923B (de)
IE (1)	IE920787A1 (de)
IL (1)	IL101186A (de)
NO (1)	NO300977B1 (de)
NZ (1)	NZ241890A (de)
PT (1)	PT503563E (de)
ZA (1)	ZA921715B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5565566A (en) *	1987-04-24	1996-10-15	Discovery Therapeutics, Inc.	N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
DE4129603A1 (de) *	1991-09-06	1993-03-11	Thomae Gmbh Dr K	Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5521315A (en) *	1993-01-12	1996-05-28	Cell Therapeutics, Inc.	Olefin substituted long chain compounds
CA2155130C (en) *	1993-02-26	1994-09-01	Janice M Hitchcock	Xanthine derivatives as adenosine a1 receptor antagonists
JPH08509977A (ja) *	1993-05-06	1996-10-22	メレルダウファーマスーティカルズインコーポレイテッド	選択的アデノシン受容体剤としての８−置換キサンチン類
FR2727315A1 (fr) *	1994-11-30	1996-05-31	Cooperative Agricole Laitiere	Utilisation d'un decapeptide a activite de type benzodiazepine pour la preparation de medicaments et de complements alimentaires
US5786360A (en) *	1996-11-19	1998-07-28	Link Technology Incorporated	A1 adenosine receptor antagonists
EP0863148A1 (de) *	1997-03-03	1998-09-09	K.U. Leuven Research & Development	Von Adenosin abgeleitete Verbindungen, Verwendung solcher Verbindungen als Medikament, Verfahren zur Herstellung solcher Verbindungen und Zwischenprodukte dafür
WO1998057651A1 (en)	1997-06-18	1998-12-23	Discovery Therapeutics, Inc.	Compositions and methods for preventing restenosis following revascularization procedures
US5998386A (en) *	1997-09-19	1999-12-07	Feldman; Arthur M.	Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue
US6060481A (en) *	1998-05-28	2000-05-09	The Penn State Research Foundation	Method for improving insulin sensitivity using an adenosine receptor antagonist
NZ508314A (en) *	1998-06-02	2004-03-26	Osi Pharm Inc	Pyrrolo[2,3d]pyrimidine compositions and their use
US6680322B2 (en)	1999-12-02	2004-01-20	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A1 receptors and uses thereof
AU2001280946A1 (en)	2000-08-01	2002-02-13	University Of Virginia Patent Foundation	Use of selective adenosine a1 receptor agonists, antagonists and allosteric enhancers to manipulate angiogenesis
US6680324B2 (en) *	2000-12-01	2004-01-20	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A1 receptors and uses thereof
US20020115635A1 (en) *	2001-02-21	2002-08-22	Pnina Fishman	Modulation of GSK-3beta activity and its different uses
UA80258C2 (en) *	2001-09-06	2007-09-10	Biogen Inc	Methods of treating pulmonary disease
JP2005529062A (ja) *	2001-11-30	2005-09-29	オーエスアイ・ファーマスーティカルズ・インコーポレーテッド	アデノシンａ１及びａ３受容体に特異的な化合物とその使用
EA007468B1 (ru)	2001-12-20	2006-10-27	Оси Фармасьютикалз, Инк.	Пиримидиновые соединения, относящиеся к a-селективным антагонистам, их синтез и применение
WO2004074247A2 (en)	2003-02-19	2004-09-02	Endacea, Inc.	A1 adenosine receptor antagonists
EP1636229A4 (de)	2003-06-06	2008-07-30	Endacea Inc	A1-adenosinrezeptorantagonisten
CA2528367A1 (en) *	2003-06-09	2004-12-23	Endacea, Inc.	A1 adenosine receptor antagonists
EP1863815A1 (de) *	2005-03-11	2007-12-12	Aderis Pharmaceuticals, Inc.	Substituierte 9-alkyladenine und deren verwendung

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4297494A (en) *	1978-08-09	1981-10-27	Baxter Travenol Laboratories, Inc.	Xanthine tracers
US4397779A (en) *	1978-08-09	1983-08-09	Baxter Travenol Laboratories, Inc.	Preparation of xanthine tracers
EP0011399A1 (de) *	1978-11-11	1980-05-28	FISONS plc	N-Substituierte Theophylline, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US4452788A (en) *	1982-04-21	1984-06-05	Warner-Lambert Company	Substituted 8-phenylxanthines
US4696932A (en) *	1984-10-26	1987-09-29	The United States Of America As Represented By The Department Of Health And Human Services	Biologically-active xanthine derivatives
DE3522230A1 (de) *	1985-06-21	1987-01-02	Thomae Gmbh Dr K	Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
HU197746B (en) *	1985-09-05	1989-05-29	Sandoz Ag	Process for producing xantin derivatives and pharmaceutical compositions containing them
US4968672A (en) *	1987-01-02	1990-11-06	The United States Of America As Represented By The Department Of Health And Human Services	Adenosine receptor prodrugs
US5047534A (en) *	1990-03-26	1991-09-10	Merrell Dow Pharmaceuticals Inc.	Selective adenosine receptor agents

1991
- 1991-03-12 US US07/667,943 patent/US5208240A/en not_active Expired - Lifetime
1992
- 1992-03-06 ZA ZA921715A patent/ZA921715B/xx unknown
- 1992-03-06 AU AU12138/92A patent/AU643599B2/en not_active Ceased
- 1992-03-09 IL IL10118692A patent/IL101186A/en not_active IP Right Cessation
- 1992-03-09 NZ NZ241890A patent/NZ241890A/en unknown
- 1992-03-10 ES ES92104089T patent/ES2207631T3/es not_active Expired - Lifetime
- 1992-03-10 AT AT92104089T patent/ATE250059T1/de not_active IP Right Cessation
- 1992-03-10 DE DE69233202T patent/DE69233202T2/de not_active Expired - Lifetime
- 1992-03-10 DK DK92104089T patent/DK0503563T3/da active
- 1992-03-10 PT PT92104089T patent/PT503563E/pt unknown
- 1992-03-10 EP EP92104089A patent/EP0503563B1/de not_active Expired - Lifetime
- 1992-03-11 NO NO920945A patent/NO300977B1/no not_active IP Right Cessation
- 1992-03-11 IE IE078792A patent/IE920787A1/en not_active Application Discontinuation
- 1992-03-11 HU HU9200822A patent/HU215923B/hu not_active IP Right Cessation
- 1992-03-11 FI FI921052A patent/FI108721B/fi not_active IP Right Cessation
- 1992-03-11 KR KR1019920003974A patent/KR100220887B1/ko not_active Expired - Fee Related
- 1992-03-12 CA CA002062837A patent/CA2062837C/en not_active Expired - Lifetime
- 1992-03-12 JP JP04087503A patent/JP3131275B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IE920787A1 (en)	1992-09-23
PT503563E (pt)	2003-12-31
AU643599B2 (en)	1993-11-18
US5208240A (en)	1993-05-04
HU9200822D0 (en)	1992-05-28
DK0503563T3 (da)	2003-12-22
FI921052L (fi)	1992-09-13
DE69233202T2 (de)	2004-06-24
IL101186A (en)	1995-08-31
EP0503563B1 (de)	2003-09-17
NZ241890A (en)	1994-04-27
FI108721B (fi)	2002-03-15
AU1213892A (en)	1992-09-17
FI921052A0 (fi)	1992-03-11
ZA921715B (en)	1992-11-25
IL101186A0 (en)	1992-11-15
ES2207631T3 (es)	2004-06-01
JP3131275B2 (ja)	2001-01-31
NO300977B1 (no)	1997-08-25
JPH05112568A (ja)	1993-05-07
EP0503563A3 (en)	1992-12-02
HU215923B (hu)	1999-03-29
NO920945D0 (no)	1992-03-11
NO920945L (no)	1992-09-14
HUT61022A (en)	1992-11-30
DE69233202D1 (de)	2003-10-23
KR920018053A (ko)	1992-10-21
EP0503563A2 (de)	1992-09-16
CA2062837C (en)	2002-08-27
KR100220887B1 (ko)	1999-09-15
CA2062837A1 (en)	1992-09-13

Legal Events

Date

Code

Title

Description

2004-05-15

UEP

Publication of translation of european patent specification

Ref document number: 0503563

Country of ref document: EP

2005-06-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE250059T1 (de)	2003-10-15	8-substituierte purine als selektive adenosine- rezeptor antagonisten
ATE424403T1 (de)	2009-03-15	Polycycloalkylpurine als adenosinrezeptorantagonisten
DE69908648D1 (de)	2003-07-10	Kondensierte 1,2,4-thiadiazinderivate, ihre herstellung und verwendung
GR3002914T3 (en)	1993-01-25	4,5,6,7-tetrahydro-1h-imidazo(4,5-c)pyridine derivatives and analogs having antihypertensive activity
DE60037578D1 (de)	2008-02-07	Verwendung von triacetyluridin zur behandlung von mitochondrialen erkrankungen
DE3887273D1 (de)	1994-03-03	2',3'-Dideoxy-2'-fluornucleoside.
DK165493C (da)	1993-04-19	Fremgangsmaade til forbedring af den mekaniske styrke af finer med spraekker fra finerskaeringen
DK322189D0 (da)	1989-06-28	Imidazo(1,2-a)-(pyridaziner eller pyraziner) til behandling af sygdomme med relation til knogletab
ATE353328T1 (de)	2007-02-15	Adenosin rezeptor antagonisten sowie methoden zu deren herstellung und verwendung
DE69509182D1 (de)	1999-05-27	Herstellung N-9-substituierter Guanin-Verbindungen
EP0415999A4 (en)	1991-10-16	Compositions having use as treatment of psoriasis and neuropsychiatric deficits
HUT51295A (en)	1990-04-28	Process for producing peptidalcohol derivatives of anticoagulant activity
ATE113591T1 (de)	1994-11-15	4-benzyl-5-phenyl-2,4-dihydro-3h-1,2,4-triazol- - one und ihre verwendung als antikonvulsiva.
DE3751362D1 (de)	1995-07-27	5-Aryl-3H-1,2,4-triazol-3-one und ihre Verwendung als Antikonvulsiva.
ITRM910041A1 (it)	1992-07-18	Processo per la preparazione di cuoio non poroso impermeabile all'acqua utilizzabile per tomaie di calzature.
IT1230135B (it)	1991-10-14	Procedimento per la preparazione dell'acido 3-idrossi-3-metilglutarico mediante ossidazione con ipoclorito del 3-metil-1,3,5pentantriolo.