ZA921715B - Novel 8-substituted purines as selective adenosine receptor agents - Google Patents

Novel 8-substituted purines as selective adenosine receptor agents

Info

Publication number
ZA921715B
ZA921715B ZA921715A ZA921715A ZA921715B ZA 921715 B ZA921715 B ZA 921715B ZA 921715 A ZA921715 A ZA 921715A ZA 921715 A ZA921715 A ZA 921715A ZA 921715 B ZA921715 B ZA 921715B
Authority
ZA
South Africa
Prior art keywords
adenosine receptor
novel
substituted purines
selective adenosine
receptor agents
Prior art date
Application number
ZA921715A
Other languages
English (en)
Inventor
Norton Paul Peet
Paul Peet Norton
Nelsen Lowell Lentz
Lowell Lentz Nelsen
Mark William Dudley
William Dudley Mark
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA921715B publication Critical patent/ZA921715B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
ZA921715A 1991-03-12 1992-03-06 Novel 8-substituted purines as selective adenosine receptor agents ZA921715B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/667,943 US5208240A (en) 1991-03-12 1991-03-12 8-substituted purines as selective adenosine receptor agents

Publications (1)

Publication Number Publication Date
ZA921715B true ZA921715B (en) 1992-11-25

Family

ID=24680310

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA921715A ZA921715B (en) 1991-03-12 1992-03-06 Novel 8-substituted purines as selective adenosine receptor agents

Country Status (18)

Country Link
US (1) US5208240A (de)
EP (1) EP0503563B1 (de)
JP (1) JP3131275B2 (de)
KR (1) KR100220887B1 (de)
AT (1) ATE250059T1 (de)
AU (1) AU643599B2 (de)
CA (1) CA2062837C (de)
DE (1) DE69233202T2 (de)
DK (1) DK0503563T3 (de)
ES (1) ES2207631T3 (de)
FI (1) FI108721B (de)
HU (1) HU215923B (de)
IE (1) IE920787A1 (de)
IL (1) IL101186A (de)
NO (1) NO300977B1 (de)
NZ (1) NZ241890A (de)
PT (1) PT503563E (de)
ZA (1) ZA921715B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565566A (en) * 1987-04-24 1996-10-15 Discovery Therapeutics, Inc. N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
DE4129603A1 (de) * 1991-09-06 1993-03-11 Thomae Gmbh Dr K Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5521315A (en) * 1993-01-12 1996-05-28 Cell Therapeutics, Inc. Olefin substituted long chain compounds
DE69412073T2 (de) * 1993-02-26 1999-02-18 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Xanthinderivate als adenosin-a1 rezeptor antagonisten
CA2159989C (en) * 1993-05-06 1994-11-24 Norton P. Peet 8-substituted xanthines as selective adenosine receptor agents
FR2727315A1 (fr) * 1994-11-30 1996-05-31 Cooperative Agricole Laitiere Utilisation d'un decapeptide a activite de type benzodiazepine pour la preparation de medicaments et de complements alimentaires
US5786360A (en) * 1996-11-19 1998-07-28 Link Technology Incorporated A1 adenosine receptor antagonists
EP0863148A1 (de) * 1997-03-03 1998-09-09 K.U. Leuven Research & Development Von Adenosin abgeleitete Verbindungen, Verwendung solcher Verbindungen als Medikament, Verfahren zur Herstellung solcher Verbindungen und Zwischenprodukte dafür
AU740770B2 (en) 1997-06-18 2001-11-15 Aderis Pharmaceuticals, Inc. Compositions and methods for preventing restenosis following revascularization procedures
US5998386A (en) * 1997-09-19 1999-12-07 Feldman; Arthur M. Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue
US6060481A (en) * 1998-05-28 2000-05-09 The Penn State Research Foundation Method for improving insulin sensitivity using an adenosine receptor antagonist
JP4611524B2 (ja) * 1998-06-02 2011-01-12 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド ピロロ［２，３ｄ］ピリミジン組成物およびその使用
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
CA2414623A1 (en) * 2000-08-01 2002-02-07 University Of Virginia Patent Foundation Use of selective adenosine a1 receptor agonists, antagonists and allosteric enhancers to manipulate angiogenesis
US6680324B2 (en) * 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US20020115635A1 (en) * 2001-02-21 2002-08-22 Pnina Fishman Modulation of GSK-3beta activity and its different uses
UA80258C2 (en) * 2001-09-06 2007-09-10 Biogen Inc Methods of treating pulmonary disease
DK1450811T3 (da) * 2001-11-30 2010-02-15 Osi Pharm Inc Forbindelser specifikke af adenosin A1- og A3-receptorer og anvendelser heraf
CN1620294A (zh) 2001-12-20 2005-05-25 Osi药物公司 嘧啶a2b选择性拮抗剂化合物,它们的合成及用途
EP1601649A4 (de) * 2003-02-19 2009-03-04 Endacea Inc A1-adenosinrezeptorantagonisten
US7247639B2 (en) * 2003-06-06 2007-07-24 Endacea, Inc. A1 adenosine receptor antagonists
US20090068101A9 (en) * 2003-06-09 2009-03-12 Endacea, Inc. A1 Adenosine Receptor Antagonists
MX2007010984A (es) * 2005-03-11 2008-03-18 Aderis Pharmaceuticals Inc 9-alquiladeninas sustituidas y uso de las mismas.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4297494A (en) * 1978-08-09 1981-10-27 Baxter Travenol Laboratories, Inc. Xanthine tracers
US4397779A (en) * 1978-08-09 1983-08-09 Baxter Travenol Laboratories, Inc. Preparation of xanthine tracers
EP0011399A1 (de) * 1978-11-11 1980-05-28 FISONS plc N-Substituierte Theophylline, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US4452788A (en) * 1982-04-21 1984-06-05 Warner-Lambert Company Substituted 8-phenylxanthines
US4696932A (en) * 1984-10-26 1987-09-29 The United States Of America As Represented By The Department Of Health And Human Services Biologically-active xanthine derivatives
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
HU197746B (en) * 1985-09-05 1989-05-29 Sandoz Ag Process for producing xantin derivatives and pharmaceutical compositions containing them
US4968672A (en) * 1987-01-02 1990-11-06 The United States Of America As Represented By The Department Of Health And Human Services Adenosine receptor prodrugs
US5047534A (en) * 1990-03-26 1991-09-10 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents

Also Published As

Publication number Publication date
EP0503563B1 (de) 2003-09-17
HU215923B (hu) 1999-03-29
NO920945D0 (no) 1992-03-11
NO920945L (no) 1992-09-14
FI921052L (fi) 1992-09-13
KR100220887B1 (ko) 1999-09-15
ATE250059T1 (de) 2003-10-15
CA2062837A1 (en) 1992-09-13
PT503563E (pt) 2003-12-31
EP0503563A2 (de) 1992-09-16
JPH05112568A (ja) 1993-05-07
IE920787A1 (en) 1992-09-23
JP3131275B2 (ja) 2001-01-31
FI108721B (fi) 2002-03-15
IL101186A (en) 1995-08-31
NZ241890A (en) 1994-04-27
EP0503563A3 (en) 1992-12-02
ES2207631T3 (es) 2004-06-01
HUT61022A (en) 1992-11-30
US5208240A (en) 1993-05-04
NO300977B1 (no) 1997-08-25
AU1213892A (en) 1992-09-17
IL101186A0 (en) 1992-11-15
HU9200822D0 (en) 1992-05-28
AU643599B2 (en) 1993-11-18
CA2062837C (en) 2002-08-27
KR920018053A (ko) 1992-10-21
DE69233202D1 (de) 2003-10-23
DE69233202T2 (de) 2004-06-24
DK0503563T3 (da) 2003-12-22
FI921052A0 (fi) 1992-03-11

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