ATE250422T1 - Komponenten mit niedrigem molekulargewicht aus knorpelgewebe von haien, verfahren zur herstellung und therapeutische verwendungen - Google Patents

Komponenten mit niedrigem molekulargewicht aus knorpelgewebe von haien, verfahren zur herstellung und therapeutische verwendungen

Info

Publication number
ATE250422T1
ATE250422T1 AT99932586T AT99932586T ATE250422T1 AT E250422 T1 ATE250422 T1 AT E250422T1 AT 99932586 T AT99932586 T AT 99932586T AT 99932586 T AT99932586 T AT 99932586T AT E250422 T1 ATE250422 T1 AT E250422T1
Authority
AT
Austria
Prior art keywords
fraction
mmp
kda
extracts
fractions
Prior art date
Application number
AT99932586T
Other languages
English (en)
Inventor
Eric Dupont
Yves Lachance
Denis Lessard
Serge Auger
Original Assignee
Aeterna Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeterna Lab Inc filed Critical Aeterna Lab Inc
Application granted granted Critical
Publication of ATE250422T1 publication Critical patent/ATE250422T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT99932586T 1998-07-23 1999-07-23 Komponenten mit niedrigem molekulargewicht aus knorpelgewebe von haien, verfahren zur herstellung und therapeutische verwendungen ATE250422T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/122,481 US6168807B1 (en) 1998-07-23 1998-07-23 Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof
PCT/CA1999/000674 WO2000004910A2 (en) 1998-07-23 1999-07-23 Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
ATE250422T1 true ATE250422T1 (de) 2003-10-15

Family

ID=22402955

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99932586T ATE250422T1 (de) 1998-07-23 1999-07-23 Komponenten mit niedrigem molekulargewicht aus knorpelgewebe von haien, verfahren zur herstellung und therapeutische verwendungen

Country Status (10)

Country Link
US (2) US6168807B1 (de)
EP (1) EP1098656B1 (de)
JP (1) JP2002521340A (de)
CN (1) CN1314816A (de)
AT (1) ATE250422T1 (de)
AU (1) AU4893199A (de)
CA (1) CA2338068A1 (de)
DE (1) DE69911614T2 (de)
ES (1) ES2207248T3 (de)
WO (1) WO2000004910A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6380366B1 (en) 1994-04-28 2002-04-30 Les Laboratoires Aeterna Inc. Shark cartilage extract:process of making, methods of using and compositions thereof
CN1245993C (zh) 1997-03-11 2006-03-22 阿特纳赞塔里斯公司 用于治疗肿瘤的含有鲨鱼软骨提取物和抗肿瘤剂的药物组合物
US6168807B1 (en) 1998-07-23 2001-01-02 Les Laboratoires Aeterna Inc. Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof
US20020009501A1 (en) * 1998-07-23 2002-01-24 Eric Dupont Preparation of cartilage extracts using organic solvents
EP1343511A4 (de) * 2000-12-20 2005-06-01 Ind Res Ltd Haifleischextrakt
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
CA2476126A1 (en) * 2002-02-15 2003-08-21 Ocean Nutrition Canada Limited Shark cartilage extracts and use thereof for immunomodulation
CN1732023A (zh) * 2002-12-27 2006-02-08 血管技术国际股份公司 组合物和使用collajolie的方法
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
JPWO2004083257A1 (ja) * 2003-03-20 2006-06-22 ホソカワミクロン株式会社 軟骨魚類から単離されたプロテオグリカンおよびその製造方法
WO2006059236A2 (en) * 2004-11-16 2006-06-08 Aeterna Zentaris Inc. Method of using cartilage extract for increasing blood parameters
US20080014190A1 (en) * 2005-10-03 2008-01-17 Yong Qian Proteinases destroy cancer tumor's solid structure and kill cancer cells locally
US9072735B2 (en) 2005-10-03 2015-07-07 Yong Qian Proteinases destroy cancer tumor's solid structure and kill cancer cells locally
US20110236395A1 (en) * 2008-09-09 2011-09-29 University Of East Anglia Treatment of fibrotic eye disorders using an mmp2 inhibitor
KR101539700B1 (ko) * 2012-09-05 2015-07-28 아주대학교산학협력단 연골세포 유래 세포외 기질막을 이용한 신생혈관질환 치료용 조성물 및 각막 또는 결막 이식재
CN104894200B (zh) * 2015-05-12 2020-10-30 浙江海洋学院 路氏双髻鲨软骨血管生成抑制因子的制备方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE28093E (en) 1962-02-28 1974-07-30 Wound-healing cartilage powder
US3478146A (en) 1965-02-26 1969-11-11 Leslie L Balassa Wound-healing cartilage powder extracting process
US3966908A (en) 1973-11-29 1976-06-29 Lescarden Ltd. Method of treating degenerative joint afflictions
US4042457A (en) 1975-11-10 1977-08-16 Rush-Presbyterian-St. Luke's Medical Center Preparation of tissue invasion inhibitor and method of treatment utilizing the inhibitor
US4822607A (en) 1976-10-29 1989-04-18 Lescarden Ltd. Anti-tumor agent and method
US4212857A (en) 1976-10-29 1980-07-15 Lescarden Ltd. Method for stimulating the production of immunoglobulin and total complement
US4243582A (en) 1979-04-26 1981-01-06 Monsanto Company Novel glycoproteins from bovine cartilage
US4350682A (en) 1979-05-11 1982-09-21 Lescarden Ltd. Cartilage extraction processes and products
US4356261A (en) 1980-04-22 1982-10-26 Rush-Presbyterian-St. Luke's Medical Center Anti-invasion factor containing cultures
US4456589A (en) 1982-07-08 1984-06-26 Genetic Laboratories, Inc. Preparation of animal tissues for surgical implantation in human recipients
US4473551A (en) 1982-08-23 1984-09-25 Faxon Pharmaceuticals, Inc. Anti-inflammatory composition
JPS5939828A (ja) 1982-08-28 1984-03-05 Ajinomoto Co Inc 抗腫瘍活性物質の製造方法
US4444752A (en) 1982-09-13 1984-04-24 Lescarden Ltd. Method for treating progressive systemic sclerosis
US4469676A (en) 1983-06-21 1984-09-04 Michel Hecmati Method for eliminating wrinkles occurring in the human skin
JPS60178820A (ja) 1984-02-22 1985-09-12 Ajinomoto Co Inc 抗腫瘍活性物質の製造方法
US4656137A (en) 1985-09-12 1987-04-07 Lescarden Inc Method of processing animal cartilage
US4749522A (en) 1985-10-31 1988-06-07 Angio-Medical Corporation Supercritical fluid extraction of animal derived materials
US4746729A (en) 1986-07-30 1988-05-24 Kuettner Klaus E Cartilage-derived leukocyte elastase-inhibitor
US5075112A (en) 1990-02-12 1991-12-24 Cartilage Technologies Inc. Method of and dosage unit for inhibiting angiogenesis or vascularization in an animal using shark cartilage
US5260205A (en) * 1990-11-14 1993-11-09 Philip Morris Incorporated Method of purifying putrescine N-methyltransferase from tobacco plant extract with a polyamine
EP0571597A4 (en) 1991-11-15 1994-06-01 Arthro Res & Dev Corp Method for treatment of acute and chronic painful arthropathic conditions in human and other mammals
WO1994012510A1 (en) 1992-11-30 1994-06-09 Lane I William Processing shark cartilage
NZ268326A (en) 1993-07-19 1997-12-19 Angiogenesis Tech Inc Stent with a coating comprising an anti-angiogenic compound, such as taxol, and a polymeric carrier
US6028118A (en) 1996-08-08 2000-02-22 Les Laboratoires Aeterna Inc. Methods of using extracts of shark cartilage
US6025334A (en) 1994-04-28 2000-02-15 Les Laboratoires Aeterna Inc. Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof
US5618925A (en) 1994-04-28 1997-04-08 Les Laboratories Aeterna Inc. Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof
JPH11502514A (ja) 1995-02-03 1999-03-02 レ ラボラトワール エテルナ インコーポレイティド サメ軟骨の抽出物、その製造法および使用
US5843920A (en) * 1996-09-16 1998-12-01 Biocell Technology, Llc Anionic saccharides for extraction of anti-angiogenic protein from cartilage
US6168807B1 (en) 1998-07-23 2001-01-02 Les Laboratoires Aeterna Inc. Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof

Also Published As

Publication number Publication date
DE69911614D1 (de) 2003-10-30
ES2207248T3 (es) 2004-05-16
JP2002521340A (ja) 2002-07-16
EP1098656B1 (de) 2003-09-24
US20010001041A1 (en) 2001-05-10
US6506414B2 (en) 2003-01-14
EP1098656A2 (de) 2001-05-16
AU4893199A (en) 2000-02-14
CA2338068A1 (en) 2000-02-03
WO2000004910A2 (en) 2000-02-03
WO2000004910A3 (en) 2000-05-04
DE69911614T2 (de) 2004-06-03
CN1314816A (zh) 2001-09-26
US6168807B1 (en) 2001-01-02
HK1035488A1 (en) 2001-11-30

Similar Documents

Publication Publication Date Title
ATE250422T1 (de) Komponenten mit niedrigem molekulargewicht aus knorpelgewebe von haien, verfahren zur herstellung und therapeutische verwendungen
DE69324006D1 (de) Zubereitungen von hyaluronsaeure mit niedrigem molekulargewicht zur foerderung der knochenbildung
ATE245416T1 (de) Neue fettanaloge zur behandlung von diabetes
CA2265508A1 (en) Bone morphogenetic protein-16 (bmp-16) compositions
DE60024638D1 (de) Methode zur behandlung der haut durch elektrostatisches aufsprühen
HK1044543A1 (en) Beta-secretase enzyme compositions and methods
BR9714341A (pt) Método de produção de composições contendo polifenol.
ATE247666T1 (de) Wasserlöslische prodrugs von 2,6- diisopropylphenol-analoga
ATE292976T1 (de) Verwendung von angiotensin analogen zur herstellung eines arzneimittels zur steigerung des ueberlebens der weissen blutzellen und mobilisierung von haematopoietischen stammzellen nach einer chemotherapeutischen behandlung
ATE119040T1 (de) Zentrale cholecystokinin-antagonisten zur behandlung von psychiatrischen krankheiten.
ATE448323T1 (de) Lösliches hyaluronidase-glycoprotein (shasegp), verfahren zu seiner herstellung, verwendungen und dieses enthaltende pharmazeutische zusammensetzungen
DE60039450D1 (de) Zusammensetzungen und methoden zur stabilisierung von biologischen molekülen nach lyophilisierung
NZ335396A (en) Methods and compositions for stimulating neurite growth using compounds with affinity for fkbp12 in combination with neurotrophic factors
EA200602191A1 (ru) 5,5-дизамещённые-2-амино-4-тиазолидиноны и способ их получения, фармацевтическая композиция и способ лечения
BR9712765A (pt) Processos e composições para estimulação do crescimento de neurites utilizando compostos com afinidade para fkbp12 em combinação com fatores neurotróficos
EP2293776B1 (de) Lagerstabiles, funktionell intaktes virus-inaktiviertes fibrinogen
ATE230272T1 (de) Haiknorpel extrakte,verfahren zur herstellung und verwendungen desselben
EP1420031A3 (de) Morphogenetisches Protein der Knochen, BMP-18, und deren Zusammensetzungen
DE3886175T2 (de) Trigramin, ein Polypeptid, das die Aggregation der Blutplättchen hemmt.
DE69031656D1 (de) Saccharinderivate zur verwendung als proteolytische enzyminhibitoren sowie verfahren zur herstellung
GB2334446A (en) Aqueous compositions compromising a lipid and a lanolin-derived surfactant,and their use
FR2861731B1 (fr) Nouvelle proteine de fixation du phosphate, compositions pharmaceutiques la contenant et ses utilisations
FR2744017B1 (fr) Associations de lipides peroxydes et de composes organosiliciques, compositions cosmetiques et dermatologiques les contenant et leurs applications notamment pour le traitement de l'alopecie
FR2818903B1 (fr) Composition transparente de traitement cosmetique, de type emulsion eau-dans-huile, et procede de traitement cosmetique des matieres keratiniques
ATE288761T1 (de) Verwendung von glykosaminoglykane zur behandlung seniler demenz

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1098656

Country of ref document: EP

REN Ceased due to non-payment of the annual fee