ATE292976T1 - Verwendung von angiotensin analogen zur herstellung eines arzneimittels zur steigerung des ueberlebens der weissen blutzellen und mobilisierung von haematopoietischen stammzellen nach einer chemotherapeutischen behandlung - Google Patents

Verwendung von angiotensin analogen zur herstellung eines arzneimittels zur steigerung des ueberlebens der weissen blutzellen und mobilisierung von haematopoietischen stammzellen nach einer chemotherapeutischen behandlung

Info

Publication number: ATE292976T1
Authority: AT; Austria
Prior art keywords: cell survival; blood cell; white blood; mobilization; producing
Prior art date: 1998-05-11

Application number

AT99922905T

Other languages

English (en)

Inventor

Kathleen Rodgers

Gere Dizerega

Original Assignee

Univ Southern California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-11

Filing date

1999-05-10

Publication date

2005-04-15

1999-05-10 Application filed by Univ Southern California filed Critical Univ Southern California

2005-04-15 Application granted granted Critical

2005-04-15 Publication of ATE292976T1 publication Critical patent/ATE292976T1/de

Links

210000000265 leukocyte Anatomy 0.000 title abstract 2
230000004083 survival effect Effects 0.000 title abstract 2
102000015427 Angiotensins Human genes 0.000 title 1
108010064733 Angiotensins Proteins 0.000 title 1
230000000973 chemotherapeutic effect Effects 0.000 title 1
230000003394 haemopoietic effect Effects 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
210000000130 stem cell Anatomy 0.000 title 1
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 5
ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 abstract 4
102000005862 Angiotensin II Human genes 0.000 abstract 3
101800000733 Angiotensin-2 Proteins 0.000 abstract 3
229950006323 angiotensin ii Drugs 0.000 abstract 3
101800000734 Angiotensin-1 Proteins 0.000 abstract 2
102400000344 Angiotensin-1 Human genes 0.000 abstract 2
102000004881 Angiotensinogen Human genes 0.000 abstract 1
108090001067 Angiotensinogen Proteins 0.000 abstract 1
210000001185 bone marrow Anatomy 0.000 abstract 1
238000002512 chemotherapy Methods 0.000 abstract 1
210000003958 hematopoietic stem cell Anatomy 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000001483 mobilizing effect Effects 0.000 abstract 1
210000005259 peripheral blood Anatomy 0.000 abstract 1
239000011886 peripheral blood Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000018 receptor agonist Substances 0.000 abstract 1
229940044601 receptor agonist Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/085—Angiotensins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT99922905T 1998-05-11 1999-05-10 Verwendung von angiotensin analogen zur herstellung eines arzneimittels zur steigerung des ueberlebens der weissen blutzellen und mobilisierung von haematopoietischen stammzellen nach einer chemotherapeutischen behandlung ATE292976T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US8490898P	1998-05-11	1998-05-11
US9263398P	1998-07-13	1998-07-13
PCT/US1999/010205 WO1999058140A1 (en)	1998-05-11	1999-05-10	Methods to increase white blood cell survival after chemotherapy

Publications (1)

Publication Number	Publication Date
ATE292976T1 true ATE292976T1 (de)	2005-04-15

Family

ID=26771571

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99922905T ATE292976T1 (de)	1998-05-11	1999-05-10	Verwendung von angiotensin analogen zur herstellung eines arzneimittels zur steigerung des ueberlebens der weissen blutzellen und mobilisierung von haematopoietischen stammzellen nach einer chemotherapeutischen behandlung

Country Status (8)

Country	Link
US (2)	US6475988B1 (de)
EP (1)	EP1073453B1 (de)
JP (1)	JP2003521441A (de)
AT (1)	ATE292976T1 (de)
AU (1)	AU759285B2 (de)
CA (1)	CA2322963C (de)
DE (1)	DE69924715T2 (de)
WO (1)	WO1999058140A1 (de)

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AU2591699A (en) *	1998-02-09	1999-08-23	University Of Southern California	Method of promoting erythropoiesis
US7173011B2 (en) *	2000-11-20	2007-02-06	University Of Southern California	Radiation therapy methods
US6762167B1 (en) *	1998-05-11	2004-07-13	University Of Southern California	Methods for treating a patient undergoing chemotherapy
US6916783B2 (en) *	1998-07-13	2005-07-12	University Of Southern California	Methods for accelerating bone and cartilage growth and repair
US6730775B1 (en)	1999-03-23	2004-05-04	University Of Southern California	Methods for limiting scar and adhesion formation
US7338938B2 (en) *	1999-05-10	2008-03-04	University Of Southern California	Methods for treating a patient undergoing chemotherapy
US6821953B1 (en)	1999-12-16	2004-11-23	University Of Southern California	Methods for treating and preventing damage to mucosal tissue
WO2002096883A1 (en)	2001-05-31	2002-12-05	Vicore Pharma Ab	Tricyclic compounds useful as angiotensin ii agonists
EP1453547B1 (de) *	2001-12-17	2016-09-21	The Trustees Of The University Of Pennsylvania	Adeno-assoziierte virus (aav) serotyp 8 sequenzen, diese enthaltende vektoren und ihre verwendung
AU2003217783A1 (en) *	2002-02-27	2003-09-09	Wake Forest University	Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth
WO2009114461A2 (en) *	2008-03-10	2009-09-17	University Of Southern California	Angiotensin (1-7) dosage forms and uses thereof
EP2455388A1 (de)	2010-11-23	2012-05-23	LanthioPep B.V.	Neuartige Rezeptoragonisten von Angiotensin des Typs 2 (AT2) und Verwendungen dafür
EP2536422B8 (de)	2011-02-02	2023-06-21	University of Southern California	Verfahren zur behandlung von diabetischen fussgeschwüren
US9688724B2 (en)	2012-05-14	2017-06-27	University Of Southern California	Methods for limiting development of a skin wound
US8557958B1 (en)	2012-06-18	2013-10-15	Tarix Pharmaceuticals Ltd.	Compositions and methods for treatment of diabetes
US8633158B1 (en)	2012-10-02	2014-01-21	Tarix Pharmaceuticals Ltd.	Angiotensin in treating brain conditions
CA2911376C (en)	2013-03-15	2021-03-30	University Of Southern California	Phenyl(sulfonylcarbamate) derivatives and pharmaceutical compositions thereof for the treatment of angiotensin-related diseases
EP2968441A1 (de)	2013-03-15	2016-01-20	University of Southern California	Verfahren zur behandlung von multipler sklerose
CA2916701A1 (en)	2013-07-03	2015-01-08	The Arizona Board Of Regents On Behalf Of The University Of Arizona	Method for treating cognitive dysfunction
US9333233B2 (en)	2014-02-25	2016-05-10	Tarix Pharmaceuticals Ltd.	Methods and compositions for the delayed treatment of stroke
AU2015294371B2 (en)	2014-07-21	2018-02-01	The Arizona Board Of Regents On Behalf Of The University Of Arizona	Ang-(1-7) derivative oligopeptides and methods for using and producing the same
US10183055B2 (en)	2014-07-21	2019-01-22	Arizona Board Of Regents On Behalf Of The University Of Arizona	Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications
WO2018002673A1 (en)	2016-07-01	2018-01-04	N4 Pharma Uk Limited	Novel formulations of angiotensin ii receptor antagonists
JP2022542437A (ja)	2019-08-02	2022-10-03	ランティオペプベスローテンヴェンノーツハップ	癌の処置に用いるアンジオテンシン２型（ａｔ２）受容体アゴニスト

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1999
- 1999-05-10 JP JP2000547991A patent/JP2003521441A/ja active Pending
- 1999-05-10 CA CA002322963A patent/CA2322963C/en not_active Expired - Fee Related
- 1999-05-10 US US09/307,940 patent/US6475988B1/en not_active Expired - Lifetime
- 1999-05-10 AT AT99922905T patent/ATE292976T1/de not_active IP Right Cessation
- 1999-05-10 DE DE69924715T patent/DE69924715T2/de not_active Expired - Lifetime
- 1999-05-10 EP EP99922905A patent/EP1073453B1/de not_active Expired - Lifetime
- 1999-05-10 WO PCT/US1999/010205 patent/WO1999058140A1/en not_active Ceased
- 1999-05-10 AU AU39798/99A patent/AU759285B2/en not_active Ceased
2000
- 2000-11-20 US US09/716,394 patent/US6566335B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1073453B1 (de)	2005-04-13
DE69924715D1 (de)	2005-05-19
DE69924715T2 (de)	2006-01-26
AU3979899A (en)	1999-11-29
WO1999058140A1 (en)	1999-11-18
US6475988B1 (en)	2002-11-05
EP1073453A1 (de)	2001-02-07
US6566335B1 (en)	2003-05-20
JP2003521441A (ja)	2003-07-15
CA2322963A1 (en)	1999-11-18
CA2322963C (en)	2004-04-13
AU759285B2 (en)	2003-04-10

Legal Events

Date	Code	Title	Description
2005-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE292976T1 (de)	2005-04-15	Verwendung von angiotensin analogen zur herstellung eines arzneimittels zur steigerung des ueberlebens der weissen blutzellen und mobilisierung von haematopoietischen stammzellen nach einer chemotherapeutischen behandlung
MY129189A (en)	2007-03-30	Prostaglandin agonists and their use to treat bone disorders
IL197686A0 (en)	2011-07-31	Pharmaceutical compositions containing alpha-4 integrin antagonists and uses thereof in the treatment of multiple myeloma and diseases associated therewith
MA23744A1 (fr)	1996-07-01	Procede pour la preparation de sulfonamides, compositions pharmaceutiques les contenant et leur utilisation
MY141384A (en)	2010-04-30	Prevention of loss and restoration of bone mass by certain prostaglandin agonists
ATE365045T1 (de)	2007-07-15	Vermehrung des weich- sowie des knochengewebes anhand von aus muskeln stammenden vorläuferzellen,sowie damit verbundene zusammensetzungen und behandlungsformen
IL125282A (en)	2003-06-24	Substituted imidazole compounds, process for their preparation, pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating cytokine mediated diseases
DE69839815D1 (de)	2008-09-11	Verwendung von ppar-gamma aktivatoren zur behandlung von hautkrankheiten
ATE319812T1 (de)	2006-03-15	Knochen-vorläufer-zellen: zusammensetzungen und methoden
ITPD920071A1 (it)	1993-10-17	Impiego di preparazioni di acido ialuronico per la formazione di tessuto osseo
AU6331898A (en)	1998-09-18	Forskohlin for promoting lean body mass
EP0863755A4 (de)	1999-01-20	Antithrombotische diamine
ATE210677T1 (de)	2001-12-15	Die verwendung von angiotensin iii und seiner analoge für die gewebeheilung
AP9801269A0 (en)	1999-12-18	Prostaglandin agonists.
DE60118558D1 (de)	2006-05-18	Verfahren zur herstellung und sammlung von kristallinen partikeln
EE05091B1 (et)	2008-10-15	Oligosahhariidid, nende valmistamismeetod ja kasutamine ning farmatseutilised kompositsioonid
DE69535264D1 (de)	2006-11-23	Verfahren zur behandlung von diabetes mittels kgf
AU6794700A (en)	2001-03-19	Methods and compositions relating to hdac 4 and 5 regulation of cardiac gene expression
MY106202A (en)	1995-03-31	Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof.
ATE158183T1 (de)	1997-10-15	Arzneimittel zur behandlung von anxietas
DE59308848D1 (de)	1998-09-10	Anwendung von urodilatin bei lungen- und bronchialerkrankungen
EA199700241A1 (ru)	1998-02-26	Новые, определенные по составу смеси ферментов для выделения клеток и лечения ран
ATE250422T1 (de)	2003-10-15	Komponenten mit niedrigem molekulargewicht aus knorpelgewebe von haien, verfahren zur herstellung und therapeutische verwendungen
DE69120287D1 (en)	1996-07-18	Aminosulfonylharnstoff-acat-inhibitoren
DE69722202D1 (de)	2003-06-26	Dihydrobenzopyran und ähnliche verbindungen verwendbar als antientzündungsmittel