ATE292976T1 - Verwendung von angiotensin analogen zur herstellung eines arzneimittels zur steigerung des ueberlebens der weissen blutzellen und mobilisierung von haematopoietischen stammzellen nach einer chemotherapeutischen behandlung - Google Patents

Verwendung von angiotensin analogen zur herstellung eines arzneimittels zur steigerung des ueberlebens der weissen blutzellen und mobilisierung von haematopoietischen stammzellen nach einer chemotherapeutischen behandlung

Info

Publication number: ATE292976T1
Authority: AT; Austria
Prior art keywords: cell survival; blood cell; white blood; mobilization; producing
Prior art date: 1998-05-11

Application number

AT99922905T

Other languages

English (en)

Inventor

Kathleen Rodgers

Gere Dizerega

Original Assignee

Univ Southern California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-11

Filing date

1999-05-10

Publication date

2005-04-15

1999-05-10 Application filed by Univ Southern California filed Critical Univ Southern California

2005-04-15 Application granted granted Critical

2005-04-15 Publication of ATE292976T1 publication Critical patent/ATE292976T1/de

Links

210000000265 leukocyte Anatomy 0.000 title abstract 2
230000004083 survival effect Effects 0.000 title abstract 2
102000015427 Angiotensins Human genes 0.000 title 1
108010064733 Angiotensins Proteins 0.000 title 1
230000000973 chemotherapeutic effect Effects 0.000 title 1
230000003394 haemopoietic effect Effects 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
210000000130 stem cell Anatomy 0.000 title 1
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 5
ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 abstract 4
102000005862 Angiotensin II Human genes 0.000 abstract 3
101800000733 Angiotensin-2 Proteins 0.000 abstract 3
229950006323 angiotensin ii Drugs 0.000 abstract 3
101800000734 Angiotensin-1 Proteins 0.000 abstract 2
102400000344 Angiotensin-1 Human genes 0.000 abstract 2
102000004881 Angiotensinogen Human genes 0.000 abstract 1
108090001067 Angiotensinogen Proteins 0.000 abstract 1
210000001185 bone marrow Anatomy 0.000 abstract 1
238000002512 chemotherapy Methods 0.000 abstract 1
210000003958 hematopoietic stem cell Anatomy 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000001483 mobilizing effect Effects 0.000 abstract 1
210000005259 peripheral blood Anatomy 0.000 abstract 1
239000011886 peripheral blood Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000018 receptor agonist Substances 0.000 abstract 1
229940044601 receptor agonist Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/085—Angiotensins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Vascular Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT99922905T 1998-05-11 1999-05-10 Verwendung von angiotensin analogen zur herstellung eines arzneimittels zur steigerung des ueberlebens der weissen blutzellen und mobilisierung von haematopoietischen stammzellen nach einer chemotherapeutischen behandlung ATE292976T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US8490898P	1998-05-11	1998-05-11
US9263398P	1998-07-13	1998-07-13
PCT/US1999/010205 WO1999058140A1 (en)	1998-05-11	1999-05-10	Methods to increase white blood cell survival after chemotherapy

Publications (1)

Publication Number	Publication Date
ATE292976T1 true ATE292976T1 (de)	2005-04-15

Family

ID=26771571

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99922905T ATE292976T1 (de)	1998-05-11	1999-05-10	Verwendung von angiotensin analogen zur herstellung eines arzneimittels zur steigerung des ueberlebens der weissen blutzellen und mobilisierung von haematopoietischen stammzellen nach einer chemotherapeutischen behandlung

Country Status (8)

Country	Link
US (2)	US6475988B1 (de)
EP (1)	EP1073453B1 (de)
JP (1)	JP2003521441A (de)
AT (1)	ATE292976T1 (de)
AU (1)	AU759285B2 (de)
CA (1)	CA2322963C (de)
DE (1)	DE69924715T2 (de)
WO (1)	WO1999058140A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6335195B1 (en) *	1997-01-28	2002-01-01	Maret Corporation	Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
JP2002509077A (ja) *	1998-02-09	2002-03-26	ユニヴァースティオブサザーンカリフォルニア	赤血球形成促進方法
US7173011B2 (en) *	2000-11-20	2007-02-06	University Of Southern California	Radiation therapy methods
US6762167B1 (en) *	1998-05-11	2004-07-13	University Of Southern California	Methods for treating a patient undergoing chemotherapy
US6916783B2 (en) *	1998-07-13	2005-07-12	University Of Southern California	Methods for accelerating bone and cartilage growth and repair
US6730775B1 (en)	1999-03-23	2004-05-04	University Of Southern California	Methods for limiting scar and adhesion formation
US7338938B2 (en) *	1999-05-10	2008-03-04	University Of Southern California	Methods for treating a patient undergoing chemotherapy
US6821953B1 (en) *	1999-12-16	2004-11-23	University Of Southern California	Methods for treating and preventing damage to mucosal tissue
DE60222409T2 (de)	2001-05-31	2008-09-25	Vicore Pharma Ab	Trizyklische verbindungen, nützlich als angiotensin ii agonisten
ES2975413T3 (es) *	2001-12-17	2024-07-05	Univ Pennsylvania	Secuencias de serotipo 8 de virus adenoasociado (AAV), vectores que las contienen y usos de las mismas
EP1485116A4 (de) *	2002-02-27	2006-06-07	Univ Wake Forest	Angiotensin-(1-7)- und angiotensin-(1-7)-agonisten zur hemmung des krebszellenwachstums
US20090227507A1 (en) *	2008-03-10	2009-09-10	University Of Southern California	Angiotensin (1-7) Dosage Forms and Uses Thereof
EP2455388A1 (de)	2010-11-23	2012-05-23	LanthioPep B.V.	Neuartige Rezeptoragonisten von Angiotensin des Typs 2 (AT2) und Verwendungen dafür
EP2536422B8 (de)	2011-02-02	2023-06-21	University of Southern California	Verfahren zur behandlung von diabetischen fussgeschwüren
EP2849773A1 (de)	2012-05-14	2015-03-25	University of Southern California	Verfahren zur begrenzung der entwicklung einer hautwunde
US8557958B1 (en)	2012-06-18	2013-10-15	Tarix Pharmaceuticals Ltd.	Compositions and methods for treatment of diabetes
US8633158B1 (en)	2012-10-02	2014-01-21	Tarix Pharmaceuticals Ltd.	Angiotensin in treating brain conditions
EP2968441A1 (de)	2013-03-15	2016-01-20	University of Southern California	Verfahren zur behandlung von multipler sklerose
AU2014233185B2 (en)	2013-03-15	2018-03-15	University Of Southern California	Methods, compounds, and compositions for the treatment of angiotensin-related diseases
AU2014284496A1 (en)	2013-07-03	2016-01-21	The Arizona Board Of Regents On Behalf Of The University Of Arizona	Method for treating cognitive dysfunction
US9333233B2 (en)	2014-02-25	2016-05-10	Tarix Pharmaceuticals Ltd.	Methods and compositions for the delayed treatment of stroke
EP3171886A4 (de)	2014-07-21	2018-01-24	The Arizona Board of Regents On Behalf of the University of Arizona	Ang-(1-7)derivat-oligopeptide und verfahren zur verwendung und herstellung davon
US10183055B2 (en)	2014-07-21	2019-01-22	Arizona Board Of Regents On Behalf Of The University Of Arizona	Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications
WO2018002673A1 (en)	2016-07-01	2018-01-04	N4 Pharma Uk Limited	Novel formulations of angiotensin ii receptor antagonists
WO2021023698A1 (en)	2019-08-02	2021-02-11	Lanthiopep B.V	Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4904584A (en) *	1987-12-23	1990-02-27	Genetics Institute, Inc.	Site-specific homogeneous modification of polypeptides
US5015629A (en)	1989-06-26	1991-05-14	University Of Southern California	Tissue repair
US5527882A (en) *	1989-07-07	1996-06-18	The Regents Of The University Of California	Polypeptide having an amino acid replaced with N-benzylglycine
CA2044468C (en) *	1990-11-21	2006-08-22	Richard A. Nash	Canine granulocyte macrophage colony stimulating factor
US5578643A (en)	1992-05-20	1996-11-26	Loyola University Of Chicago	Protective prostaglandins for use in conjunction with chemotherapeutic agents
US5589452A (en)	1992-07-14	1996-12-31	Syntex (U.S.A.) Inc.	Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
DE69435301D1 (de)	1993-09-24	2010-08-26	Univ Southern California	Verwendung von Angiotensin-II-Analogen zur Gewebewiederherstellung
ES2168312T3 (es)	1993-09-24	2002-06-16	Univ Southern California	Utilizacion de angiotensina iii y sus analogos para la reparacion tisular.
US5955430A (en)	1993-09-24	1999-09-21	University Of Southern California	Use of angiotensin II fragments and analogs thereof in tissue repair
JP3403794B2 (ja) *	1994-01-27	2003-05-06	仙味エキス株式会社	血圧降下剤及び血圧降下性機能食品
US5739110A (en) *	1994-09-12	1998-04-14	Biomeasure Inc.	Protection of hemopoietic cells
US5595973A (en)	1994-09-12	1997-01-21	Biomeasure Incorporated	Protection of hemopoietic cells during chemotherapy or radiotherapy
US5614515A (en)	1994-11-17	1997-03-25	University Of Southern California	Lazaroid-based compositions and method for preventing adhesion formation using the same
US5834432A (en)	1995-06-06	1998-11-10	The University Of Southern California	Use of angiotensin II Type 2 receptor agonists in tissue repair
JPH11507038A (ja)	1995-06-07	1999-06-22	ユニヴァースティオブサザーンカリフォルニア	５−リポキシゲナーゼ阻害剤を用いる、術後癒着形成を低減又は阻止する方法
DE19549232C2 (de) *	1995-12-20	1998-05-20	Boehringer Mannheim Gmbh	Verwendung von G-CSF in Kombination mit einem Chemotherapeutikum bei der Behandlung von Erkrankungen, die eine periphere Stammzelltransplantation erfordern
WO1997034627A2 (en) *	1996-03-19	1997-09-25	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.	Protection of hemopoietic cells during chemotherapy or radiotherapy
US6110895A (en)	1996-12-16	2000-08-29	University Of Southern California	Method of promoting healing in skin grafts
US6335195B1 (en) *	1997-01-28	2002-01-01	Maret Corporation	Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
AU6650098A (en)	1997-02-04	1998-08-25	University Of Southern California	Method for accelerating healing of thermal injuries
US6248587B1 (en) *	1997-11-26	2001-06-19	University Of Southern Cailfornia	Method for promoting mesenchymal stem and lineage-specific cell proliferation
EP1047441A1 (de) *	1997-11-26	2000-11-02	University Of Southern California	Verfahren zur förderung der proliferation und differenzierung von hämatopoietischen und mesenchymalen zellen
CA2315266C (en) *	1997-12-12	2004-08-10	University Of Southern California	Wound healing compositions
JP2002509077A (ja) *	1998-02-09	2002-03-26	ユニヴァースティオブサザーンカリフォルニア	赤血球形成促進方法

1999
- 1999-05-10 AU AU39798/99A patent/AU759285B2/en not_active Ceased
- 1999-05-10 CA CA002322963A patent/CA2322963C/en not_active Expired - Fee Related
- 1999-05-10 EP EP99922905A patent/EP1073453B1/de not_active Expired - Lifetime
- 1999-05-10 JP JP2000547991A patent/JP2003521441A/ja active Pending
- 1999-05-10 AT AT99922905T patent/ATE292976T1/de not_active IP Right Cessation
- 1999-05-10 US US09/307,940 patent/US6475988B1/en not_active Expired - Lifetime
- 1999-05-10 DE DE69924715T patent/DE69924715T2/de not_active Expired - Lifetime
- 1999-05-10 WO PCT/US1999/010205 patent/WO1999058140A1/en not_active Ceased
2000
- 2000-11-20 US US09/716,394 patent/US6566335B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69924715T2 (de)	2006-01-26
US6475988B1 (en)	2002-11-05
EP1073453A1 (de)	2001-02-07
EP1073453B1 (de)	2005-04-13
CA2322963A1 (en)	1999-11-18
AU759285B2 (en)	2003-04-10
AU3979899A (en)	1999-11-29
CA2322963C (en)	2004-04-13
DE69924715D1 (de)	2005-05-19
US6566335B1 (en)	2003-05-20
JP2003521441A (ja)	2003-07-15
WO1999058140A1 (en)	1999-11-18

Legal Events

Date	Code	Title	Description
2005-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69924715D1 (de)	2005-05-19	Verwendung von angiotensin analogen zur herstellung eines arzneimittels zur steigerung des ueberlebens der weissen blutzellen und mobilisierung von haematopoietischen stammzellen nach einer chemotherapeutischen behandlung
MY129189A (en)	2007-03-30	Prostaglandin agonists and their use to treat bone disorders
IL197686A0 (en)	2011-07-31	Pharmaceutical compositions containing alpha-4 integrin antagonists and uses thereof in the treatment of multiple myeloma and diseases associated therewith
IL116385A0 (en)	1996-03-31	Sulphonamides their manufacture and pharmaceutical compositions containing them
MY141384A (en)	2010-04-30	Prevention of loss and restoration of bone mass by certain prostaglandin agonists
ATE365045T1 (de)	2007-07-15	Vermehrung des weich- sowie des knochengewebes anhand von aus muskeln stammenden vorläuferzellen,sowie damit verbundene zusammensetzungen und behandlungsformen
IL125282A (en)	2003-06-24	Substituted imidazole compounds, process for their preparation, pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating cytokine mediated diseases
DE69839815D1 (de)	2008-09-11	Verwendung von ppar-gamma aktivatoren zur behandlung von hautkrankheiten
ATE319812T1 (de)	2006-03-15	Knochen-vorläufer-zellen: zusammensetzungen und methoden
ITPD920071A1 (it)	1993-10-17	Impiego di preparazioni di acido ialuronico per la formazione di tessuto osseo
DE69429450D1 (de)	2002-01-24	Die verwendung von angiotensin iii und seiner analoge für die gewebeheilung
AU6331898A (en)	1998-09-18	Forskohlin for promoting lean body mass
AP9801269A0 (en)	1999-12-18	Prostaglandin agonists.
HUP0301349A2 (hu)	2003-08-28	IL-11-tartalmú készítmények
DE60118558D1 (de)	2006-05-18	Verfahren zur herstellung und sammlung von kristallinen partikeln
DE69535264D1 (de)	2006-11-23	Verfahren zur behandlung von diabetes mittels kgf
ATE311853T1 (de)	2005-12-15	Verwendung von krillenzymen zur behandlung von zahnbelag
MY106202A (en)	1995-03-31	Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof.
IL153147A0 (en)	2003-06-24	Phospholipid derivatives of valporic acid and mixtures thereof
ATE169225T1 (de)	1998-08-15	Anwendung von urodilatin bei lungen- und bronchialerkrankungen
DE69120287D1 (en)	1996-07-18	Aminosulfonylharnstoff-acat-inhibitoren
EA199700241A1 (ru)	1998-02-26	Новые, определенные по составу смеси ферментов для выделения клеток и лечения ран
IL126235A (en)	2003-02-12	Compounds with growth hormone releasing properties, pharmaceutical compositions comprising them and their use
ATE250422T1 (de)	2003-10-15	Komponenten mit niedrigem molekulargewicht aus knorpelgewebe von haien, verfahren zur herstellung und therapeutische verwendungen
ATE290857T1 (de)	2005-04-15	Bretyliumhaltige zusammensetzungen und kits und deren verwendung zur vorbeugung und behandlung cardiovaskulärer erkrankungen