ATE250623T1 - 4'-c-ethynyl-purin-nukleoside - Google Patents

4'-c-ethynyl-purin-nukleoside

Info

Publication number: ATE250623T1
Authority: AT; Austria
Prior art keywords: ethynyl; purine nucleosides; hydrogen atom; pyrimidine; ethynyl purine
Prior art date: 1999-05-12

Application number

AT00925625T

Other languages

English (en)

Inventor

Hiroshi Ohrui

Eiichi Kodama

Satoru Kohgo

Hiroaki Mitsuya

Masao Matsuoka

Kenji Kitano

Original Assignee

Yamasa Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-12

Filing date

2000-05-11

Publication date

2003-10-15

2000-05-11 Application filed by Yamasa Corp filed Critical Yamasa Corp

2003-10-15 Application granted granted Critical

2003-10-15 Publication of ATE250623T1 publication Critical patent/ATE250623T1/de

Links

239000002212 purine nucleoside Substances 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
LLKVXAAJAGWZGF-YGOYTEALSA-N 1-[(2r,4s,5r)-5-ethynyl-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@@](CO)(C#C)[C@@H](O)C1 LLKVXAAJAGWZGF-YGOYTEALSA-N 0.000 abstract 1
208000030507 AIDS Diseases 0.000 abstract 1
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
239000002259 anti human immunodeficiency virus agent Substances 0.000 abstract 1
229940124411 anti-hiv antiviral agent Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract 1
239000002718 pyrimidine nucleoside Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
AIDS & HIV (AREA)
Animal Behavior & Ethology (AREA)
Tropical Medicine & Parasitology (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT00925625T 1999-05-12 2000-05-11 4'-c-ethynyl-purin-nukleoside ATE250623T1 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
JP13153999		1999-05-12
JP17492099		1999-06-22
JP31824699		1999-11-09
JP2000081117		2000-03-23
PCT/JP2000/003025 WO2000069877A1 (en)	1999-05-12	2000-05-11	4'-c-ethynyl purine nucleosides

Publications (1)

Publication Number	Publication Date
ATE250623T1 true ATE250623T1 (de)	2003-10-15

Family

ID=27471622

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT00925625T ATE250623T1 (de)	1999-05-12	2000-05-11	4'-c-ethynyl-purin-nukleoside
AT00925624T ATE250622T1 (de)	1999-05-12	2000-05-11	4'-c-ethynyl-pyrimidine nukleoside

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT00925624T ATE250622T1 (de)	1999-05-12	2000-05-11	4'-c-ethynyl-pyrimidine nukleoside

Country Status (10)

Country	Link
US (3)	US6333315B1 (de)
EP (2)	EP1177201B1 (de)
AT (2)	ATE250623T1 (de)
AU (2)	AU4431200A (de)
BR (1)	BR0011521B8 (de)
CA (2)	CA2308192C (de)
DE (2)	DE60005502T2 (de)
ES (1)	ES2207504T3 (de)
MX (1)	MXPA01011517A (de)
WO (2)	WO2000069877A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60005502T2 (de) *	1999-05-12	2004-06-24	Yamasa Corp., Choshi	4'-c-ethynyl-purin-nukleoside
GB0114286D0 (en) *	2001-06-12	2001-08-01	Hoffmann La Roche	Nucleoside Derivatives
EP1438054A4 (de) *	2001-09-28	2006-07-26	Idenix Cayman Ltd	Verfahren und zusammensetzungen zur behandlung von flaviviren und pestiviren mit 4'-modifiziertem nucleosid
WO2003068796A1 (en) *	2002-02-15	2003-08-21	Yamasa Corporation	4’-c-cyano-2’-deoxypurine nucleosides
CA2514466C (en)	2003-02-19	2015-05-26	Yale University	Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections
CA2502109C (en) *	2004-03-24	2010-02-23	Yamasa Corporation	4'-c-substituted-2-haloadenosine derivative
US7645459B2 (en) *	2004-05-24	2010-01-12	The Procter & Gamble Company	Dosage forms of bisphosphonates
EP1794172B1 (de)	2004-08-23	2009-07-15	F.Hoffmann-La Roche Ag	Antivirale 4'-azidonucleoside
NZ597544A (en) *	2005-09-26	2013-04-26	Gilead Pharmasset Llc	Modified 4'-nucleosides as antiviral agents
CN101573370B (zh)	2006-10-10	2013-09-11	美迪维尔公司	Hcv核苷类抑制剂
US20090318380A1 (en)	2007-11-20	2009-12-24	Pharmasset, Inc.	2',4'-substituted nucleosides as antiviral agents
EP2794627B1 (de) *	2011-12-22	2018-09-26	Alios Biopharma, Inc.	Substituierte nukleoside, nukleotide und analoga davon
USRE48171E1 (en)	2012-03-21	2020-08-25	Janssen Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en)	2012-03-21	2016-09-13	Alios Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
WO2015054465A1 (en)	2013-10-11	2015-04-16	Alios Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
WO2015143712A1 (en)	2014-03-28	2015-10-01	Merck Sharp & Dohme Corp.	4'-substituted nucleoside reverse transcriptase inhibitors
MA41213A (fr)	2014-12-19	2017-10-24	Alios Biopharma Inc	Nucléosides substitués, nucléotides et analogues de ceux-ci
CA2998646C (en)	2015-09-23	2021-05-18	Merck Sharp & Dohme Corp.	4'-substituted nucleoside reverse transcriptase inhibitors and preparations thereof
WO2018092728A1 (ja)	2016-11-16	2018-05-24	国立研究開発法人国立国際医療研究センター	抗ウイルス活性等の生理活性を有するヌクレオシド誘導体
US11040975B2 (en)	2017-12-08	2021-06-22	Merck Sharp & Dohme Corp.	Carbocyclic nucleoside reverse transcriptase inhibitors
CN111971284A (zh) *	2017-12-27	2020-11-20	埃默里大学	核苷和/或nadph氧化酶(nox)抑制剂作为髓样特异性抗病毒剂的联合模式
CN112996511B (zh) *	2018-07-09	2024-08-09	默沙东有限责任公司	4’-乙炔基核苷类似物的酶促合成
WO2020044257A1 (en) *	2018-08-30	2020-03-05	Glaxosmithkline Intellectual Property (No.2) Limited	Compounds useful in hiv therapy
US12227536B2 (en)	2018-12-20	2025-02-18	Merck Sharp & Dohme Llc	Crystalline forms of an NRTTI compound
AU2020211600A1 (en)	2019-01-25	2021-07-22	Brown University	Compositions and methods for treating, preventing or reversing age-associated inflammation and disorders
BR112021017604A2 (pt)	2019-03-06	2021-11-16	Glaxosmithkline Ip No 2 Ltd	Compostos úteis na terapia para hiv
US20220298160A1 (en) *	2019-08-28	2022-09-22	Glaxosmithkline Intellectual Property (No.2) Limited	Compounds useful in hiv therapy
JP7719769B2 (ja)	2019-09-11	2025-08-06	ザスクリプスリサーチインスティテュート	抗ウイルスプロドラッグ及びその医薬組成物
TWI845826B (zh)	2020-03-20	2024-06-21	美商基利科學股份有限公司	4'-c-經取代-2-鹵基-2'-去氧腺苷核苷之前藥及其製造與使用方法
KR20250004956A (ko)	2022-03-15	2025-01-08	롬 테라퓨틱스, 인크.	질환을 치료하기 위한 화합물 및 방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60005502T2 (de) *	1999-05-12	2004-06-24	Yamasa Corp., Choshi	4'-c-ethynyl-purin-nukleoside

2000
- 2000-05-11 DE DE60005502T patent/DE60005502T2/de not_active Expired - Lifetime
- 2000-05-11 BR BRPI0011521A patent/BR0011521B8/pt not_active IP Right Cessation
- 2000-05-11 MX MXPA01011517A patent/MXPA01011517A/es active IP Right Grant
- 2000-05-11 AT AT00925625T patent/ATE250623T1/de active
- 2000-05-11 AU AU44312/00A patent/AU4431200A/en not_active Abandoned
- 2000-05-11 EP EP00925624A patent/EP1177201B1/de not_active Expired - Lifetime
- 2000-05-11 EP EP00925625A patent/EP1177202B1/de not_active Expired - Lifetime
- 2000-05-11 WO PCT/JP2000/003025 patent/WO2000069877A1/en not_active Ceased
- 2000-05-11 AT AT00925624T patent/ATE250622T1/de not_active IP Right Cessation
- 2000-05-11 WO PCT/JP2000/003024 patent/WO2000069876A1/en not_active Ceased
- 2000-05-11 ES ES00925625T patent/ES2207504T3/es not_active Expired - Lifetime
- 2000-05-11 AU AU44313/00A patent/AU4431300A/en not_active Abandoned
- 2000-05-11 DE DE60005501T patent/DE60005501T2/de not_active Expired - Lifetime
- 2000-05-12 US US09/570,042 patent/US6333315B1/en not_active Expired - Lifetime
- 2000-05-12 CA CA002308192A patent/CA2308192C/en not_active Expired - Lifetime
- 2000-05-12 CA CA002308677A patent/CA2308677C/en not_active Expired - Lifetime
- 2000-05-12 US US09/570,041 patent/US6291670B1/en not_active Expired - Lifetime
2001
- 2001-08-30 US US09/941,845 patent/US6403568B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60005501D1 (de)	2003-10-30
CA2308192C (en)	2007-09-18
DE60005501T2 (de)	2004-06-24
WO2000069877A1 (en)	2000-11-23
AU4431300A (en)	2000-12-05
EP1177201A1 (de)	2002-02-06
EP1177202B1 (de)	2003-09-24
EP1177202A1 (de)	2002-02-06
US20020022722A1 (en)	2002-02-21
BR0011521B8 (pt)	2021-05-25
BR0011521B1 (pt)	2013-12-24
CA2308677C (en)	2007-09-18
US6291670B1 (en)	2001-09-18
AU4431200A (en)	2000-12-05
BR0011521A (pt)	2002-03-26
WO2000069876A1 (en)	2000-11-23
US6403568B1 (en)	2002-06-11
CA2308192A1 (en)	2000-11-12
CA2308677A1 (en)	2000-11-12
DE60005502D1 (de)	2003-10-30
DE60005502T2 (de)	2004-06-24
EP1177201B1 (de)	2003-09-24
MXPA01011517A (es)	2003-08-20
US6333315B1 (en)	2001-12-25
ES2207504T3 (es)	2004-06-01
ATE250622T1 (de)	2003-10-15

Legal Events

Date

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Title

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2004-05-15

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Publication	Publication Date	Title
ATE250623T1 (de)	2003-10-15	4'-c-ethynyl-purin-nukleoside
WO1997030677A3 (en)	1997-11-20	Pentafluorobenzenesulfonamides and analogs
AP2002002455A0 (en)	2002-06-30	5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dIhydropyrazolo[4,3-D] pyrimidin-7-ones as phosphodiesterase inhibitors.
AP9801378A0 (en)	2000-04-29	9-amino-3- keto erythromycin derivatives.
IL127965A0 (en)	1999-11-30	Pentafluorobenzenesulfonamide derivatives analogs thereof and pharmaceutical compositions containing the same
TR200103395T2 (tr)	2002-04-22	13-metil eritromisin türevleri.
GEP20084284B (en)	2008-01-10	Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
CA2336412A1 (en)	2000-01-13	Medicament for treatment of diabetes
CA2238875A1 (en)	1997-06-26	Tri-aryl ethane derivatives as pde iv inhibitors
ATE233754T1 (de)	2003-03-15	Diphenyl-piperidin derivate
SE9904129D0 (sv)	1999-11-15	Novel compounds
MD1560F2 (en)	2000-11-30	Cyclic compounds, pharmaceutical compositions on base thereof and methods of treatment of infections or diseases provoked by retroviruses.
DE69031340D1 (de)	1997-10-02	3'-azido-2',3'-dideoxy-5-methylcytidin enthaltende antivirale zusammensetzungen
MX9805023A (es)	1998-11-30	Derivados de 1-metilcarbapenem.
BRPI9916820B8 (pt)	2023-04-25	composição compreendendo 9[2[[bis[(pivaloilóxi)metil]fosfono]metóxi]etil]adenina, comprimido ou cápsula e método
GB9426090D0 (en)	1995-02-22	Pharmaceutical compounds
EP1019047A4 (de)	2001-06-13	Antithrombotische mittel
ATE251162T1 (de)	2003-10-15	Triazolo(4,5-d)pyrimidin-verbindungen
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DE69007356D1 (de)	1994-04-21	Zyklisches Tetrapeptid und Verfahren zu dessen Herstellung.
IL147307A0 (en)	2002-08-14	Indolocarbazole alkaloid derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
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FR2823749B1 (fr)	2004-02-20	Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant
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