BR0011521A - Composto nucleósidos de purina de 4' -c-etinila - Google Patents

Composto nucleósidos de purina de 4' -c-etinila

Info

Publication number
BR0011521A
BR0011521A BR0011521-5A BR0011521A BR0011521A BR 0011521 A BR0011521 A BR 0011521A BR 0011521 A BR0011521 A BR 0011521A BR 0011521 A BR0011521 A BR 0011521A
Authority
BR
Brazil
Prior art keywords
ethynyl
purine nucleoside
nucleoside compound
hydrogen atom
pyrimidine
Prior art date
Application number
BR0011521-5A
Other languages
English (en)
Other versions
BR0011521B8 (pt
BR0011521B1 (pt
Inventor
Hiroshi Ohrui
Eiichi Kodama
Satoru Kohgo
Hiroaki Mitsuya
Masao Matsuoka
Kenji Kitano
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Publication of BR0011521A publication Critical patent/BR0011521A/pt
Publication of BR0011521B1 publication Critical patent/BR0011521B1/pt
Publication of BR0011521B8 publication Critical patent/BR0011521B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Patente de Invenção "COMPOSTOS NUCLEóSIDOS DE PURINA DE 4'-C-ETINILA". Representados pela fórmula [I]: em que B representa uma base selecionada a partir do grupo que consiste de purina e seus derivados; X representa um átomo de hidrogênio ou um grupo hidroxila; e R representa um átomo de hidrogênio ou um resíduo de fosfato; e uma composição farmacêutica que contém qualquer dos compostos e um veículo farmaceuticamente aceitável. Preferencialmente, a composição é utilizada como agente anti-HIV ou uma droga para o tratamento da AIDS.
BRPI0011521A 1999-05-12 2000-05-11 compostos nucleósidos de purina de 4 -c-etinila BR0011521B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP13153999 1999-05-12
JP17492099 1999-06-22
JP31824699 1999-11-09
JP2000081117 2000-03-23
PCT/JP2000/003025 WO2000069877A1 (en) 1999-05-12 2000-05-11 4'-c-ethynyl purine nucleosides

Publications (3)

Publication Number Publication Date
BR0011521A true BR0011521A (pt) 2002-03-26
BR0011521B1 BR0011521B1 (pt) 2013-12-24
BR0011521B8 BR0011521B8 (pt) 2021-05-25

Family

ID=27471622

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0011521A BR0011521B8 (pt) 1999-05-12 2000-05-11 compostos nucleósidos de purina de 4 -c-etinila

Country Status (10)

Country Link
US (3) US6333315B1 (pt)
EP (2) EP1177202B1 (pt)
AT (2) ATE250623T1 (pt)
AU (2) AU4431300A (pt)
BR (1) BR0011521B8 (pt)
CA (2) CA2308677C (pt)
DE (2) DE60005502T2 (pt)
ES (1) ES2207504T3 (pt)
MX (1) MXPA01011517A (pt)
WO (2) WO2000069876A1 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE250623T1 (de) * 1999-05-12 2003-10-15 Yamasa Corp 4'-c-ethynyl-purin-nukleoside
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
JP2005536440A (ja) * 2001-09-28 2005-12-02 イデニクス（ケイマン）リミテツド ４’位が修飾されたヌクレオシドを使用するフラビウイルスおよびペスチウイルスの治療のための方法および組成物
WO2003068796A1 (en) * 2002-02-15 2003-08-21 Yamasa Corporation 4’-c-cyano-2’-deoxypurine nucleosides
EA012844B1 (ru) 2003-02-19 2009-12-30 Йельский Университет Аналоги противовирусных нуклеозидов и способы лечения вирусных инфекций, в частности вич-инфекций
CA2502109C (en) 2004-03-24 2010-02-23 Yamasa Corporation 4'-c-substituted-2-haloadenosine derivative
US7645459B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
DE602005015466D1 (de) 2004-08-23 2009-08-27 Hoffmann La Roche Antivirale 4'-azidonucleoside
NZ567272A (en) 2005-09-26 2012-02-24 Pharmasset Inc Modified 4'-nucleosides as antiviral agents
WO2008043704A1 (en) 2006-10-10 2008-04-17 Medivir Ab Hcv nucleoside inhibitor
US20090318380A1 (en) 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
UA117095C2 (uk) 2011-12-22 2018-06-25 Аліос Біофарма, Інк. Нуклеозидна сполука або її фармацевтично прийнятна сіль
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
EP3055319A4 (en) 2013-10-11 2018-01-10 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2015143712A1 (en) 2014-03-28 2015-10-01 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
CN108289931B (zh) 2015-09-23 2022-10-11 默沙东公司 4’-取代的核苷逆转录酶抑制剂及其制备
US10933067B2 (en) 2016-11-16 2021-03-02 National Center For Global Health And Medicine Nucleoside derivative having physiological activity such as antiviral activity
US11040975B2 (en) 2017-12-08 2021-06-22 Merck Sharp & Dohme Corp. Carbocyclic nucleoside reverse transcriptase inhibitors
MX2020006864A (es) * 2017-12-27 2020-11-11 Univ Emory Modalidades combinadas para inhibidores de nucleosidos y/o nadph oxidasa (nox) como agentes antivirales especificos de mieloides.
KR102868585B1 (ko) 2018-07-09 2025-10-13 머크 샤프 앤드 돔 엘엘씨 4'-에티닐 뉴클레오시드 유사체의 효소적 합성
JP2021536444A (ja) * 2018-08-30 2021-12-27 グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited Ｈｉｖ療法に有用な化合物
JP7530899B2 (ja) 2018-12-20 2024-08-08 メルク・シャープ・アンド・ドーム・エルエルシー Ｎｒｔｔｉ化合物の新規結晶形態
SG11202107145SA (en) 2019-01-25 2021-08-30 Univ Brown Compositions and methods for treating, preventing or reversing age-associated inflammation and disorders
AU2020231934B2 (en) 2019-03-06 2023-04-20 Glaxosmithkline Intellectual Property (No.2) Limited Compounds useful in HIV therapy
US20220298160A1 (en) * 2019-08-28 2022-09-22 Glaxosmithkline Intellectual Property (No.2) Limited Compounds useful in hiv therapy
PE20221037A1 (es) 2019-09-11 2022-06-17 Scripps Research Inst Profarmacos antivirales y composiciones farmaceuticas de los mismos
US11718637B2 (en) 2020-03-20 2023-08-08 Gilead Sciences, Inc. Prodrugs of 4′-C-substituted-2-halo-2′- deoxyadenosine nucleosides and methods of making and using the same
TW202400134A (zh) 2022-03-15 2024-01-01 美商羅米醫療公司 用於治療疾病之化合物及方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE250623T1 (de) * 1999-05-12 2003-10-15 Yamasa Corp 4'-c-ethynyl-purin-nukleoside

Also Published As

Publication number Publication date
MXPA01011517A (es) 2003-08-20
BR0011521B8 (pt) 2021-05-25
WO2000069876A1 (en) 2000-11-23
US6291670B1 (en) 2001-09-18
CA2308677C (en) 2007-09-18
AU4431200A (en) 2000-12-05
DE60005502D1 (de) 2003-10-30
CA2308677A1 (en) 2000-11-12
AU4431300A (en) 2000-12-05
ES2207504T3 (es) 2004-06-01
DE60005502T2 (de) 2004-06-24
US6403568B1 (en) 2002-06-11
EP1177201A1 (en) 2002-02-06
BR0011521B1 (pt) 2013-12-24
CA2308192A1 (en) 2000-11-12
ATE250622T1 (de) 2003-10-15
DE60005501T2 (de) 2004-06-24
WO2000069877A1 (en) 2000-11-23
CA2308192C (en) 2007-09-18
US6333315B1 (en) 2001-12-25
DE60005501D1 (de) 2003-10-30
EP1177201B1 (en) 2003-09-24
EP1177202A1 (en) 2002-02-06
US20020022722A1 (en) 2002-02-21
EP1177202B1 (en) 2003-09-24
ATE250623T1 (de) 2003-10-15

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B08G Application fees: restoration [chapter 8.7 patent gazette]
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B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
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