BR0011521A - Composto nucleósidos de purina de 4' -c-etinila - Google Patents

Composto nucleósidos de purina de 4' -c-etinila

Info

Publication number
BR0011521A
BR0011521A BR0011521-5A BR0011521A BR0011521A BR 0011521 A BR0011521 A BR 0011521A BR 0011521 A BR0011521 A BR 0011521A BR 0011521 A BR0011521 A BR 0011521A
Authority
BR
Brazil
Prior art keywords
ethynyl
purine nucleoside
nucleoside compound
hydrogen atom
pyrimidine
Prior art date
Application number
BR0011521-5A
Other languages
English (en)
Other versions
BR0011521B1 (pt
BR0011521B8 (pt
Inventor
Hiroshi Ohrui
Eiichi Kodama
Satoru Kohgo
Hiroaki Mitsuya
Masao Matsuoka
Kenji Kitano
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Publication of BR0011521A publication Critical patent/BR0011521A/pt
Publication of BR0011521B1 publication Critical patent/BR0011521B1/pt
Publication of BR0011521B8 publication Critical patent/BR0011521B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Patente de Invenção "COMPOSTOS NUCLEóSIDOS DE PURINA DE 4'-C-ETINILA". Representados pela fórmula [I]: em que B representa uma base selecionada a partir do grupo que consiste de purina e seus derivados; X representa um átomo de hidrogênio ou um grupo hidroxila; e R representa um átomo de hidrogênio ou um resíduo de fosfato; e uma composição farmacêutica que contém qualquer dos compostos e um veículo farmaceuticamente aceitável. Preferencialmente, a composição é utilizada como agente anti-HIV ou uma droga para o tratamento da AIDS.
BRPI0011521A 1999-05-12 2000-05-11 compostos nucleósidos de purina de 4 -c-etinila BR0011521B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP13153999 1999-05-12
JP17492099 1999-06-22
JP31824699 1999-11-09
JP2000081117 2000-03-23
PCT/JP2000/003025 WO2000069877A1 (en) 1999-05-12 2000-05-11 4'-c-ethynyl purine nucleosides

Publications (3)

Publication Number Publication Date
BR0011521A true BR0011521A (pt) 2002-03-26
BR0011521B1 BR0011521B1 (pt) 2013-12-24
BR0011521B8 BR0011521B8 (pt) 2021-05-25

Family

ID=27471622

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0011521A BR0011521B8 (pt) 1999-05-12 2000-05-11 compostos nucleósidos de purina de 4 -c-etinila

Country Status (10)

Country Link
US (3) US6333315B1 (pt)
EP (2) EP1177201B1 (pt)
AT (2) ATE250622T1 (pt)
AU (2) AU4431300A (pt)
BR (1) BR0011521B8 (pt)
CA (2) CA2308677C (pt)
DE (2) DE60005501T2 (pt)
ES (1) ES2207504T3 (pt)
MX (1) MXPA01011517A (pt)
WO (2) WO2000069877A1 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE250622T1 (de) * 1999-05-12 2003-10-15 Yamasa Corp 4'-c-ethynyl-pyrimidine nukleoside
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
US20040006002A1 (en) * 2001-09-28 2004-01-08 Jean-Pierre Sommadossi Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
AU2003211483A1 (en) * 2002-02-15 2003-09-04 Yamasa Corporation 4'-c-cyano-2'-deoxypurine nucleosides
CN102174038A (zh) * 2003-02-19 2011-09-07 耶鲁大学 用于治疗病毒感染的抗病毒核苷
CA2502109C (en) * 2004-03-24 2010-02-23 Yamasa Corporation 4'-c-substituted-2-haloadenosine derivative
US7645459B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
WO2006021341A1 (en) 2004-08-23 2006-03-02 F. Hoffmann-La Roche Ag Antiviral 4’-azido-nucleosides
EA200800932A1 (ru) 2005-09-26 2008-10-30 Фармассет, Инк. Модифицированные 4`-нуклеозиды в качестве противовирусных агентов
AP2009004812A0 (en) 2006-10-10 2009-04-30 Medivir Ab HCV nucleoside inhibitor
US20090318380A1 (en) * 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
SG10201913554YA (en) * 2011-12-22 2020-03-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2015054465A1 (en) 2013-10-11 2015-04-16 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2015143712A1 (en) 2014-03-28 2015-10-01 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
MX391226B (es) 2015-09-23 2025-03-21 Merck Sharp & Dohme Llc Inhibidores de transcriptasa inversa de nucleosido 4'-substituido y preparaciones de los mismos.
WO2018092728A1 (ja) 2016-11-16 2018-05-24 国立研究開発法人国立国際医療研究センター 抗ウイルス活性等の生理活性を有するヌクレオシド誘導体
US11040975B2 (en) 2017-12-08 2021-06-22 Merck Sharp & Dohme Corp. Carbocyclic nucleoside reverse transcriptase inhibitors
CN111971284A (zh) * 2017-12-27 2020-11-20 埃默里大学 核苷和/或nadph氧化酶(nox)抑制剂作为髓样特异性抗病毒剂的联合模式
JP7773906B2 (ja) 2018-07-09 2025-11-20 メルク・シャープ・アンド・ドーム・エルエルシー ４’－エチルヌクレオシド類似体の酵素的合成
JP2021536444A (ja) * 2018-08-30 2021-12-27 グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited Ｈｉｖ療法に有用な化合物
CA3122576C (en) 2018-12-20 2025-11-25 Merck Sharp & Dohme Llc CRYSTALLINE FORMS OF THE NRTTI COMPOUND OF 4'-ETHYNYL-2-FLUORO-2'-DESOXYADENOSINE
EP3914604B1 (en) 2019-01-25 2026-03-04 Brown University Compositions comprising censavudine or elvucitabine for treating age-associated inflammation and disorders
CN113811360A (zh) 2019-03-06 2021-12-17 葛兰素史密斯克莱知识产权（第2 号）有限公司 用于hiv治疗的化合物
WO2021038509A1 (en) * 2019-08-28 2021-03-04 Glaxosmithkline Intellectual Property (No.2) Limited 4'-ethynyl-2'-deoxyadenosine derivatives and their use in hiv therapy
KR20220066303A (ko) 2019-09-11 2022-05-24 더 스크립스 리서치 인스티튜트 항바이러스 전구약물 및 이의 약제학적 조성물
WO2021188959A1 (en) 2020-03-20 2021-09-23 Gilead Sciences, Inc. Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same
IL315480A (en) 2022-03-15 2024-11-01 Rome Therapeutics Inc Compounds and methods for treating disease

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE250622T1 (de) * 1999-05-12 2003-10-15 Yamasa Corp 4'-c-ethynyl-pyrimidine nukleoside

Also Published As

Publication number Publication date
EP1177201A1 (en) 2002-02-06
EP1177201B1 (en) 2003-09-24
EP1177202A1 (en) 2002-02-06
US6291670B1 (en) 2001-09-18
US20020022722A1 (en) 2002-02-21
ES2207504T3 (es) 2004-06-01
CA2308192C (en) 2007-09-18
DE60005501T2 (de) 2004-06-24
ATE250623T1 (de) 2003-10-15
DE60005501D1 (de) 2003-10-30
AU4431300A (en) 2000-12-05
DE60005502D1 (de) 2003-10-30
EP1177202B1 (en) 2003-09-24
US6403568B1 (en) 2002-06-11
AU4431200A (en) 2000-12-05
WO2000069876A1 (en) 2000-11-23
DE60005502T2 (de) 2004-06-24
MXPA01011517A (es) 2003-08-20
CA2308192A1 (en) 2000-11-12
ATE250622T1 (de) 2003-10-15
WO2000069877A1 (en) 2000-11-23
US6333315B1 (en) 2001-12-25
CA2308677A1 (en) 2000-11-12
BR0011521B1 (pt) 2013-12-24
CA2308677C (en) 2007-09-18
BR0011521B8 (pt) 2021-05-25

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
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