ATE250663T1 - Kulturmedium und verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht - Google Patents

Kulturmedium und verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht

Info

Publication number
ATE250663T1
ATE250663T1 AT94925419T AT94925419T ATE250663T1 AT E250663 T1 ATE250663 T1 AT E250663T1 AT 94925419 T AT94925419 T AT 94925419T AT 94925419 T AT94925419 T AT 94925419T AT E250663 T1 ATE250663 T1 AT E250663T1
Authority
AT
Austria
Prior art keywords
hyaluronic acid
molecular weight
culture medium
high molecular
producing high
Prior art date
Application number
AT94925419T
Other languages
English (en)
Inventor
Flavia Cazzola
Michael O'regan
Vincenza Corsa
Original Assignee
Fidia Advanced Biopolymers Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl
Application granted granted Critical
Publication of ATE250663T1 publication Critical patent/ATE250663T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT94925419T 1993-07-30 1994-07-29 Kulturmedium und verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht ATE250663T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITPD930164A IT1263393B (it) 1993-07-30 1993-07-30 Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare
PCT/EP1994/002537 WO1995004132A1 (en) 1993-07-30 1994-07-29 Process for the preparation and purification of high molecular weight hyaluronic acid

Publications (1)

Publication Number Publication Date
ATE250663T1 true ATE250663T1 (de) 2003-10-15

Family

ID=11390424

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94925419T ATE250663T1 (de) 1993-07-30 1994-07-29 Kulturmedium und verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht

Country Status (7)

Country Link
EP (1) EP0716688B1 (de)
AT (1) ATE250663T1 (de)
AU (1) AU7534294A (de)
DE (1) DE69433177T2 (de)
ES (1) ES2211883T3 (de)
IT (1) IT1263393B (de)
WO (1) WO1995004132A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7044134B2 (en) 1999-11-08 2006-05-16 Ev3 Sunnyvale, Inc Method of implanting a device in the left atrial appendage
ITPD20020064A1 (it) 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
ITPD20050206A1 (it) 2005-07-07 2007-01-08 Fidia Advanced Biopolymers Srl Biomateriali in forma di fibra da impiegarsi come dispositivi medici nel trattamento delle ferite e loro processi di produzione
US7972359B2 (en) 2005-09-16 2011-07-05 Atritech, Inc. Intracardiac cage and method of delivering same
US20070135826A1 (en) 2005-12-01 2007-06-14 Steve Zaver Method and apparatus for delivering an implant without bias to a left atrial appendage
CN100478360C (zh) * 2006-10-31 2009-04-15 山东福瑞达生物化工有限公司 将浓缩用于透明质酸或其盐的生产的方法
ITMI20071267A1 (it) 2007-06-22 2008-12-23 Fidia Farmaceutici Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative
ITMI20071724A1 (it) 2007-09-05 2009-03-06 Fidia Farmaceutici Formulazioni topiche antivirali in forma di gel bioadesivo
CA2705850C (en) * 2007-11-13 2016-07-19 Bio-Technology General (Israel) Ltd. Dilute filtration sterilization process for viscoelastic biopolymers
IT1393945B1 (it) 2009-04-21 2012-05-17 Fidia Farmaceutici Composizioni comprendenti acido ialuronico, acido ialuronico solfatato, calcio e vitamina d3 nel trattamento delle malattie osteoarticolari e muscoloscheletriche
JP2011195604A (ja) * 2010-03-17 2011-10-06 Denki Kagaku Kogyo Kk ヒアルロン酸及び／又はその塩の含有液中の異物除去方法
CZ304072B6 (cs) 2011-04-26 2013-09-25 Contipro Biotech S.R.O. Amfoterní materiál na bázi sítované kyseliny hyaluronové, zpusob jeho prípravy, materiály obsahující aktivní cinidla uzavrené v síti hyaluronanu, zpusob jejich prípravy a jejich pouzití
KR101322227B1 (ko) * 2011-09-30 2013-10-28 일동제약주식회사 스트렙토코커스 디스갈락티애 ｉｄ9103 균주 및 이를 이용한 히알루론산 생산 방법
ITPD20120098A1 (it) 2012-03-30 2013-10-01 Fidia Farmaceutici "nuove formulazioni faramaceutiche contenenti condroitin solfato e derivati dell'acido ialuronico"
ITMI20120664A1 (it) 2012-04-20 2013-10-21 Anika Therapeutics Srl Biomateriali a base di gellano per l'uso come filler in chirurgia
ITPD20130110A1 (it) 2013-04-24 2014-10-25 Fidia Farmaceutici Composizioni farmaceutiche comprendenti acido ialuronico per il trattamento del black disc
IT201600079633A1 (it) 2016-07-28 2018-01-28 Fidia Farm Spa Procedimento di preparazione e purificazione del sale sodico dell’acido ialuronico
CN110831520B (zh) 2017-04-27 2022-11-15 波士顿科学国际有限公司 具有织物保持倒钩的闭塞医疗装置
IT201700081449A1 (it) * 2017-07-18 2019-01-18 Fidia Farm Spa Procedimento di purificazione dell'acido ialuronico
IT201900006250A1 (it) 2019-04-23 2020-10-23 Fidia Farm Spa Medicazione per il trattamento della cute lesa
EP3840670B1 (de) 2018-08-21 2023-11-15 Boston Scientific Scimed, Inc. Vorspringendes element mit widerhaken für kardiovaskuläre vorrichtungen
IT201800009444A1 (it) 2018-10-15 2020-04-15 Fidia Farm Spa Coniugati tra acido ialuronico e amminobisfosfonati e loro impiego terapeutico
IT201800009731A1 (it) 2018-10-25 2020-04-25 Fidia Farm Spa Coniugato paclitaxel - acido ialuronico nel trattamento del carcinoma vescicale non infiltrante
EP3998962B1 (de) 2019-07-17 2024-05-08 Boston Scientific Scimed, Inc. Linkes herzohrimplantat mit kontinuierlicher abdeckung
EP4563099A3 (de) 2019-08-30 2025-08-06 Boston Scientific Scimed, Inc. Implantat für linkes herzohr mit dichtscheibe
IT201900019762A1 (it) 2019-10-24 2021-04-24 Fidia Farm Spa Composizione farmaceutica per uso nel trattamento della cistite di varia eziologia
WO2021108790A1 (en) * 2019-11-30 2021-06-03 Lacerta Life Sciences, Llc Purification of reptilian hyaluronic acid and its use for soft and hard tissue repair and regeneration
US11903589B2 (en) 2020-03-24 2024-02-20 Boston Scientific Scimed, Inc. Medical system for treating a left atrial appendage
IT202000007747A1 (it) 2020-04-10 2021-10-10 Fidia Farm Spa Coniugato acido ialuronico-paclitaxel nel trattamento del mesotelioma
IT202000008209A1 (it) 2020-04-17 2021-10-17 Fidia Farm Spa Procedimento di sintesi di un coniugato acido ialuronico-paclitaxel
IT202000014017A1 (it) 2020-06-11 2021-12-11 Fidia Farm Spa Nuovi derivati ottenuti da acido ialuronico e carnosina
WO2022115690A1 (en) 2020-11-30 2022-06-02 Boston Scientific Scimed, Inc. Implantable passive mean pressure sensor
IT202000032243A1 (it) 2020-12-23 2022-06-23 Fidia Farm Spa Nuovi agenti antivirali
WO2022155344A1 (en) 2021-01-14 2022-07-21 Boston Scientific Scimed, Inc. Medical system for treating a left atrial appendage
US12383201B2 (en) 2021-02-03 2025-08-12 Boston Scientific Scimed, Inc. Medical system for treating a left atrial appendage
US12318092B2 (en) 2021-06-22 2025-06-03 Boston Scientific Scimed, Inc. Left atrial appendage implant
CN117615720A (zh) 2021-07-08 2024-02-27 波士顿科学医学有限公司 左心耳闭合装置
WO2023038929A1 (en) 2021-09-08 2023-03-16 Boston Scientific Scimed, Inc. Occlusive implant with multi-sharpness split tip soft tissue anchors
IT202100032111A1 (it) 2021-12-22 2023-06-22 Fidia Farm Spa Nuovi sostituti biocompatibili dell’umor vitreo
EP4572684A1 (de) 2022-08-16 2025-06-25 Boston Scientific Scimed, Inc. Medizinische vorrichtung zum verschliessen des linken herzohrs
IT202300023433A1 (it) 2023-11-07 2025-05-07 Univ Degli Studi Di Catania Derivati di acido ialuronico fotogeneratori di ossido nitrico
IT202300025521A1 (it) 2023-11-30 2025-05-30 Fidia Farm Spa Composizioni farmaceutiche oftalmiche e relativo uso
IT202300026142A1 (it) 2023-12-06 2025-06-06 Fidia Farm Spa Composizioni mucoadesive per il trattamento locale delle affezioni vaginali
WO2025132905A1 (en) * 2023-12-22 2025-06-26 Novozymes A/S Fermentation method

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2975104A (en) * 1959-05-21 1961-03-14 American Home Prod Medium and method for producing and isolating hyaluronic acid
JPS51139685A (en) * 1975-05-26 1976-12-02 Hitachi Chem Co Ltd Process for preparing glutathione
JPS51139692A (en) * 1975-05-27 1976-12-02 Chugai Pharmaceut Co Ltd Process for preparing a new antibiotic substance ta-146
US4517295A (en) * 1983-02-18 1985-05-14 Diagnostic, Inc. Hyaluronic acid from bacterial culture
US4780414A (en) * 1985-01-18 1988-10-25 Bio-Technology General Corp. Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus
US4784990A (en) * 1985-01-18 1988-11-15 Bio-Technology General Corporation High molecular weight sodium hyaluronate
JPS6232893A (ja) * 1985-08-01 1987-02-12 Kyowa Hakko Kogyo Co Ltd ヒアルロン酸の製造法
JPS6251999A (ja) * 1985-09-02 1987-03-06 Kyowa Hakko Kogyo Co Ltd ヒアルロン酸の製造法
US5023175A (en) * 1986-05-01 1991-06-11 Kabushiki Kaisha Yakult Honsha Novel production process of hyaluronic acid and bacterium strain therefor
JPH072117B2 (ja) * 1986-10-09 1995-01-18 三菱レイヨン株式会社 ヒアルロン酸の製造法
US4897349A (en) * 1989-04-28 1990-01-30 Medchem Products, Inc. Biosynthesis of hyaluronic acid
GB9024223D0 (en) * 1990-11-07 1990-12-19 Fermentech Ltd Production of hyaluronic acid

Also Published As

Publication number Publication date
DE69433177D1 (de) 2003-10-30
IT1263393B (it) 1996-08-05
WO1995004132A1 (en) 1995-02-09
AU7534294A (en) 1995-02-28
EP0716688B1 (de) 2003-09-24
EP0716688A1 (de) 1996-06-19
ES2211883T3 (es) 2004-07-16
ITPD930164A1 (it) 1995-01-30
ITPD930164A0 (it) 1993-07-30
DE69433177T2 (de) 2004-06-17

Similar Documents

Publication Publication Date Title
ATE250663T1 (de) Kulturmedium und verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht
ATE457037T1 (de) Verfahren zur herstellung von pektinhydrolyseprodukten
GEP20002205B (en) Copolymer-1; Composition for Treating Disseminated Sclerosis, Method for Production of Copolymer-1
ATE315050T2 (de) Verfahren zur herstellung von mehrfach vernetzten hyaluronsäurederivaten
ATE201704T1 (de) Harnstoff- und urethangruppen enthaltendes lineares blockpolymer, verfahren zur herstellung von linearen blockpolymeren sowie verwendung der blockpolymeren als implantate
DE69326341D1 (de) Poly-3-hydroxyalkanoate und verfahren zu ihrer herstellung
EP1281722A4 (de) Hyaluronsäuregel, verfahren zu dessen herstellung sowie das gel enthaltendes medizinisches material
KR900700617A (ko) 뼈 및 연골 유도 조성물
DE60226243D1 (de) Peptidsynthasegen, peptidsynthase und verfahren zur herstellung eines dipeptids
ATE306945T1 (de) Arzneimittelformen mit zellregulierendem faktor und/oder einem promoter zur proliferation von zellen
ATE317911T1 (de) Verfahren zur herstellung von l-aminosäuren durch fermentation
DE59606773D1 (de) Verfahren zur herstellung von polymeren aus olefinisch ungesättigten monomeren
ATE524496T1 (de) Von k5-polysaccharid abgeleitete glycosaminoglycane mit hoher anthithrombinwirkung und verfahren zu ihrer herstellung
DE60002871D1 (de) Verfahren zur herstellung von celluloseethern mit verminderter vergilbung und verfärbung
DE60207914D1 (de) Verfahren zur Herstellung von L-Glutaminsäure
DE60038565D1 (de) Verfahren zur herstellung von ubiquinon-10
ATE397088T1 (de) Verfahren zur herstellung von (s)- oder (r)-3,3,3-trifluor-2-hydroxy-2-methylpropionsaü e
AU583970B2 (en) Guanidinobenzoic ester derivative
ATE160367T1 (de) Verfahren zur herstellung resorbierbarem polymer
DE69404454D1 (de) Verfahren zur herstellung von aminomethanphosphonsäure
ATE124449T1 (de) Mikrobiologisches verfahren zur herstellung von hydroxylierten heterocyclen.
ATE299851T1 (de) Verfahren zur herstellung von zwischenprodukten
ATE167683T1 (de) Partiell hydrierte aminotelechele oligomere von 1,3-dienen und methode zur herstellung derselben
DE69313138D1 (de) Oligosaccharide mit biologischer aktivität und verfahren zur herstellung aus glykosaminoglykanen
DE69905218D1 (de) Verfahren zur Herstellung von L-Allysin Acetal

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties