ITPD20020064A1 - Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem - Google Patents
Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistemInfo
- Publication number
- ITPD20020064A1 ITPD20020064A1 IT2002PD000064A ITPD20020064A ITPD20020064A1 IT PD20020064 A1 ITPD20020064 A1 IT PD20020064A1 IT 2002PD000064 A IT2002PD000064 A IT 2002PD000064A IT PD20020064 A ITPD20020064 A IT PD20020064A IT PD20020064 A1 ITPD20020064 A1 IT PD20020064A1
- Authority
- IT
- Italy
- Prior art keywords
- hyaluronic acid
- biomedical
- sanitary
- hydrogeld
- preparation
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
- 229920002674 hyaluronan Polymers 0.000 abstract 3
- 229960003160 hyaluronic acid Drugs 0.000 abstract 3
- -1 hyaluronic acid ester Chemical class 0.000 abstract 3
- 238000013270 controlled release Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000017 hydrogel Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000016 photochemical curing Methods 0.000 abstract 1
- KRIOVPPHQSLHCZ-UHFFFAOYSA-N propiophenone Chemical class CCC(=O)C1=CC=CC=C1 KRIOVPPHQSLHCZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/043—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Surgery (AREA)
- Polymers & Plastics (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Prostheses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002PD000064A ITPD20020064A1 (it) | 2002-03-12 | 2002-03-12 | Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem |
| CA2478655A CA2478655C (en) | 2002-03-12 | 2003-03-12 | Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring |
| ES03743875T ES2294305T3 (es) | 2002-03-12 | 2003-03-12 | Derivados ester del acido hialuronico para la preparacion de materiales de hidrogel mediante fotocurado. |
| PCT/EP2003/002538 WO2003076475A1 (en) | 2002-03-12 | 2003-03-12 | Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring |
| DE60316291T DE60316291T2 (de) | 2002-03-12 | 2003-03-12 | Esterderivate von hyaluronsäure zur herstellung von hydrogelmaterialien durch photohärtung |
| JP2003574690A JP4458852B2 (ja) | 2002-03-12 | 2003-03-12 | 光硬化によるハイドロゲル材料の調製のためのヒアルロン酸のエステル誘導体 |
| AT03743875T ATE373018T1 (de) | 2002-03-12 | 2003-03-12 | Esterderivate von hyaluronsäure zur herstellung von hydrogelmaterialien durch photohärtung |
| US10/507,472 US7462606B2 (en) | 2002-03-12 | 2003-03-12 | Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring |
| AU2003227050A AU2003227050B2 (en) | 2002-03-12 | 2003-03-12 | Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring |
| EP03743875A EP1519962B1 (en) | 2002-03-12 | 2003-03-12 | Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring |
| US12/246,970 US8178663B2 (en) | 2002-03-12 | 2008-10-07 | Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring |
| US12/246,805 US8178499B2 (en) | 2002-03-12 | 2008-10-07 | Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002PD000064A ITPD20020064A1 (it) | 2002-03-12 | 2002-03-12 | Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITPD20020064A1 true ITPD20020064A1 (it) | 2003-09-12 |
Family
ID=27799887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2002PD000064A ITPD20020064A1 (it) | 2002-03-12 | 2002-03-12 | Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7462606B2 (it) |
| EP (1) | EP1519962B1 (it) |
| JP (1) | JP4458852B2 (it) |
| AT (1) | ATE373018T1 (it) |
| AU (1) | AU2003227050B2 (it) |
| CA (1) | CA2478655C (it) |
| DE (1) | DE60316291T2 (it) |
| ES (1) | ES2294305T3 (it) |
| IT (1) | ITPD20020064A1 (it) |
| WO (1) | WO2003076475A1 (it) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITPD20020064A1 (it) | 2002-03-12 | 2003-09-12 | Fidia Advanced Biopolymers Srl | Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem |
| US6982298B2 (en) | 2003-01-10 | 2006-01-03 | The Cleveland Clinic Foundation | Hydroxyphenyl cross-linked macromolecular network and applications thereof |
| US8137688B2 (en) | 2003-01-10 | 2012-03-20 | The Cleveland Clinic Foundation | Hydroxyphenyl cross-linked macromolecular network and applications thereof |
| US8138265B2 (en) | 2003-01-10 | 2012-03-20 | The Cleveland Clinic Foundation | Hydroxyphenyl cross-linked macromolecular network and applications thereof |
| US7465766B2 (en) | 2004-01-08 | 2008-12-16 | The Cleveland Clinic Foundation | Hydroxyphenyl cross-linked macromolecular network and applications thereof |
| ITPD20040053A1 (it) * | 2004-02-27 | 2004-05-27 | Fidia Advanced Biopolymers Srl | Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi |
| CA2577022A1 (en) * | 2004-08-13 | 2006-02-23 | Angiotech International Ag | Compositions and methods using hyaluronic acid and hyluronidase inhibitors |
| US9205046B2 (en) * | 2005-04-25 | 2015-12-08 | The Governing Council Of The University Of Toronto | Enhanced stability of inverse thermal gelling composite hydrogels |
| US9205047B2 (en) * | 2005-04-25 | 2015-12-08 | The Governing Council Of The University Of Toronto | Tunable sustained release of a sparingly soluble hydrophobic therapeutic agent from a hydrogel matrix |
| WO2007004675A1 (ja) * | 2005-07-06 | 2007-01-11 | Seikagaku Corporation | 薬剤導入光架橋ヒアルロン酸誘導体ゲル |
| US20100215720A1 (en) * | 2006-08-08 | 2010-08-26 | Fundacion Inasmet | Implantable optical system, method for developing it and applications |
| US8062364B1 (en) * | 2007-04-27 | 2011-11-22 | Knee Creations, Llc | Osteoarthritis treatment and device |
| EP2222715B1 (en) * | 2007-12-19 | 2019-07-24 | Evonik Degussa GmbH | Crosslinked hyaluronic acid in emulsion |
| EP2249891B1 (en) | 2008-02-13 | 2016-05-25 | The Cleveland Clinic Foundation | Molecular enhancement of extracellular matrix and methods of use |
| JP5758797B2 (ja) | 2008-04-04 | 2015-08-05 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション | アルキル化半合成グリコサミノグリカンエーテルならびにその製造および使用方法 |
| EP2300042A4 (en) | 2008-04-30 | 2012-05-02 | Cleveland Clinic Foundation | COMPOSITIONS AND METHODS FOR TREATING URINARY INCONTINENCE |
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| US20110125264A1 (en) * | 2009-11-20 | 2011-05-26 | Knee Creations, Llc | Implantable devices for subchondral treatment of joint pain |
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| US11311376B2 (en) | 2019-06-20 | 2022-04-26 | Neovase Tiara Inc. | Low profile prosthetic mitral valve |
| JP2026500565A (ja) | 2022-12-27 | 2026-01-07 | アヴィータ・メディカル・アメリカズ,リミテッド・ライアビリティ・カンパニー | 再生上皮懸濁液の自動調製のためのシステムおよび関連する使用方法 |
| US12570949B2 (en) | 2022-12-27 | 2026-03-10 | AVITA Medical Americas, LLC | Systems and devices for wound therapy and related methods of use |
| USD1112812S1 (en) | 2023-12-22 | 2026-02-10 | AVITA Medical Americas, LLC | Tissue processing cartridge |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2553099B1 (fr) | 1983-10-11 | 1989-09-08 | Fidia Spa | Fractions d'acide hyaluronique ayant une activite pharmaceutique, procedes pour leur preparation et compositions pharmaceutiques les contenant |
| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| IT1219587B (it) | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
| US5529914A (en) | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
| US5410016A (en) | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| JP2855307B2 (ja) | 1992-02-05 | 1999-02-10 | 生化学工業株式会社 | 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法 |
| US5573934A (en) | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
| IT1263393B (it) | 1993-07-30 | 1996-08-05 | Fidia Advanced Biopolymers Srl | Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare |
| IT1268954B1 (it) | 1994-03-11 | 1997-03-18 | Fidia Advanced Biopolymers Srl | Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche |
| ITPD940054A1 (it) | 1994-03-23 | 1995-09-23 | Fidia Advanced Biopolymers Srl | Polisaccaridi solfatati |
| PL182804B1 (pl) | 1995-02-07 | 2002-03-29 | Fidia Advanced Biopolymers | Sposób powlekania powierzchni przedmiotu kwasem hialuronowym lub pochodną kwasu hialuronowego i sposób powlekania powierzchni przedmiotu polimerem półsyntetycznym |
| IT1281886B1 (it) | 1995-05-22 | 1998-03-03 | Fidia Advanced Biopolymers Srl | Processo per la preparazione di idrogel ottenuti da derivati chimici dell'acido ialuronico mediante irradiazioni ultraviolette e loro |
| US5612321A (en) * | 1995-06-22 | 1997-03-18 | Hercules Incorporated | Antioxidant grafted polysaccharides |
| ATE221086T1 (de) | 1995-11-15 | 2002-08-15 | Seikagaku Kogyo Co Ltd | Photovernetztes hyaluronsäuregel und verfahren zu dessen herstellung |
| DK0971961T3 (da) | 1997-04-04 | 2003-03-24 | Fidia Advanced Biopolymers Srl | N-sulfaterede hyaluronsyreforbindelser, derivater deraf og en fremgangsmåde til deres fremstilling |
| ITPD980169A1 (it) | 1998-07-06 | 2000-01-06 | Fidia Advanced Biopolymers Srl | Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione. |
| US6630457B1 (en) | 1998-09-18 | 2003-10-07 | Orthogene Llc | Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same |
| ITPD20020064A1 (it) | 2002-03-12 | 2003-09-12 | Fidia Advanced Biopolymers Srl | Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem |
-
2002
- 2002-03-12 IT IT2002PD000064A patent/ITPD20020064A1/it unknown
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2003
- 2003-03-12 CA CA2478655A patent/CA2478655C/en not_active Expired - Lifetime
- 2003-03-12 JP JP2003574690A patent/JP4458852B2/ja not_active Expired - Fee Related
- 2003-03-12 AT AT03743875T patent/ATE373018T1/de active
- 2003-03-12 EP EP03743875A patent/EP1519962B1/en not_active Expired - Lifetime
- 2003-03-12 ES ES03743875T patent/ES2294305T3/es not_active Expired - Lifetime
- 2003-03-12 WO PCT/EP2003/002538 patent/WO2003076475A1/en not_active Ceased
- 2003-03-12 DE DE60316291T patent/DE60316291T2/de not_active Expired - Lifetime
- 2003-03-12 US US10/507,472 patent/US7462606B2/en not_active Expired - Lifetime
- 2003-03-12 AU AU2003227050A patent/AU2003227050B2/en not_active Ceased
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2008
- 2008-10-07 US US12/246,805 patent/US8178499B2/en not_active Expired - Fee Related
- 2008-10-07 US US12/246,970 patent/US8178663B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2478655C (en) | 2012-05-08 |
| ES2294305T3 (es) | 2008-04-01 |
| US8178663B2 (en) | 2012-05-15 |
| JP4458852B2 (ja) | 2010-04-28 |
| EP1519962B1 (en) | 2007-09-12 |
| AU2003227050A1 (en) | 2003-09-22 |
| US20090076257A1 (en) | 2009-03-19 |
| US20050119219A1 (en) | 2005-06-02 |
| US20090075911A1 (en) | 2009-03-19 |
| EP1519962A1 (en) | 2005-04-06 |
| AU2003227050B2 (en) | 2008-11-06 |
| US8178499B2 (en) | 2012-05-15 |
| CA2478655A1 (en) | 2003-09-18 |
| ATE373018T1 (de) | 2007-09-15 |
| JP2005535736A (ja) | 2005-11-24 |
| WO2003076475A1 (en) | 2003-09-18 |
| DE60316291T2 (de) | 2008-06-05 |
| DE60316291D1 (de) | 2007-10-25 |
| US7462606B2 (en) | 2008-12-09 |
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