ATE251930T1 - 1h-imidazo(4,5-d)pyridazin-7-one, 3h-imidazo(4,5- c)pyridin-4-one und korrespondierende thione als corticotropin freisetzende factor-(crf)- receptorliganden - Google Patents

1h-imidazo(4,5-d)pyridazin-7-one, 3h-imidazo(4,5- c)pyridin-4-one und korrespondierende thione als corticotropin freisetzende factor-(crf)- receptorliganden

Info

Publication number
ATE251930T1
ATE251930T1 AT99966736T AT99966736T ATE251930T1 AT E251930 T1 ATE251930 T1 AT E251930T1 AT 99966736 T AT99966736 T AT 99966736T AT 99966736 T AT99966736 T AT 99966736T AT E251930 T1 ATE251930 T1 AT E251930T1
Authority
AT
Austria
Prior art keywords
imidazo
crf
releasing factor
pyridazine
pyridine
Prior art date
Application number
AT99966736T
Other languages
English (en)
Inventor
Paul Joseph Gilligan
Rajagopal Bakthavatchalam
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Application granted granted Critical
Publication of ATE251930T1 publication Critical patent/ATE251930T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT99966736T 1998-12-30 1999-12-30 1h-imidazo(4,5-d)pyridazin-7-one, 3h-imidazo(4,5- c)pyridin-4-one und korrespondierende thione als corticotropin freisetzende factor-(crf)- receptorliganden ATE251930T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11418898P 1998-12-30 1998-12-30
PCT/US1999/031325 WO2000039127A1 (en) 1998-12-30 1999-12-30 1h-imidazo[4,5-d]pyridazin-7-ones, 3h-imidazo[4,5-c]pyridin-4-ones and corresponding thiones as corticotropin releasing factor (crf) receptor ligands

Publications (1)

Publication Number Publication Date
ATE251930T1 true ATE251930T1 (de) 2003-11-15

Family

ID=22353834

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99966736T ATE251930T1 (de) 1998-12-30 1999-12-30 1h-imidazo(4,5-d)pyridazin-7-one, 3h-imidazo(4,5- c)pyridin-4-one und korrespondierende thione als corticotropin freisetzende factor-(crf)- receptorliganden

Country Status (10)

Country Link
US (2) US6271380B1 (de)
EP (1) EP1140929B1 (de)
AT (1) ATE251930T1 (de)
AU (1) AU2222500A (de)
CA (1) CA2351724A1 (de)
DE (1) DE69912153T2 (de)
DK (1) DK1140929T3 (de)
ES (1) ES2209550T3 (de)
PT (1) PT1140929E (de)
WO (1) WO2000039127A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19837387A1 (de) * 1998-08-18 2000-02-24 Aventis Res & Tech Gmbh & Co 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung
KR20040034594A (ko) 2001-01-26 2004-04-28 브리스톨-마이어스스퀴브컴파니 코르티코트로핀 방출 인자 억제제로서의 이미다졸릴 유도체
TWI312347B (en) 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
HUP0401292A3 (en) 2001-04-27 2011-01-28 Eisai R & D Man Co Pyrazolo[1,5-a]pyridines, pharmaceutical compositions containing the same and process for preparation thereof
EP1485384A1 (de) 2002-03-13 2004-12-15 Pharmacia & Upjohn Company LLC Pyrazolo(1,5-a-)pyridinderivate als neurotransmittermodulatoren
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
TWI283679B (en) 2002-10-22 2007-07-11 Eisai Co Ltd 7-phenylpyrazolopyridine compounds
US7176216B2 (en) 2002-10-22 2007-02-13 Eisai Co., Ltd. 7-phenylpyrazolopyridine compounds
EP2161273B1 (de) 2003-12-22 2015-04-15 K.U.Leuven Research & Development Imidazo[4,5-c]pyridin-Verbindungen und Verfahren zur Antivirusbehandlung
US7572805B2 (en) 2004-07-14 2009-08-11 Bristol-Myers Squibb Company Pyrrolo(oxo)isoquinolines as 5HT ligands
EP1846410B1 (de) * 2005-02-10 2009-01-21 Bristol-Myers Squibb Company Dihydrochinazolinone als 5ht-modulatoren
KR20080034171A (ko) * 2005-07-28 2008-04-18 브리스톨-마이어스 스큅 컴퍼니 세로토닌 수용체 효능제 및 길항제로서의 치환된테트라히드로-1ｈ-피리도[4,3,ｂ]인돌
US7795436B2 (en) * 2005-08-24 2010-09-14 Bristol-Myers Squibb Company Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists
EP2266990B1 (de) 2008-04-15 2012-09-26 Eisai R&D Management Co., Ltd. 3-PHENYLPYRAZOL[5,1-b]THIAZOL-VERBINDUNG
AR078521A1 (es) 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
WO2013097052A1 (en) 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
WO2014206150A1 (en) * 2013-06-28 2014-12-31 Abbvie Inc. Bromodomain inhibitors
AR096758A1 (es) * 2013-06-28 2016-02-03 Abbvie Inc Inhibidores cristalinos de bromodominios
EP3089970B1 (de) * 2013-12-09 2018-10-17 AbbVie Inc. Dihydropyridinon- und dihydropyridazinonderivate als bromdomänenhemmer
PT3442972T (pt) 2016-04-15 2020-05-29 Abbvie Inc Inibidores de bromodomínio

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019715A1 (en) * 1990-06-15 1991-12-26 G.D. Searle & Co. 1H-SUBSTITUTED-IMIDAZO[4,5-d]PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS
WO1995010506A1 (en) 1993-10-12 1995-04-20 The Du Pont Merck Pharmaceutical Company 1n-alkyl-n-arylpyrimidinamines and derivatives thereof
FI964893A7 (fi) 1994-06-06 1996-12-05 Pfizer Substituoituja pyratsoleja, jotka ovat aktiivisia kortikotropiinin vap auttamistekijän (CRF) antagonisteina
TW530047B (en) 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
DK0765327T3 (da) 1994-06-16 1999-11-29 Pfizer Pyrazolo- og pyrrolopyridiner
PT778277E (pt) 1995-12-08 2003-11-28 Pfizer Derivados heterociclicos substituidos como antagonistas do crf
AU6279598A (en) * 1997-02-18 1998-09-08 Neurocrine Biosciences, Inc. Biazacyclic CRF antagonists
PL337888A1 (en) * 1997-07-03 2000-09-11 Du Pont Pharm Co Imidazoprimidines and imidazopyridines for use in treating neurological disorders
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists

Also Published As

Publication number Publication date
CA2351724A1 (en) 2000-07-06
US6271380B1 (en) 2001-08-07
PT1140929E (pt) 2004-02-27
AU2222500A (en) 2000-07-31
EP1140929B1 (de) 2003-10-15
EP1140929A4 (de) 2002-04-17
DK1140929T3 (da) 2004-02-16
WO2000039127A1 (en) 2000-07-06
ES2209550T3 (es) 2004-06-16
DE69912153D1 (de) 2003-11-20
EP1140929A1 (de) 2001-10-10
DE69912153T2 (de) 2004-08-26
US6518271B1 (en) 2003-02-11

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