DK1140929T3 - 1 H-Imidazo[4,5-d]pyridazin-7-oner, 3H-imidazo[4,5-c]pyridin-4-oner og tilsvarende thioner som corticotropinfrigivende faktor (CRF)-receptorligander - Google Patents

1 H-Imidazo[4,5-d]pyridazin-7-oner, 3H-imidazo[4,5-c]pyridin-4-oner og tilsvarende thioner som corticotropinfrigivende faktor (CRF)-receptorligander

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Publication number
DK1140929T3
DK1140929T3 DK99966736T DK99966736T DK1140929T3 DK 1140929 T3 DK1140929 T3 DK 1140929T3 DK 99966736 T DK99966736 T DK 99966736T DK 99966736 T DK99966736 T DK 99966736T DK 1140929 T3 DK1140929 T3 DK 1140929T3
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DK
Denmark
Prior art keywords
imidazo
ones
crf
releasing factor
thions
Prior art date
Application number
DK99966736T
Other languages
English (en)
Inventor
Paul Joseph Gilligan
Rajagopal Bakthavatchalam
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Application granted granted Critical
Publication of DK1140929T3 publication Critical patent/DK1140929T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK99966736T 1998-12-30 1999-12-30 1 H-Imidazo[4,5-d]pyridazin-7-oner, 3H-imidazo[4,5-c]pyridin-4-oner og tilsvarende thioner som corticotropinfrigivende faktor (CRF)-receptorligander DK1140929T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11418898P 1998-12-30 1998-12-30
PCT/US1999/031325 WO2000039127A1 (en) 1998-12-30 1999-12-30 1h-imidazo[4,5-d]pyridazin-7-ones, 3h-imidazo[4,5-c]pyridin-4-ones and corresponding thiones as corticotropin releasing factor (crf) receptor ligands

Publications (1)

Publication Number Publication Date
DK1140929T3 true DK1140929T3 (da) 2004-02-16

Family

ID=22353834

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99966736T DK1140929T3 (da) 1998-12-30 1999-12-30 1 H-Imidazo[4,5-d]pyridazin-7-oner, 3H-imidazo[4,5-c]pyridin-4-oner og tilsvarende thioner som corticotropinfrigivende faktor (CRF)-receptorligander

Country Status (10)

Country Link
US (2) US6271380B1 (da)
EP (1) EP1140929B1 (da)
AT (1) ATE251930T1 (da)
AU (1) AU2222500A (da)
CA (1) CA2351724A1 (da)
DE (1) DE69912153T2 (da)
DK (1) DK1140929T3 (da)
ES (1) ES2209550T3 (da)
PT (1) PT1140929E (da)
WO (1) WO2000039127A1 (da)

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DE19837387A1 (de) * 1998-08-18 2000-02-24 Aventis Res & Tech Gmbh & Co 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung
US6888004B2 (en) 2001-01-26 2005-05-03 Bristol-Myers Squibb Company Imidazolyl derivatives as corticotropin releasing factor inhibitors
TWI312347B (en) 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
BR0209252A (pt) 2001-04-27 2004-07-20 Eisai Co Ltd Pirazolo[1,5-a]piridinas e medicamentos contendo as mesmas
AU2003220190A1 (en) 2002-03-13 2003-09-29 Pharmacia & Upjohn Company Llc Pyrazolo(1,5-a)pyridine derivatives as neurotransmitter modulators
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
US7176216B2 (en) 2002-10-22 2007-02-13 Eisai Co., Ltd. 7-phenylpyrazolopyridine compounds
AU2003275589B2 (en) 2002-10-22 2009-05-28 Eisai R & D Management Co., Ltd. 7-phenyl pyrazolopyridine compounds
DK2161273T3 (da) 2003-12-22 2015-07-20 Leuven K U Res & Dev Imidazo[4,5-c]pyridinforbindelser og fremgangsmåder til antiviral behandling
US7572805B2 (en) 2004-07-14 2009-08-11 Bristol-Myers Squibb Company Pyrrolo(oxo)isoquinolines as 5HT ligands
WO2006086464A2 (en) * 2005-02-10 2006-08-17 Bristol-Myers Squibb Company Dihydroquinazolinones as 5ht modulators
MX2008000811A (es) * 2005-07-28 2008-03-18 Squibb Bristol Myers Co Tetrahidro-1h-pitido[4,3-b]indoles substituidos como agonistas y antagonistas del receptor de serotonina.
US7795436B2 (en) * 2005-08-24 2010-09-14 Bristol-Myers Squibb Company Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists
MY152687A (en) 2008-04-15 2014-10-31 Eisai R&D Man Co Ltd 3-phenylpyrazolo[5,1-b]thiazole compound
AR078521A1 (es) 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
WO2013097052A1 (en) 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
AR096758A1 (es) * 2013-06-28 2016-02-03 Abbvie Inc Inhibidores cristalinos de bromodominios
HK1223364A1 (zh) * 2013-06-28 2017-07-28 Abbvie Inc. 布罗莫结构域抑制剂
EP3089970B1 (en) * 2013-12-09 2018-10-17 AbbVie Inc. Dihydropyridinone and dihydropyridazinone derivatives useful as bromodomain inhibitors
AU2017251537B2 (en) 2016-04-15 2020-10-08 Abbvie Inc. Bromodomain inhibitors

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Publication number Priority date Publication date Assignee Title
WO1991019715A1 (en) * 1990-06-15 1991-12-26 G.D. Searle & Co. 1H-SUBSTITUTED-IMIDAZO[4,5-d]PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS
JP3398152B2 (ja) 1993-10-12 2003-04-21 ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー １ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体
EP0764153A1 (en) 1994-06-06 1997-03-26 Pfizer Inc. Substituted pyrazoles having corticotropin-releasing factor (crf) antagonist activity
TW574214B (en) 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
ES2135062T3 (es) 1994-06-16 1999-10-16 Pfizer Pirazolo y pirrolopiridinas.
DK0778277T3 (da) 1995-12-08 2003-10-27 Pfizer Substituerede heterocycliske derivater som CRF antagonister
JP2001511813A (ja) * 1997-02-18 2001-08-14 ニューロクライン バイオサイエンシーズ，インコーポレイテッド Ｃｒｆレセプターアンタゴニストおよびそれらに関連する方法
JP2002507996A (ja) * 1997-07-03 2002-03-12 デュポン ファーマシューティカルズ カンパニー 神経学的障害を治療するためのイミダゾピリミジン類およびイミダゾピリジン類
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists

Also Published As

Publication number Publication date
WO2000039127A1 (en) 2000-07-06
EP1140929A1 (en) 2001-10-10
DE69912153T2 (de) 2004-08-26
EP1140929B1 (en) 2003-10-15
US6518271B1 (en) 2003-02-11
CA2351724A1 (en) 2000-07-06
US6271380B1 (en) 2001-08-07
DE69912153D1 (de) 2003-11-20
ATE251930T1 (de) 2003-11-15
ES2209550T3 (es) 2004-06-16
EP1140929A4 (en) 2002-04-17
PT1140929E (pt) 2004-02-27
AU2222500A (en) 2000-07-31

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