ATE252570T1 - Verfahren zur herstellung von 5-cyanophthalid - Google Patents

Verfahren zur herstellung von 5-cyanophthalid

Info

Publication number: ATE252570T1
Authority: AT; Austria
Prior art keywords: sup; sub; cyanophthalide; alkyl; hydrogen
Prior art date: 2000-01-14

Application number

AT00900501T

Other languages

English (en)

Inventor

Hans Petersen

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-14

Filing date

2000-01-14

Publication date

2003-11-15

2000-01-14 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE252570T1 publication Critical patent/ATE252570T1/de

Links

XEEGWTLAFIZLSF-UHFFFAOYSA-N 1-oxo-3h-2-benzofuran-5-carbonitrile Chemical compound N#CC1=CC=C2C(=O)OCC2=C1 XEEGWTLAFIZLSF-UHFFFAOYSA-N 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229960001653 citalopram Drugs 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000018044 dehydration Effects 0.000 abstract 1
238000006297 dehydration reaction Methods 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
239000003999 initiator Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000002978 peroxides Chemical class 0.000 abstract 1
239000002243 precursor Chemical group 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1
125000002769 thiazolinyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Cephalosporin Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT00900501T 2000-01-14 2000-01-14 Verfahren zur herstellung von 5-cyanophthalid ATE252570T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/DK2000/000016 WO2001051477A1 (en)	2000-01-14	2000-01-14	Method for the preparation of 5-cyanophthalide

Publications (1)

Publication Number	Publication Date
ATE252570T1 true ATE252570T1 (de)	2003-11-15

Family

ID=8149377

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00900501T ATE252570T1 (de)	2000-01-14	2000-01-14	Verfahren zur herstellung von 5-cyanophthalid

Country Status (27)

Country	Link
US (1)	US6911548B2 (de)
EP (1)	EP1254129B1 (de)
JP (1)	JP2003519691A (de)
KR (1)	KR100660802B1 (de)
CN (1)	CN1195749C (de)
AT (1)	ATE252570T1 (de)
AU (1)	AU3033700A (de)
CA (1)	CA2397270C (de)
CZ (1)	CZ20022601A3 (de)
DE (1)	DE60006163T2 (de)
DK (1)	DK1254129T3 (de)
EA (1)	EA005134B1 (de)
ES (1)	ES2206177T3 (de)
HK (1)	HK1054392B (de)
HU (1)	HUP0300343A2 (de)
IL (2)	IL150561A0 (de)
IS (1)	IS2168B (de)
IT (1)	ITMI20010040A1 (de)
MX (1)	MXPA02006915A (de)
NO (1)	NO20023405L (de)
PL (1)	PL197821B1 (de)
PT (1)	PT1254129E (de)
SI (1)	SI1254129T1 (de)
SK (1)	SK286879B6 (de)
TR (1)	TR200201783T2 (de)
UA (1)	UA72569C2 (de)
WO (1)	WO2001051477A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL145615A0 (en) *	1999-04-14	2002-06-30	Lundbeck & Co As H	Method for the preparation of citalopram
NZ519739A (en)	1999-12-28	2004-03-26	H	Method for the preparation of citalopram
PT1246813E (pt)	1999-12-30	2004-02-27	Lundbeck & Co As H	Metodo para a preparacao de citalopram
WO2001051477A1 (en)	2000-01-14	2001-07-19	H. Lundbeck A/S	Method for the preparation of 5-cyanophthalide
IES20010157A2 (en)	2000-03-03	2002-03-06	Lundbeck & Co As H	Method for the preparation of citalopram
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
SK14602002A3 (sk)	2000-03-13	2003-02-04	H. Lundbeck A/S	Spôsob výroby citalopramu a medziprodukty
BR0109364A (pt)	2000-03-13	2002-12-24	Lundbeck & Co As H	Métodos para fabricação de citalopram através de alquilação escalonada de 5-substituìda 1- (4-fluorofenil) - 1,3- diidroisobenzofuranos e citalopram
NL1017500C1 (nl)	2000-03-13	2001-04-26	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
IL151488A0 (en)	2000-03-14	2003-04-10	Lundbeck & Co As H	Method for the preparation of citalopram
AR032455A1 (es)	2000-05-12	2003-11-12	Lundbeck & Co As H	Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
US6903220B2 (en)	2002-05-15	2005-06-07	Genzyme Corporation	Synthesis of chiral 2-alkyl amino acids
WO2005111010A1 (en) *	2004-05-13	2005-11-24	Suven Life Sciences Ltd,	An improved process for the preparation of 5-cyanophthalide
CN116022748B (zh) *	2022-12-16	2024-02-27	山东惟普新能源有限公司	一种含水双氟磺酰亚胺锂的除水方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1143703A (de)	1965-03-18
GB1526331A (en)	1976-01-14	1978-09-27	Kefalas As	Phthalanes
GB8419963D0 (en)	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
GB8814057D0 (en)	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
US5296507A (en)	1990-09-06	1994-03-22	H.Lundbeck A/S	Treatment of cerbrovascular disorders
DE19626659A1 (de)	1996-07-03	1998-01-08	Basf Ag	Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de)	1996-07-10	1998-01-15	Basf Ag	Verfahren zur Herstellung von Phthaliden
JP3526581B2 (ja)	1997-07-08	2004-05-17	ハー・ルンドベック・アクティーゼルスカブ	シタロプラムの製造方法
UA62985C2 (en)	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
CN1286687A (zh)	1997-11-11	2001-03-07	H·隆德贝克有限公司	制备西酞普兰的方法
WO2000023431A1 (en)	1998-10-20	2000-04-27	H. Lundbeck A/S	Method for the preparation of citalopram
HK1043130B (zh)	1998-12-23	2005-03-04	H‧隆德贝克有限公司	制备5-氰基2-苯并[c]呋喃酮的方法
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
IL145615A0 (en)	1999-04-14	2002-06-30	Lundbeck & Co As H	Method for the preparation of citalopram
ITMI991581A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
GB2360281B (en)	1999-10-25	2002-01-16	Lundbeck & Co As H	Method for the preparation of citalopram
AR026063A1 (es)	1999-11-01	2002-12-26	Lundbeck & Co As H	Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en)	1999-11-01	2001-10-30	Sumika Fine Chemicals Co., Ltd.	Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
NZ519739A (en)	1999-12-28	2004-03-26	H	Method for the preparation of citalopram
PT1246813E (pt)	1999-12-30	2004-02-27	Lundbeck & Co As H	Metodo para a preparacao de citalopram
WO2001051477A1 (en)	2000-01-14	2001-07-19	H. Lundbeck A/S	Method for the preparation of 5-cyanophthalide
NL1017415C1 (nl)	2000-02-24	2001-05-18	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en)	2000-02-24	2001-07-25	Lundbeck & Co As H	Method for the preparation of citalopram
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
IL144816A (en)	2000-08-18	2005-09-25	Lundbeck & Co As H	Method for the preparation of citalopram
TR200201166T1 (tr)	2000-12-22	2002-10-21	H.Lundbecks A/S	Saf sitalopram hazırlanması için yöntem
JP2003519121A (ja)	2000-12-28	2003-06-17	ハー・ルンドベック・アクチエゼルスカベット	純粋なシタロプラムの製造方法

2000
- 2000-01-14 WO PCT/DK2000/000016 patent/WO2001051477A1/en not_active Ceased
- 2000-01-14 HU HU0300343A patent/HUP0300343A2/hu unknown
- 2000-01-14 CN CNB008183759A patent/CN1195749C/zh not_active Expired - Fee Related
- 2000-01-14 DE DE60006163T patent/DE60006163T2/de not_active Expired - Fee Related
- 2000-01-14 JP JP2001551859A patent/JP2003519691A/ja not_active Withdrawn
- 2000-01-14 HK HK03106740.7A patent/HK1054392B/zh not_active IP Right Cessation
- 2000-01-14 PL PL356712A patent/PL197821B1/pl not_active IP Right Cessation
- 2000-01-14 CZ CZ20022601A patent/CZ20022601A3/cs unknown
- 2000-01-14 ES ES00900501T patent/ES2206177T3/es not_active Expired - Lifetime
- 2000-01-14 KR KR1020027008951A patent/KR100660802B1/ko not_active Expired - Fee Related
- 2000-01-14 IL IL15056100A patent/IL150561A0/xx active IP Right Grant
- 2000-01-14 AU AU30337/00A patent/AU3033700A/en not_active Abandoned
- 2000-01-14 MX MXPA02006915A patent/MXPA02006915A/es active IP Right Grant
- 2000-01-14 EA EA200200758A patent/EA005134B1/ru not_active IP Right Cessation
- 2000-01-14 TR TR2002/01783T patent/TR200201783T2/xx unknown
- 2000-01-14 CA CA002397270A patent/CA2397270C/en not_active Expired - Fee Related
- 2000-01-14 UA UA2002075750A patent/UA72569C2/uk unknown
- 2000-01-14 SK SK1166-2002A patent/SK286879B6/sk not_active IP Right Cessation
- 2000-01-14 PT PT00900501T patent/PT1254129E/pt unknown
- 2000-01-14 DK DK00900501T patent/DK1254129T3/da active
- 2000-01-14 EP EP00900501A patent/EP1254129B1/de not_active Expired - Lifetime
- 2000-01-14 SI SI200030247T patent/SI1254129T1/xx unknown
- 2000-01-14 AT AT00900501T patent/ATE252570T1/de not_active IP Right Cessation
2001
- 2001-01-11 IT IT2001MI000040A patent/ITMI20010040A1/it unknown
2002
- 2002-06-28 IS IS6449A patent/IS2168B/is unknown
- 2002-07-03 IL IL150561A patent/IL150561A/en not_active IP Right Cessation
- 2002-07-08 US US10/191,808 patent/US6911548B2/en not_active Expired - Fee Related
- 2002-07-15 NO NO20023405A patent/NO20023405L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
IS2168B (is)	2006-11-15
NO20023405L (no)	2002-08-30
TR200201783T2 (tr)	2002-12-23
HK1054392B (zh)	2005-11-18
NO20023405D0 (no)	2002-07-15
SI1254129T1 (en)	2004-02-29
MXPA02006915A (es)	2002-10-23
KR100660802B1 (ko)	2006-12-26
EP1254129A1 (de)	2002-11-06
IS6449A (is)	2002-06-28
DE60006163D1 (de)	2003-11-27
CA2397270C (en)	2007-08-21
ITMI20010040A1 (it)	2002-07-11
EP1254129B1 (de)	2003-10-22
SK11662002A3 (sk)	2003-01-09
US6911548B2 (en)	2005-06-28
AU3033700A (en)	2001-07-24
CN1423643A (zh)	2003-06-11
WO2001051477A1 (en)	2001-07-19
PT1254129E (pt)	2004-03-31
US20030013895A1 (en)	2003-01-16
PL356712A1 (en)	2004-06-28
KR20020073501A (ko)	2002-09-26
ES2206177T3 (es)	2004-05-16
CA2397270A1 (en)	2001-07-19
CZ20022601A3 (cs)	2002-10-16
HK1054392A1 (en)	2003-11-28
SK286879B6 (sk)	2009-07-06
PL197821B1 (pl)	2008-04-30
DK1254129T3 (da)	2004-03-29
HUP0300343A2 (hu)	2003-06-28
IL150561A0 (en)	2003-02-12
JP2003519691A (ja)	2003-06-24
DE60006163T2 (de)	2004-04-15
EA005134B1 (ru)	2004-12-30
CN1195749C (zh)	2005-04-06
EA200200758A1 (ru)	2002-12-26
UA72569C2 (uk)	2005-03-15
IL150561A (en)	2007-07-04

Legal Events

Date

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Title

Description

2004-06-15

UEP

Publication of translation of european patent specification

Ref document number: 1254129

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REN

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Publication	Publication Date	Title
BG105457A (en)	2001-12-29	Method for the preparation of citalopram
DE60006163D1 (de)	2003-11-27	Verfahren zur herstellung von 5-cyanophthalid
WO2002003984A3 (en)	2003-03-06	Anticonvulsant derivatives useful for treating and preventing the development of type ii diabetes mellitus and syndrome x
EA200500037A1 (ru)	2005-06-30	Фенилбензамиды
EA199900301A2 (ru)	1999-10-28	Замещенные трициклические соединения
KR970027031A (ko)	1997-06-24	일차 또는 이차 알콜의 산화방법
EA199900304A2 (ru)	1999-10-28	Замещенные трициклические соединения
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