TR200201166T1 - Saf sitalopram hazırlanması için yöntem - Google Patents

Saf sitalopram hazırlanması için yöntem

Info

Publication number
TR200201166T1
TR200201166T1 TR2002/01166T TR200201166T TR200201166T1 TR 200201166 T1 TR200201166 T1 TR 200201166T1 TR 2002/01166 T TR2002/01166 T TR 2002/01166T TR 200201166 T TR200201166 T TR 200201166T TR 200201166 T1 TR200201166 T1 TR 200201166T1
Authority
TR
Turkey
Prior art keywords
citalopram
treated
preparation
amide
subjected
Prior art date
Application number
TR2002/01166T
Other languages
English (en)
Inventor
Villa Marco
Sbrogio Federico
Dancer Robert
Original Assignee
H.Lundbecks A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H.Lundbecks A/S filed Critical H.Lundbecks A/S
Publication of TR200201166T1 publication Critical patent/TR200201166T1/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Mevcut bulus sitalopram (I)'in hazirlanmasi ve saflastirilmasi için bir yöntem ile ilgili olup, formülde Z'nin iyodo, bromo, kloro ya da n'nin 0,1,2,3,4,5,6,7 ya da 8 oldugu CF3-(CF2)n-SO2-O-'yu ifade ettigi formül (II)'ye göre olan bir bilesik bir siyanid kaynagi ile bir siyanid degisim tepkimesine tabi tutulmakta, sonuçta elde edilen ham sitalopram ürün istege bagli olarak bazi birincil saflastirma islemine tabi tutulmakta ve ardindan bir amid veya bir amid benzeri grup olusturucu madde ile muamele edilmekte; tepkime karisimi bir asit/baz yikamasina ve/veya sitalopram'in kristalizasyon ve yeniden kristalizasyonuna tabi tutulmakta ve bu sekilde ham sitalopram karisimindan olusan amidler uzaklastirilmakta; ve sonuçta ortaya çikan sitalopram ürünü daha sonra istege bagli olarak ayrica saflastirilmakta, islenmekte ve baz ya da onun farmasötik olarak kabul edilebilir olan tuzu olarak izole edilmektedir.
TR2002/01166T 2000-12-22 2001-03-07 Saf sitalopram hazırlanması için yöntem TR200201166T1 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001929 2000-12-22

Publications (1)

Publication Number Publication Date
TR200201166T1 true TR200201166T1 (tr) 2002-10-21

Family

ID=8159922

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/01166T TR200201166T1 (tr) 2000-12-22 2001-03-07 Saf sitalopram hazırlanması için yöntem

Country Status (43)

Country Link
US (1) US6455710B1 (tr)
EP (2) EP1181713B1 (tr)
JP (1) JP3798982B2 (tr)
KR (1) KR100439329B1 (tr)
CN (1) CN1282648C (tr)
AR (1) AR030056A1 (tr)
AT (2) ATE277920T1 (tr)
AU (2) AU2001100405B4 (tr)
BE (2) BE1013212A6 (tr)
BG (1) BG65131B1 (tr)
BR (1) BR0106272A (tr)
CA (1) CA2360303C (tr)
CH (1) CH691535A5 (tr)
CZ (1) CZ292200B6 (tr)
DE (2) DE60105926T2 (tr)
DK (1) DK1181713T3 (tr)
EA (1) EA003581B1 (tr)
ES (2) ES2228824T3 (tr)
FI (2) FI108639B (tr)
FR (1) FR2812877B1 (tr)
GB (1) GB2357763B (tr)
GR (1) GR1003874B (tr)
HK (1) HK1048812B (tr)
HR (1) HRP20020004A2 (tr)
HU (2) HU0101029D0 (tr)
IE (1) IES20010254A2 (tr)
IL (1) IL147226A (tr)
IS (1) IS2060B (tr)
IT (1) ITMI20010602A1 (tr)
MX (1) MXPA01013151A (tr)
NL (2) NL1017525C1 (tr)
NO (1) NO20011271A (tr)
NZ (1) NZ516298A (tr)
PL (1) PL205724B1 (tr)
PT (1) PT1181713E (tr)
SE (1) SE517623C2 (tr)
SG (1) SG167655A1 (tr)
SI (1) SI1181713T1 (tr)
SK (2) SK286283B6 (tr)
TR (1) TR200201166T1 (tr)
UA (1) UA71634C2 (tr)
WO (1) WO2001045483A2 (tr)
ZA (1) ZA200110179B (tr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
IL145615A0 (en) * 1999-04-14 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
NZ519739A (en) 1999-12-28 2004-03-26 H Method for the preparation of citalopram
PT1246813E (pt) 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
WO2001051477A1 (en) 2000-01-14 2001-07-19 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
SK14602002A3 (sk) 2000-03-13 2003-02-04 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
BR0109364A (pt) 2000-03-13 2002-12-24 Lundbeck & Co As H Métodos para fabricação de citalopram através de alquilação escalonada de 5-substituìda 1- (4-fluorofenil) - 1,3- diidroisobenzofuranos e citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IL151488A0 (en) 2000-03-14 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
TR200202168T2 (tr) * 2000-03-16 2002-12-23 H. Lundbeck A/S 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144816A (en) 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
JP2003519121A (ja) 2000-12-28 2003-06-17 ハー・ルンドベック・アクチエゼルスカベット 純粋なシタロプラムの製造方法
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
HRP20030811A2 (en) * 2001-03-09 2005-08-31 Ranbaxy Laboratories Limited Process for the preparation of citalopram
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
CA2465186A1 (en) * 2001-11-08 2003-05-15 Sepracor, Inc. Methods for treating depression and other cns disorders using enantiomerically enriched desmethyl- and didesmethyl-metabolites of citalopram
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
MXPA05005155A (es) * 2002-11-15 2005-07-22 Akzo Nobel Nv Tratamiento de purificacion/decoloracion para nitrilos grasos.
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
EP1486492A3 (en) * 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran.
WO2005042473A1 (en) * 2003-10-28 2005-05-12 Wockhardt Limited Improved process for the manufacture of citalopram hydrobromide
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
CN114763343B (zh) * 2021-01-14 2026-02-10 浙江华海药业股份有限公司 一种西酞普兰或s-西酞普兰的纯化方法

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US4943591A (en) 1984-10-17 1990-07-24 Glaxo Group Limited Dichloroaniline derivatives
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) * 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
EP0993524B1 (en) * 1997-06-30 2002-11-20 Beloit Technologies, Inc. Method and apparatus for the high speed application of coating to a traveling paper web
JP3526581B2 (ja) 1997-07-08 2004-05-17 ハー・ルンドベック・アクティーゼルスカブ シタロプラムの製造方法
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
CN1286687A (zh) * 1997-11-11 2001-03-07 H·隆德贝克有限公司 制备西酞普兰的方法
WO2000023431A1 (en) * 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
HK1043130B (zh) 1998-12-23 2005-03-04 H‧隆德贝克有限公司 制备5-氰基2-苯并[c]呋喃酮的方法
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
IL145615A0 (en) 1999-04-14 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IL144816A (en) 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
JP2003519121A (ja) 2000-12-28 2003-06-17 ハー・ルンドベック・アクチエゼルスカベット 純粋なシタロプラムの製造方法

Also Published As

Publication number Publication date
FR2812877B1 (fr) 2003-04-04
DE60105926D1 (de) 2004-11-04
WO2001045483A2 (en) 2001-06-28
IS5883A (is) 2001-06-20
HK1048812A1 (en) 2003-04-17
HRP20020004A2 (en) 2003-04-30
SE0103045D0 (sv) 2001-09-14
NO20011271D0 (no) 2001-03-13
BG65131B1 (bg) 2007-03-30
ZA200110179B (en) 2002-12-11
MXPA01013151A (es) 2002-08-12
IL147226A0 (en) 2002-08-14
PL205724B1 (pl) 2010-05-31
ES2170732A1 (es) 2002-08-01
DE60105926T2 (de) 2005-11-24
HU0101029D0 (en) 2001-05-28
AU2001100405A4 (en) 2001-11-01
HU0102817D0 (en) 2001-09-28
ITMI20010602A0 (it) 2001-03-22
DK1181713T3 (da) 2005-01-31
CN1282648C (zh) 2006-11-01
BR0106272A (pt) 2004-06-15
NO312462B1 (no) 2002-05-13
GB2357763B (en) 2002-01-16
SE0103045L (sv) 2002-06-23
SI1181713T1 (en) 2005-02-28
AT4367U1 (de) 2001-06-25
EA003581B1 (ru) 2003-06-26
CZ2001890A3 (cs) 2002-08-14
NL1017525C1 (nl) 2001-04-26
IES20010254A2 (en) 2002-03-06
SE517623C2 (sv) 2002-06-25
CZ292200B6 (cs) 2003-08-13
ES2228824T3 (es) 2005-04-16
CH691535A5 (de) 2001-08-15
ITMI20010602A1 (it) 2002-09-22
CA2360303C (en) 2003-08-12
BE1013212A6 (fr) 2001-10-02
KR20020065345A (ko) 2002-08-13
PT1181713E (pt) 2005-02-28
NO20011271A (no) 2002-05-13
FI20011577A0 (fi) 2001-07-26
DE10112829C1 (de) 2002-07-25
NZ516298A (en) 2002-12-20
US20020120005A1 (en) 2002-08-29
ES2170732B2 (es) 2003-09-16
HUP0102817A3 (en) 2003-07-28
WO2001045483A3 (en) 2001-12-27
PL353398A1 (en) 2003-11-17
SG167655A1 (en) 2011-01-28
SK18482001A3 (sk) 2002-05-09
NL1018360C1 (nl) 2001-10-04
FR2812877A1 (fr) 2002-02-15
IS2060B (is) 2005-11-15
BE1013213A6 (fr) 2001-10-02
GB0105983D0 (en) 2001-05-02
HUP0102817A2 (hu) 2001-12-28
FI109024B (fi) 2002-05-15
FI20010500A0 (fi) 2001-03-13
GB2357763A (en) 2001-07-04
BG106203A (bg) 2002-08-30
EP1181713B1 (en) 2004-09-29
EP1181713A2 (en) 2002-02-27
JP3798982B2 (ja) 2006-07-19
AU2001100405B4 (en) 2002-03-21
EP1462447A3 (en) 2004-11-17
HK1048812B (zh) 2007-06-01
SK284428B6 (sk) 2005-04-01
IL147226A (en) 2006-04-10
SK286283B6 (sk) 2008-06-06
EA200200018A1 (ru) 2002-04-25
US6455710B1 (en) 2002-09-24
UA71634C2 (uk) 2004-12-15
GR1003874B (el) 2002-04-24
KR100439329B1 (ko) 2004-07-07
AR030056A1 (es) 2003-08-13
ATE277920T1 (de) 2004-10-15
AU3920101A (en) 2001-07-03
EP1462447A2 (en) 2004-09-29
JP2003517484A (ja) 2003-05-27
CN1366525A (zh) 2002-08-28
FI108639B (fi) 2002-02-28
CA2360303A1 (en) 2001-06-28

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